assoc_id FEATURE Drug id Drug name Drug Target N_FEATURE_pos N_FEATURE_neg log max.Conc.tested log max.Conc.tested2 FEATUREpos_logIC50_MEAN FEATUREneg_logIC50_MEAN FEATURE_deltaMEAN_IC50 FEATUREpos_IC50_sd FEATUREneg_IC50_sd FEATURE_IC50_effect_size FEATUREpos_Glass_delta FEATUREneg_Glass_delta FEATURE_ANOVA_pval Tissue_ANOVA_pval MEDIA_ANOVA_pval MSI_ANOVA_pval FEATURE_IC50_T_pval ANOVA FEATURE FDR % a1 loss_cnaBLCA18_(CHD9,CNOT1,CYLD,MMP2,NUP93) 1230 IOX2 EGLN1 3 16 -2.30258509299405 NA -1.36676151347767 0.0769253277664631 -1.44368684124413 1.02822231512369 0.276575909255955 3.29581191487871 1.40406098954433 5.21985752529185 6.67356877345832e-05 NA NA NA 0.133693112957712 10.6609031962839 a2 TP53_mut 136 Mitomycin C DNA crosslinker 15 4 2.77258872223978 NA -1.83609809498663 1.10585433296728 -2.94195242795391 1.09126554462168 0.72383988124717 2.83988994834799 2.69590883946934 4.06436907411754 9.94064347362696e-05 NA NA NA 0.000327147319037585 10.6609031962839 a3 gain_cnaBLCA15_(ASXL1) 269 NSC-207895 MDM4 6 13 2.99573227355399 NA 5.00912119505505 2.95612444420083 2.05299675085422 1.19564405398256 0.687034512959628 2.36485168684453 1.71706348893377 2.98820031909351 0.000169872343309715 NA NA NA 0.00652154408538659 12.1453747775009 a4 ARID1A_mut 1529 MLN4924 NEDD8-activating enzyme 3 13 0 NA 2.21133019122593 -0.795990022047968 3.0073202132739 0.689219388161304 1.12445960214007 2.80234312236465 4.36337146767854 2.67445820868118 0.000634454496037445 NA NA NA 0.00205124737065481 24.2194996486581 a5 TP53_mut 133 Doxorubicin DNA intercalating 15 4 0.0237165266173161 NA -2.68805629083123 0.220591693140499 -2.90864798397173 1.21455006819961 1.42480540989218 2.31909327101513 2.39483579979817 2.04143524707127 0.000713356805306145 NA NA NA 0.0181625943391 24.2194996486581 a6 TP53_mut 135 Gemcitabine DNA replication 15 4 0.0237165266173161 NA -3.36177649273382 1.45855930720397 -4.82033579993778 2.20517284972969 1.37557444846508 2.31421734445393 2.18592197909958 3.50423476193273 0.000726847145633068 NA NA NA 0.000722545312400782 24.2194996486581 a7 ARID1A_mut 305 TPCA-1 IKK 5 14 2.99573227355399 NA 5.31030710318302 2.93625465326342 2.3740524499196 0.73853292731376 1.22706565413497 2.09859333149387 3.21455193413605 1.9347395487108 0.000872445272902502 NA NA NA 0.00025194916295768 24.2194996486581 a8 ARID1A_mut 228 KIN001-102 AKT1 5 14 2.32630161961136 NA 4.79710140315386 2.83019716137155 1.96690424178231 0.609144821076602 1.02536856583093 2.08338789193507 3.22895996769045 1.91824121328353 0.000929384897419016 NA NA NA 0.000245553486637054 24.2194996486581 a9 TP53_mut 134 Etoposide TOP2 15 4 2.77258872223978 NA 0.642094801060813 3.10145022422518 -2.45935542316437 1.13690941995858 0.93708508847631 2.22711837686413 2.16319381297233 2.62447397083572 0.00101624443077571 NA NA NA 0.00505560682904014 24.2194996486581 a10 gain_cnaBLCA15_(ASXL1) 268 YM155 BIRC5 (Survivin) 6 13 1.63315443905142 NA -1.7897969575336 -4.79475197700984 3.00495501947624 2.62428197260135 0.863437158657185 1.88111280080165 1.14505798189725 3.4802243444671 0.0013958475035831 NA NA NA 0.0369850353317671 27.5807579457029 a11 ARID1A_mut 1003 Camptothecin TOP1 3 11 -2.30258509299405 NA -1.4353855789293 -5.02948346115341 3.59409788222411 1.90643274769261 1.19293498570153 2.68511071813892 1.88524766298423 3.01281957969447 0.00141445581141205 NA NA NA 0.0696271470837319 27.5807579457029 a12 TP53_mut 201 Epothilone B Microtubules 15 4 -3.44201937618241 NA -6.0446846740599 -2.22332185900217 -3.82136281505773 1.84260642657402 1.72060997955301 2.09772343966417 2.07388987683215 2.22093493613844 0.00167386325867264 NA NA NA 0.0114919505969154 28.5782581856836 a13 ARID1A_mut 245 UNC0638 G9a(EHMT2), GLP(EHMT1) 5 14 3.68887945411394 NA 5.27145512408846 3.5482408076767 1.72321431641176 1.33732767741423 0.710151568368014 1.91887610877426 1.28855055160726 2.42654440709305 0.00184409263139157 NA NA NA 0.0420016080962035 28.5782581856836 a14 ARID1A_mut 331 QL-X-138 MNK2, PRKDC (DNAPK), MTOR, BTK, JAK3 5 14 2.32630161961136 NA 3.54734243949338 1.53191176654758 2.0154306729458 1.34337930339186 0.967271376845088 1.88754328943818 1.50026925966263 2.08362484530397 0.00210130434415007 NA NA NA 0.0238628835999973 28.5782581856836 a15 ARID1A_mut 306 TG101348 JAK2 5 14 2.32630161961136 NA 4.00004807130919 2.64018379272598 1.35986427858321 0.376241596507203 0.80160533937991 1.87735319204138 3.61433794457434 1.69642617355212 0.00219243737395262 NA NA NA 0.000154860503766716 28.5782581856836 a16 ARID1A_mut 299 OSI-027 MTORC1/2 5 14 2.99573227355399 NA 3.81756177355635 1.20772991742923 2.60983185612712 1.40924791939963 1.41097802133815 1.85019514554277 1.85193238194665 1.84966159405658 0.00245501173772279 NA NA NA 0.00909094729430842 28.5782581856836 a17 ARID1A_mut 222 BX-912 PDPK1 (PDK1) 5 14 2.32630161961136 NA 4.88248143565402 2.7401061182582 2.14237531739582 0.525783980790256 1.29718553599978 1.84262829419687 4.07463025818288 1.65155658765855 0.00253359260717592 NA NA NA 9.60565729592787e-05 28.5782581856836 a18 ARID1A_mut 208 SB-715992 KIF11 5 14 -2.05572501506252 NA 0.464102883873875 -1.74890934583912 2.21301222971299 0.462353605439876 1.36574077599071 1.8211378354692 4.78640634284135 1.6203750145101 0.0027706702471364 NA NA NA 6.19235210863797e-05 28.5782581856836 a19 ARID1A_mut 179 5-Fluorouracil DNA antimetabolite 5 14 3.46573590279973 NA 5.5141884122335 3.82027156418092 1.69391684805259 0.743975604744536 0.981314943266888 1.81959607712594 2.27684461325078 1.72617044066748 0.00278850237726803 NA NA NA 0.00285803425535264 28.5782581856836 a20 gain_cnaBLCA15_(ASXL1) 328 SNX-2112 HSP90 6 12 0.940007258491471 NA 1.39905090592467 -1.38875502306224 2.78780592898691 1.63177433010872 1.55612010480211 1.76426530164058 1.70845065861599 1.79151077116984 0.00279022957720535 NA NA NA 0.00632971777200627 28.5782581856836 a21 ARID1A_mut 238 CAL-101 PI3Kdelta 5 14 2.99573227355399 2.32630161961136 5.73460705218273 4.50179859036142 1.23280846182131 0.26646181054091 0.7608956647387 1.81878010272115 4.62658592358412 1.62020697311329 0.00279798609944395 NA NA NA 6.8361637369385e-05 28.5782581856836 a22 ARID1A_mut 263 FR-180204 ERK 5 14 2.99573227355399 NA 5.73149100926969 4.79082012669198 0.940670882577712 0.275816207081688 0.577451761214895 1.8007055638235 3.41049894250455 1.62900340038559 0.00301646644433574 NA NA NA 0.000251969959965132 29.2813164859291 a23 NRAS_mut 186 Bexarotene Retinioic acid X family agonist 3 16 2.07944154167984 NA 2.12317381834113 3.80873023986377 -1.68555642152264 0.0763485211774764 0.836398792745048 2.14421145668375 22.0771325433333 2.01525448881946 0.00334860651056773 NA NA NA 6.32234946732545e-07 29.2813164859291 a24 gain_cnaBLCA15_(ASXL1) 1498 AZD6244 MAP2K1 (MEK1), MAP2K2 (MEK2) 6 13 1.38629436111989 NA 0.261413396384888 1.88234748254215 -1.62093408615726 0.993301708823914 0.953632179981647 1.67890864364595 1.63186479169202 1.69974768069222 0.00339517434494697 NA NA NA 0.00799168586520316 29.2813164859291 a25 ARID1A_mut 257 NPK76-II-72-1 PLK3 5 14 2.32630161961136 NA 4.85620227937481 2.95778996671116 1.89841231266365 0.531536893147413 1.19537225422449 1.76325676309131 3.571553239555 1.58813483076472 0.00352441404185804 NA NA NA 0.000219955571126346 29.2813164859291 a26 ARID1A_mut 260 NG-25 MAP3K7 (TAK1) 5 14 2.32630161961136 NA 4.61623963346205 2.56451919058458 2.05172044287746 1.16218066933405 1.16550108508169 1.7615558039983 1.76540575576183 1.76037626145467 0.00354939594653175 NA NA NA 0.0113980314430243 29.2813164859291 a27 ARID1A_mut 312 AV-951 VEGFR 5 14 -2.05572501506252 NA 0.795724189537795 0.27121623547426 0.524507954063535 0.300910882794111 0.300513371304367 1.74482976133504 1.74306741315971 1.74537309866423 0.00380457221170566 NA NA NA 0.0120976121465845 30.223973863704 a28 ARID1A_mut 277 ABT-869 VEGFR and PDGFR family 5 14 0.0237165266173161 NA 2.79351133615816 2.16850506670526 0.625006269452902 0.315110786989703 0.379105624942259 1.71207072615893 1.98344929865357 1.64863359531554 0.00435799213066846 NA NA NA 0.00629852383301193 33.3839643555158 a29 EP300_mut 1038 NU-7441 PRKDC (DNAPK) 4 11 0.693147180559945 NA 1.0019831475679 2.63519474919849 -1.63321160163059 0.679511436259828 0.855048580831379 1.99685795205377 2.40350863058336 1.91008047758244 0.00456345219059833 NA NA NA 0.00687592740628995 33.7524268503035 a30 ARID1A_mut 271 VNLG/124 HDAC, RAR 5 14 1.63315443905142 NA 4.42162518714572 3.77428979802673 0.647335389118997 0.310511466988707 0.405902364900166 1.67883351132039 2.08473907709998 1.59480566041593 0.00500050544871211 NA NA NA 0.00484389148453386 35.7069904590587 a31 ARID1A_mut 281 CH5424802 ALK 5 14 1.63315443905142 NA 4.45370769881723 3.96773365303266 0.48597404578457 0.328163359832011 0.279874276229341 1.66454636168591 1.48089063335207 1.73640125963682 0.00530454192708411 NA NA NA 0.0245445428956268 35.7069904590587 a32 ARID1A_mut 261 TL-1-85 MAP3K7 (TAK1) 5 14 2.32630161961136 NA 4.71304684104597 3.12278805255724 1.59025878848873 0.592705259039801 1.04524996221352 1.65964135911128 2.68305159138455 1.52141482514006 0.00541305487356654 NA NA NA 0.00120126746413877 35.7069904590587 a33 RB1_mut 178 BAY 61-3606 SYK 6 13 2.07944154167984 NA 0.934934096541879 2.8082442192473 -1.87331012270542 0.861315190362188 1.31640450545096 1.56031533715182 2.17494146587346 1.42305052508437 0.00570134598313919 NA NA NA 0.00226092287228005 35.7069904590587 a34 ARID1A_mut 223 ZSTK474 PI3K 5 14 1.63315443905142 2.32630161961136 3.1732131200867 1.18031646915683 1.99289665092988 0.596170316214973 1.34781958907487 1.64214678368599 3.34283106140303 1.47860786939429 0.00581813024331753 NA NA NA 0.000419622621250957 35.7069904590587 a35 ARID1A_mut 310 YM201636 FYV1 5 14 1.63315443905142 NA 3.97124401269369 2.37629217204142 1.59495184065227 0.646922474166925 1.05363677624578 1.63862023311457 2.46544509480238 1.51375870376816 0.00590331548221658 NA NA NA 0.00196059099171329 35.7069904590587 a36 ARID1A_mut 287 KIN001-244 PDPK1 (PDK1) 5 14 2.99573227355399 NA 4.83196294864105 3.27454326464124 1.55741968399981 1.01687139822005 0.931897663313833 1.63495983204323 1.53157979143276 1.67123467019073 0.00599302722519957 NA NA NA 0.0213698100693957 35.7069904590587 a37 MLL2_mut 1038 NU-7441 PRKDC (DNAPK) 3 12 0.693147180559945 NA 0.791472777789244 2.5517213748406 -1.76024859705136 0.653235021493615 0.86501870256927 2.10572103663614 2.69466354242087 2.03492547828514 0.00618174201284331 NA NA NA 0.0176819087346797 35.8359275548328 a38 TP53_mut 184 BMS-754807 IGF1R 15 4 0.940007258491471 NA 0.392289588297056 2.81063279013677 -2.41834320183971 1.50709578989883 0.617619491338935 1.73724164351671 1.60463801839832 3.91558756767375 0.00668593889535385 NA NA NA 0.00030414737106038 37.7388189092699 a39 gain_cnaBLCA15_(ASXL1) 276 CAY10603 HDAC6 6 13 2.99573227355399 NA 2.26734795713866 0.780892227585981 1.48645572955268 1.39654711407909 0.740153267701975 1.51684537590244 1.06437922112844 2.00830800108175 0.00688656904936931 NA NA NA 0.0474648523631075 37.8081658578172 a40 TP53_mut 204 Tipifarnib Farnesyl-transferase (FNTA) 15 4 2.77258872223978 NA 0.910440483154433 2.7128621990683 -1.80242171591387 0.937415112247908 1.44856382064557 1.72327239062797 1.9227572634195 1.24428188128473 0.00705076277806037 NA NA NA 0.0829632777831272 37.8081658578172 a41 ARID1A_mut 229 LY317615 PRKCB (PKCbeta) 5 14 2.99573227355399 2.32630161961136 5.38665384379665 3.23241603588104 2.15423780791562 0.762503381386389 1.50769048335398 1.57319970530596 2.82521738329706 1.42883292804458 0.00772411280903606 NA NA NA 0.00106971615595743 40.4086413828475 a42 loss_cnaBLCA5_(FAT1,IRF2) 1149 TW 37 BCL2, BCL2L1 5 14 1.6094379124341 NA -1.97498339562813 -0.0678047665193492 -1.90717862910878 1.60466633228962 1.10544995199546 1.53667017621939 1.18852037381972 1.72525099455304 0.00896836038613092 NA NA NA 0.0535817729679912 45.4356136209094 a43 ARID1A_mut 254 AC220 FLT3 5 14 0.0237165266173161 NA 2.86608485499822 2.20822004344994 0.657864811548288 0.283287823123205 0.466347849990219 1.52871443994531 2.32224881498763 1.41067405277431 0.00926413253143028 NA NA NA 0.00301667351188567 45.4356136209094 a44 ARID1A_mut 158 PF-562271 FAK 5 14 0.940007258491471 NA 2.61510100744756 1.36813471548107 1.24696629196649 0.948768012413224 0.77280443752673 1.52511392845228 1.31430051988661 1.61355995309403 0.00940108298254996 NA NA NA 0.0383171319494812 45.4356136209094 a45 RB1_mut 1526 RDEA119 (rescreen) MAP2K1 (MEK1), MAP2K2 (MEK2) 6 13 1.6094379124341 NA 2.22729438865202 1.0764208751864 1.15087351346562 0.500259328129914 0.893676528861232 1.44156355307252 2.30055383028609 1.28779650835422 0.00953233757322572 NA NA NA 0.0024719512881528 45.4356136209094 a46 EP300_mut 1494 SN-38 TOP1 4 14 -2.99573227355399 NA -6.7144249997275 -4.37807999447661 -2.33634500525089 0.271566907316272 1.55933166185981 1.65642664762578 8.60320216605015 1.4982989587118 0.00998172414219692 NA NA NA 8.1003056701392e-05 45.6245948864413 a47 CDKN1A_mut 199 Pazopanib VEGFR, PDGFRA, PDGFRB, KIT 3 16 2.07944154167984 NA 1.10176894831518 3.19501188787997 -2.09324293956479 1.36894850318648 1.11514615306248 1.82350704027431 1.52908815393156 1.87710187926148 0.00999740720044471 NA NA NA 0.103822886052288 45.6245948864413 a48 ARID1A_mut 346 THZ-2-102-1 CDK7 5 14 0.916290731874155 2.99573227355399 1.92855991575786 -1.12895174662723 3.05751166238509 2.10899444446199 2.01096357120596 1.50286546549301 1.44974856164928 1.5204212081035 0.0102919380981412 NA NA NA 0.026699669029698 45.9902135014053 a49 ARID1A_mut 279 BIX02189 MAP2K5 (MEK5) 5 14 2.99573227355399 NA 5.68734231139626 4.33230237539878 1.35503993599748 0.28660550491516 1.02750270648317 1.49033774936967 4.72789221685952 1.31877018663568 0.0108290041218501 NA NA NA 0.000349419578211939 46.3519093804003 a50 RB1_mut 1054 PD-0332991 CDK4, CDK6 5 10 1.38629436111989 0.693147180559945 3.42988185738249 1.20749985509506 2.22238200228743 0.88443252899443 1.53517337355525 1.62417486151442 2.51277732266836 1.44764235790561 0.0109447497602595 NA NA NA 0.00376650625598557 46.3519093804003 a51 EP300_mut 1259 BMN-673 PARP1 3 15 2.30258509299405 NA -0.130509887571438 2.30686140490447 -2.43737129247591 0.539039990682235 1.43232904678981 1.8010476448021 4.52168917818334 1.70168390981013 0.0116360718102247 NA NA NA 0.000683965597240468 46.3519093804003 a52 ARID1A_mut 1007 Docetaxel Microtubules 3 11 -4.38202663467388 NA -3.8593728063875 -6.30558341867444 2.44621061228694 0.3957727996241 1.37391935727595 1.93441237202671 6.18084571403168 1.78046156736375 0.0117033327854141 NA NA NA 0.000257701856965716 46.3519093804003 a53 ARID1A_mut 266 Zibotentan, ZD4054 Endothelin A Receptor 5 14 2.99573227355399 NA 5.80721259120209 5.33666424607611 0.470548345125978 0.327196173159922 0.317632260464498 1.47088500145063 1.43812300914653 1.48142491709708 0.0117170530444661 NA NA NA 0.0276170186202849 46.3519093804003 a54 TP53_mut 167 OSU-03012 PDPK1 (PDK1) 15 4 2.77258872223978 NA 1.3465188786069 3.85647648802343 -2.50995760941653 1.536585110276 1.78512729484558 1.58528667608172 1.63346474766093 1.40603844704176 0.0118694667747876 NA NA NA 0.0582246087728334 46.3519093804003 a55 gain_cnaBLCA15_(ASXL1) 273 CUDC-101 HDAC, EGFR 6 13 1.63315443905142 NA 1.09801519122148 -0.587025960641414 1.68504115186289 1.37865026891015 1.1366646100823 1.38931325907378 1.2222397440904 1.48244357826966 0.0119240699486223 NA NA NA 0.0301264642905186 46.3519093804003 a56 ARID1A_mut 303 PIK-93 PI4K, PI3K 5 14 2.99573227355399 NA 4.80510141367215 2.81575179829615 1.989349615376 1.18567415394054 1.4339366082994 1.44203086246103 1.67782152353112 1.38733442180216 0.0131649254749665 NA NA NA 0.014845057300953 46.3519093804003 a57 ARID1A_mut 249 XL-184 VEGFR, MET, RET, KIT, FLT1, FLT3, FLT4, Tie2,AXL 5 14 1.63315443905142 NA 3.9376690526295 2.75735332530576 1.18031572732373 0.587193793845069 0.87917004443521 1.43962317781355 2.01009571234528 1.34253405788181 0.0132932409146204 NA NA NA 0.00661613627358658 46.3519093804003 a58 TP53_mut 1006 Cytarabine DNA synthesis 9 4 0.693147180559945 NA -0.240309395732824 1.16266081263397 -1.40297020836679 0.846350508340709 0.627551494618379 1.76988453465709 1.65767042678021 2.23562563454646 0.0133216994348416 NA NA NA 0.0106907244780496 46.3519093804003 a59 EP300_mut 1030 KU-55933 ATM 4 11 2.30258509299405 NA 2.5623265253212 3.83585362412564 -1.27352709880444 0.497775627439928 0.830690891343521 1.6608284457244 2.55843602740098 1.53309385244937 0.013801786372519 NA NA NA 0.00539725798405085 46.3519093804003 a60 loss_cnaBLCA18_(CHD9,CNOT1,CYLD,MMP2,NUP93) 222 BX-912 PDPK1 (PDK1) 3 16 2.32630161961136 NA 1.45587010509351 3.65039265741277 -2.19452255231925 1.09648420948873 1.29921366689108 1.7184518442313 2.00141737868028 1.68911596933134 0.0142117881668552 NA NA NA 0.050314779356736 46.3519093804003 a61 MLL2_mut 245 UNC0638 G9a(EHMT2), GLP(EHMT1) 3 16 3.68887945411394 NA 5.44961233366571 3.73023812043244 1.71937421323327 0.792396660752868 1.0303987284604 1.71026325946373 2.16984030649457 1.66864939342688 0.0146040416215797 NA NA NA 0.0384964520488707 46.3519093804003 a62 ARID1A_mut 286 KIN001-236 TIE2 5 14 2.32630161961136 NA 5.06307643342953 4.06753047398973 0.995545959439797 0.339299971299666 0.784176042954548 1.41168845630968 2.93411742897125 1.26954396067606 0.014872697447902 NA NA NA 0.00142919354562347 46.3519093804003 a63 TP53_mut 180 Thapsigargin sarco-endoplasmic reticulum Ca2+-ATPases 15 4 -0.669430653942629 NA -4.8218964814417 -2.64136462092117 -2.18053186052053 1.32515330590448 1.85385382388362 1.5219724449175 1.64549403514653 1.17621563924202 0.0150294910590125 NA NA NA 0.0944395152810695 46.3519093804003 a64 ARID1A_mut 332 XMD15-27 CAMK2B, CLK2, DYRK1A, MAST1, STK39 5 14 2.32630161961136 NA 5.2022925046811 4.60237747472251 0.59991502995859 0.311431249796242 0.455916264041725 1.40710211750958 1.92631609817927 1.31584476640581 0.0151486550569826 NA NA NA 0.00825315926956017 46.3519093804003 a65 ARID1A_mut 292 Masitinib KIT 5 14 2.99573227355399 NA 5.07776659462026 3.98505085293666 1.0927157416836 1.01835325251726 0.686836605118005 1.40513193070187 1.07302229259103 1.59093987353202 0.0152687013736524 NA NA NA 0.0729910371622211 46.3519093804003 a66 gain_cnaBLCA15_(ASXL1) 1014 RDEA119 MAP2K1 (MEK1), MAP2K2 (MEK2) 4 11 1.6094379124341 NA -0.147911076487084 1.53483778955632 -1.6827488660434 1.44278451830129 0.872433209386819 1.62992522161976 1.16632029571862 1.92879964671004 0.0152741975905133 NA NA NA 0.0965432007785613 46.3519093804003 a67 ARID1A_mut 326 GSK690693 AKT 5 14 2.32630161961136 NA 5.10133443661916 3.96251838395199 1.13881605266717 0.368449531713433 0.905209608068915 1.40333256113284 3.09083322041756 1.25806889643671 0.0153791356513614 NA NA NA 0.00124788135579056 46.3519093804003 a68 loss_cnaBLCA18_(CHD9,CNOT1,CYLD,MMP2,NUP93) 290 KIN001-260 IKK 3 16 2.99573227355399 NA 3.58290867077841 5.27870369473059 -1.69579502395218 1.92948911542234 0.800930629266437 1.69240343186364 0.878882917969189 2.1172807756214 0.0154959174817105 NA NA NA 0.265410949743744 46.3519093804003 a69 NRAS_mut 1372 Trametinib MAP2K1 (MEK1), MAP2K2 (MEK2) 3 12 0 NA -4.02371398602478 -0.891242353044519 -3.13247163298026 3.07480125281084 1.37267510519861 1.79397809204276 1.01875580742551 2.28201970088693 0.0156393920759742 NA NA NA 0.215513749313874 46.3519093804003 a70 gain_cnaBLCA15_(ASXL1) 346 THZ-2-102-1 CDK7 6 13 0.916290731874155 2.99573227355399 1.56102464189417 -1.19451328656592 2.75553792846008 2.33389979968103 1.96633815960864 1.32401775414692 1.18065819656725 1.40135505940063 0.0157342268355354 NA NA NA 0.0349437862745564 46.3519093804003 a71 loss_cnaBLCA18_(CHD9,CNOT1,CYLD,MMP2,NUP93) 330 XMD13-2 RIPK 3 16 2.32630161961136 NA 2.63772351890898 3.99938136584902 -1.36165784694004 0.755918716629827 0.816687790711048 1.68152570353051 1.80132839283412 1.66729301261442 0.0160644494822597 NA NA NA 0.067654545786313 46.3519093804003 a72 NRAS_mut 1219 PFI-1 BRD2, BRD3, BRD4 3 16 2.30258509299405 NA 1.20929143601111 2.50998077392053 -1.30068933790942 0.919167039269569 0.755481755835159 1.67499828279953 1.4150739553749 1.72166876018278 0.0164151358236194 NA NA NA 0.120212881647505 46.3519093804003 a73 ARID1A_mut 330 XMD13-2 RIPK 5 14 2.32630161961136 NA 4.610942608726 3.4891828119058 1.1217597968202 0.807560410400054 0.812733268960668 1.38229624855187 1.38907230019422 1.38023117751131 0.0167282838377985 NA NA NA 0.0318440693796233 46.3519093804003 a74 gain_cnaBLCA15_(ASXL1) 235 QL-XII-47 BTK, BMX 6 13 2.32630161961136 NA 3.16898520582898 1.24053937084295 1.92844583498602 2.19525162790347 1.04348889471081 1.30431327342356 0.878462318612533 1.84807509189686 0.0170969901744304 NA NA NA 0.0859812667163607 46.3519093804003 a75 ARID1A_mut 1004 Vinblastine Microtubules 3 11 -2.30258509299405 NA -2.78181935747207 -4.81567707715014 2.03385771967807 1.16786507572599 1.12306402203328 1.79883275723485 1.74151771634557 1.81099000571297 0.0172233480365473 NA NA NA 0.0715646283967641 46.3519093804003 a76 TP53_mut 153 Midostaurin KIT 15 4 -0.669430653942629 NA -0.636395683820154 0.892546957894536 -1.52894264171469 0.94606868316263 1.35261882981753 1.48506606683807 1.61610110230429 1.13035735420077 0.0172287034622358 NA NA NA 0.103878557456756 46.3519093804003 a77 loss_cnaBLCA18_(CHD9,CNOT1,CYLD,MMP2,NUP93) 184 BMS-754807 IGF1R 3 16 0.940007258491471 NA -1.14522910404056 1.28516014357029 -2.43038924761084 1.68942644659581 1.43250189236532 1.65889094360218 1.43858837566328 1.6966045633614 0.0173120889841819 NA NA NA 0.115890863402335 46.3519093804003 a78 TP53_mut 156 AZD6482 PI3Kbeta 15 4 1.63315443905142 NA 1.62658979729218 3.39911968526662 -1.77252988797445 1.22627892672652 1.0416536408157 1.48233203758813 1.44545408825227 1.70164997127683 0.0174033171564988 NA NA NA 0.0301295342831135 46.3519093804003 a79 gain_cnaBLCA9 1526 RDEA119 (rescreen) MAP2K1 (MEK1), MAP2K2 (MEK2) 4 15 1.6094379124341 NA 2.40437500576306 1.18264917908554 1.22172582667752 0.513097972998189 0.877061849511047 1.48161571970715 2.38107708658174 1.39297568051629 0.0174493446146841 NA NA NA 0.00672875618741227 46.3519093804003 a80 RB1_mut 182 Obatoclax Mesylate BCL2, BCL2L1, MCL1 6 13 2.77258872223978 NA -1.90055102767045 -0.388312560686319 -1.51223846698413 0.567546107254525 1.33614885480902 1.299150362486 2.66452090438872 1.13178891823417 0.0174722887702792 NA NA NA 0.00299501948986192 46.3519093804003 a81 TP53_mut 238 CAL-101 PI3Kdelta 15 4 2.99573227355399 2.32630161961136 4.59283020630119 5.70144060786391 -1.10861040156272 0.808174014428552 0.358097442106334 1.4807638142341 1.37174715070071 3.09583446070392 0.0175042355962279 NA NA NA 0.00167512855085743 46.3519093804003 a82 TP53_mut 151 QS11 ARFGAP 15 4 2.32630161961136 NA 2.61015932394474 4.7040146737684 -2.09385534982366 1.53733826760542 0.758190083469715 1.46320403745922 1.36200040937319 2.76164961198322 0.0186730365171844 NA NA NA 0.00312551295863989 48.4407357849682 a83 ARID1A_mut 265 Tubastatin A HDAC6 5 14 2.99573227355399 NA 5.63771643034066 4.55492804298114 1.08278838735952 0.36739356028822 0.894670443113125 1.3494253485193 2.94721656664334 1.21026507100404 0.0190652267219352 NA NA NA 0.00175863708896 48.4407357849682 a84 TP53_mut 1149 TW 37 BCL2, BCL2L1 15 4 1.6094379124341 NA -0.965719663572446 0.915402811043791 -1.88112247461624 1.21880758009664 1.59324403671426 1.45508832840472 1.54341218854832 1.1806869702746 0.0192380092576837 NA NA NA 0.0932387211476047 48.4407357849682 a85 ARID1A_mut 252 WZ3105 CLK2, CNSK1E, FLT3, ULK1 5 14 0.246860077931526 2.32630161961136 2.05074061617701 0.178177398218837 1.87256321795817 1.499539770952 1.35658291349514 1.34567523335051 1.24875862196663 1.38035294365727 0.0193507955961238 NA NA NA 0.0462490590435804 48.4407357849682 a86 MLL2_mut 147 NSC-87877 PTPN6 (SHP-1), PTPN11 (SHP-2) 3 16 2.77258872223978 NA 4.24580260876286 5.2179133516707 -0.972110742907836 1.38552061982085 0.387508114179046 1.62393391769491 0.701621274343454 2.50862035487256 0.0194222564752998 NA NA NA 0.347977636045826 48.4407357849682 a87 gain_cnaBLCA15_(ASXL1) 274 PXD101, Belinostat HDAC 6 13 2.99573227355399 NA 1.52038911160221 -0.0412312553992328 1.56162036700144 1.7256555191106 0.957631886488982 1.26531650335644 0.904943280803978 1.63071049432877 0.0201331471315511 NA NA NA 0.0800321567722613 48.9014818328015 a88 ARID1A_mut 283 GSK2126458 PI3K, MTOR 5 14 -2.05572501506252 0.0237165266173161 -0.860603197618739 -2.70285959098771 1.84225639336897 1.01325378707179 1.47593480544836 1.33391981834535 1.81815890241371 1.24819632043932 0.0202725562923824 NA NA NA 0.0112815933932307 48.9014818328015 a89 NRAS_mut 1526 RDEA119 (rescreen) MAP2K1 (MEK1), MAP2K2 (MEK2) 3 16 1.6094379124341 NA 0.312517386053602 1.65123034694841 -1.33871296089481 1.10884071306127 0.786810140694071 1.61058412383551 1.20730862884617 1.70144345078456 0.0202909569049094 NA NA NA 0.162320500974794 48.9014818328015 a90 ARID1A_mut 329 QL-XI-92 DDR1 5 14 2.32630161961136 NA 5.03134357317952 3.96225669669343 1.06908687648609 0.389509068096975 0.896124054970926 1.3262570834818 2.74470343324568 1.19301213995509 0.020895696282718 NA NA NA 0.0023663536986926 49.7993684837669 a91 ARID1A_mut 152 CP466722 ATM 5 14 2.77258872223978 NA 4.13087921907673 2.71567804303912 1.41520117603761 1.03756618179607 1.08432265142477 1.31830035566201 1.36396231957737 1.30514766446876 0.0215619528848474 NA NA NA 0.0345019862139391 50.325992309321 a92 gain_cnaBLCA15_(ASXL1) 291 KIN001-266 MAP3K8 (COT) 6 13 2.99573227355399 NA 4.50534327534342 3.26320551362818 1.24213776171523 1.47427474549232 0.704572288662674 1.24859962748133 0.842541572059847 1.76296709607029 0.0215859256373141 NA NA NA 0.096655088592737 50.325992309321 a93 TP53_mut 140 Vinorelbine Microtubules 15 4 -2.74887219562247 NA -4.32726024712623 -2.72123770848783 -1.6060225386384 1.11795181889994 1.22098456412012 1.41274140018069 1.43657580898138 1.31535040313613 0.0224592981320741 NA NA NA 0.0697010722794086 51.3445934743188 a94 EP300_mut 1149 TW 37 BCL2, BCL2L1 4 15 1.6094379124341 NA -2.02215140627175 -0.182371872288303 -1.83977953398344 1.86071430357858 1.14988141884325 1.41109641508527 0.988749068271862 1.59997327014312 0.0225942075039101 NA NA NA 0.139837688120135 51.3445934743188 a95 EP300_mut 1028 VX-702 p38 3 11 0.693147180559945 NA 2.09630587077009 3.12007107816839 -1.0237652073983 1.12694545369843 0.425352345802738 1.70052644062456 0.908442555084183 2.40686390353913 0.0227673152273836 NA NA NA 0.253726464543134 51.3445934743188 a96 gain_cnaBLCA15_(ASXL1) 193 GW-2580 CSF1R (cFMS) 6 13 2.99573227355399 NA 5.64600367479163 5.13934495397211 0.506658720819522 0.224815245203238 0.466842762496024 1.23352864645069 2.25366709611482 1.08528772752225 0.0229803402715565 NA NA NA 0.00537546285350778 51.3445934743188 a97 gain_cnaBLCA9 1042 BIRB 0796 p38, JNK2 3 12 2.30258509299405 NA 5.02856256232551 3.72827210943781 1.3002904528877 0.500923818194391 0.827890604435089 1.65329151961351 2.59578483924896 1.57060660662402 0.0236821585738302 NA NA NA 0.0167199104599213 52.0493925731905 a98 MLL2_mut 1030 KU-55933 ATM 3 12 2.30258509299405 NA 2.4439864049004 3.75931139599714 -1.31532499109674 0.536325049109739 0.835236691781467 1.65120550482166 2.45247726780631 1.5747931143821 0.0238274744609713 NA NA NA 0.02134482873073 52.0493925731905 a99 loss_cnaBLCA18_(CHD9,CNOT1,CYLD,MMP2,NUP93) 275 I-BET BRD2, BRD3, BRD4 3 16 2.99573227355399 NA 3.35821323732993 4.88065168689208 -1.52243844956214 1.44549766400037 0.897757941946099 1.55629130575418 1.05322788647672 1.69582286987281 0.0242184262199715 NA NA NA 0.203607479312463 52.0493925731905 a100 gain_cnaBLCA15_(ASXL1) 252 WZ3105 CLK2, CNSK1E, FLT3, ULK1 6 13 0.246860077931526 2.32630161961136 1.84681514166765 0.128253523534065 1.71856161813359 1.30333932758324 1.44968637702043 1.22037623144584 1.31858341244124 1.18547131667595 0.0242664455845208 NA NA NA 0.0259594924238479 52.0493925731905 a101 NRAS_mut 1373 Dabrafenib BRAF 3 14 2.30258509299405 NA 2.08515890781859 3.87105081715352 -1.78589190933493 2.17890072537782 0.852530274657622 1.58916202067737 0.819629774103296 2.0948134775063 0.024609446339415 NA NA NA 0.290024259847581 52.2624742970858 a102 RB1_mut 207 AS601245 JNK 6 13 2.07944154167984 NA 1.32947374071711 2.63021752246578 -1.30074378174867 0.614590234978631 1.21161893081363 1.21435286208738 2.11644069124186 1.07355848333865 0.0248778563723848 NA NA NA 0.0065987837573365 52.3020910595986 a103 ARID1A_mut 206 Ruxolitinib JAK1, JAK2, TYK2 5 14 1.65632149833295 0.0237165266173161 4.52098130761481 3.98888714789349 0.532094159721325 0.336532918793424 0.437411647100285 1.27943308500944 1.58110582949522 1.21646088586967 0.025115786321921 NA NA NA 0.0204592121964036 52.3020910595986 a104 TP53_mut 1067 CCT007093 PPM1D 14 4 1.88706964903238 NA 3.65745248763279 4.28368397007625 -0.626231482443464 0.465822908600872 0.360782040788693 1.39781423109429 1.34435527081394 1.73576123987347 0.025372030672799 NA NA NA 0.0278148530732125 52.3276686521033 a105 gain_cnaBLCA9 301 PHA-793887 CDK-pan 4 15 2.32630161961136 NA 4.51615819622176 2.89373334475403 1.62242485146772 1.49525001468861 1.11371365308787 1.36342098889596 1.08505255678302 1.45677019130492 0.0268536563433971 NA NA NA 0.113957971300404 53.7523463538256 a106 loss_cnaBLCA18_(CHD9,CNOT1,CYLD,MMP2,NUP93) 1025 SB 216763 GSK3A, GSK3B 3 9 2.30258509299405 NA 2.71666854820433 4.04787105777448 -1.33120250957015 0.14088848412536 0.859752441674889 1.72533243228027 9.44862539926021 1.54835560219733 0.0270426566506452 NA NA NA 0.0015138974800661 53.7523463538256 a107 ARID1A_mut 294 MPS-1-IN-1 MPS1 5 14 2.99573227355399 NA 5.32832440326441 4.02907180065346 1.29925260261095 0.701889362231963 1.11374247718211 1.2592899756134 1.85107892001584 1.16656464957519 0.0271682533624326 NA NA NA 0.0114203881953954 53.7523463538256 a108 EP300_mut 245 UNC0638 G9a(EHMT2), GLP(EHMT1) 4 15 3.68887945411394 NA 5.11622243910166 3.7045171447673 1.41170529433436 0.929080333360853 1.06123400653579 1.35853920439215 1.51946526435196 1.33024882885408 0.0273301194818313 NA NA NA 0.0445510353702884 53.7523463538256 a109 MLL2_mut 1060 PD-0325901 MAP2K1 (MEK1), MAP2K2 (MEK2) 3 12 -1.38629436111989 0.693147180559945 -2.64592404028422 -0.69273696455915 -1.95318707572507 1.72480813405939 1.10450061221534 1.60015186826804 1.13240831670256 1.76838931017656 0.0276649483684085 NA NA NA 0.179912731508081 53.7523463538256 a110 ARID1A_mut 308 XL-880 MET 5 14 1.63315443905142 NA 1.83202926401793 0.236406593267126 1.5956226707508 1.78723922775388 1.06877234670182 1.25167627298199 0.892786285110869 1.49294906036334 0.0279843311425379 NA NA NA 0.118186703716843 53.7523463538256 a111 ARID1A_mut 154 CHIR-99021 GSK3B 5 14 0.940007258491471 NA 3.35206112849274 2.50276943093421 0.849291697558524 0.514185148862908 0.722880210267895 1.24975587975354 1.65172350744996 1.1748719711718 0.0281937736168467 NA NA NA 0.0177675867906461 53.7523463538256 a112 ARID1A_mut 301 PHA-793887 CDK-pan 5 14 2.32630161961136 NA 4.33195181570176 2.84363384840633 1.48831796729543 1.14517365724324 1.20824694125345 1.24680442871544 1.29964390804992 1.23179949104728 0.0285185347830246 NA NA NA 0.0415595142105024 53.7523463538256 a113 loss_cnaBLCA18_(CHD9,CNOT1,CYLD,MMP2,NUP93) 219 AT-7519 CDK9 3 16 2.32630161961136 NA -0.220262726575733 2.13999721463516 -2.36025994121089 0.577758079317461 1.65593458131933 1.50521756698054 4.08520456174184 1.42533404872214 0.0285590361820017 NA NA NA 0.00131743191891246 53.7523463538256 a114 TP53_mut 173 FH535 unknown 15 4 3.46573590279973 NA 1.4315195134366 2.90013215926986 -1.46861264583326 1.02752412201325 1.36871090879779 1.34060811363824 1.42927315706787 1.07298965500554 0.0291491895057775 NA NA NA 0.11688443799259 53.7523463538256 a115 loss_cnaBLCA18_(CHD9,CNOT1,CYLD,MMP2,NUP93) 329 QL-XI-92 DDR1 3 16 2.32630161961136 NA 3.20957438000047 4.43747427997526 -1.2278998999748 0.444974306284832 0.858378195168198 1.49630042326222 2.75948494695513 1.43048822405629 0.0293880736857649 NA NA NA 0.0125718419928831 53.7523463538256 a116 gain_cnaBLCA15_(ASXL1) 272 AR-42 HDAC 6 13 1.63315443905142 NA 1.06208559431536 -0.406444697069798 1.46853029138516 1.65415862579914 1.04594539552241 1.16940578973521 0.887780814053247 1.40402194767699 0.0299196721397328 NA NA NA 0.0863527289058327 53.7523463538256 a117 gain_cnaBLCA23_(MYC) 182 Obatoclax Mesylate BCL2, BCL2L1, MCL1 4 15 2.77258872223978 NA -2.12607045306663 -0.529805842845221 -1.59626461022141 0.67895966282131 1.28153884276372 1.33306217697673 2.35104483760991 1.24558425929484 0.0299481343238545 NA NA NA 0.00761806818927785 53.7523463538256 a118 ARID1A_mut 300 CX-5461 RNA Pol I 5 14 2.32630161961136 NA 5.08955104690735 3.67241767539323 1.41713337151412 0.390279671518753 1.2959547376673 1.23338054682598 3.63107144678947 1.09350529792802 0.0300403636561793 NA NA NA 0.00198180371568018 53.7523463538256 a119 MLL2_mut 1029 AMG-706 VEGFR, RET, c-KIT, PDGFR 3 12 0.693147180559945 NA 1.79496931754334 2.82148629240846 -1.02651697486512 0.782639802249153 0.62801099214016 1.56915792338958 1.31160844607585 1.6345525599272 0.0302780757565279 NA NA NA 0.136192162902721 53.7523463538256 a120 loss_cnaBLCA18_(CHD9,CNOT1,CYLD,MMP2,NUP93) 1007 Docetaxel Microtubules 3 11 -4.38202663467388 NA -7.48718686358366 -5.31617958489367 -2.17100727869 1.10298744308145 1.40541144111823 1.5966966826872 1.96829736576583 1.54474854492618 0.0305145705080176 NA NA NA 0.0468666922488063 53.7523463538256 a121 gain_cnaBLCA23_(MYC) 157 JNK-9L JNK 4 15 1.63315443905142 NA -1.33494796561798 -0.17628275373944 -1.15866521187854 1.07865145555514 0.823409382380951 1.32587661724594 1.07417943573091 1.40715570732042 0.0307279345782198 NA NA NA 0.116572347055679 53.7523463538256 a122 TP53_mut 1019 Bosutinib SRC, ABL, TEC 10 4 0.693147180559945 NA 1.09170078833337 2.29676835339324 -1.20506756505986 0.738975675140462 1.06508592290377 1.44741422449742 1.630726971941 1.13142755823348 0.0307853741233843 NA NA NA 0.10342153692905 53.7523463538256 a123 ARID1A_mut 1262 UNC1215 LMBL3 4 14 0 NA 2.73709760278852 2.26976307425679 0.467334528531728 0.219316231797232 0.371552451011141 1.34246479441518 2.13087068249376 1.25778884585454 0.0308242870419963 NA NA NA 0.012238138212631 53.7523463538256 a124 NRAS_mut 1026 17-AAG HSP90 3 12 0 NA 0.23158500675349 -2.02332604264 2.25491104939349 1.20786437874827 1.48494062557722 1.55965677511937 1.86685781041932 1.518519333739 0.0311254897689842 NA NA NA 0.0557308283908056 53.8398704730469 a125 TP53_mut 292 Masitinib KIT 15 4 2.99573227355399 NA 4.04869723261771 5.1122716062372 -1.06357437361948 0.790078782135398 0.888552841580975 1.31576957536634 1.34616243046661 1.19697369008139 0.031856953839798 NA NA NA 0.0896251170862965 54.6642924137634 a126 gain_cnaBLCA15_(ASXL1) 287 KIN001-244 PDPK1 (PDK1) 6 13 2.99573227355399 NA 4.50448610278641 3.30588491011262 1.19860119267378 1.58514497590308 0.701235413917042 1.15009565458217 0.756146100763384 1.70927076540316 0.0323672389852711 NA NA NA 0.127092385886569 54.8454275300312 a127 gain_cnaBLCA23_(MYC) 1502 Bicalutamide ANDR (androgen receptor) 4 13 2.30258509299405 NA 3.74222119037859 4.46301224965945 -0.720791059280853 0.247267730616096 0.585218559417431 1.3473015431123 2.91502274674063 1.23166131299455 0.0324739149966864 NA NA NA 0.00377129006741647 54.8454275300312 a128 loss_cnaBLCA18_(CHD9,CNOT1,CYLD,MMP2,NUP93) 341 EX-527 SIRT1 3 16 2.99573227355399 NA 4.80314322722192 5.43492422359119 -0.631780996369272 0.469323759500035 0.429445497996852 1.4546201148046 1.34615174190691 1.47115524395113 0.0335704244925361 NA NA NA 0.129823772320492 55.417382729901 a129 TP53_mut 1037 BX-795 TBK1, PDPK1, IKK, AURKB, AURKC 11 4 1.6094379124341 NA 1.55944253669502 3.01375529407555 -1.45431275738053 0.793901634978356 1.63238417943825 1.38678641017914 1.83185509804395 0.890913288488864 0.0336113757596041 NA NA NA 0.171916162211993 55.417382729901 a130 MLL2_mut 1149 TW 37 BCL2, BCL2L1 3 16 1.6094379124341 NA -2.19796322626817 -0.264393376912938 -1.93356984935524 2.23783998601556 1.15832604553948 1.45211448591755 0.864034006648494 1.66927943716805 0.0338387497836732 NA NA NA 0.270546833633232 55.417382729901 a131 gain_cnaBLCA15_(ASXL1) 179 5-Fluorouracil DNA antimetabolite 6 13 3.46573590279973 NA 5.09575115246211 3.88309515730213 1.21265599515999 1.21220276047783 0.9966578433888 1.13907915336225 1.0003738934582 1.21672247221449 0.0338460357579491 NA NA NA 0.0637362665818313 55.417382729901 a132 gain_cnaBLCA23_(MYC) 221 TAK-715 p38a 4 15 2.99573227355399 2.32630161961136 3.89031918381578 4.78881142736768 -0.898492243551892 0.323146789370666 0.751693227830512 1.29181608801226 2.78044614121564 1.19529112447249 0.0346891006381397 NA NA NA 0.00376198037470049 56.367478357839 a133 gain_cnaBLCA15_(ASXL1) 303 PIK-93 PI4K, PI3K 6 13 2.99573227355399 NA 4.46092455282835 2.82157576365667 1.63934878917168 1.81980656421758 1.26960085143353 1.12808507490453 0.900836836950582 1.29123163970838 0.0353843396265199 NA NA NA 0.0844670767414976 57.0648856733944 a134 loss_cnaBLCA18_(CHD9,CNOT1,CYLD,MMP2,NUP93) 226 GSK1070916 AURKB 3 16 0.940007258491471 2.32630161961136 -0.179683126083788 2.49178057176985 -2.67146369785364 3.31431306898114 1.57212554042985 1.43347276215713 0.806038428552822 1.69926868379939 0.0358986175604787 NA NA NA 0.295757933833757 57.462223063436 a135 gain_cnaBLCA15_(ASXL1) 301 PHA-793887 CDK-pan 6 13 2.32630161961136 NA 4.16319810851371 2.80703417731656 1.35616393119716 1.11989437732282 1.24377119195857 1.12204339435239 1.21097485500298 1.09036448179959 0.0362571209063187 NA NA NA 0.0375873396190264 57.6061756049283 a136 ARID1A_mut 1021 Axitinib PDGFR, KIT, VEGFR 3 11 0.693147180559945 NA 3.2528788636325 1.67941424728544 1.57346461634706 0.506527217280763 1.10689402813006 1.5255708129667 3.10637723436469 1.4215133304181 0.0372360798733067 NA NA NA 0.00768412550825571 58.6203555026356 a137 loss_cnaBLCA18_(CHD9,CNOT1,CYLD,MMP2,NUP93) 1042 BIRB 0796 p38, JNK2 3 12 2.30258509299405 NA 3.01789134952912 4.2309399126369 -1.21304856310778 1.39516405504188 0.651889527264556 1.49424624743067 0.869466611273445 1.86081922223532 0.0376056151257178 NA NA NA 0.268182049141482 58.6203555026356 a138 MLL2_mut 1378 Bleomycin (50 uM) DNA damage 3 15 3.91202300542815 NA -0.825368115985346 1.18965560500355 -2.01502372098889 0.779673750952552 1.47671498267108 1.43053911442812 2.58444473541283 1.36453123631489 0.0379812438010832 NA NA NA 0.0163139386816905 58.6203555026356 a139 gain_cnaBLCA15_(ASXL1) 1025 SB 216763 GSK3A, GSK3B 4 8 2.30258509299405 NA 4.49011283358095 3.32754922878244 1.1625636047985 1.03736151493944 0.666313674782772 1.4605054126478 1.12069282314408 1.74476924126991 0.0382844446403955 NA NA NA 0.106147171471695 58.6203555026356 a140 TP53_mut 1013 Nilotinib ABL 10 4 0.693147180559945 NA 2.71089575426896 3.41778629304835 -0.706890538779397 0.558727577121807 0.344858503821077 1.37613776142337 1.26517925322539 2.04979877528597 0.0383409122452664 NA NA NA 0.0182409898978081 58.6203555026356 a141 NRAS_mut 1242 (5Z)-7-Oxozeaenol MAP3K7 (TAK1) 3 16 2.30258509299405 NA -0.530968122396425 0.746374503769093 -1.27734262616552 1.60105467608212 0.766156280287473 1.4110098999035 0.797813244761417 1.66720897423988 0.0385352395338533 NA NA NA 0.299483254921586 58.6203555026356 a142 loss_cnaBLCA5_(FAT1,IRF2) 1248 FK866 NAMPT 5 14 0 NA -4.23769142669894 -1.20859264447625 -3.02909878222269 1.91644473692267 2.78320130401249 1.16265399590865 1.58058237937331 1.08835059032765 0.0393893433768358 NA NA NA 0.0226839873016888 58.9101337168771 a143 NRAS_mut 185 OSI-906 IGF1R 3 16 0.940007258491471 NA 0.9624865986354 2.51981107059456 -1.55732447195916 1.79338864833706 0.98385041291304 1.40278707828084 0.868369761012598 1.58288745069298 0.0395444426510868 NA NA NA 0.268541195032945 58.9101337168771 a144 gain_cnaBLCA15_(ASXL1) 1199 Tamoxifen ER 6 13 1.6094379124341 NA 3.13672024159736 3.71195254847978 -0.575232306882422 0.589842393421986 0.492097443493036 1.10040362752963 0.975230524793575 1.16893984004321 0.0395496826438168 NA NA NA 0.0697833403692892 58.9101337168771 a145 TP53_mut 1052 RO-3306 CDK1 11 4 1.6094379124341 NA 2.39502810665352 3.88985175875956 -1.49482365210604 1.20901094414969 0.795256895076066 1.32626577681028 1.23640208497647 1.87967392846441 0.0407557985628847 NA NA NA 0.0231949128000484 59.8057740573213 a146 TP53_mut 1192 GSK269962A ROCK1, ROCK2 15 4 1.6094379124341 NA 1.59715238578639 2.66975181227293 -1.07259942648653 0.827674085179562 1.01367474543304 1.24227671944558 1.29592003143826 1.05812977122984 0.0413034753483329 NA NA NA 0.120661515450944 59.8057740573213 a147 TP53_mut 302 PI-103 PI3Ka, PRKDC (DNAPK) 15 4 2.32630161961136 NA 1.66850552734606 4.24426646189187 -2.57576093454581 2.21167906437783 1.25731527197563 1.24109117745649 1.16461785800301 2.04861977895051 0.041475184351929 NA NA NA 0.0146984917205963 59.8057740573213 a148 TP53_mut 326 GSK690693 AKT 15 4 2.32630161961136 NA 4.03943910624461 5.09758574118862 -1.058146634944 0.934438282782392 0.266505561247836 1.23709583478704 1.13238793234504 3.97044860898787 0.0420587118402757 NA NA NA 0.00136179322523455 59.8057740573213 a149 gain_cnaBLCA23_(MYC) 238 CAL-101 PI3Kdelta 4 15 2.99573227355399 2.32630161961136 4.06267178999601 5.02983522439929 -0.96716343440328 1.27469072923484 0.631405507666082 1.23322690837283 0.758743601268552 1.53176274622356 0.0426309776783919 NA NA NA 0.227417707154981 59.8057740573213 a150 ARID1A_mut 1022 AZD7762 CHEK1, CHEK2 3 11 0.693147180559945 NA 1.091898217563 -0.0806705844130462 1.17256880197605 0.603720858570673 0.826987455936079 1.47651288315166 1.94223668990358 1.41787979195984 0.0426770464908637 NA NA NA 0.047654067988668 59.8057740573213 a151 ARID1A_mut 253 XMD14-99 EPHB3, CAMK1 5 14 2.32630161961136 NA 5.08208569734418 4.59515500382526 0.486930693518924 0.276051902776111 0.463596043375602 1.14049966055526 1.76390993368317 1.05033401487514 0.0428318164613031 NA NA NA 0.0162188902965635 59.8057740573213 a152 TP53_mut 172 Embelin XIAP 15 4 3.46573590279973 NA 2.54991426049931 3.382353360046 -0.832439099546693 0.664580824993751 0.728019538512172 1.23103910531817 1.25257766736577 1.14342961350724 0.0429577485448325 NA NA NA 0.100561082861656 59.8057740573213 a153 gain_cnaBLCA9 1529 MLN4924 NEDD8-activating enzyme 4 12 0 NA 1.134753455 -0.687741127745484 1.82249458274549 1.81175691188738 1.29178521259575 1.28404769988686 1.00592666200838 1.41083406511777 0.0431106375111596 NA NA NA 0.135090574240599 59.8057740573213 a154 ARID1A_mut 211 TL-2-105 CRAF 5 14 2.32630161961136 1.63315443905142 5.01567534492311 4.15247705731637 0.863198287606737 0.558335317267988 0.810959564141249 1.13710388267347 1.54602129027138 1.064415941035 0.0433833345773372 NA NA NA 0.0251260737896376 59.8057740573213 a155 TP53_mut 262 VX-11e ERK 15 4 1.63315443905142 NA 3.18726166275049 1.57347001627057 1.61379164647992 1.10906393873949 2.02087605713543 1.22564893157848 1.45509342618613 0.798560426693093 0.043772687772617 NA NA NA 0.209180083353501 59.8057740573213 a156 loss_cnaBLCA18_(CHD9,CNOT1,CYLD,MMP2,NUP93) 306 TG101348 JAK2 3 16 2.32630161961136 NA 2.01649112683462 3.18208375463786 -1.16559262780325 0.64940302423531 0.873952496742614 1.37029047922651 1.79486787757997 1.33370249773029 0.0437763276931354 NA NA NA 0.0626067786535416 59.8057740573213 a157 NRAS_mut 262 VX-11e ERK 3 16 1.63315443905142 NA 1.32936640555938 3.13216911185384 -1.80280270629446 2.03861690718824 1.18809731182874 1.36888849678806 0.884326378309582 1.51738640290294 0.0439679577864848 NA NA NA 0.261861084265588 59.8057740573213 a158 RB1_mut 1062 AZD6244 MAP2K1 (MEK1), MAP2K2 (MEK2) 5 9 1.38629436111989 0.693147180559945 3.16643469728253 1.42398581930689 1.74244887797565 0.831965344928564 1.59603444906015 1.25458690695348 2.09437675330727 1.09173638388677 0.0440545434689367 NA NA NA 0.019892149164156 59.8057740573213 a159 ARID1A_mut 302 PI-103 PI3Ka, PRKDC (DNAPK) 5 14 2.32630161961136 NA 3.94280862326677 1.59218611724461 2.35062250602216 1.13265961030278 2.29860414927151 1.12804273460134 2.07531237508663 1.02263041105496 0.0448871085582244 NA NA NA 0.0100852866014217 60.2964738565251 a160 ARID1A_mut 1218 JQ1 BRD2, BRD3, BRD4 5 14 0 NA 2.5094954926334 1.78298831343419 0.726507179199208 0.337522047224482 0.712660752627193 1.1275026560644 2.15247325374279 1.0194291975824 0.0449782340793426 NA NA NA 0.00911471745497903 60.2964738565251 a161 RB1_mut 1372 Trametinib MAP2K1 (MEK1), MAP2K2 (MEK2) 5 10 0 NA 0.00092841396820166 -2.27706922644496 2.27799764041316 0.850833035999703 2.18560633420522 1.21248826639934 2.67737328480268 1.04227262007892 0.0453421291475953 NA NA NA 0.013006469644647 60.3273284068285 a162 gain_cnaBLCA15_(ASXL1) 294 MPS-1-IN-1 MPS1 6 13 2.99573227355399 NA 5.14302002832459 4.01465438888638 1.1283656394382 1.00648884430626 1.08102136158317 1.06485314633004 1.12109105413478 1.04379587632357 0.0455637656976718 NA NA NA 0.0496115605403341 60.3273284068285 a163 gain_cnaBLCA23_(MYC) 1008 Methotrexate Dihydrofolate reductase (DHFR) 4 10 -1.6094379124341 NA 0.584663777590781 -0.606805257371019 1.1914690349618 0.496963135201281 1.01026440823785 1.31000388281024 2.39749983563515 1.17936356586096 0.0469157264305928 NA NA NA 0.0132955085749024 61.7362631555338 a164 ARID1A_mut 136 Mitomycin C DNA crosslinker 5 14 2.77258872223978 NA -0.0238031105185558 -1.64278846716697 1.61898535664841 1.05147471635341 1.55653938835863 1.11379515828859 1.53972828016557 1.04011846327617 0.0473486581561409 NA NA NA 0.026167407187539 61.9260423395249 a165 loss_cnaBLCA18_(CHD9,CNOT1,CYLD,MMP2,NUP93) 301 PHA-793887 CDK-pan 3 16 2.32630161961136 NA 1.84941922418968 3.49514845522678 -1.64572923103709 1.12303679914253 1.23881608577421 1.34261646786097 1.4654276977332 1.32846937486171 0.047704482762536 NA NA NA 0.106043718084711 62.0132860229347 a166 TP53_mut 207 AS601245 JNK 15 4 2.07944154167984 NA 1.93982445136468 3.26807586647193 -1.32825141510725 1.0362536204347 1.39593020619925 1.19852225072491 1.28178217080686 0.951517066690413 0.0480938067942476 NA NA NA 0.151524870438896 62.0180563255522 a167 ARID1A_mut 256 JW-7-24-1 LCK 5 14 2.32630161961136 NA 3.06030310141396 1.8413989478704 1.21890415354356 1.37205121872168 1.00349213284352 1.10672216288984 0.888380941550562 1.21466239111377 0.0486160497893006 NA NA NA 0.121988399147712 62.0180563255522 a168 CDKN1A_mut 261 TL-1-85 MAP3K7 (TAK1) 3 16 2.32630161961136 NA 2.33005074892117 3.76838216839173 -1.43833141947056 1.00682327977394 1.08540556857111 1.33617002362723 1.42858379257332 1.32515574004661 0.0486647248310756 NA NA NA 0.112312022673585 62.0180563255522 a169 TP53_mut 194 AUY922 HSP90 15 4 -1.36257783450257 NA -3.30113286246626 -0.902259721072821 -2.39887314139344 1.86180202566205 2.63641699889566 1.18744474404614 1.28846843452134 0.909898981230311 0.04996810510839 NA NA NA 0.165547542813826 62.0180563255522 a170 MLL2_mut 1494 SN-38 TOP1 3 15 -2.99573227355399 NA -6.62123563648782 -4.55247420080793 -2.06876143567989 0.241903561771812 1.64743305184213 1.34038881076812 8.55200899287028 1.25574841015035 0.0500541045029483 NA NA NA 0.000288336019103723 62.0180563255522 a171 EP300_mut 1060 PD-0325901 MAP2K1 (MEK1), MAP2K2 (MEK2) 4 11 -1.38629436111989 0.693147180559945 -2.25846378953758 -0.656069139764742 -1.60239464977283 1.60742356474979 1.150724108929 1.26096480513546 0.996871443789157 1.39250984431378 0.0500656012319107 NA NA NA 0.138081119624797 62.0180563255522 a172 gain_cnaBLCA23_(MYC) 177 GSK-650394 SGK3 4 15 2.77258872223978 NA 1.15967402619315 3.40802180151987 -2.24834777532671 1.33443727848907 1.99656601962111 1.18546738435321 1.68486583189015 1.12610740302661 0.0503096072979269 NA NA NA 0.0317107145210122 62.0180563255522 a173 NRAS_mut 153 Midostaurin KIT 3 16 -0.669430653942629 NA 0.900207484399928 -0.542273117432747 1.44248060183268 1.83160432146373 0.946407144872475 1.3251116310697 0.787550337662403 1.52416495336903 0.050353197094104 NA NA NA 0.304072968452337 62.0180563255522 a174 gain_cnaBLCA23_(MYC) 180 Thapsigargin sarco-endoplasmic reticulum Ca2+-ATPases 4 15 -0.669430653942629 NA -5.79012784849759 -3.98222628742133 -1.80790156107626 1.04733106485471 1.61017637095915 1.18472387273902 1.72619873671661 1.12279722500171 0.0504385665389971 NA NA NA 0.0291052116575976 62.0180563255522 a175 gain_cnaBLCA23_(MYC) 298 OSI-930 KIT, VEGFR, PDGFR 4 15 2.32630161961136 NA 3.67468201198863 4.50062372792328 -0.825941715934648 1.35834046503171 0.442412136288212 1.18379812518009 0.608052058520811 1.86690564789702 0.0505995555508102 NA NA NA 0.312293338289493 62.0180563255522 a176 TP53_mut 291 KIN001-266 MAP3K8 (COT) 15 4 2.99573227355399 NA 3.39741490791138 4.62312692763906 -1.22571201972769 0.939189016754349 1.42186980174403 1.1777047180795 1.30507490809838 0.862042374220379 0.0516709592715493 NA NA NA 0.183228289936896 62.9714007762187 a177 gain_cnaBLCA15_(ASXL1) 152 CP466722 ATM 6 13 2.77258872223978 NA 3.8796469986117 2.72276974663548 1.15687725197622 1.53219979113631 0.90079557218587 1.02929860644551 0.755043342695052 1.28428390158373 0.0524077258112313 NA NA NA 0.131818088873882 63.3280251770694 a178 loss_cnaBLCA18_(CHD9,CNOT1,CYLD,MMP2,NUP93) 225 Genentech Cpd 10 AURKA, AURKB 3 16 2.32630161961136 NA 1.46249402108911 3.31364108178137 -1.85114706069226 1.65870887932311 1.37828832700555 1.30900077896422 1.11601685127994 1.34307678910264 0.0529089075325928 NA NA NA 0.182681914295917 63.3280251770694 a179 gain_cnaBLCA9 261 TL-1-85 MAP3K7 (TAK1) 4 15 2.32630161961136 NA 4.53972893419654 3.27502341361634 1.2647055205802 0.915751899224743 1.11350815974307 1.16967914537883 1.38105694528275 1.13578469049748 0.0531136403223348 NA NA NA 0.0605851995089755 63.3280251770694 a180 MLL2_mut 223 ZSTK474 PI3K 3 16 1.63315443905142 2.32630161961136 3.20446379844724 1.42356904833046 1.78089475011678 0.221602848443867 1.45050356584443 1.3050391856263 8.036425355642 1.2277768852502 0.0535551789759718 NA NA NA 0.000238888530413272 63.3280251770694 a181 ARID1A_mut 282 EKB-569 EGFR 5 14 0.916290731874155 2.99573227355399 3.05409876527033 1.5113488196457 1.54274994562462 0.686803054327644 1.58793340793422 1.08034793710003 2.24627705992793 0.971545744875805 0.0536200262597948 NA NA NA 0.00953274035098329 63.3280251770694 a182 gain_cnaBLCA15_(ASXL1) 1062 AZD6244 MAP2K1 (MEK1), MAP2K2 (MEK2) 4 10 1.38629436111989 0.693147180559945 0.775174781633831 2.55473467336393 -1.7795598917301 1.17743974331237 1.47945439251555 1.26207380202905 1.51138085990188 1.2028487669054 0.0542355989933856 NA NA NA 0.0496192314348548 63.3280251770694 a183 ARID1A_mut 203 BMS-345541 IKBKB 5 14 2.77258872223978 NA 4.08076336500512 3.30687805342289 0.773885311582226 0.968866651034713 0.621721367371661 1.07685894390539 0.798753172849685 1.24474620335769 0.0543160057937679 NA NA NA 0.153700739048061 63.3280251770694 a184 ARID1A_mut 304 SB52334 ALK5 5 14 2.99573227355399 NA 5.47589513508641 4.48048513300262 0.995410002083786 0.740477778224418 0.974035870958968 1.07681129479847 1.34428072165875 1.02194388498626 0.0543255673461203 NA NA NA 0.0413340640571595 63.3280251770694 a185 loss_cnaBLCA18_(CHD9,CNOT1,CYLD,MMP2,NUP93) 345 KIN001-270 CDK9 3 16 2.99573227355399 NA 4.0102836712379 5.09696022974963 -1.08667655851173 1.16836881986143 0.784122661714276 1.29594979572073 0.930080074064805 1.38585021396525 0.0550651822572006 NA NA NA 0.243575164943354 63.8400202470819 a186 TP53_mut 1194 SB-505124 TGFR1 (ALK5) 15 4 2.30258509299405 NA 3.85300995015716 4.93940596485098 -1.08639601469382 1.0325054613821 0.127591919174535 1.15756886061643 1.05219396441699 8.51461457529862 0.0553600485920664 NA NA NA 0.00119056877187584 63.8400202470819 a187 CDKN1A_mut 1371 PLX4720 (rescreen) BRAF 3 15 2.30258509299405 NA 4.83384512600264 3.74752674232207 1.08631838368058 0.0312485224491782 0.891224808668994 1.30294985593547 34.7638319682902 1.21890500927925 0.0560347815230748 NA NA NA 0.000326603131745023 64.2725564077088 a188 gain_cnaBLCA15_(ASXL1) 331 QL-X-138 MNK2, PRKDC (DNAPK), MTOR, BTK, JAK3 6 13 2.32630161961136 NA 2.93867176974178 1.65780356236018 1.2808682073816 1.64151191368328 1.08546357162041 1.0050398250354 0.780297844142686 1.1800195242568 0.0576015594935971 NA NA NA 0.12416343645138 65.228577001667 a189 TP53_mut 182 Obatoclax Mesylate BCL2, BCL2L1, MCL1 15 4 2.77258872223978 NA -1.16446001157232 0.253882679659998 -1.41834269123232 1.30592423613369 0.855062125423581 1.14535220919158 1.08608344342506 1.65875981295476 0.0577132404485863 NA NA NA 0.0339610032973592 65.228577001667 a190 gain_cnaBLCA23_(MYC) 1066 AZD6482 PI3Kbeta 3 15 1.6094379124341 NA 0.949984988509691 2.22160495080648 -1.27161996229679 0.874919877297668 0.998256867278936 1.29270946847063 1.45341304420286 1.27384043524087 0.0577805947123725 NA NA NA 0.106576271981679 65.228577001667 a191 CDKN1A_mut 158 PF-562271 FAK 3 16 0.940007258491471 NA 0.729980950091129 1.87746551273121 -1.14748456264008 0.641205982274817 0.928960638919178 1.27513063713227 1.7895724530971 1.23523485771706 0.0586704598621846 NA NA NA 0.0614964201192184 65.3480722973486 a192 loss_cnaBLCA18_(CHD9,CNOT1,CYLD,MMP2,NUP93) 158 PF-562271 FAK 3 16 0.940007258491471 NA 0.732837602708624 1.87692989036543 -1.14409228765681 0.289888081721777 0.952833555611929 1.27045515975132 3.94666893810026 1.20072627681762 0.059508938197411 NA NA NA 0.00205129667807518 65.3480722973486 a193 NRAS_mut 192 LFM-A13 BTK 3 16 2.77258872223978 NA 3.74278991671811 4.51032283222364 -0.767532915505523 0.422536598171212 0.624393795072965 1.27042045895899 1.81648860436586 1.22924494375514 0.0595152015638075 NA NA NA 0.0587007468335235 65.3480722973486 a194 gain_cnaBLCA23_(MYC) 1020 Lenalidomide TNFA 4 10 1.6094379124341 NA 3.06418841880655 4.04272276292515 -0.978534344118597 1.21256915656539 0.594456546991185 1.23028677180296 0.806992606417847 1.64609902787917 0.0596689594595546 NA NA NA 0.205897240939402 65.3480722973486 a195 MLL2_mut 1043 JNK Inhibitor VIII JNK 3 11 2.30258509299405 NA 3.12562163093329 4.11177723978255 -0.98615560884926 1.03342352952112 0.650335034138899 1.35402644701861 0.954260843379705 1.51638087613566 0.0597460479095838 NA NA NA 0.234055036617508 65.3480722973486 a196 ARID1A_mut 225 Genentech Cpd 10 AURKA, AURKB 5 14 2.32630161961136 NA 4.12104172699888 2.62860933834106 1.49243238865782 1.48262252204787 1.40483043774797 1.04841208313825 1.00661656386847 1.0623576686239 0.0603037398857502 NA NA NA 0.0924515080258211 65.3480722973486 a197 gain_cnaBLCA9 286 KIN001-236 TIE2 4 15 2.32630161961136 NA 5.00664848094913 4.14894765861382 0.857700822335307 0.416977962623084 0.813342300727914 1.13064141618116 2.05694520866227 1.0545385645966 0.060666825264909 NA NA NA 0.0159153515490735 65.3480722973486 a198 ARID1A_mut 1264 SGC0946 Q8TEK3 (DOT1L) 4 14 -0.693147180559945 NA 1.94259286542742 1.48272542119757 0.45986744422985 0.185231942236075 0.437916359826537 1.14167978081982 2.48265735746461 1.05012620312246 0.0611718568244879 NA NA NA 0.00894397326042936 65.3480722973486 a199 ARID1A_mut 328 SNX-2112 HSP90 5 13 0.940007258491471 NA 0.979007521464309 -1.0127532652708 1.99176078673511 1.9634178429986 1.85498821355407 1.05793844760342 1.01443551296917 1.07373231386683 0.0615577271205322 NA NA NA 0.0915301698529581 65.3480722973486 a200 gain_cnaBLCA9 1372 Trametinib MAP2K1 (MEK1), MAP2K2 (MEK2) 4 11 0 NA 0.161412418037893 -2.12833635152365 2.28974876956154 0.120821044649527 2.18545210098459 1.19404090824133 18.9515723540014 1.04772315464153 0.0616463604140149 NA NA NA 0.00597260544447517 65.3480722973486 a201 ARID1A_mut 1049 PD-173074 FGFR1, FGFR3 5 10 0.693147180559945 NA 3.18966337985485 2.28705077176312 0.902612608091729 0.627384133273424 0.873856193048615 1.11974762030997 1.43869211894518 1.03290749126901 0.0617198270628897 NA NA NA 0.0427356744752502 65.3480722973486 a202 gain_cnaBLCA9 262 VX-11e ERK 4 15 1.63315443905142 NA 4.03550114269187 2.53072002903814 1.50478111365373 1.06002242770891 1.39321689050526 1.1225942938432 1.4195747885317 1.08007670873701 0.0623396232083041 NA NA NA 0.0562831754039837 65.3480722973486 a203 gain_cnaBLCA9 252 WZ3105 CLK2, CNSK1E, FLT3, ULK1 4 15 0.246860077931526 2.32630161961136 1.98090404974391 0.321638030464874 1.65926601927904 2.1698717065657 1.28224215608948 1.1225395370018 0.764683927744829 1.29403483686684 0.062351146836735 NA NA NA 0.225394344229746 65.3480722973486 a204 TP53_mut 178 BAY 61-3606 SYK 15 4 2.07944154167984 NA 1.89483206181961 3.42357462554301 -1.5287425637234 1.3338114996644 1.48593605019072 1.12251354099978 1.14614588651248 1.0288077764364 0.0623566183915292 NA NA NA 0.129039021150056 65.3480722973486 a205 loss_cnaBLCA18_(CHD9,CNOT1,CYLD,MMP2,NUP93) 260 NG-25 MAP3K7 (TAK1) 3 16 2.32630161961136 NA 1.67581761959181 3.37231337354493 -1.69649575395312 0.411197047413407 1.43669772046166 1.25028019139991 4.12574887058346 1.18082998935084 0.0632524920725479 NA NA NA 0.00175672594408426 65.3480722973486 a206 RB1_mut 262 VX-11e ERK 6 13 1.63315443905142 NA 3.74767301747958 2.43205899242016 1.31561402505942 0.795837077518879 1.51173137410632 0.980748814469758 1.65311979326348 0.870269710342662 0.0632650517267785 NA NA NA 0.0242652406762419 65.3480722973486 a207 ARID1A_mut 1067 CCT007093 PPM1D 4 14 1.88706964903238 NA 4.21066269102753 3.67831571021814 0.532346980809383 0.242619935400522 0.509387568713022 1.1301972090462 2.19416009624508 1.04507258030338 0.0635447245523863 NA NA NA 0.0137001960540679 65.3480722973486 a208 NRAS_mut 1175 AG-014699 PARP1, PARP2 3 16 1.6094379124341 NA 2.29600339607888 3.29214287944818 -0.996139483369298 0.392124204768588 0.83737272504957 1.24830944849658 2.54036723888843 1.18960106243051 0.0636293149049751 NA NA NA 0.0168210265612039 65.3480722973486 a209 gain_cnaBLCA15_(ASXL1) 197 Bryostatin 1 PRKC 6 13 -4.8283137373023 NA -2.58802725137195 -3.3346766494376 0.746649398065646 0.549570087104909 0.837453623384066 0.977129917636019 1.35860632808262 0.891571040135346 0.0641504639919209 NA NA NA 0.0359098095886 65.3480722973486 a210 ARID1A_mut 290 KIN001-260 IKK 5 14 2.99573227355399 NA 5.82978115152511 4.71850566931423 1.11127548221089 0.381545414994033 1.21532274463122 1.03013799063785 2.91256411043038 0.914387134709713 0.0644584615065988 NA NA NA 0.00758735740258213 65.3480722973486 a211 RB1_mut 249 XL-184 VEGFR, MET, RET, KIT, FLT1, FLT3, FLT4, Tie2,AXL 6 13 1.63315443905142 NA 3.66134370162143 2.79409458520766 0.867249116413766 0.634816645637534 0.977131449078045 0.974195193958772 1.36614110920611 0.887546007481433 0.064876650470964 NA NA NA 0.0357375586269868 65.3480722973486 a212 TP53_mut 1039 SL 0101-1 RSK, AURKB, PIM3 11 4 2.30258509299405 NA 4.00813626554738 4.83190442442382 -0.823768158876442 0.764956669751018 0.418380235066677 1.17619204407817 1.07688211823104 1.96894616387688 0.0651299533309837 NA NA NA 0.0241158611790213 65.3480722973486 a213 gain_cnaBLCA23_(MYC) 207 AS601245 JNK 4 15 2.07944154167984 NA 1.23414521271335 2.48220595903363 -1.24806074632028 0.629501516051933 1.20543287735344 1.10897121759061 1.98261753863245 1.035363121222 0.0652664403283998 NA NA NA 0.0186233688305157 65.3480722973486 a214 loss_cnaBLCA5_(FAT1,IRF2) 269 NSC-207895 MDM4 5 14 2.99573227355399 NA 2.69685404037683 3.92857676736122 -1.23172272698439 0.620973073429342 1.32963179699455 1.02548513641456 1.98353645220423 0.926363772112348 0.0655566441503423 NA NA NA 0.015290148775674 65.3480722973486 a215 loss_cnaBLCA18_(CHD9,CNOT1,CYLD,MMP2,NUP93) 253 XMD14-99 EPHB3, CAMK1 3 16 2.32630161961136 NA 4.26843089950702 4.80858161510959 -0.54015071560257 0.662553729860644 0.39642463737713 1.23818634797997 0.815255716266484 1.36255586730526 0.0655969490241049 NA NA NA 0.290973534402509 65.3480722973486 a216 TP53_mut 225 Genentech Cpd 10 AURKA, AURKB 15 4 2.32630161961136 NA 2.68829453649404 4.27033033108963 -1.58203579459558 1.38023289335052 1.64119425379727 1.10651203350304 1.14620931164391 0.963954017591268 0.0658077487949642 NA NA NA 0.148206940485904 65.3480722973486 a217 CDKN1A_mut 219 AT-7519 CDK9 3 16 2.32630161961136 NA 0.0684784815770662 2.08585823810651 -2.01737975652944 0.918122982010406 1.71085776081142 1.23188619772374 2.19728706944249 1.17916275843566 0.0668489350580153 NA NA NA 0.0302585279016369 65.6008205015993 a218 TP53_mut 287 KIN001-244 PDPK1 (PDK1) 15 4 2.99573227355399 NA 3.43378761707955 4.62415154799733 -1.19036393091778 1.03612344912359 1.27248388069565 1.1005645831007 1.14886303550475 0.935464840833204 0.067133579867595 NA NA NA 0.157468509105314 65.6008205015993 a219 gain_cnaBLCA23_(MYC) 196 Phenformin AAPK1 (AMPK) agonist 4 15 8.29404964010203 NA 7.99184877990746 9.26325865364073 -1.27140987373328 1.17386218020554 1.15470361983701 1.09783400410091 1.08309978392068 1.10107031093636 0.0677502768094105 NA NA NA 0.115224386351719 65.6008205015993 a220 gain_cnaBLCA15_(ASXL1) 223 ZSTK474 PI3K 6 13 1.63315443905142 2.32630161961136 2.61368808890918 1.28525904885954 1.32842904004964 1.73312276711516 1.20439558681309 0.961878390440689 0.766494483400535 1.10298398183669 0.0680055795007217 NA NA NA 0.131443245094153 65.6008205015993 a221 ARID1A_mut 193 GW-2580 CSF1R (cFMS) 5 14 2.99573227355399 NA 5.6241259799622 5.18334832504116 0.440777654921043 0.364192722926477 0.453661775111594 1.01498130415503 1.21028682665366 0.971599722750761 0.0680977882152871 NA NA NA 0.0586126397422619 65.6008205015993 a222 MLL2_mut 1242 (5Z)-7-Oxozeaenol MAP3K7 (TAK1) 3 16 2.30258509299405 NA -0.416562110915614 0.72492337661644 -1.14148548753205 1.59840093067139 0.802167821155604 1.22496640325166 0.714142156469207 1.42300084524411 0.0682487180421219 NA NA NA 0.34093146359316 65.6008205015993 a223 TP53_mut 332 XMD15-27 CAMK2B, CLK2, DYRK1A, MAST1, STK39 15 4 2.32630161961136 NA 4.65402123661862 5.15860715506032 -0.504585918441703 0.495242581025339 0.243815660376905 1.0946685394336 1.01886618351156 2.06953859182664 0.0684715414180302 NA NA NA 0.0162975695519796 65.6008205015993 a224 gain_cnaBLCA15_(ASXL1) 1142 HG-5-113-01 LOK, LTK, TRCB, ABL(T315I) 3 4 2.30258509299405 NA 1.17742807454006 2.13783804459908 -0.96040997005902 0.584977282617939 0.5163683037593 1.7627065206186 1.64179020040045 1.85993207380658 0.0690858772598488 NA NA NA 0.0852981892280916 65.6008205015993 a225 gain_cnaBLCA23_(MYC) 135 Gemcitabine DNA replication 4 15 0.0237165266173161 NA -4.63865836214909 -1.73585178090634 -2.90280658124275 2.51172631596366 2.69385149429478 1.0902080328556 1.15570178279119 1.07756741134042 0.0694995559964479 NA NA NA 0.0988746724922955 65.6008205015993 a226 ARID1A_mut 1261 rTRAIL TR10A (DR4), TR10B (DR5) 4 14 -2.30258509299405 NA 0.0682978656950862 -1.40932116257051 1.47761902826559 0.540154753544751 1.46343981712156 1.10294590400506 2.73554757885358 1.0096889608839 0.0695125816239659 NA NA NA 0.00754449115359877 65.6008205015993 a227 RB1_mut 167 OSU-03012 PDPK1 (PDK1) 6 13 2.77258872223978 NA 0.740195044356558 2.39865529731215 -1.65846025295559 1.4131501374789 1.85367380092585 0.955470274820604 1.17359097874366 0.894688295280023 0.0696863872359283 NA NA NA 0.0517182437403348 65.6008205015993 a228 TP53_mut 1030 KU-55933 ATM 11 4 2.30258509299405 NA 3.23271908736118 4.22094650142347 -0.988227414062286 0.836673983910084 0.919492027710034 1.15380150080529 1.18113797377078 1.07475365123441 0.0697562351625688 NA NA NA 0.118855299493071 65.6008205015993 a229 TP53_mut 177 GSK-650394 SGK3 15 4 2.77258872223978 NA 2.49313066778423 4.59051577770178 -2.09738510991755 2.04844764827128 1.22144969254416 1.08760049254316 1.02389002310485 1.71712770711735 0.0701068914097195 NA NA NA 0.0311747595123253 65.6008205015993 a230 EP300_mut 283 GSK2126458 PI3K, MTOR 4 15 -2.05572501506252 0.0237165266173161 -0.95590960083176 -2.55462745723964 1.59871785640788 0.404145033637743 1.61175002520659 1.0857464997502 3.95580230695325 0.991914274177204 0.0705415957274153 NA NA NA 0.00302507693015012 65.6008205015993 a231 ARID1A_mut 221 TAK-715 p38a 5 14 2.99573227355399 2.32630161961136 5.13351575861155 4.40899066805147 0.724525090560084 0.634511269059739 0.745695638107785 1.00477962672906 1.14186323535866 0.971609666912599 0.0706499328794983 NA NA NA 0.0688369425043077 65.6008205015993 a232 TP53_mut 158 PF-562271 FAK 15 4 0.940007258491471 NA 1.48938183349957 2.4721658878698 -0.982784054370222 0.88990886259333 0.992645198389858 1.08130970872321 1.104364835188 0.990065791850269 0.0715916789149433 NA NA NA 0.14050893903651 66.188731818132 a233 gain_cnaBLCA9 1036 PLX4720 BRAF 3 12 2.30258509299405 NA 3.14291951547888 3.9090611911147 -0.766141675635818 0.292147725399324 0.647069790560614 1.26395244683183 2.62244614291832 1.18401706711117 0.0720309208374277 NA NA NA 0.0164861521978195 66.2663357745873 a234 EP300_mut 1010 Gefitinib EGFR 3 11 -0.693147180559945 NA -0.318797458109394 0.828416303069906 -1.1472137611793 0.370157779586189 0.965562862444619 1.28281441080253 3.09925611306023 1.18812954163831 0.0724205504845812 NA NA NA 0.0103044590260776 66.2663357745873 a235 TP53_mut 266 Zibotentan, ZD4054 Endothelin A Receptor 15 4 2.99573227355399 NA 5.3807485992776 5.75953335297799 -0.378784753700394 0.36439096806195 0.284912787971776 1.07709351902628 1.03950093965007 1.32947614038973 0.0726024575197735 NA NA NA 0.068724781501907 66.2663357745873 a236 NRAS_mut 1114 Cetuximab EGFR 3 15 4.18661983833127 NA 6.3400751929556 5.70516451596526 0.634910676990338 0.165207221997211 0.560656860777598 1.20319082740977 3.84311696132179 1.13244075192401 0.0752737197726528 NA NA NA 0.00308215876404602 67.2090110545811 a237 ARID1A_mut 226 GSK1070916 AURKB 5 14 0.940007258491471 2.32630161961136 3.47659192092645 1.56760572610243 1.90898619482401 0.641923084080516 2.18382624419097 0.98659726548814 2.97385503367343 0.8741474739128 0.0754110960479294 NA NA NA 0.00931696768170902 67.2090110545811 a238 gain_cnaBLCA15_(ASXL1) 260 NG-25 MAP3K7 (TAK1) 6 13 2.32630161961136 NA 3.97926273324164 2.70068387969573 1.27857885354591 1.39561997845331 1.35771694334731 0.933968801709229 0.916136823265376 0.941712379602264 0.0756005941370805 NA NA NA 0.0920461272802034 67.2090110545811 a239 ARID1A_mut 1018 ABT-888 PARP1, PARP2 3 11 1.6094379124341 NA 4.49633031810263 3.84227642465501 0.654053893447618 0.373647307833742 0.540403135763713 1.26665302294126 1.7504579311425 1.21030736160198 0.0756239377830291 NA NA NA 0.0641658691061799 67.2090110545811 a240 loss_cnaBLCA18_(CHD9,CNOT1,CYLD,MMP2,NUP93) 193 GW-2580 CSF1R (cFMS) 3 16 2.99573227355399 NA 4.86179075921922 5.3813833857956 -0.519592626576371 0.555371865430798 0.41816482849396 1.19022242029074 0.9355760687901 1.24255458893496 0.0756809056747502 NA NA NA 0.240818348367287 67.2090110545811 a241 EP300_mut 1018 ABT-888 PARP1, PARP2 3 11 1.6094379124341 NA 3.4697406360123 4.12225542886146 -0.652514792849163 0.969463539315253 0.363950694324692 1.26273736578693 0.673067904451615 1.79286591020221 0.0764194528871615 NA NA NA 0.363702358439287 67.2090110545811 a242 ARID1A_mut 255 CP724714 ERBB2 5 14 2.32630161961136 NA 4.92361960537827 4.06430455537514 0.85931505000313 0.410750903768875 0.974954275860773 0.981463508307562 2.09205881744488 0.881390103391724 0.076806111645135 NA NA NA 0.0158196520802508 67.2090110545811 a243 loss_cnaBLCA18_(CHD9,CNOT1,CYLD,MMP2,NUP93) 294 MPS-1-IN-1 MPS1 3 16 2.99573227355399 NA 3.28739351951999 4.57415291668191 -1.28675939716192 0.923793647960411 1.10831725633949 1.18242921107983 1.39290782092179 1.16100276324469 0.077443770365244 NA NA NA 0.116247525110565 67.2090110545811 a244 gain_cnaBLCA15_(ASXL1) 265 Tubastatin A HDAC6 6 13 2.99573227355399 NA 5.3864036360161 4.58762714902636 0.798776486989732 0.590694290430147 0.953113953056434 0.926143043220816 1.3522671539758 0.838070289946155 0.0778615614555692 NA NA NA 0.0411170213450327 67.2090110545811 a245 EP300_mut 147 NSC-87877 PTPN6 (SHP-1), PTPN11 (SHP-2) 4 15 2.77258872223978 NA 4.52856539470579 5.20731732494644 -0.678751930240647 1.26475192472252 0.398702528796051 1.05592847487401 0.536668035029525 1.70240186910841 0.0778710768566313 NA NA NA 0.363580036908337 67.2090110545811 a246 ARID1A_mut 341 EX-527 SIRT1 5 14 2.99573227355399 NA 5.66156253378751 5.21860032787052 0.44296220591699 0.515875202192386 0.432154254475884 0.977309267904685 0.858661560072033 1.02500947596643 0.0779516859891817 NA NA NA 0.135699016825971 67.2090110545811 a247 ARID1A_mut 345 KIN001-270 CDK9 5 14 2.99573227355399 NA 5.53916141587935 4.70617197216507 0.832989443714283 0.759018182812634 0.880355440977223 0.976130079912972 1.09745650707278 0.946196734797979 0.0782796093541088 NA NA NA 0.0776353745149005 67.2090110545811 a248 TP53_mut 175 PAC-1 CASP3 agonist 15 4 0.940007258491471 NA 2.42404908058656 3.33672221070369 -0.912673130117128 0.949546225999999 0.196876160940979 1.05431023625991 0.961167666330263 4.63577268956771 0.0782875422483832 NA NA NA 0.00306407267258865 67.2090110545811 a249 ARID1A_mut 180 Thapsigargin sarco-endoplasmic reticulum Ca2+-ATPases 5 14 -0.669430653942629 NA -3.24101962504167 -4.76348625572157 1.5224666306799 1.25983820418357 1.64132321893293 0.975954136714108 1.20846202760339 0.927584898037144 0.078328642581907 NA NA NA 0.0609255370228938 67.2090110545811 a250 gain_cnaBLCA23_(MYC) 230 GSK429286A ROCK2 4 15 2.99573227355399 2.32630161961136 3.49225208157742 5.14639361211322 -1.6541415305358 3.2745861605729 0.832837023352553 1.05389406682823 0.505145215127398 1.98615273355298 0.0783949652501744 NA NA NA 0.388056005511833 67.2090110545811 a251 TP53_mut 341 EX-527 SIRT1 15 4 2.99573227355399 NA 5.23478976268047 5.71159270472944 -0.476802942048961 0.467321015324081 0.38292250358606 1.05122295077945 1.02028996431565 1.24516824575133 0.0790875586518963 NA NA NA 0.0824563202571512 67.2090110545811 a252 gain_cnaBLCA23_(MYC) 172 Embelin XIAP 4 15 3.46573590279973 NA 2.14724003831506 2.8792778129609 -0.73203777464584 0.451711992416376 0.739559794259747 1.0495922522856 1.62058521123138 0.989829058215047 0.0795130427582978 NA NA NA 0.0385784074413507 67.2090110545811 a253 ARID1A_mut 1042 BIRB 0796 p38, JNK2 5 10 2.30258509299405 NA 4.58030821352599 3.69234119326003 0.887967020265963 0.786689443567425 0.881620192077455 1.04033924672767 1.12873895477645 1.00719905039102 0.0799271832614007 NA NA NA 0.0792251740403521 67.2090110545811 a254 ARID1A_mut 134 Etoposide TOP2 5 14 2.77258872223978 NA 2.15633509459666 0.803967674273544 1.35236742032312 1.0702816489764 1.4809174662263 0.969291042256492 1.26356218628666 0.913195671713729 0.0802057173633929 NA NA NA 0.0547112922326886 67.2090110545811 a255 loss_cnaBLCA18_(CHD9,CNOT1,CYLD,MMP2,NUP93) 208 SB-715992 KIF11 3 16 -2.05572501506252 NA -2.597480788777 -0.898235878502952 -1.69924491027405 1.01223388076943 1.50116933167132 1.17010409673858 1.67870779921178 1.13194752545484 0.0803062055421627 NA NA NA 0.0723084919936227 67.2090110545811 a256 loss_cnaBLCA18_(CHD9,CNOT1,CYLD,MMP2,NUP93) 1009 ATRA Retinoic acid and retinoid X receptor agonist 3 11 2.30258509299405 NA 4.39575782398664 3.91665478997588 0.479103034010756 0.141248276417912 0.417807254117765 1.24204069754071 3.39192127621602 1.14670827107208 0.0807533767019562 NA NA NA 0.00883180444991063 67.2090110545811 a257 RB1_mut 286 KIN001-236 TIE2 6 13 2.32630161961136 NA 4.81099877845729 4.10729354863539 0.703705229821893 0.353422656240421 0.887346729289744 0.914181906396998 1.99111521968526 0.793044259469078 0.0814332324877121 NA NA NA 0.024647660502762 67.2090110545811 a258 loss_cnaBLCA18_(CHD9,CNOT1,CYLD,MMP2,NUP93) 207 AS601245 JNK 3 16 2.07944154167984 NA 1.10388606707237 2.4286257521963 -1.32473968512392 0.706874276051915 1.1837179791479 1.16405713185544 1.87408104949434 1.11913454763739 0.081744526342272 NA NA NA 0.0518909259939807 67.2090110545811 a259 gain_cnaBLCA9 346 THZ-2-102-1 CDK7 4 15 0.916290731874155 2.99573227355399 1.53724328038438 -0.820766533035298 2.35800981341968 2.77870751874456 2.13946395816365 1.04087236596641 0.848599500851764 1.10214981861326 0.0818228187816683 NA NA NA 0.189866924819974 67.2090110545811 a260 loss_cnaBLCA18_(CHD9,CNOT1,CYLD,MMP2,NUP93) 261 TL-1-85 MAP3K7 (TAK1) 3 16 2.32630161961136 NA 2.45918358893755 3.74416976088866 -1.28498617195111 1.11834127209724 1.10310470220663 1.16298008791199 1.14901077516469 1.16488142003261 0.0820030859568647 NA NA NA 0.171732378368111 67.2090110545811 a261 gain_cnaBLCA15_(ASXL1) 196 Phenformin AAPK1 (AMPK) agonist 6 13 8.29404964010203 NA 8.26587432119915 9.33238684592661 -1.06651252472746 1.30972652107082 1.10524740019252 0.912245640537823 0.814301693956298 0.964953660638951 0.0820248464011086 NA NA NA 0.119808925389391 67.2090110545811 a262 ARID1A_mut 309 Y-39983 ROCK 5 14 2.99573227355399 NA 5.36747319303517 3.99640377171248 1.37106942132269 0.7893921034182 1.56862073290632 0.962720869826011 1.73686741403383 0.874060499495245 0.0820954898753232 NA NA NA 0.0249706432402872 67.2090110545811 a263 gain_cnaBLCA15_(ASXL1) 257 NPK76-II-72-1 PLK3 6 13 2.32630161961136 NA 4.24965040387276 3.09170526981491 1.15794513405785 1.12189796579705 1.32872233704321 0.910771677256353 1.03213052288155 0.871472618300838 0.0824777492478565 NA NA NA 0.0733160075934941 67.2652173815866 a264 gain_cnaBLCA23_(MYC) 258 STF-62247 stimulates autophagy 4 15 2.32630161961136 NA 3.96015261701781 4.69408127850199 -0.73392866148418 1.25333131505325 0.523302607745967 1.03511308390031 0.585582321824455 1.40249379731824 0.0833807050415257 NA NA NA 0.328799527939723 67.3390329904464 a265 TP53_mut 329 QL-XI-92 DDR1 15 4 2.32630161961136 NA 4.05535188917661 4.94950832048914 -0.894156431312534 0.930691399516869 0.449379815217377 1.03319474983069 0.960744272243946 1.98975655121494 0.0839053959125309 NA NA NA 0.0203524015255404 67.3390329904464 a266 gain_cnaBLCA23_(MYC) 170 Shikonin unknown 4 15 2.77258872223978 NA -1.3199934254555 0.103480728656287 -1.42347415411179 1.56422126824006 1.33621064705354 1.03210908323834 0.910020968908943 1.06530669939704 0.0842036293206176 NA NA NA 0.167039604711312 67.3390329904464 a267 gain_cnaBLCA23_(MYC) 253 XMD14-99 EPHB3, CAMK1 4 15 2.32630161961136 NA 4.36433182585963 4.81901808245573 -0.454686256596107 0.75301263398303 0.339998035060236 1.02896882408008 0.603822879028021 1.33732024808776 0.0850715281850874 NA NA NA 0.316674362680417 67.3390329904464 a268 gain_cnaBLCA15_(ASXL1) 312 AV-951 VEGFR 6 13 -2.05572501506252 NA 0.627612095232312 0.308459667148827 0.319152428083485 0.31332290187793 0.369768386998404 0.901300776188947 1.01860549028052 0.863114423258856 0.085440875509284 NA NA NA 0.0763881489097824 67.3390329904464 a269 loss_cnaBLCA18_(CHD9,CNOT1,CYLD,MMP2,NUP93) 235 QL-XII-47 BTK, BMX 3 16 2.32630161961136 NA 0.297230433841304 2.14057698465052 -1.84334655080922 0.365930248673364 1.70444730073156 1.1478147880476 5.03742600534405 1.08149225266046 0.0857211507421295 NA NA NA 0.00133776063962125 67.3390329904464 a270 CDKN1A_mut 312 AV-951 VEGFR 3 16 -2.05572501506252 NA 0.0670207512912118 0.473411624403436 -0.406390873112225 0.165057229018522 0.372204008521159 1.14741712394171 2.4621210202591 1.09184980228154 0.0858206126406687 NA NA NA 0.0192012946415632 67.3390329904464 a271 TP53_mut 1010 Gefitinib EGFR 10 4 -0.693147180559945 NA 0.296279549074298 1.29834786717445 -1.00206831810015 0.678657829956788 1.37661689389418 1.10713895757053 1.47654425229862 0.727920979718255 0.0858601384665054 NA NA NA 0.244322617647886 67.3390329904464 a272 gain_cnaBLCA23_(MYC) 201 Epothilone B Microtubules 4 15 -3.44201937618241 NA -7.05861250811759 -4.75527383429579 -2.3033386738218 2.35778863486517 2.22160052201172 1.02542250245916 0.976906343410852 1.03679246156103 0.0860611204258048 NA NA NA 0.145276054678407 67.3390329904464 a273 loss_cnaBLCA18_(CHD9,CNOT1,CYLD,MMP2,NUP93) 273 CUDC-101 HDAC, EGFR 3 16 1.63315443905142 NA -1.35168087154122 0.188237267100884 -1.5399181386421 1.49274950781753 1.32202923339645 1.14642016117651 1.03159849028758 1.16481398424592 0.0860704150900502 NA NA NA 0.206705832494215 67.3390329904464 a274 gain_cnaBLCA23_(MYC) 333 T0901317 LXR 4 15 2.32630161961136 NA 3.98493804558241 4.59877843597656 -0.613840390394152 1.05381649321668 0.444844374093675 1.02457525203017 0.582492677183728 1.37989918754124 0.0862990379323828 NA NA NA 0.331052640113002 67.3390329904464 a275 NRAS_mut 150 Bicalutamide ANDR (androgen receptor) 3 16 0.0237165266173161 NA 1.92368798181823 2.44994984731434 -0.526261865496112 0.978387610230715 0.337305619112416 1.1402641025222 0.537886886539797 1.56019299909949 0.0876271180701658 NA NA NA 0.450476878719527 67.3390329904464 a276 EP300_mut 1031 Elesclomol HSP70 3 11 -1.6094379124341 NA -4.96799117870142 -3.2941306599818 -1.67386051871962 0.101482539445778 1.51350786001391 1.2109606831156 16.4940740334347 1.10594768811061 0.0876851214729593 NA NA NA 0.00432415187447733 67.3390329904464 a277 gain_cnaBLCA15_(ASXL1) 225 Genentech Cpd 10 AURKA, AURKB 6 13 2.32630161961136 NA 3.90827270009244 2.61200793624727 1.29626476384517 1.60988300082193 1.37834902529893 0.893797310033787 0.805191907227646 0.940447404868329 0.0878546252287395 NA NA NA 0.124191077013735 67.3390329904464 a278 EP300_mut 341 EX-527 SIRT1 4 15 2.99573227355399 NA 4.968415809266 5.43297026813739 -0.464554458871389 0.279882814936251 0.485411604345479 1.01892796564843 1.6598177311358 0.95703204190552 0.0878996929201681 NA NA NA 0.0366779867224111 67.3390329904464 a279 TP53_mut 283 GSK2126458 PI3K, MTOR 15 4 -2.05572501506252 0.0237165266173161 -2.53728102869044 -1.02095870789128 -1.51632232079916 1.62320749055529 0.510431243032159 1.01864949312657 0.934151874989455 2.97066909892038 0.0879792932855025 NA NA NA 0.00701371995033149 67.3390329904464 a280 gain_cnaBLCA23_(MYC) 329 QL-XI-92 DDR1 4 15 2.32630161961136 NA 3.54675189998304 4.42942026797823 -0.882668367995198 1.37101138487918 0.715036490415752 1.01734834537988 0.64380819716751 1.23443821375043 0.0883520614712673 NA NA NA 0.291606236663872 67.3390329904464 a281 MLL2_mut 1170 CCT018159 HSP90 3 16 2.30258509299405 NA 1.81863133458412 2.78765213813881 -0.969020803554688 0.262578862118866 0.901928909035353 1.13736386011043 3.69039912708597 1.07438712058924 0.0883690498046144 NA NA NA 0.00365525276549387 67.3390329904464 a282 ARID1A_mut 275 I-BET BRD2, BRD3, BRD4 5 14 2.99573227355399 NA 5.36498095685657 4.38144013699858 0.983540819857982 0.768881300790762 1.11615290161142 0.941297581684953 1.27918421067914 0.881188247988261 0.0885332660989486 NA NA NA 0.0548799967560813 67.3390329904464 a283 gain_cnaBLCA9 152 CP466722 ATM 4 15 2.77258872223978 NA 4.013172387785 2.84141327645276 1.17175911133224 1.74027512112157 0.983731601999963 1.01550826482489 0.673318314507116 1.19113700215588 0.0888815971372428 NA NA NA 0.274282072798606 67.3650927523835 a284 gain_cnaBLCA15_(ASXL1) 204 Tipifarnib Farnesyl-transferase (FNTA) 6 13 2.77258872223978 NA 2.01616296516061 0.954698327125079 1.06146463803554 1.71490378333536 0.891005746393315 0.889084012095251 0.618964543871415 1.19131065353082 0.0894012837584295 NA NA NA 0.200589389678238 67.5203854250965 a285 TP53_mut 1008 Methotrexate Dihydrofolate reductase (DHFR) 10 4 -1.6094379124341 NA 0.0304051965130161 -1.00836235711931 1.03876755363232 0.88257955533234 1.13858602413524 1.08994010746856 1.17696761425792 0.912331199938337 0.0902597298738998 NA NA NA 0.168324505680156 67.7591760828266 a286 TP53_mut 1003 Camptothecin TOP1 10 4 -2.30258509299405 NA -4.8312403814235 -2.8295177488101 -2.0017226326134 1.84496390797414 1.8133856990891 1.0895980486351 1.08496574050134 1.10385928025069 0.0903492708562871 NA NA NA 0.115566024857906 67.7591760828266 a287 ARID1A_mut 219 AT-7519 CDK9 5 14 2.32630161961136 NA 2.90929339578028 1.35947859110957 1.54981480467071 1.82826895685175 1.60895562738138 0.931848046533874 0.847695192144744 0.963242726086286 0.0915111329494429 NA NA NA 0.141554112400135 68.0609099405792 a288 TP53_mut 206 Ruxolitinib JAK1, JAK2, TYK2 15 4 1.65632149833295 0.0237165266173161 4.03492834830154 4.48135034601496 -0.446421997713419 0.473081440487372 0.271264541428468 1.0050462674141 0.943647244443814 1.64570715863776 0.0919455788574365 NA NA NA 0.0381174309366918 68.0609099405792 a289 NRAS_mut 1072 BMS-708163 g-secretase 3 15 1.6094379124341 NA 2.87812999423511 3.55097575366575 -0.67284575943064 0.407537398539762 0.615546423451223 1.13360466102913 1.6510037160798 1.09308694486137 0.0919982761482894 NA NA NA 0.0749791876194814 68.0609099405792 a290 ARID1A_mut 1006 Cytarabine DNA synthesis 3 10 0.693147180559945 NA 1.05709915291372 -0.068343876980069 1.12544302989378 0.923161102065208 0.927077646140821 1.21490003267665 1.21911877285129 1.21396846809834 0.09202085229011 NA NA NA 0.152321996637526 68.0609099405792 a291 TP53_mut 171 AKT inhibitor VIII AKT1, AKT2, AKT3 15 4 0.940007258491471 NA 1.81892842813413 2.81830563665993 -0.999377208525803 0.943237499083728 1.21493326656675 1.00280599401041 1.05951810598774 0.822577861704223 0.092613579071418 NA NA NA 0.201127728971619 68.2639126008184 a292 gain_cnaBLCA15_(ASXL1) 305 TPCA-1 IKK 6 13 2.99573227355399 NA 4.43361511765821 3.15826230428106 1.27535281337715 1.45330975557904 1.45150805817221 0.878319049932001 0.877550576180516 0.878639843710631 0.0930236304439726 NA NA NA 0.106263840272337 68.3313389780373 a293 ARID1A_mut 140 Vinorelbine Microtubules 5 14 -2.74887219562247 NA -3.15622877235905 -4.28662219136068 1.13039341900163 1.12287824394259 1.25158223454694 0.92464316155405 1.0066927782238 0.903171511866992 0.0938402184238686 NA NA NA 0.0985391164546722 68.33584781322 a294 loss_cnaBLCA18_(CHD9,CNOT1,CYLD,MMP2,NUP93) 177 GSK-650394 SGK3 3 16 2.77258872223978 NA 1.09824848006627 3.27901735546074 -2.18076887539446 1.96798183602973 1.95538510885161 1.11441610473487 1.10812449356444 1.11526310879764 0.0944363510940267 NA NA NA 0.182735131525711 68.33584781322 a295 EP300_mut 292 Masitinib KIT 4 15 2.99573227355399 NA 4.94422977592307 4.09350838736815 0.850721388554927 0.445252498208347 0.918060801660752 0.99631854259635 1.91064933263294 0.926650377639467 0.0945719920800821 NA NA NA 0.0244765535989178 68.33584781322 a296 gain_cnaBLCA15_(ASXL1) 283 GSK2126458 PI3K, MTOR 6 13 -2.05572501506252 0.0237165266173161 -1.3252125835095 -2.63013652006651 1.30492393655701 1.53696455191089 1.47557169637558 0.873507176329323 0.849026696767084 0.884351427831173 0.0946838926582085 NA NA NA 0.113912323654934 68.33584781322 a297 TP53_mut 312 AV-951 VEGFR 15 4 -2.05572501506252 NA 0.334641500235206 0.689006435200132 -0.354364934964926 0.362760043250964 0.321908981147651 0.9957093988206 0.976857681979517 1.10082338710018 0.0947577230074505 NA NA NA 0.112704791342859 68.33584781322 a298 CDKN1A_mut 204 Tipifarnib Farnesyl-transferase (FNTA) 3 16 2.77258872223978 NA 0.168075710618289 1.50023930698343 -1.33216359636514 0.917982601444204 1.22984725262326 1.11256480635877 1.4511861055638 1.08319435078108 0.0949413391846478 NA NA NA 0.104667151323753 68.33584781322 a299 ARID1A_mut 1025 SB 216763 GSK3A, GSK3B 3 9 2.30258509299405 NA 4.50620143881671 3.45136009423702 1.05484134457969 0.773941021675085 0.883090878031384 1.22319332625287 1.36294797024279 1.19448787301617 0.0964173456980038 NA NA NA 0.121283488735694 68.9569962716411 a300 gain_cnaBLCA15_(ASXL1) 254 AC220 FLT3 6 13 0.0237165266173161 NA 2.66996055569724 2.24813396531591 0.421826590381336 0.362574908796789 0.528751945335471 0.868289647226693 1.16341914497386 0.797777850469571 0.0965132976864171 NA NA NA 0.0624230278781794 68.9569962716411 a301 NRAS_mut 224 AS605240 PI3Kgamma 3 16 2.99573227355399 2.32630161961136 2.10130950279116 3.57169810028519 -1.47038859749402 1.91558231142339 1.23172631575669 1.10509869349888 0.767593534731189 1.19376242813382 0.0970018981749176 NA NA NA 0.313320701147809 68.9569962716411 a302 EP300_mut 1378 Bleomycin (50 uM) DNA damage 4 14 3.91202300542815 NA -0.295283705937294 1.18213318220331 -1.47741688814061 1.23661582516705 1.53216128703186 0.997415543489117 1.19472584619482 0.964269819793383 0.0976354361598461 NA NA NA 0.0938767314941582 68.9569962716411 a303 RB1_mut 173 FH535 unknown 6 13 3.46573590279973 NA 1.05166445432245 2.05871804713028 -1.00705359280784 0.561479644461338 1.33768246132542 0.864869781805639 1.79357097401806 0.752834564198454 0.0977290428993648 NA NA NA 0.0337823192668961 68.9569962716411 a304 EP300_mut 1026 17-AAG HSP90 4 11 0 NA -0.380816052027087 -2.0056266621192 1.62481061009212 2.36909906300332 1.21632997893307 1.04161642624277 0.685834811834476 1.33583043930015 0.0977739303898593 NA NA NA 0.26757388585587 68.9569962716411 a305 gain_cnaBLCA23_(MYC) 293 MP470 PDGFR 4 15 2.99573227355399 NA 2.92180136390332 4.25290875308192 -1.3311073891786 1.88797048191175 1.20559236642882 0.985065781539274 0.705046716530613 1.10411066480254 0.0980547591559606 NA NA NA 0.257267219276858 68.9569962716411 a306 ARID1A_mut 171 AKT inhibitor VIII AKT1, AKT2, AKT3 5 14 0.940007258491471 NA 2.69897714936414 1.79016165870221 0.908815490661931 0.807840238360891 1.05190405828671 0.908950471146667 1.12499408609049 0.863971845628362 0.0990929670762213 NA NA NA 0.0774761080949849 69.4405748348298 a307 loss_cnaBLCA18_(CHD9,CNOT1,CYLD,MMP2,NUP93) 178 BAY 61-3606 SYK 3 16 2.07944154167984 NA 0.930638635622941 2.45780397016233 -1.52716533453939 1.14875610548034 1.42313482122619 1.09579356125094 1.32940780662996 1.0730995488 0.0996244538277355 NA NA NA 0.127617454476113 69.4405748348298 a308 TP53_mut 346 THZ-2-102-1 CDK7 15 4 0.916290731874155 2.99573227355399 -0.796148421532938 1.44492536225053 -2.24107378378347 2.13339851857234 2.89970071820853 0.979764493114895 1.05047123838972 0.772863823397619 0.0997338658895563 NA NA NA 0.223535505757952 69.4405748348298 a309 gain_cnaBLCA23_(MYC) 1373 Dabrafenib BRAF 4 13 2.30258509299405 NA 2.62219208507812 3.84318614025327 -1.22099405517516 0.938836390634046 1.27863929037165 1.00222394640187 1.30053976108718 0.954916734038622 0.100037375425521 NA NA NA 0.077511330743537 69.4405748348298 a310 gain_cnaBLCA23_(MYC) 1006 Cytarabine DNA synthesis 4 9 0.693147180559945 NA -0.503699975254191 0.500295398884136 -1.00399537413833 1.0639899000421 0.878568199772865 1.07632403820419 0.943613632139363 1.14276316215165 0.100798882002657 NA NA NA 0.16008165942702 69.5609578420548 a311 ARID1A_mut 235 QL-XII-47 BTK, BMX 5 14 2.32630161961136 NA 2.92755030988326 1.46451225046543 1.46303805941783 1.81940964556902 1.55172777582517 0.903835727698448 0.80412790103697 0.942844538978379 0.100859415011868 NA NA NA 0.158535825927347 69.5609578420548 a312 gain_cnaBLCA9 219 AT-7519 CDK9 4 15 2.32630161961136 NA 3.05070886739731 1.42508878565641 1.62562008174091 1.95654479081195 1.60454006516745 0.972230558132395 0.830862697023299 1.01313773151015 0.102163089182982 NA NA NA 0.198282710800771 69.9134479102756 a313 loss_cnaBLCA18_(CHD9,CNOT1,CYLD,MMP2,NUP93) 266 Zibotentan, ZD4054 Endothelin A Receptor 3 16 2.99573227355399 NA 5.13396806439041 5.52171613799405 -0.387748073603635 0.0887714739959978 0.379469466257646 1.08385932470075 4.36793551069251 1.02181626739994 0.103078022644417 NA NA NA 0.00258043658497972 69.9134479102756 a314 ARID1A_mut 1024 CEP-701 FLT3, JAK2, NTRK1, RET 3 11 0.693147180559945 NA 0.935001668069235 -0.477836643208053 1.41283831127729 1.50845789064814 1.16749737863913 1.14780873168121 0.936611038356683 1.21014259828501 0.103458564752208 NA NA NA 0.239565862541178 69.9134479102756 a315 gain_cnaBLCA23_(MYC) 1268 XAV 939 TNKS1 (tankyrase-1) 4 14 1.6094379124341 NA 2.6666431837891 3.35975864618036 -0.693115462391265 0.409533943523477 0.760534577124189 0.978836475152204 1.6924493643383 0.911352992012727 0.103510041650173 NA NA NA 0.0379809635209809 69.9134479102756 a316 CDKN1A_mut 1502 Bicalutamide ANDR (androgen receptor) 3 14 2.30258509299405 NA 4.81166631176186 4.18236036227154 0.629305949490319 0.0964089062052077 0.613023219401749 1.100611802151 6.52746695570669 1.02656135946116 0.104154345540708 NA NA NA 0.00246174568486519 69.9134479102756 a317 TP53_mut 253 XMD14-99 EPHB3, CAMK1 15 4 2.32630161961136 NA 4.63267771191917 5.06310821537173 -0.430430503452558 0.488281165146299 0.128327468812005 0.964279774532095 0.881521824262037 3.35415719983634 0.104782197340308 NA NA NA 0.0073902307559224 69.9134479102756 a318 loss_cnaBLCA18_(CHD9,CNOT1,CYLD,MMP2,NUP93) 1036 PLX4720 BRAF 3 12 2.30258509299405 NA 3.19685151471067 3.89557819130675 -0.698726676596081 0.371409385021359 0.656264429334532 1.12515588924035 1.8812843853041 1.06470295411959 0.104905692864104 NA NA NA 0.0524072053336611 69.9134479102756 a319 RB1_mut 172 Embelin XIAP 6 13 3.46573590279973 NA 2.3166357396135 2.91371637769174 -0.597080638078246 0.359609106370495 0.808884091488241 0.844493169431312 1.66036017303492 0.738153518360951 0.105252493395551 NA NA NA 0.0397544476778794 69.9134479102756 a320 gain_cnaBLCA9 287 KIN001-244 PDPK1 (PDK1) 4 15 2.99573227355399 NA 4.52462744356455 3.46032737826162 1.06430006530293 1.22051651403224 1.07954894292643 0.962529644919346 0.872007918833303 0.985874769529054 0.10536645676458 NA NA NA 0.182248339239606 69.9134479102756 a321 gain_cnaBLCA15_(ASXL1) 261 TL-1-85 MAP3K7 (TAK1) 6 13 2.32630161961136 NA 4.18696776555949 3.24326618059033 0.943701584969161 1.14113797751797 1.10899299420648 0.843688022292604 0.826982892131729 0.850953603764113 0.105559796620885 NA NA NA 0.123241879904269 69.9134479102756 a322 MLL2_mut 186 Bexarotene Retinioic acid X family agonist 3 16 2.07944154167984 NA 2.69188775655529 3.70209637644862 -1.01020861989332 0.766196915770421 0.963685437373681 1.07172394083112 1.31847126906997 1.04827631581362 0.106695682368792 NA NA NA 0.129627546560272 69.9134479102756 a323 gain_cnaBLCA9 202 GSK-1904529A IGF1R 4 15 0.0237165266173161 NA 2.46511811429668 1.97524286856554 0.489875245731147 0.377136173935712 0.537511139503428 0.955170493577281 1.29893465434226 0.911376918036919 0.10785413429761 NA NA NA 0.0764422889314591 69.9134479102756 a324 gain_cnaBLCA23_(MYC) 134 Etoposide TOP2 4 15 2.77258872223978 NA 0.0934408062746551 1.44423064584762 -1.35078983957296 1.14084088994392 1.46784625636953 0.954190941582606 1.18403000057209 0.920252944551504 0.108189052994537 NA NA NA 0.0961638913041104 69.9134479102756 a325 TP53_mut 282 EKB-569 EGFR 15 4 0.916290731874155 2.99573227355399 1.62074317201971 3.02955743027395 -1.40881425825424 1.60548646819704 0.600430878450202 0.952785116949012 0.877499926758239 2.34633878572433 0.108671285594105 NA NA NA 0.0153697665139656 69.9134479102756 a326 MLL2_mut 228 KIN001-102 AKT1 3 16 2.32630161961136 NA 4.43905640330035 3.14319362906687 1.29586277423348 0.516240243882127 1.28140494246865 1.06512940655551 2.51019324740859 1.01128279694082 0.108707175912633 NA NA NA 0.018392938228928 69.9134479102756 a327 MLL2_mut 283 GSK2126458 PI3K, MTOR 3 16 -2.05572501506252 0.0237165266173161 -0.871185766572289 -2.4705933101378 1.59940754356551 0.449367381739395 1.59296685681237 1.06325973450092 3.55924263433314 1.00404320198226 0.109283386842303 NA NA NA 0.00509864777879905 69.9134479102756 a328 RB1_mut 1373 Dabrafenib BRAF 6 11 2.30258509299405 NA 4.23854652822531 3.18353718129574 1.05500934692957 0.471357835975091 1.46257697743683 0.861369314782484 2.23823445036632 0.721335945529836 0.110301111991765 NA NA NA 0.0468055585324366 69.9134479102756 a329 loss_cnaBLCA18_(CHD9,CNOT1,CYLD,MMP2,NUP93) 257 NPK76-II-72-1 PLK3 3 16 2.32630161961136 NA 2.306988741734 3.67306904410177 -1.36608030236776 0.927988265166335 1.33033648572998 1.05935990579985 1.47208790633026 1.02686825252197 0.110493740120056 NA NA NA 0.100496494125504 69.9134479102756 a330 EP300_mut 1242 (5Z)-7-Oxozeaenol MAP3K7 (TAK1) 4 15 2.30258509299405 NA -0.168557118873111 0.73488774457391 -0.903444863447021 1.39616722772004 0.829296988356183 0.946880344685324 0.647089292392546 1.08941052015372 0.110717050405868 NA NA NA 0.290855743197496 69.9134479102756 a331 gain_cnaBLCA9 268 YM155 BIRC5 (Survivin) 4 15 1.63315443905142 NA -2.34022318020656 -4.24731098170022 1.90708780149365 3.76376984271133 1.37495404344538 0.946850002953564 0.506696179944901 1.38701930481607 0.110727647608203 NA NA NA 0.388230972845921 69.9134479102756 a332 MLL2_mut 159 HG-6-64-1 BRAFV600E, TAK, MAP4K5 3 16 1.63315443905142 NA 1.29002927374617 0.146843603259179 1.14318567048699 1.40695947043135 1.02849280918085 1.05857914502005 0.812522104944861 1.11151547223503 0.110737438823334 NA NA NA 0.2917842131221 69.9134479102756 a333 MLL2_mut 1014 RDEA119 MAP2K1 (MEK1), MAP2K2 (MEK2) 3 12 1.6094379124341 NA 0.0437026859395132 1.34670527677939 -1.30300259083987 1.8983745290787 0.994531594929875 1.10465223000696 0.686378041256292 1.31016711533609 0.110760565651803 NA NA NA 0.356334216648002 69.9134479102756 a334 ARID1A_mut 1194 SB-505124 TGFR1 (ALK5) 5 14 2.30258509299405 NA 4.70784190491242 3.85811168479994 0.849730220112479 0.231204832841997 1.10338410371979 0.874768418606063 3.67522689585461 0.770112798659889 0.111425331019101 NA NA NA 0.0154045485340268 69.9134479102756 a335 gain_cnaBLCA15_(ASXL1) 345 KIN001-270 CDK9 6 13 2.99573227355399 NA 5.41744971974985 4.69827049009297 0.719179229656877 0.442682325233782 0.993016429913622 0.828398439732844 1.62459440700976 0.724236989431721 0.111544199296259 NA NA NA 0.0433343508114084 69.9134479102756 a336 ARID1A_mut 1494 SN-38 TOP1 5 13 -2.99573227355399 NA -3.87026485239704 -5.2922688968921 1.42200404449505 2.70195581182524 1.0127806702245 0.882834811489979 0.526286935660303 1.40405922654491 0.11283967028202 NA NA NA 0.309690630453922 69.9134479102756 a337 gain_cnaBLCA9 1060 PD-0325901 MAP2K1 (MEK1), MAP2K2 (MEK2) 3 12 -1.38629436111989 0.693147180559945 0.0930396476148432 -1.37747788653392 1.47051753414876 0.781099207525949 1.41790097499346 1.097582025919 1.88262581754048 1.03710876858346 0.112845386387307 NA NA NA 0.0527898604689097 69.9134479102756 a338 CDKN1A_mut 304 SB52334 ALK5 3 16 2.99573227355399 NA 3.8941801504444 4.90148294288347 -1.00730279243907 1.09142960751718 0.939205581523438 1.0510582817944 0.922920530560395 1.07250511736225 0.113108692425465 NA NA NA 0.244890796479569 69.9134479102756 a339 ARID1A_mut 157 JNK-9L JNK 5 14 1.63315443905142 NA 0.177819924149984 -0.633795199236674 0.811615123386658 0.718145009905537 0.989646784388103 0.869991618504212 1.13015492998192 0.820105856139854 0.113249903518839 NA NA NA 0.0800361510336325 69.9134479102756 a340 gain_cnaBLCA15_(ASXL1) 256 JW-7-24-1 LCK 6 13 2.32630161961136 NA 2.80943480271938 1.86342245853378 0.946012344185593 1.90150392166707 0.601542259539012 0.823750118274927 0.497507437879071 1.57264486274092 0.113420482537714 NA NA NA 0.282619307436013 69.9134479102756 a341 TP53_mut 1114 Cetuximab EGFR 14 4 4.18661983833127 NA 5.69726318281561 6.20900218973179 -0.51173900691618 0.500873105123115 0.679946874292337 0.949422249167618 1.02169392143823 0.752616162032921 0.113439615778507 NA NA NA 0.234276818197297 69.9134479102756 a342 RB1_mut 1498 AZD6244 MAP2K1 (MEK1), MAP2K2 (MEK2) 6 13 1.38629436111989 NA 2.02363734023699 1.06901335461042 0.954623985626569 0.955939629016468 1.23565894187456 0.822661557082766 0.998623717073794 0.772562681558681 0.113863772699983 NA NA NA 0.0898006190460768 69.9134479102756 a343 EP300_mut 206 Ruxolitinib JAK1, JAK2, TYK2 4 15 1.65632149833295 0.0237165266173161 3.79682831192626 4.21746755739186 -0.420639245465594 0.494087773482136 0.438525557922587 0.937189038825972 0.851345182053574 0.959212611137821 0.114146506555306 NA NA NA 0.190866562165253 69.9134479102756 a344 gain_cnaBLCA15_(ASXL1) 275 I-BET BRD2, BRD3, BRD4 6 13 2.99573227355399 NA 5.23502034487142 4.36576497177188 0.869255373099535 0.828941197233494 1.13967592714949 0.821756523354607 1.04863333611671 0.762721535475158 0.114233456640257 NA NA NA 0.0825904069494375 69.9134479102756 a345 gain_cnaBLCA15_(ASXL1) 140 Vinorelbine Microtubules 6 13 -2.74887219562247 NA -3.29566322702667 -4.30922116759114 1.01355794056447 1.62982318552344 1.02534825004994 0.821187928435629 0.621882146215114 0.988501165838143 0.114466239799255 NA NA NA 0.204643601499143 69.9134479102756 a346 gain_cnaBLCA15_(ASXL1) 231 FMK RSK 5 9 2.99573227355399 2.32630161961136 5.50356519738173 5.12735160398726 0.376213593394476 0.432522153750345 0.376937665206079 0.949236226625711 0.86981346535056 0.998079067499908 0.114528330640507 NA NA NA 0.144433395638329 69.9134479102756 a347 ARID1A_mut 207 AS601245 JNK 5 14 2.07944154167984 NA 2.95757486807068 1.95584256400032 1.00173230407036 1.27997928201543 1.11632339912484 0.865864864305093 0.782616029919682 0.897349553772399 0.114846773635616 NA NA NA 0.169160845562615 69.9134479102756 a348 MLL2_mut 260 NG-25 MAP3K7 (TAK1) 3 16 2.32630161961136 NA 4.33430050750032 2.87384783206209 1.46045267543823 0.829763147142038 1.45614117487996 1.04534398917745 1.76008380279178 1.00296090834642 0.114939378131225 NA NA NA 0.0620498399264194 69.9134479102756 a349 ARID1A_mut 291 KIN001-266 MAP3K8 (COT) 5 14 2.99573227355399 NA 4.3454126645852 3.40904771473578 0.936364949849426 1.39925302101699 0.964630492744572 0.864837616980453 0.669189157203941 0.970698061996025 0.115247260443744 NA NA NA 0.220731636944059 69.9134479102756 a350 loss_cnaBLCA5_(FAT1,IRF2) 202 GSK-1904529A IGF1R 5 14 0.0237165266173161 NA 2.40610700439982 1.96132717597648 0.444779828423342 0.347606911694592 0.55589210553026 0.864445623516193 1.27954828704363 0.800118987117241 0.11540039976981 NA NA NA 0.061539166888445 69.9134479102756 a351 gain_cnaBLCA15_(ASXL1) 304 SB52334 ALK5 6 13 2.99573227355399 NA 5.27978668995017 4.49442672290521 0.785359967044958 0.813912981903428 1.01378148397665 0.818655498198517 0.964918835928018 0.774683676372063 0.115507964450634 NA NA NA 0.0960553766109332 69.9134479102756 a352 gain_cnaBLCA9 157 JNK-9L JNK 4 15 1.63315443905142 NA 0.267708775738869 -0.603657884767933 0.871366660506802 1.0375082264235 0.910062906871118 0.933122581831533 0.839864820648778 0.957479591715964 0.115612421861241 NA NA NA 0.195556001822628 69.9134479102756 a353 TP53_mut 290 KIN001-260 IKK 15 4 2.99573227355399 NA 4.79292491146999 5.82852786399371 -1.03560295252372 1.21816565893003 0.239052991015764 0.932959486326816 0.850133103763027 4.33210623353139 0.115671551006777 NA NA NA 0.00692761752753305 69.9134479102756 a354 CDKN1A_mut 260 NG-25 MAP3K7 (TAK1) 3 16 2.32630161961136 NA 1.87802493348415 3.33439950219012 -1.45637456870597 0.790876479068937 1.4597100221162 1.0419533084535 1.84146906280548 0.99771498903228 0.116037611469813 NA NA NA 0.0541627099459979 69.9134479102756 a355 gain_cnaBLCA9 312 AV-951 VEGFR 4 15 -2.05572501506252 NA 0.673467464517332 0.338785225750619 0.334682238766712 0.385854095456986 0.353490982763016 0.931188823329 0.867380294021065 0.946791446137359 0.116315161405352 NA NA NA 0.184816450792433 69.9134479102756 a356 MLL2_mut 341 EX-527 SIRT1 3 16 2.99573227355399 NA 4.93045295074932 5.41105365042981 -0.480600699680492 0.329931073687235 0.477076032408756 1.0398051278865 1.45667000779711 1.00738806192786 0.116738042123603 NA NA NA 0.102923050720674 69.9134479102756 a357 TP53_mut 1020 Lenalidomide TNFA 10 4 1.6094379124341 NA 3.52492529198918 4.35868209614647 -0.833756804157287 0.957755461275329 0.168694875130399 1.00004623460592 0.870532028130722 4.94239557374107 0.116740829146097 NA NA NA 0.0237385515903299 69.9134479102756 a358 gain_cnaBLCA23_(MYC) 286 KIN001-236 TIE2 4 15 2.32630161961136 NA 3.75575972589514 4.48251799329488 -0.726758267399742 1.15177633592031 0.67920035610356 0.927475991920065 0.630989059884647 1.07002044517322 0.117674680251857 NA NA NA 0.301085825608206 69.9134479102756 a359 gain_cnaBLCA15_(ASXL1) 228 KIN001-102 AKT1 6 13 2.32630161961136 NA 4.02714417165287 3.03426171115799 0.992882460494878 1.31256414932761 1.18124840916808 0.812947048299841 0.756444902905132 0.840536548272804 0.117885974911802 NA NA NA 0.148682611358841 69.9134479102756 a360 loss_cnaBLCA18_(CHD9,CNOT1,CYLD,MMP2,NUP93) 185 OSI-906 IGF1R 3 16 0.940007258491471 NA 1.25243830047146 2.4654451265003 -1.21300682602884 2.25730847469143 0.937045496457964 1.03475018264331 0.537368658129306 1.29450152699524 0.118400530828782 NA NA NA 0.451180358863382 69.9134479102756 a361 gain_cnaBLCA15_(ASXL1) 1003 Camptothecin TOP1 4 10 -2.30258509299405 NA -2.92948695270323 -4.79125269986624 1.86176574716301 1.57399285096474 1.96108497243999 0.994622381918458 1.18282986229695 0.949354960813655 0.118540402354762 NA NA NA 0.105598037572513 69.9134479102756 a362 TP53_mut 223 ZSTK474 PI3K 15 4 1.63315443905142 2.32630161961136 1.4285326273074 2.74062668975451 -1.31209406244711 1.46107931602114 1.20373187322085 0.924621731124364 0.898030687355325 1.09002186586313 0.118729035120958 NA NA NA 0.117417320278521 69.9134479102756 a363 RB1_mut 133 Doxorubicin DNA intercalating 6 13 0.0237165266173161 NA -2.98957590176836 -1.65392478302279 -1.33565111874556 1.14604933866679 1.81585141491069 0.810779024384995 1.16543945682071 0.735550886916184 0.118800030112848 NA NA NA 0.0711035334443361 69.9134479102756 a364 gain_cnaBLCA15_(ASXL1) 281 CH5424802 ALK 6 13 1.63315443905142 NA 4.28578762490286 4.00785260670201 0.277935018200845 0.355516821885549 0.337894046773718 0.809902001141195 0.781777404306117 0.822550799147323 0.119171506016292 NA NA NA 0.140833477021472 69.9134479102756 a365 loss_cnaBLCA5_(FAT1,IRF2) 1199 Tamoxifen ER 5 14 1.6094379124341 NA 3.87779988271877 3.40619322615911 0.471606656559665 0.443817395795087 0.581548153583234 0.85398862371988 1.06261417652364 0.810950311945521 0.119550411024974 NA NA NA 0.0930216354574269 69.9134479102756 a366 gain_cnaBLCA23_(MYC) 185 OSI-906 IGF1R 4 15 0.940007258491471 NA 1.4198903007892 2.50165838148416 -1.08176808069496 1.88321797774102 0.954085698809059 0.922368352390678 0.574425315327848 1.13382695290924 0.119567116962991 NA NA NA 0.338320423253978 69.9134479102756 a367 gain_cnaBLCA23_(MYC) 178 BAY 61-3606 SYK 4 15 2.07944154167984 NA 1.19443572155843 2.48926910288216 -1.29483338132374 0.591047774641992 1.5252262896957 0.920794211454232 2.19074233399836 0.848945097571109 0.120155566722675 NA NA NA 0.0199860587342765 69.9134479102756 a368 gain_cnaBLCA15_(ASXL1) 300 CX-5461 RNA Pol I 6 13 2.32630161961136 NA 4.7256454381542 3.73136385085514 0.994281587299063 0.649437237214581 1.40458606893752 0.807356880173009 1.53098949417115 0.707882278834771 0.120255148804456 NA NA NA 0.0500207802580742 69.9134479102756 a369 MLL2_mut 1053 MK-2206 AKT1, AKT2 3 12 1.38629436111989 0.693147180559945 1.06690699778156 2.16748320755007 -1.10057620976851 0.697838871578938 1.07564322379141 1.07204958177887 1.57712081483558 1.02317960586338 0.120664496035049 NA NA NA 0.0853822147264263 69.9134479102756 a370 EP300_mut 249 XL-184 VEGFR, MET, RET, KIT, FLT1, FLT3, FLT4, Tie2,AXL 4 15 1.63315443905142 NA 3.73347834826839 2.89049189495698 0.842986453311412 0.327905089331091 0.999764193369179 0.918617608799061 2.5708245487469 0.843185281991917 0.120973299222434 NA NA NA 0.0142434608029691 69.9134479102756 a371 MLL2_mut 199 Pazopanib VEGFR, PDGFRA, PDGFRB, KIT 3 16 2.07944154167984 NA 3.99247539998318 2.65300442819222 1.33947097179096 0.419201472233715 1.38049857832714 1.02665074291927 3.19529166883311 0.970280587622269 0.1211064660486 NA NA NA 0.00806072298684545 69.9134479102756 a372 loss_cnaBLCA5_(FAT1,IRF2) 179 5-Fluorouracil DNA antimetabolite 5 14 3.46573590279973 NA 3.55567349141074 4.51974117876047 -0.964067687349734 1.25206629502015 1.09576627075711 0.849786899956722 0.769981342988087 0.879811427927619 0.121253466354553 NA NA NA 0.175305471407098 69.9134479102756 a373 RB1_mut 136 Mitomycin C DNA crosslinker 6 13 2.77258872223978 NA -2.05426086552291 -0.830191453830221 -1.22406941169269 1.6717715178055 1.45632298082979 0.803797684399929 0.732198986916287 0.840520562955915 0.121784645514911 NA NA NA 0.158377641197332 69.9624342746062 a374 MLL2_mut 299 OSI-027 MTORC1/2 3 16 2.99573227355399 NA 3.3867321605686 1.61473945188033 1.77199270868828 1.29374559359626 1.78211449781498 1.02319553235274 1.36966086490205 0.994320348586403 0.122276760791629 NA NA NA 0.118707298974505 69.9624342746062 a375 TP53_mut 1050 ZM-447439 AURKB 11 4 1.38629436111989 0.693147180559945 1.89539273623511 3.06085904563486 -1.16546630939975 1.10012554065496 1.51517243007047 0.964292670391882 1.05939392035739 0.76919714632449 0.122564246561963 NA NA NA 0.228108949557283 69.9624342746062 a376 MLL2_mut 207 AS601245 JNK 3 16 2.07944154167984 NA 3.2183595720601 2.0321619700111 1.186197602049 1.81860863689009 1.04183563131869 1.02211961521787 0.652255563944455 1.138565015815 0.122643139459055 NA NA NA 0.376137846429582 69.9624342746062 a377 EP300_mut 1001 AICAR AAPK1 (AMPK) agonist 3 11 7.60090245954208 NA 7.46319121464645 8.10814034169515 -0.644949127048693 0.227711562484076 0.645846618424901 1.08057255394314 2.83230732780113 0.99861036451906 0.12300335795545 NA NA NA 0.0199830941583382 69.9818010295316 a378 TP53_mut 200 LAQ824 HDAC 15 4 0.0237165266173161 NA -2.94170260350414 -2.06694462710979 -0.874757976394345 0.866950915591052 1.30525999548045 0.912185898439485 1.00900519356159 0.67017910563662 0.123417411336435 NA NA NA 0.278098127015688 70.0316132235707 a379 loss_cnaBLCA18_(CHD9,CNOT1,CYLD,MMP2,NUP93) 346 THZ-2-102-1 CDK7 3 16 0.916290731874155 2.99573227355399 -2.30382040004467 0.0468085203838797 -2.35062892042855 0.40847694417141 2.45644370615485 1.01685016754241 5.75461835476852 0.956923586133414 0.124451049595601 NA NA NA 0.00234436770108169 70.4017842475678 a380 loss_cnaBLCA18_(CHD9,CNOT1,CYLD,MMP2,NUP93) 298 OSI-930 KIT, VEGFR, PDGFR 3 16 2.32630161961136 NA 3.70355238122902 4.44358917644479 -0.740036795215771 0.987711877299741 0.687750902809284 1.01448451939865 0.749243592411709 1.0760244620442 0.12527002588453 NA NA NA 0.322553773789314 70.4017842475678 a381 TP53_mut 1025 SB 216763 GSK3A, GSK3B 9 3 2.30258509299405 NA 3.46940955227769 4.45205306469471 -0.982643512417027 0.923767419573721 0.685920882517598 1.11493234432575 1.06373475790094 1.43259016814059 0.125393595883067 NA NA NA 0.11086997068047 70.4017842475678 a382 gain_cnaBLCA23_(MYC) 1036 PLX4720 BRAF 3 12 2.30258509299405 NA 3.22502268349986 3.88853539910945 -0.66351271560959 0.165130872350899 0.679170221895945 1.05639042172353 4.01810216444351 0.97694612369393 0.125691160942827 NA NA NA 0.00951760338993812 70.4017842475678 a383 gain_cnaBLCA15_(ASXL1) 1243 piperlongumine Increases ROS levels 6 13 2.30258509299405 NA 0.838932029646041 1.50686277109681 -0.667930741450765 0.402723313003352 0.966236622187797 0.794523703535097 1.65853507826403 0.691270363918111 0.125847980253129 NA NA NA 0.0486302525506358 70.4017842475678 a384 gain_cnaBLCA15_(ASXL1) 293 MP470 PDGFR 6 13 2.99573227355399 NA 3.23048319043752 4.31522596993977 -1.08474277950225 2.10008246879236 0.901604392940568 0.793037729807815 0.51652389638109 1.20312499361763 0.126509636619972 NA NA NA 0.27110950316486 70.4017842475678 a385 gain_cnaBLCA23_(MYC) 302 PI-103 PI3Ka, PRKDC (DNAPK) 4 15 2.32630161961136 NA 0.645816723921611 2.62809212413813 -1.98227540021652 3.42849061853813 1.82253224056343 0.903859809972569 0.578177285799818 1.08764901717388 0.126643679492499 NA NA NA 0.336116861506653 70.4017842475678 a386 ARID1A_mut 295 NVP-BHG712 EPHB4 5 14 2.32630161961136 NA 4.49134411327983 3.33172433178511 1.15961978149472 1.44939986717125 1.3672588620009 0.836048905967321 0.800068916632312 0.848134770761466 0.126966742315774 NA NA NA 0.164751756210233 70.4017842475678 a387 gain_cnaBLCA9 1259 BMN-673 PARP1 4 14 2.30258509299405 NA 2.99253602644494 1.58866052179093 1.40387550465402 1.42031243263607 1.56823172264139 0.910674108243358 0.988427244876293 0.895196471532568 0.127765727800503 NA NA NA 0.146020295310044 70.4017842475678 a388 TP53_mut 1066 AZD6482 PI3Kbeta 14 4 1.6094379124341 NA 1.80226635526517 2.73557506347849 -0.933308708213321 0.984141322512721 1.18656695586605 0.910415994401681 0.948348257372616 0.786562194066931 0.127866115048926 NA NA NA 0.219636089266459 70.4017842475678 a389 gain_cnaBLCA9 263 FR-180204 ERK 4 15 2.99573227355399 NA 5.4902172923575 4.91787117670708 0.572346115650417 0.616312781436312 0.63948552911124 0.900683368318586 0.928661765405171 0.895010269342398 0.127893236462896 NA NA NA 0.163920944386105 70.4017842475678 a390 gain_cnaBLCA9 172 Embelin XIAP 4 15 3.46573590279973 NA 2.21812726509344 2.86037455248666 -0.642247287393225 0.377487100345836 0.766792965021789 0.899892466913689 1.70137545575684 0.837575873397554 0.128205983002808 NA NA NA 0.0396340764481739 70.4017842475678 a391 RB1_mut 272 AR-42 HDAC 6 13 1.63315443905142 NA 0.78623748410131 -0.279130184663314 1.06536766876462 1.67954594018009 1.18668579098545 0.788899639249095 0.634318861590885 0.897767274924495 0.128367764137211 NA NA NA 0.201771451368972 70.4017842475678 a392 loss_cnaBLCA5_(FAT1,IRF2) 1219 PFI-1 BRD2, BRD3, BRD4 5 14 2.30258509299405 NA 2.83249451361126 2.11607815162182 0.716416361989437 0.922931506451287 0.842472958644239 0.831032131148203 0.77624001020844 0.85037312431053 0.129109270733216 NA NA NA 0.174252204467251 70.4017842475678 a393 TP53_mut 1264 SGC0946 Q8TEK3 (DOT1L) 14 4 -0.693147180559945 NA 1.50055980678483 1.88017251587201 -0.379612709087187 0.461209976059739 0.11585112020785 0.906549155504331 0.823080004318937 3.27672886033487 0.129378089282079 NA NA NA 0.0131858765749386 70.4017842475678 a394 CDKN1A_mut 135 Gemcitabine DNA replication 3 16 0.0237165266173161 NA -4.66336155652805 -1.91264534328795 -2.7507162132401 0.931169888321758 2.90151642051333 1.00239276091974 2.95404334669552 0.948027105341506 0.129527934588248 NA NA NA 0.0110781967267303 70.4017842475678 a395 loss_cnaBLCA18_(CHD9,CNOT1,CYLD,MMP2,NUP93) 1052 RO-3306 CDK1 3 12 1.6094379124341 NA 1.77851396066828 3.04743119385184 -1.26891723318356 0.554730487028462 1.2999681066196 1.04400606277595 2.2874481624055 0.976114126740557 0.129794824841428 NA NA NA 0.0317962490754157 70.4017842475678 a396 gain_cnaBLCA15_(ASXL1) 310 YM201636 FYV1 6 13 1.63315443905142 NA 3.40933539098347 2.51294600970366 0.896389381279812 1.48800364960755 0.962147682908595 0.784775015210917 0.602410741073267 0.931654669239556 0.130242796015406 NA NA NA 0.218692682760355 70.4017842475678 a397 gain_cnaBLCA23_(MYC) 151 QS11 ARFGAP 4 15 2.32630161961136 NA 1.93608846556074 3.34827297946679 -1.41218451390605 0.873342690158514 1.69181554676163 0.894623468590087 1.61698784431313 0.834715413633104 0.13030607848987 NA NA NA 0.0455765198418152 70.4017842475678 a398 CDKN1A_mut 179 5-Fluorouracil DNA antimetabolite 3 16 3.46573590279973 NA 3.30885171715585 4.44551180051455 -1.1366600833587 0.848279651034874 1.17191820852896 0.998271954377072 1.33995915376729 0.969914175824162 0.131006721347338 NA NA NA 0.124483422038847 70.6024876382571 a399 ARID1A_mut 1011 ABT-263 BCL2, BCL2L1, BCL2L2 5 10 0.693147180559945 NA 2.70000948342137 2.02646818020634 0.673541303215032 0.733024353649338 0.778050695234111 0.881046242640434 0.918852559075055 0.865677914486494 0.131716582231581 NA NA NA 0.136444614437735 70.7100947228081 a400 TP53_mut 328 SNX-2112 HSP90 14 4 0.940007258491471 NA -0.851287638315133 0.91181802380325 -1.76310566211838 1.87968313715926 2.26824169888449 0.900269931935512 0.937980251705053 0.777300612622311 0.131865720696318 NA NA NA 0.22416382765823 70.7100947228081 a401 gain_cnaBLCA9 333 T0901317 LXR 4 15 2.32630161961136 NA 4.89788261068106 4.35532655195026 0.542556058730804 0.399717052583788 0.648238946834409 0.886873235331016 1.35735029372327 0.836969240093189 0.133447937898438 NA NA NA 0.0716140592889993 70.9288258674143 a402 loss_cnaBLCA18_(CHD9,CNOT1,CYLD,MMP2,NUP93) 274 PXD101, Belinostat HDAC 3 16 2.99573227355399 NA -0.680510782272634 0.664241293515071 -1.3447520757877 0.871560848336188 1.40991143919851 0.990462506625105 1.54292391444021 0.953784782789017 0.133848353182327 NA NA NA 0.0889792844085515 70.9288258674143 a403 MLL2_mut 150 Bicalutamide ANDR (androgen receptor) 3 16 0.0237165266173161 NA 1.97421948046059 2.4404751913189 -0.466255710858306 0.553641485740177 0.45887785260707 0.989891234393849 0.842161801215017 1.01607804388318 0.134058247355122 NA NA NA 0.278301763995059 70.9288258674143 a404 loss_cnaBLCA18_(CHD9,CNOT1,CYLD,MMP2,NUP93) 165 DMOG Prolyl-4-Hydroxylase 3 16 8.29404964010203 NA 6.51686137023465 5.59497473457248 0.921886635662169 0.158486616292882 0.990608335003001 0.989041553955151 5.81681063818365 0.930626770528209 0.134370946033499 NA NA NA 0.00279353485479259 70.9288258674143 a405 gain_cnaBLCA9 1264 SGC0946 Q8TEK3 (DOT1L) 4 14 -0.693147180559945 NA 1.87618188414122 1.50169998727934 0.374481896861877 0.291528936024328 0.443987585257241 0.892383975000064 1.2845445188694 0.843451279487707 0.135047288253663 NA NA NA 0.0837033032267103 70.9288258674143 a406 NRAS_mut 305 TPCA-1 IKK 3 16 2.99573227355399 NA 4.78888090106201 3.33077862240106 1.45810227866095 1.4858647198107 1.47724233397151 0.986364324980753 0.981315633395423 0.987043388298315 0.135360238623435 NA NA NA 0.222834576605843 70.9288258674143 a407 TP53_mut 331 QL-X-138 MNK2, PRKDC (DNAPK), MTOR, BTK, JAK3 15 4 2.32630161961136 NA 1.81553602066952 2.98760915477254 -1.17207313410302 1.2676401336969 1.5823858869177 0.882178218690743 0.924610307725765 0.740699941647024 0.135382143479626 NA NA NA 0.241415139985553 70.9288258674143 a408 NRAS_mut 202 GSK-1904529A IGF1R 3 16 0.0237165266173161 NA 1.64838564425943 2.15899740955572 -0.510611765296286 0.630556762588316 0.501697050657058 0.984745024121562 0.809779223047775 1.01776911908801 0.135961575159856 NA NA NA 0.293014541877827 70.9288258674143 a409 loss_cnaBLCA18_(CHD9,CNOT1,CYLD,MMP2,NUP93) 153 Midostaurin KIT 3 16 -0.669430653942629 NA -1.26219049967806 -0.136823495418125 -1.12536700425993 0.278733904463537 1.21234313822846 0.984741769531438 4.03742417495231 0.928257824681865 0.135962786030127 NA NA NA 0.00490628560654376 70.9288258674143 a410 NRAS_mut 219 AT-7519 CDK9 3 16 2.32630161961136 NA 0.364531377629019 2.03034832009677 -1.66581694246775 1.02807423493688 1.76538576840758 0.982569111885939 1.62032748789783 0.943599394692274 0.136773150332278 NA NA NA 0.0782888670307283 70.9288258674143 a411 gain_cnaBLCA15_(ASXL1) 1164 XMD8-92 MAP2K5 (ERK5) 3 4 2.30258509299405 NA 1.94933021028139 2.78960032678668 -0.840270116505286 0.360024067192478 0.746423966647106 1.3522241058115 2.33392762616633 1.12572767495627 0.136863491556075 NA NA NA 0.112687550042978 70.9288258674143 a412 gain_cnaBLCA9 154 CHIR-99021 GSK3B 4 15 0.940007258491471 NA 3.23561471751686 2.59044125369835 0.645173463818517 0.383051811573616 0.790728535285087 0.877315065980835 1.68429816626654 0.815922829427052 0.137410443688545 NA NA NA 0.0422533216487774 70.9288258674143 a413 loss_cnaBLCA18_(CHD9,CNOT1,CYLD,MMP2,NUP93) 312 AV-951 VEGFR 3 16 -2.05572501506252 NA 0.110197134686644 0.465316052516793 -0.355118917830149 0.147125790461209 0.381913677570597 0.98024048167261 2.41370949795358 0.929840795671699 0.137646194432067 NA NA NA 0.022750300977707 70.9288258674143 a414 TP53_mut 277 ABT-869 VEGFR and PDGFR family 15 4 0.0237165266173161 NA 2.25243017032342 2.63504376495328 -0.382613594629857 0.445495909797972 0.393234509183222 0.87609132060976 0.858848726138404 0.972990888883519 0.137924840799836 NA NA NA 0.150824680646941 70.9288258674143 a415 CDKN1A_mut 331 QL-X-138 MNK2, PRKDC (DNAPK), MTOR, BTK, JAK3 3 16 2.32630161961136 NA 0.966491455094631 2.26775016024057 -1.30125870514594 0.492063550101117 1.4043924661765 0.978426998044377 2.64449318564347 0.926563433289168 0.13832933973943 NA NA NA 0.0167692503149502 70.9288258674143 a416 NRAS_mut 298 OSI-930 KIT, VEGFR, PDGFR 3 16 2.32630161961136 NA 3.72354464004922 4.43984062791601 -0.716295987866785 0.977499016637977 0.693902325526655 0.977232722807595 0.73278435647989 1.03227206699896 0.138780780132295 NA NA NA 0.33115489844888 70.9288258674143 a417 MLL2_mut 310 YM201636 FYV1 3 16 1.63315443905142 NA 3.73822021671558 2.61935311386885 1.11886710284673 0.766702934256212 1.1871500560362 0.976560627530529 1.45932283920651 0.942481615662423 0.139035377907428 NA NA NA 0.102162035251968 70.9288258674143 a418 gain_cnaBLCA15_(ASXL1) 1067 CCT007093 PPM1D 5 13 1.88706964903238 NA 3.50641279137125 3.90823128848522 -0.401818497113974 0.490023428135916 0.490570281188404 0.819312699123707 0.819998543013586 0.819084466634567 0.139043569433503 NA NA NA 0.161410445899454 70.9288258674143 a419 EP300_mut 310 YM201636 FYV1 4 15 1.63315443905142 NA 3.58597405066068 2.58536095129371 1.00061309936697 0.69613540822055 1.22073065723633 0.873330783154163 1.43738285332264 0.819683763519391 0.139091164228173 NA NA NA 0.0630185083321984 70.9288258674143 a420 ARID1A_mut 175 PAC-1 CASP3 agonist 5 14 0.940007258491471 NA 3.14596031985597 2.42698738945238 0.718972930403582 0.404635376094318 0.992676371612555 0.807849689467822 1.77684150442643 0.724277267963622 0.139410904230704 NA NA NA 0.0393739030340779 70.9288258674143 a421 TP53_mut 1007 Docetaxel Microtubules 10 4 -4.38202663467388 NA -6.18672692219063 -4.76806670066876 -1.41866022152186 1.5304946179978 1.46774566577253 0.936377838172343 0.926929245512647 0.966557254846446 0.13945956375212 NA NA NA 0.159310266176223 70.9288258674143 a422 loss_cnaBLCA18_(CHD9,CNOT1,CYLD,MMP2,NUP93) 1061 SB590885 BRAF 3 12 1.6094379124341 NA 3.14546572624326 3.92976033366064 -0.784294607417373 1.17037907402045 0.674801773302354 1.01587884121204 0.670120155791228 1.16225925663945 0.139548677181034 NA NA NA 0.365963044029744 70.9288258674143 a423 TP53_mut 299 OSI-027 MTORC1/2 15 4 2.99573227355399 NA 1.57481760867999 3.09344089539779 -1.5186232867178 1.82598650231075 1.28544402422704 0.871358901285019 0.831672788816352 1.18139977945051 0.139929339434686 NA NA NA 0.100438792857868 70.954168376231 a424 CDKN1A_mut 231 FMK RSK 3 11 2.99573227355399 2.32630161961136 5.5862032525319 5.17321642410893 0.412986828422969 0.0810309986571567 0.4387180267832 1.02769638104825 5.09665233388424 0.941349119960035 0.140590624154941 NA NA NA 0.0125513403487917 70.9800948844212 a425 ARID1A_mut 1377 Afatinib (rescreen) ERBB2, EGFR 4 14 2.30258509299405 NA 4.22528466596599 3.09758953092541 1.12769513504058 1.08435012190119 1.32472698167922 0.878889346477373 1.03997326349112 0.851266072659828 0.140642315520172 NA NA NA 0.133429628273743 70.9800948844212 a426 TP53_mut 176 IPA-3 PAK1, PAK2, PAK3 15 4 3.46573590279973 NA 3.42706930249909 4.77575231584023 -1.34868301334114 1.50924675546851 1.75183451278456 0.867426750330352 0.893613326286381 0.769868959367282 0.141613397909578 NA NA NA 0.227942656855545 71.1580077482977 a427 ARID1A_mut 230 GSK429286A ROCK2 5 14 2.99573227355399 2.32630161961136 5.75355592185252 4.4569380641961 1.29661785765642 0.402745977267713 1.83297136889263 0.802984459462071 3.21944334851677 0.707385766990873 0.141658343092672 NA NA NA 0.0245866597818367 71.1580077482977 a428 gain_cnaBLCA15_(ASXL1) 308 XL-880 MET 6 13 1.63315443905142 NA 1.37469592883307 0.32474331175623 1.04995261707684 1.81385620473414 1.15580022178183 0.759592016126445 0.578851076693111 0.908420501475752 0.142199189119333 NA NA NA 0.234675249118693 71.2627944551236 a429 CDKN1A_mut 1241 CHIR-99021 GSK3B 3 16 2.30258509299405 NA 4.30572140577596 3.48456578735 0.821155618425965 0.781304641705801 0.858279474012211 0.966536571308292 1.05100568279379 0.956746191991867 0.142879330334682 NA NA NA 0.199137097935742 71.277201235851 a430 loss_cnaBLCA5_(FAT1,IRF2) 1377 Afatinib (rescreen) ERBB2, EGFR 4 14 2.30258509299405 NA 4.22068076560661 3.09890493102809 1.12177583457852 0.9609679500332 1.34771068586429 0.873589379848709 1.16733948779432 0.832356563129212 0.142892553221068 NA NA NA 0.105071510544535 71.277201235851 a431 EP300_mut 1015 CI-1040 MAP2K1 (MEK1), MAP2K2 (MEK2) 3 11 2.30258509299405 NA 1.47061960876991 2.50884886243908 -1.03822925366917 0.768626120572066 1.06150082622341 1.01931745244264 1.35075978539012 0.978076726857536 0.143569583545522 NA NA NA 0.124329421164178 71.2833247956606 a432 CDKN1A_mut 290 KIN001-260 IKK 3 16 2.99573227355399 NA 4.10059555743586 5.18163740348232 -1.08104184604646 2.3530787716993 0.828928677142386 0.96395105624506 0.459415918858411 1.30414337910614 0.143885105735069 NA NA NA 0.51068024602633 71.2833247956606 a433 loss_cnaBLCA18_(CHD9,CNOT1,CYLD,MMP2,NUP93) 1024 CEP-701 FLT3, JAK2, NTRK1, RET 3 11 0.693147180559945 NA -1.18168118331858 0.0994404980795338 -1.28112168139812 1.50643141106924 1.20329246277125 1.0176557271777 0.850434790448769 1.06468021784797 0.144166824514684 NA NA NA 0.275054946262383 71.2833247956606 a434 TP53_mut 1004 Vinblastine Microtubules 10 4 -2.30258509299405 NA -4.72742930661727 -3.51090321372377 -1.2165260928935 1.10379856664983 1.81634429622914 0.922629205285131 1.10212690036898 0.669766241686165 0.144843081163945 NA NA NA 0.28055429807323 71.2833247956606 a435 gain_cnaBLCA15_(ASXL1) 1230 IOX2 EGLN1 6 13 -2.30258509299405 NA 0.191676584106574 -0.309195292369926 0.500871876476499 0.33045262861073 0.761108309884083 0.75421478633159 1.51571460811868 0.658082259741432 0.144867973228198 NA NA NA 0.0618187939760222 71.2833247956606 a436 NRAS_mut 225 Genentech Cpd 10 AURKA, AURKB 3 16 2.32630161961136 NA 4.2238027390978 2.79589569715474 1.42790704194306 1.4143492662745 1.49450398337401 0.96136029150851 1.00958587527979 0.955438766191447 0.144898850267096 NA NA NA 0.212865058774345 71.2833247956606 a437 TP53_mut 1166 QL-VIII-58 MTOR, ATR 4 3 2.30258509299405 NA -1.08355120419712 -2.10691784335183 1.02336663915471 0.63940066352246 0.94695530789967 1.31678994248954 1.60050919171241 1.0806915919026 0.145295395878057 NA NA NA 0.19523877193368 71.2838704064927 a438 RB1_mut 1199 Tamoxifen ER 6 13 1.6094379124341 NA 3.24320777992387 3.66280445386755 -0.419596673943674 0.569481410762832 0.552235224747239 0.7528247321152 0.736804864941274 0.75981512069558 0.145564638052262 NA NA NA 0.164173162431967 71.2838704064927 a439 TP53_mut 1053 MK-2206 AKT1, AKT2 11 4 1.38629436111989 0.693147180559945 1.69758968486897 2.63425823759672 -0.936668552727752 1.01688667901758 1.10964767863531 0.901485070071673 0.921113996333077 0.844113470213995 0.146582080965076 NA NA NA 0.199865216821648 71.6186054641079 a440 CDKN1A_mut 345 KIN001-270 CDK9 3 16 2.99573227355399 NA 4.21949135628441 5.05773378880341 -0.838242432518994 1.43390470438491 0.776696198144829 0.952684994488987 0.584587267170286 1.07924106558159 0.148336912095064 NA NA NA 0.419019920448903 71.8603215282708 a441 NRAS_mut 1498 AZD6244 MAP2K1 (MEK1), MAP2K2 (MEK2) 3 16 1.38629436111989 NA 0.428335639424628 1.54712442081772 -1.11878878139309 1.43228797082289 1.13629328109203 0.952166568298028 0.781120001133787 0.984595086506078 0.148544499975066 NA NA NA 0.306726220890155 71.8603215282708 a442 RB1_mut 203 BMS-345541 IKBKB 6 13 2.77258872223978 NA 3.89611621464504 3.33257017577507 0.563546038869971 0.931561068655309 0.66729983239611 0.746724040679071 0.604948035970888 0.844516979490936 0.148655296554431 NA NA NA 0.221913358227018 71.8603215282708 a443 gain_cnaBLCA9 332 XMD15-27 CAMK2B, CLK2, DYRK1A, MAST1, STK39 4 15 2.32630161961136 NA 5.08184802043142 4.67449033918632 0.407357681245098 0.401247060656857 0.493461072476559 0.851355794792833 1.01522907252763 0.825511279340983 0.148673497818719 NA NA NA 0.139875685579972 71.8603215282708 a444 EP300_mut 186 Bexarotene Retinioic acid X family agonist 4 15 2.07944154167984 NA 2.89917639539323 3.71416664741805 -0.81499025202482 0.750497254040646 0.996256506957972 0.851180850776899 1.0859336894798 0.818052626339534 0.148751936603745 NA NA NA 0.121908299582021 71.8603215282708 a445 loss_cnaBLCA18_(CHD9,CNOT1,CYLD,MMP2,NUP93) 252 WZ3105 CLK2, CNSK1E, FLT3, ULK1 3 16 0.246860077931526 2.32630161961136 -0.562453686409171 0.902221732198517 -1.46467541860769 0.817539927831596 1.61412261619139 0.949905677531312 1.79156438572061 0.907412735510559 0.149452632207387 NA NA NA 0.0594509355075769 72.0365748446849 a446 gain_cnaBLCA23_(MYC) 1052 RO-3306 CDK1 3 12 1.6094379124341 NA 1.82458753272706 3.03591280083715 -1.21132526811009 1.50260833641092 1.16898156749228 0.987844055278237 0.806148374634616 1.03622272736827 0.149891505488079 NA NA NA 0.295077703529063 72.0767414643918 a447 TP53_mut 1026 17-AAG HSP90 11 4 0 NA -1.95352376401058 -0.524099021825785 -1.4294247421848 1.48793877469087 1.93591829735923 0.892011739790736 0.960674435332038 0.738370386877722 0.150534620478927 NA NA NA 0.245780259942405 72.0767414643918 a448 ARID1A_mut 133 Doxorubicin DNA intercalating 5 14 0.0237165266173161 NA -1.11415958595486 -2.41911997572372 1.30496038976887 1.11568779370791 1.80182865058139 0.783287812179653 1.16964655984263 0.724242224335704 0.151068904278906 NA NA NA 0.0847869991900294 72.0767414643918 a449 loss_cnaBLCA5_(FAT1,IRF2) 268 YM155 BIRC5 (Survivin) 5 14 1.63315443905142 NA -5.02508365184196 -3.42465279907998 -1.60043085276198 0.558897411930771 2.31656175635277 0.783052983920546 2.86355030207265 0.69086474745302 0.151184161390534 NA NA NA 0.0289361778343412 72.0767414643918 a450 CDKN1A_mut 1230 IOX2 EGLN1 3 16 -2.30258509299405 NA -0.680861828182995 -0.0516808632262881 -0.629180964956707 1.62140901907898 0.388955822327636 0.945545278580094 0.388045803096682 1.61761549471477 0.151217111429127 NA NA NA 0.571352501243189 72.0767414643918 a451 gain_cnaBLCA23_(MYC) 184 BMS-754807 IGF1R 4 15 0.940007258491471 NA -0.187596885041723 1.19181750167799 -1.37941438671971 2.17918524738325 1.49179502076241 0.844068160882199 0.632995468547753 0.924667509625242 0.151970282561035 NA NA NA 0.302054500171597 72.0767414643918 a452 loss_cnaBLCA18_(CHD9,CNOT1,CYLD,MMP2,NUP93) 172 Embelin XIAP 3 16 3.46573590279973 NA 2.15349652981884 2.83235235988857 -0.678855830069725 0.537110083421245 0.740290401111578 0.943678985958395 1.26390446022833 0.917012876366347 0.1519775943033 NA NA NA 0.140827632524049 72.0767414643918 a453 EP300_mut 1005 Cisplatin DNA crosslinker 3 11 1.79175946922805 2.30258509299405 1.74674264097543 2.71906801788928 -0.97232537691385 0.823197987831804 1.00543931622808 0.994779276127912 1.18115616326375 0.967065203459061 0.152609401895118 NA NA NA 0.162785512178177 72.0767414643918 a454 loss_cnaBLCA18_(CHD9,CNOT1,CYLD,MMP2,NUP93) 333 T0901317 LXR 3 16 2.32630161961136 NA 3.98157996461707 4.56104305175793 -0.579463087140859 0.650510885083791 0.610861954618121 0.941207733989871 0.890781538676666 0.948599078335315 0.152989468026523 NA NA NA 0.25752737140985 72.0767414643918 a455 gain_cnaBLCA23_(MYC) 208 SB-715992 KIF11 4 15 -2.05572501506252 NA -2.16159699008163 -0.901188564136781 -1.26040842594485 2.07465565421038 1.34209673034303 0.84159656736948 0.607526566342195 0.939133817592044 0.153102071247249 NA NA NA 0.318165711308176 72.0767414643918 a456 RB1_mut 263 FR-180204 ERK 6 13 2.99573227355399 NA 5.36142274690281 4.88926156450918 0.472161182393631 0.511228624471433 0.687821857479494 0.736654515949077 0.92358127028158 0.686458531753925 0.153875905913245 NA NA NA 0.118747618514248 72.0767414643918 a457 RB1_mut 1218 JQ1 BRD2, BRD3, BRD4 6 13 0 NA 1.62938909334405 2.13330609932164 -0.503917005977587 0.970728138001335 0.520315800621588 0.736408072160811 0.519112392286391 0.968482997009872 0.154005557744646 NA NA NA 0.274761343162926 72.0767414643918 a458 gain_cnaBLCA9 255 CP724714 ERBB2 4 15 2.32630161961136 NA 4.88957050808755 4.13067198465288 0.75889852343467 0.598031872032508 0.958447086626794 0.838255133127663 1.26899344152918 0.791800125456664 0.154643274849325 NA NA NA 0.0875125892250206 72.0767414643918 a459 ARID1A_mut 156 AZD6482 PI3Kbeta 5 14 1.63315443905142 NA 2.76255704283531 1.72732432044804 1.03523272238728 1.08150674546736 1.40335905620759 0.775670065948586 0.957213375437537 0.737682005049276 0.15484518321348 NA NA NA 0.124170454157702 72.0767414643918 a460 EP300_mut 153 Midostaurin KIT 4 15 -0.669430653942629 NA 0.445594957013066 -0.517208483585096 0.962803440598162 1.1903312706988 1.14091048943655 0.837376083990467 0.80885335393477 0.843890427437173 0.155050854907682 NA NA NA 0.211799381304047 72.0767414643918 a461 ARID1A_mut 288 KIN001-055 JAK3, MNK1 5 14 2.32630161961136 NA 4.58344341624078 3.96808245155988 0.615360964680896 0.747794804592829 0.807422790575269 0.775213233244878 0.822900829079653 0.762129793540341 0.155074107420129 NA NA NA 0.162537006938002 72.0767414643918 a462 RB1_mut 268 YM155 BIRC5 (Survivin) 6 13 1.63315443905142 NA -2.81805330245625 -4.32017212550708 1.50211882305083 2.95729239580319 1.51270277330306 0.734054007192057 0.507937201334081 0.993003284955231 0.155248574871349 NA NA NA 0.282766453008111 72.0767414643918 a463 gain_cnaBLCA23_(MYC) 300 CX-5461 RNA Pol I 4 15 2.32630161961136 NA 3.22378750362039 4.26443017837069 -1.0406426747503 2.11182145959877 0.965196608667976 0.834727313242501 0.492770196088457 1.07816652628571 0.156284361583895 NA NA NA 0.401606690353793 72.1562127573086 a464 gain_cnaBLCA15_(ASXL1) 255 CP724714 ERBB2 6 13 2.32630161961136 NA 4.7440267937056 4.08109238768537 0.662934406020237 0.369607984493667 1.05139173123357 0.731874794420736 1.7936149483578 0.630530359262416 0.156406652431172 NA NA NA 0.0600743701205393 72.1562127573086 a465 gain_cnaBLCA9 159 HG-6-64-1 BRAFV600E, TAK, MAP4K5 4 15 1.63315443905142 NA -0.395674177906916 0.520152145667536 -0.915826323574452 1.01773287917643 1.11392550351778 0.83441792156019 0.899869054358901 0.822161195414121 0.156428969986373 NA NA NA 0.176683604095656 72.1562127573086 a466 gain_cnaBLCA9 345 KIN001-270 CDK9 4 15 2.99573227355399 NA 5.50426078334357 4.7710114370889 0.733249346254668 0.537088054992771 0.940094582030349 0.830922194833972 1.36523115611748 0.779974015668774 0.158070553525571 NA NA NA 0.0746656603524046 72.2706186421081 a467 RB1_mut 194 AUY922 HSP90 6 13 -1.36257783450257 NA -3.86080739524705 -2.30470672690791 -1.55610066833914 0.695380773626043 2.50323652105648 0.728278456718486 2.23776774877582 0.621635492790906 0.158333426066648 NA NA NA 0.0552684127678538 72.2706186421081 a468 gain_cnaBLCA15_(ASXL1) 1072 BMS-708163 g-secretase 5 13 1.6094379124341 NA 3.09578356960949 3.57077757228031 -0.474994002670823 0.543875743926467 0.630515723077626 0.778665337898359 0.873350223787592 0.753342042530388 0.158375397470035 NA NA NA 0.149476038021977 72.2706186421081 a469 NRAS_mut 1014 RDEA119 MAP2K1 (MEK1), MAP2K2 (MEK2) 3 12 1.6094379124341 NA 0.154192833876573 1.31908273979512 -1.16488990591855 2.47201956597103 0.779507285163489 0.965962066579194 0.471230050908181 1.49439258373863 0.158412376238137 NA NA NA 0.501211132070489 72.2706186421081 a470 TP53_mut 1031 Elesclomol HSP70 10 4 -1.6094379124341 NA -4.01849019503422 -2.73862721139046 -1.27986298364376 1.06699642258354 2.20646391051329 0.889355387744236 1.19950072610815 0.580051628103006 0.158619317158695 NA NA NA 0.336226103120986 72.2706186421081 a471 gain_cnaBLCA9 341 EX-527 SIRT1 4 15 2.99573227355399 NA 5.6422592062504 5.25327869560822 0.388980510642182 0.385867102662523 0.484824334195763 0.829592636806776 1.00806860174961 0.802312266952177 0.15869863152642 NA NA NA 0.143118633940623 72.2706186421081 a472 loss_cnaBLCA18_(CHD9,CNOT1,CYLD,MMP2,NUP93) 276 CAY10603 HDAC6 3 16 2.99573227355399 NA 0.352346495849408 1.41866545086884 -1.06631895501943 0.83688140514632 1.18668094803666 0.926381001760419 1.27415778204918 0.898572574864064 0.159178207592605 NA NA NA 0.138495843302171 72.3354369296405 a473 TP53_mut 1377 Afatinib (rescreen) ERBB2, EGFR 14 4 2.30258509299405 NA 3.10823661927737 4.18801985673413 -1.07978323745677 1.33130578802926 1.09989920357477 0.836340919587955 0.811070790171488 0.981711082204055 0.159574039187689 NA NA NA 0.152029903456334 72.3620055566052 a474 gain_cnaBLCA9 281 CH5424802 ALK 4 15 1.63315443905142 NA 4.32254452455698 4.03510876922103 0.287435755335958 0.495392906338848 0.307293142720062 0.826068852774065 0.580217745668228 0.935379659928845 0.160373215560306 NA NA NA 0.336763818961485 72.5096052465988 a475 EP300_mut 1033 Vismodegib SMO 3 11 2.30258509299405 NA 3.93730245443506 4.65717942649298 -0.719876972057921 0.93885100934547 0.69209474045514 0.974169055259276 0.766763804791338 1.04014223772964 0.160575636710608 NA NA NA 0.314468833321319 72.5096052465988 a476 CDKN1A_mut 301 PHA-793887 CDK-pan 3 16 2.32630161961136 NA 2.22670866797819 3.42440668451643 -1.19769801653824 0.481165934495977 1.37350516710796 0.920812912599673 2.48915796126098 0.872001099974091 0.161555070754618 NA NA NA 0.022347392430535 72.5806219366975 a477 loss_cnaBLCA18_(CHD9,CNOT1,CYLD,MMP2,NUP93) 291 KIN001-266 MAP3K8 (COT) 3 16 2.99573227355399 NA 2.80280664953945 3.81533196128803 -1.01252531174859 0.208882051438918 1.16851102312858 0.920510367736393 4.84735430724488 0.866508994530183 0.16168505113077 NA NA NA 0.00524424256869174 72.5806219366975 a478 EP300_mut 258 STF-62247 stimulates autophagy 4 15 2.32630161961136 NA 4.06404031684153 4.66637789188233 -0.602337575040808 0.249216709258711 0.798002704249312 0.823198386658665 2.41692291352552 0.754806433403546 0.161748061419765 NA NA NA 0.0235443998450562 72.5806219366975 a479 loss_cnaBLCA18_(CHD9,CNOT1,CYLD,MMP2,NUP93) 1016 Temsirolimus MTOR 3 11 -1.6094379124341 NA -1.62895527139416 -2.94371446753166 1.3147591961375 0.0235286378228848 1.48443590271632 0.970207170486144 55.8791038407977 0.885696171678188 0.162146977832158 NA NA NA 0.0148551585737996 72.6077272430485 a480 gain_cnaBLCA9 1059 AZD8055 MTORC1/2 3 12 0.693147180559945 NA 0.76409280657848 0.104560039154256 0.659532767424225 0.237995835636353 0.744442948715778 0.954293800718861 2.77119457010988 0.885941318353501 0.163121379439733 NA NA NA 0.0247426599332016 72.8918790177332 a481 CDKN1A_mut 305 TPCA-1 IKK 3 16 2.99573227355399 NA 2.41060808746573 3.77670477495036 -1.36609668748463 0.367343785698206 1.58189384188949 0.916066980607712 3.71885068067263 0.863583036553771 0.163603962821802 NA NA NA 0.00802877575239489 72.9425089097969 a482 gain_cnaBLCA9 1373 Dabrafenib BRAF 4 13 2.30258509299405 NA 4.35644937680526 3.30956851202954 1.04688086477572 0.717653426226523 1.35172764402147 0.836905177107542 1.45875547516062 0.774476181948298 0.163914826250981 NA NA NA 0.0709865299818202 72.9425089097969 a483 gain_cnaBLCA9 175 PAC-1 CASP3 agonist 4 15 0.940007258491471 NA 2.03780047173586 2.77042821097799 -0.732627739242129 1.14219392144539 0.83498724493534 0.816863234012757 0.641421500750961 0.877411893038992 0.164816685861803 NA NA NA 0.297876986338205 73.1919881014695 a484 gain_cnaBLCA9 305 TPCA-1 IKK 4 15 2.99573227355399 NA 4.52173723109195 3.30481011581568 1.21692711527627 1.6079500915885 1.46597828925252 0.815627087253537 0.756818959520107 0.830112645049309 0.165420988233264 NA NA NA 0.236175835875146 73.3085698334907 a485 loss_cnaBLCA5_(FAT1,IRF2) 229 LY317615 PRKCB (PKCbeta) 5 14 2.99573227355399 2.32630161961136 4.68619997085785 3.48257813335918 1.20362183749867 0.829746108485069 1.77336182025824 0.751259025182816 1.45059051822034 0.678723215842888 0.167475221164367 NA NA NA 0.0637135082762456 73.7377614955228 a486 gain_cnaBLCA23_(MYC) 266 Zibotentan, ZD4054 Endothelin A Receptor 4 15 2.99573227355399 NA 5.22604034325658 5.52301340186998 -0.296973058613392 0.62439624485489 0.281250858376358 0.811439455523792 0.475616343084204 1.05590098578826 0.167481667688138 NA NA NA 0.416294950008406 73.7377614955228 a487 gain_cnaBLCA15_(ASXL1) 1502 Bicalutamide ANDR (androgen receptor) 5 12 2.30258509299405 NA 3.9739632361789 4.42651898551606 -0.452555749337163 0.650035898103884 0.561599961202396 0.771636564002286 0.696201164669892 0.805832942666578 0.167740973090887 NA NA NA 0.218301848550203 73.7377614955228 a488 TP53_mut 1018 ABT-888 PARP1, PARP2 10 4 1.6094379124341 NA 3.84716977796072 4.32058346147644 -0.473413683515717 0.608070802021923 0.282747686071121 0.868248378834349 0.778550264116528 1.67433265358938 0.167926649962678 NA NA NA 0.0719501006180313 73.7377614955228 a489 EP300_mut 1248 FK866 NAMPT 4 15 0 NA -3.79225945384828 -1.52931442271794 -2.26294503113034 4.07753535442781 2.43700350329136 0.808969856973998 0.554978641368 0.928576847786247 0.168706745710873 NA NA NA 0.354921689353516 73.7377614955228 a490 TP53_mut 179 5-Fluorouracil DNA antimetabolite 15 4 3.46573590279973 NA 4.06998001052276 5.00126095046474 -0.931280939941983 1.12155691301665 1.28514336453884 0.808323500226578 0.830346573708078 0.724651401266943 0.169028587075843 NA NA NA 0.252258952813163 73.7377614955228 a491 loss_cnaBLCA18_(CHD9,CNOT1,CYLD,MMP2,NUP93) 224 AS605240 PI3Kgamma 3 16 2.99573227355399 2.32630161961136 2.3001774555706 3.53441035913904 -1.23423290356845 0.940896230456532 1.41277913177051 0.903701928472628 1.31176304423027 0.873620565177583 0.169042502040685 NA NA NA 0.130343196070902 73.7377614955228 a492 MLL2_mut 1039 SL 0101-1 RSK, AURKB, PIM3 3 12 2.30258509299405 NA 3.66867003156537 4.36759221033503 -0.698922178769657 0.952036016223088 0.699488709911613 0.93948293743278 0.734134178602211 0.999190078218665 0.1692680596204 NA NA NA 0.331196428315828 73.7377614955228 a493 RB1_mut 206 Ruxolitinib JAK1, JAK2, TYK2 6 13 1.65632149833295 0.0237165266173161 3.90750215951645 4.23110105011417 -0.323598890597719 0.608398139052972 0.376691063674864 0.707788672579359 0.53188671993874 0.859056457142367 0.169687540619724 NA NA NA 0.26972571216737 73.7377614955228 a494 NRAS_mut 203 BMS-345541 IKBKB 3 16 2.77258872223978 NA 2.93381218841044 3.61866706298217 -0.684854874571733 0.319073653920153 0.799905873374742 0.901944689845493 2.1463849056717 0.856169328626608 0.169827259160351 NA NA NA 0.0358459349853465 73.7377614955228 a495 TP53_mut 1022 AZD7762 CHEK1, CHEK2 10 4 0.693147180559945 NA -0.0450971997934366 0.709822555519967 -0.754919755313403 0.984719741107371 0.388829040500187 0.863088617448708 0.766634123191696 1.94152101998935 0.170271088939257 NA NA NA 0.0622761592437387 73.7811146762857 a496 gain_cnaBLCA9 254 AC220 FLT3 4 15 0.0237165266173161 NA 2.69851788003081 2.29676222421113 0.401755655819673 0.547245955261806 0.488041610512244 0.805121364840405 0.734140932348182 0.823199594391131 0.170630440691729 NA NA NA 0.247655846902648 73.7877612030056 a497 gain_cnaBLCA23_(MYC) 344 THZ-2-49 CDK9 4 15 2.99573227355399 NA 3.05123578735659 4.56743705045211 -1.51620126309552 2.84144801442449 1.60956800347175 0.803774947545255 0.533601619807432 0.94199267121685 0.171307671256792 NA NA NA 0.370696450275578 73.8231851926078 a498 ARID1A_mut 177 GSK-650394 SGK3 5 14 2.77258872223978 NA 4.0373529881439 2.54087558477508 1.49647740336882 1.50995732394763 2.14373743666994 0.74353639538926 0.991072647971554 0.698069352044079 0.171642386233063 NA NA NA 0.121331767265462 73.8231851926078 a499 EP300_mut 229 LY317615 PRKCB (PKCbeta) 4 15 2.99573227355399 2.32630161961136 4.81565379237087 3.52829857012228 1.28735522224859 0.335754910632419 1.76072403214338 0.802568429248643 3.83421115069847 0.731151048515794 0.17191639611589 NA NA NA 0.0168361890260446 73.8231851926078 a500 gain_cnaBLCA23_(MYC) 194 AUY922 HSP90 4 15 -1.36257783450257 NA -4.1544952395645 -2.43387005753514 -1.72062518202936 0.875103361958205 2.3284919931095 0.802226817918211 1.96619651669392 0.738943997712278 0.172089069419337 NA NA NA 0.0361529016974595 73.8231851926078 a501 TP53_mut 1046 681640 WEE1, CHEK1 11 4 0.693147180559945 NA 1.44138774004749 2.17817349109583 -0.736785751048344 0.80460753109533 1.07420654924998 0.842779253330982 0.915708246038092 0.685888343878348 0.172563415943276 NA NA NA 0.275021662437176 73.8784809109265 a502 ARID1A_mut 1052 RO-3306 CDK1 5 10 1.6094379124341 NA 3.44481886409737 2.46806218877401 0.976756675323355 1.09975377137486 1.29318254480179 0.789686314238093 0.888159423270045 0.755312294656021 0.173023661517137 NA NA NA 0.15953448377409 73.8784809109265 a503 CDKN1A_mut 205 BMS-708163 g-secretase 3 16 2.32630161961136 0.940007258491471 4.99289688302863 4.67795230100492 0.314944582023717 0.0855719447016303 0.373585151698276 0.894354278172338 3.68046540395753 0.843032921924263 0.173251276965177 NA NA NA 0.00907939365316608 73.8784809109265 a504 loss_cnaBLCA5_(FAT1,IRF2) 134 Etoposide TOP2 5 14 2.77258872223978 NA 0.371426007507439 1.44143520537684 -1.0700091978694 1.20049242991789 1.51524856462576 0.73928360580289 0.891308575717202 0.706160839118613 0.173973094874376 NA NA NA 0.146214507635572 74.0390862983916 a505 TP53_mut 333 T0901317 LXR 15 4 2.32630161961136 NA 4.36582515501971 4.8585128491706 -0.492687694150887 0.600860380486821 0.700208983081106 0.795233223814949 0.819970346108872 0.703629496415384 0.175655275013033 NA NA NA 0.263723588993109 74.0461125063017 a506 NRAS_mut 292 Masitinib KIT 3 16 2.99573227355399 NA 4.93033197361632 4.14928431208534 0.781047661530981 1.18160403423549 0.830517236084817 0.888433278111863 0.661006258358221 0.940435222287447 0.175961095551736 NA NA NA 0.371561288877919 74.0461125063017 a507 TP53_mut 263 FR-180204 ERK 15 4 2.99573227355399 NA 4.93059062521891 5.44251936043814 -0.51192873521923 0.63664868610517 0.682416710347693 0.793735414067837 0.804099256610517 0.750170280792802 0.176426805715489 NA NA NA 0.240413298779342 74.0461125063017 a508 NRAS_mut 159 HG-6-64-1 BRAFV600E, TAK, MAP4K5 3 16 1.63315443905142 NA 1.15148353318983 0.172820929613492 0.978662603576342 1.37398409892094 1.06245898098651 0.886724873168397 0.712280880357303 0.921129776386884 0.176749341100641 NA NA NA 0.342513502688353 74.0461125063017 a509 RB1_mut 1018 ABT-888 PARP1, PARP2 5 9 1.6094379124341 NA 3.70114564671912 4.13870037687971 -0.437554730160588 0.858084257544493 0.284453711014208 0.799690352194295 0.509920472626664 1.53822823615309 0.177191666264593 NA NA NA 0.324016110044437 74.0461125063017 a510 gain_cnaBLCA9 303 PIK-93 PI4K, PI3K 4 15 2.99573227355399 NA 4.32269644767122 3.0770164302548 1.24568001741642 1.71412718667069 1.54038501574608 0.792195093696642 0.726713879286796 0.808680949686516 0.177223102671709 NA NA NA 0.251989790632808 74.0461125063017 a511 loss_cnaBLCA18_(CHD9,CNOT1,CYLD,MMP2,NUP93) 1004 Vinblastine Microtubules 3 11 -2.30258509299405 NA -5.35911831977027 -4.11277736015973 -1.24634095961054 1.37503965468867 1.32846061016755 0.932655006094689 0.906403648331682 0.938184354185219 0.177699770281712 NA NA NA 0.252599908061919 74.0461125063017 a512 loss_cnaBLCA18_(CHD9,CNOT1,CYLD,MMP2,NUP93) 292 Masitinib KIT 3 16 2.99573227355399 NA 3.6174150533875 4.39545623462825 -0.778041181240745 0.463780401891634 0.920884235689636 0.884614883648574 1.67760685459611 0.844884895502725 0.177726830030122 NA NA NA 0.0726527003457609 74.0461125063017 a513 loss_cnaBLCA18_(CHD9,CNOT1,CYLD,MMP2,NUP93) 304 SB52334 ALK5 3 16 2.99573227355399 NA 4.01430548722036 4.87895944223798 -0.864653955017615 0.840444929659502 0.995856649201279 0.883332513127893 1.02880501089812 0.868251425253932 0.178323050303189 NA NA NA 0.206414121662232 74.0461125063017 a514 gain_cnaBLCA9 1054 PD-0332991 CDK4, CDK6 3 12 1.38629436111989 0.693147180559945 3.1569504765183 1.64612970069234 1.51082077582596 0.781696458537154 1.76075093524482 0.916526200833521 1.93274609258595 0.858054791046238 0.179178236517284 NA NA NA 0.0570994871538541 74.0461125063017 a515 EP300_mut 1029 AMG-706 VEGFR, RET, c-KIT, PDGFR 4 11 0.693147180559945 NA 2.1699892235863 2.77843514247149 -0.608445918885185 0.985347532476207 0.639822387018404 0.828789908696423 0.617493725646364 0.950960659130052 0.179295167437892 NA NA NA 0.314793479898392 74.0461125063017 a516 gain_cnaBLCA15_(ASXL1) 205 BMS-708163 g-secretase 6 13 2.32630161961136 0.940007258491471 4.89437527225036 4.65074429474327 0.24363097750709 0.169023948576949 0.40540112794811 0.690712032606634 1.44139916004965 0.600962751979008 0.179651106855314 NA NA NA 0.0823003109775982 74.0461125063017 a517 TP53_mut 197 Bryostatin 1 PRKC 15 4 -4.8283137373023 NA -3.23195894690686 -2.59989393682941 -0.632065010077444 0.754919120773304 0.995734981626676 0.787440212178833 0.837261890293606 0.634772325709472 0.17969964146149 NA NA NA 0.303066849944701 74.0461125063017 a518 loss_cnaBLCA18_(CHD9,CNOT1,CYLD,MMP2,NUP93) 283 GSK2126458 PI3K, MTOR 3 16 -2.05572501506252 0.0237165266173161 -3.35890001483689 -2.00414688858819 -1.35475312624871 1.01219103792072 1.59674340740079 0.879975007665965 1.3384361997827 0.848447609033189 0.179891760371097 NA NA NA 0.125034795846635 74.0461125063017 a519 CDKN1A_mut 1261 rTRAIL TR10A (DR4), TR10B (DR5) 3 15 -2.30258509299405 NA -0.042638396707907 -1.2886259748722 1.2459875781643 0.456968078480527 1.49309476783862 0.886208406502635 2.72664029904966 0.83449999625139 0.180246796304484 NA NA NA 0.0206365509503067 74.0461125063017 a520 NRAS_mut 136 Mitomycin C DNA crosslinker 3 16 2.77258872223978 NA -0.0708365997956415 -1.43159651834646 1.36075991855082 1.89581205100167 1.49910240268408 0.877315602707892 0.71777153111346 0.907716454936261 0.181142217296045 NA NA NA 0.339599689021376 74.0461125063017 a521 gain_cnaBLCA23_(MYC) 1494 SN-38 TOP1 3 15 -2.99573227355399 NA -3.68267276385959 -5.14018677533358 1.457514011474 1.79521228036496 1.62692801245079 0.883929471650416 0.811889506001869 0.895868778655064 0.181307544579573 NA NA NA 0.292466992658641 74.0461125063017 a522 gain_cnaBLCA15_(ASXL1) 208 SB-715992 KIF11 6 13 -2.05572501506252 NA -0.45776964047813 -1.49366142919304 1.03589178871491 1.27136119655451 1.59842122536424 0.686202520357892 0.814789527572697 0.64807184256381 0.182359959325404 NA NA NA 0.154510189774165 74.0461125063017 a523 gain_cnaBLCA15_(ASXL1) 219 AT-7519 CDK9 6 13 2.32630161961136 NA 2.57381465141698 1.39509841122565 1.17871624019132 1.33878792427964 1.85309569670893 0.686142909314327 0.880435369048874 0.636079530207053 0.182395987451046 NA NA NA 0.139483583429648 74.0461125063017 a524 RB1_mut 295 NVP-BHG712 EPHB4 6 13 2.32630161961136 NA 4.29816817643361 3.33168093482993 0.966487241603687 1.12090080670577 1.51499760963366 0.685178251938917 0.862241543428011 0.637946380547354 0.182979813654939 NA NA NA 0.14359232730866 74.0461125063017 a525 RB1_mut 290 KIN001-260 IKK 6 13 2.99573227355399 NA 4.48021328903879 5.25590041490708 -0.775687125868286 1.6353275944316 0.841209631941254 0.683998765895014 0.474331337959166 0.922109182319083 0.183695707677435 NA NA NA 0.313127614598197 74.0461125063017 a526 loss_cnaBLCA18_(CHD9,CNOT1,CYLD,MMP2,NUP93) 150 Bicalutamide ANDR (androgen receptor) 3 16 0.0237165266173161 NA 2.01626452562563 2.43259174535045 -0.416327219724821 0.6290445865989 0.453982494327725 0.871126852426197 0.661840557242224 0.917055668283718 0.184079403830994 NA NA NA 0.371195763322723 74.0461125063017 a527 loss_cnaBLCA18_(CHD9,CNOT1,CYLD,MMP2,NUP93) 182 Obatoclax Mesylate BCL2, BCL2L1, MCL1 3 16 2.77258872223978 NA -1.82592015081393 -0.685850562656439 -1.14006958815749 0.868129932873703 1.35723619756733 0.870805380098636 1.31324764299235 0.839993503121213 0.184233019216309 NA NA NA 0.130356523104112 74.0461125063017 a528 ARID1A_mut 135 Gemcitabine DNA replication 5 14 0.0237165266173161 NA -0.867482248078475 -2.87535706584279 2.00787481776431 2.14247586413055 2.96021571478677 0.719808438163652 0.937174999905607 0.6782866558456 0.184977108151808 NA NA NA 0.137499535883723 74.0461125063017 a529 EP300_mut 207 AS601245 JNK 4 15 2.07944154167984 NA 2.94423955739155 2.02618080045278 0.918058756938773 1.58286408530498 1.07811794964485 0.77607879614424 0.579998475840006 0.851538328659861 0.18573068703388 NA NA NA 0.338675341531244 74.0461125063017 a530 ARID1A_mut 178 BAY 61-3606 SYK 5 14 2.07944154167984 NA 2.97499147176072 1.94584443361875 1.02914703814197 1.13624468060681 1.51516984203911 0.717155167378755 0.905744207834135 0.679228829394428 0.186518854837399 NA NA NA 0.145860873436063 74.0461125063017 a531 ARID1A_mut 258 STF-62247 stimulates autophagy 5 14 2.32630161961136 NA 4.92860493520825 4.40062892639713 0.527976008811113 0.687252243636318 0.750952865038002 0.716910303361142 0.768241957301647 0.703074764598435 0.186661659060478 NA NA NA 0.189677574567157 74.0461125063017 a532 TP53_mut 330 XMD13-2 RIPK 15 4 2.32630161961136 NA 3.63521500999716 4.34376181508847 -0.708546805091312 0.922557150180523 0.881406899975136 0.774004552596121 0.768024837217582 0.803881618252932 0.186849192370963 NA NA NA 0.217310926608863 74.0461125063017 a533 TP53_mut 229 LY317615 PRKCB (PKCbeta) 15 4 2.99573227355399 2.32630161961136 3.53708373483199 4.78270942470949 -1.2456256898775 1.65060626121221 1.40606509181177 0.77360707180588 0.754647379662007 0.885894754895353 0.187064145971657 NA NA NA 0.185388241739807 74.0461125063017 a534 RB1_mut 1371 PLX4720 (rescreen) BRAF 6 12 2.30258509299405 NA 4.33590950306661 3.72491495786994 0.610994545196671 0.59052193093285 0.992484355715127 0.68909122337611 1.03466867730294 0.615621336173529 0.187115947838773 NA NA NA 0.123190173684002 74.0461125063017 a535 TP53_mut 166 FTI-277 Farnesyl transferase (FNTA) 15 4 0.0237165266173161 NA 1.38455853827546 1.9825432139977 -0.597984675722247 0.768735378804017 0.793169112901795 0.773486095676948 0.777881039705209 0.753918257778005 0.18712960813459 NA NA NA 0.239744230387463 74.0461125063017 a536 EP300_mut 1014 RDEA119 MAP2K1 (MEK1), MAP2K2 (MEK2) 4 11 1.6094379124341 NA 0.360180801711134 1.35007710657515 -0.989896304864016 1.67427123235333 1.04300159574551 0.812675051755174 0.591240108373977 0.949084171013629 0.187318801762818 NA NA NA 0.332127709888385 74.0461125063017 a537 RB1_mut 1248 FK866 NAMPT 6 13 0 NA -0.70317302114825 -2.60690123302098 1.90372821187273 1.97161011075181 3.09410146395835 0.677271224497043 0.965570323204929 0.615276594529401 0.187822330004193 NA NA NA 0.126707399156298 74.0461125063017 a538 gain_cnaBLCA9 256 JW-7-24-1 LCK 4 15 2.32630161961136 NA 2.87874767911467 1.97107400405312 0.907673675061559 1.77767914037909 1.00045188402267 0.772118886547364 0.51059477182592 0.907263697092494 0.187870709559942 NA NA NA 0.389230494941911 74.0461125063017 a539 loss_cnaBLCA5_(FAT1,IRF2) 1218 JQ1 BRD2, BRD3, BRD4 5 14 0 NA 2.3375459433679 1.84439886674329 0.493147076624607 0.268917073443497 0.775466285831307 0.714128700310816 1.83382583452153 0.63593619172747 0.188290070924604 NA NA NA 0.0552780651487391 74.0461125063017 a540 ARID1A_mut 1009 ATRA Retinoic acid and retinoid X receptor agonist 3 11 2.30258509299405 NA 3.72789176991927 4.0988000774488 -0.370908307529531 0.314647601802443 0.424770961297263 0.908011886906782 1.17880544903187 0.873196007553732 0.188573133244368 NA NA NA 0.165945300205619 74.0461125063017 a541 CDKN1A_mut 134 Etoposide TOP2 3 16 2.77258872223978 NA 0.106732311215827 1.35731412369784 -1.25058181248201 1.39230975721521 1.46064993317695 0.860821724131493 0.898206599502206 0.856181747642959 0.189055374916584 NA NA NA 0.254753631133859 74.0461125063017 a542 RB1_mut 158 PF-562271 FAK 6 13 0.940007258491471 NA 1.25672016346478 1.89915923639878 -0.642439072933992 0.695913837938059 1.03992882799056 0.675012013548695 0.923158928463746 0.617772154826567 0.189224727381393 NA NA NA 0.1344180985712 74.0461125063017 a543 loss_cnaBLCA18_(CHD9,CNOT1,CYLD,MMP2,NUP93) 331 QL-X-138 MNK2, PRKDC (DNAPK), MTOR, BTK, JAK3 3 16 2.32630161961136 NA 1.08496222639502 2.24553689062175 -1.16057466422673 0.422153598884674 1.42799543959639 0.860219684754814 2.74917628866119 0.812729951402899 0.189349389247354 NA NA NA 0.0195408209323946 74.0461125063017 a544 ARID1A_mut 273 CUDC-101 HDAC, EGFR 5 14 1.63315443905142 NA 0.676651748526303 -0.316178934545788 0.992830683072091 1.2093173888482 1.44601382155523 0.71224721200067 0.820984376994447 0.686598335556899 0.189397997729658 NA NA NA 0.171642529946712 74.0461125063017 a545 CDKN1A_mut 299 OSI-027 MTORC1/2 3 16 2.99573227355399 NA 0.614621994961542 2.13451010793165 -1.51988811297011 1.15312450496344 1.83346174328964 0.860117634073638 1.31806071801266 0.828971817128342 0.18939926350949 NA NA NA 0.129506991797669 74.0461125063017 a546 loss_cnaBLCA5_(FAT1,IRF2) 205 BMS-708163 g-secretase 5 14 2.32630161961136 0.940007258491471 4.91309210917686 4.66146192280573 0.251630186371131 0.321293351088378 0.362949985476432 0.711643526075301 0.783178940736669 0.693291628158695 0.189754589850135 NA NA NA 0.184862108400645 74.0461125063017 a547 MLL2_mut 249 XL-184 VEGFR, MET, RET, KIT, FLT1, FLT3, FLT4, Tie2,AXL 3 16 1.63315443905142 NA 3.74364013285915 2.94127321367817 0.802366919180979 0.400827955883109 0.986991940266283 0.85608106594613 2.00177384686952 0.812941713550879 0.191380492621513 NA NA NA 0.0459326049267049 74.0461125063017 a548 NRAS_mut 158 PF-562271 FAK 3 16 0.940007258491471 NA 2.38260800342508 1.5675979402311 0.815010063193982 1.2550925414829 0.904236795496247 0.85588057464558 0.649362526074008 0.90132370995443 0.191479329482754 NA NA NA 0.378742734936774 74.0461125063017 a549 gain_cnaBLCA9 1129 PF-4708671 RPS6KB1 (p70S6KA) 4 15 2.30258509299405 NA 4.19860026740091 3.54628391708537 0.652316350315538 0.754495116701258 0.871765888760952 0.765409940655033 0.864573323108495 0.748270101784644 0.191541586223318 NA NA NA 0.193749207013932 74.0461125063017 a550 EP300_mut 279 BIX02189 MAP2K5 (MEK5) 4 15 2.99573227355399 NA 5.32387773557177 4.51956225801847 0.804315477553298 0.350721601482216 1.14661747566158 0.765346162224331 2.29331604940816 0.701468008839845 0.191576757432231 NA NA NA 0.0325371414845397 74.0461125063017 a551 MLL2_mut 203 BMS-345541 IKBKB 3 16 2.77258872223978 NA 4.06046355968555 3.40741993086809 0.653043628817457 1.05161424875364 0.716337563896275 0.855370808220559 0.620991613218855 0.911642306268916 0.191730815046107 NA NA NA 0.39616983972625 74.0461125063017 a552 loss_cnaBLCA18_(CHD9,CNOT1,CYLD,MMP2,NUP93) 202 GSK-1904529A IGF1R 3 16 0.0237165266173161 NA 1.69903633841476 2.14950040440159 -0.45046406598683 0.50442496322946 0.529644598334562 0.855192020894871 0.893024927043343 0.85050252075314 0.191819079762203 NA NA NA 0.256916587175124 74.0461125063017 a553 TP53_mut 256 JW-7-24-1 LCK 15 4 2.32630161961136 NA 1.97282176845871 2.87219356259368 -0.899371794134965 1.16162179871475 1.2449024714953 0.7642866214617 0.774238048158235 0.722443576688137 0.192161808816516 NA NA NA 0.255639533845631 74.0461125063017 a554 MLL2_mut 222 BX-912 PDPK1 (PDK1) 3 16 2.32630161961136 NA 4.35059141229469 3.10763241231255 1.24295899998214 0.430796177113927 1.54091446236213 0.854291015620246 2.88526005107383 0.806637247129703 0.192264388769495 NA NA NA 0.0177538315975149 74.0461125063017 a555 ARID1A_mut 1248 FK866 NAMPT 5 14 0 NA -3.47234232422264 -1.48193160964636 -1.99041071457629 3.00921972924736 2.7509234411364 0.707366337556307 0.661437480032111 0.72354275106764 0.192296549908159 NA NA NA 0.238045650984422 74.0461125063017 a556 ARID1A_mut 199 Pazopanib VEGFR, PDGFRA, PDGFRB, KIT 5 14 2.07944154167984 NA 3.55906014083328 2.61644259620419 0.942617544629088 0.850111090765501 1.44931010347556 0.707255386830584 1.10881690036568 0.650390515024092 0.192362850021761 NA NA NA 0.107032753789149 74.0461125063017 a557 gain_cnaBLCA9 271 VNLG/124 HDAC, RAR 4 15 1.63315443905142 NA 4.22496764525297 3.86988750180606 0.355080143446908 0.570691300927747 0.438840266828481 0.763886369173356 0.622193019009875 0.809133004163653 0.192383190159456 NA NA NA 0.311838016000101 74.0461125063017 a558 loss_cnaBLCA5_(FAT1,IRF2) 275 I-BET BRD2, BRD3, BRD4 5 14 2.99573227355399 NA 5.20450460535949 4.43875311967611 0.765751485683372 0.586303309273893 1.19578338238095 0.706629916633313 1.30606713892118 0.640376423494589 0.192736950919838 NA NA NA 0.0841293823810441 74.0461125063017 a559 CDKN1A_mut 1236 UNC0638 G9a(EHMT2), GLP(EHMT1) 3 16 2.99573227355399 NA 2.7450553674406 3.79799623756178 -1.05294087012117 0.484786954993769 1.30236667997893 0.852853518926136 2.17196617869948 0.808482654161733 0.19297656551135 NA NA NA 0.0368929098689856 74.0461125063017 a560 gain_cnaBLCA9 295 NVP-BHG712 EPHB4 4 15 2.32630161961136 NA 4.48610045208913 3.41043062686895 1.07566982522019 1.53605412999996 1.38685524117602 0.760551564851345 0.700281197264977 0.775617954407443 0.194235636615334 NA NA NA 0.267279114771606 74.1317625880164 a561 CDKN1A_mut 155 AP-24534 ABL 3 16 -0.669430653942629 NA -0.487807690208823 0.342516837511493 -0.830324527720316 0.86637669980918 0.991732371873846 0.849159643567207 0.958387417278414 0.837246571019402 0.194816305502593 NA NA NA 0.231406422521672 74.1317625880164 a562 RB1_mut 1017 Olaparib PARP1, PARP2 5 9 1.6094379124341 NA 3.20231886377665 3.82399229179351 -0.621673428016861 1.16467337128896 0.561726848176857 0.763774568893597 0.533774913501153 1.10671838106825 0.195979108789909 NA NA NA 0.311819941219229 74.1317625880164 a563 TP53_mut 1372 Trametinib MAP2K1 (MEK1), MAP2K2 (MEK2) 12 3 0 NA -1.15492582647938 -2.96898009228533 1.81405426580595 1.82849867233855 3.0421814623945 0.879649346092951 0.992100400863768 0.596300479846493 0.196103286974954 NA NA NA 0.412456804265149 74.1317625880164 a564 EP300_mut 199 Pazopanib VEGFR, PDGFRA, PDGFRB, KIT 4 15 2.07944154167984 NA 3.66114213681601 2.65206190025073 1.00908023656528 0.745841923380972 1.42894645669228 0.756396705917445 1.35294115942293 0.706170781864771 0.196563543828843 NA NA NA 0.0840777532177921 74.1317625880164 a565 gain_cnaBLCA15_(ASXL1) 1018 ABT-888 PARP1, PARP2 4 10 1.6094379124341 NA 4.30066854054478 3.85513574633339 0.445532794211394 0.275998319702351 0.615744123689366 0.808858077199847 1.61425908205484 0.723568081400252 0.196621115501454 NA NA NA 0.0874788687577818 74.1317625880164 a566 gain_cnaBLCA9 266 Zibotentan, ZD4054 Endothelin A Receptor 4 15 2.99573227355399 NA 5.68046058979654 5.40183466945932 0.27862592033722 0.383920272507535 0.365298856511356 0.75579382426283 0.725739014815246 0.762734170586044 0.196903172799301 NA NA NA 0.254490709599209 74.1317625880164 a567 RB1_mut 1242 (5Z)-7-Oxozeaenol MAP3K7 (TAK1) 6 13 2.30258509299405 NA 0.98878113479016 0.339723144951942 0.649057989838218 0.489056254453402 1.12280531055724 0.662357192334823 1.3271642759454 0.578068151027978 0.197236241463648 NA NA NA 0.0973334118495653 74.1317625880164 a568 TP53_mut 230 GSK429286A ROCK2 15 4 2.99573227355399 2.32630161961136 4.53753596253663 5.77546826748965 -1.23793230495302 1.79800596511864 0.374617550512872 0.75518889316996 0.688502890963065 3.30452298152667 0.197244426821343 NA NA NA 0.0243647027223792 74.1317625880164 a569 ARID1A_mut 1061 SB590885 BRAF 5 10 1.6094379124341 NA 4.16406769299026 3.57731827177061 0.586749421219642 0.74978883113069 0.804741040820485 0.744378385976197 0.782552896039833 0.729115816712186 0.197244546922021 NA NA NA 0.198090548151094 74.1317625880164 a570 TP53_mut 1527 GDC0941 (rescreen) PI3K 15 4 1.38629436111989 NA 0.665369239718306 1.51706687007607 -0.851697630357769 0.77847765925031 2.09274508516849 0.755180235189681 1.09405532739112 0.406976289847168 0.197249314388145 NA NA NA 0.478789364335642 74.1317625880164 a571 MLL2_mut 175 PAC-1 CASP3 agonist 3 16 0.940007258491471 NA 3.25869016856611 2.49572215911968 0.762968009446434 0.263848826659651 0.957768239379809 0.843798027092051 2.89168619434726 0.796610263397839 0.197511580996584 NA NA NA 0.01831517202158 74.1317625880164 a572 TP53_mut 1502 Bicalutamide ANDR (androgen receptor) 14 3 2.30258509299405 NA 4.38291719522303 3.8757344246549 0.507182770568133 0.486614614581654 1.04128146615885 0.857552382419378 1.04226785503383 0.487075576634495 0.197692802194984 NA NA NA 0.489699897306478 74.1317625880164 a573 ARID1A_mut 1017 Olaparib PARP1, PARP2 3 11 1.6094379124341 NA 4.1698749137288 3.44708183671259 0.722793077016215 0.580359031565136 0.853658476219843 0.887404966354871 1.24542401807198 0.84670052152106 0.198085632504925 NA NA NA 0.151196792761499 74.1456201696119 a574 NRAS_mut 245 UNC0638 G9a(EHMT2), GLP(EHMT1) 3 16 3.68887945411394 NA 4.81336668755683 3.84953417907785 0.963832508478975 1.25573537601321 1.12987908332096 0.841478431095465 0.767544282728587 0.853040402912905 0.198686818945398 NA NA NA 0.314019077469207 74.1456201696119 a575 TP53_mut 281 CH5424802 ALK 15 4 1.63315443905142 NA 4.03996255899415 4.30434281290778 -0.264380253913629 0.35092106593728 0.353264354795236 0.752500347898455 0.753389521394198 0.748392104453541 0.198766801441855 NA NA NA 0.243656249023436 74.1456201696119 a576 ARID1A_mut 190 Bleomycin DNA damage 5 14 4.15888308335967 NA 2.48367819017651 0.848299475040134 1.63537871513638 1.51121916137964 2.55764437284687 0.694823488736007 1.08215853592234 0.639408172808663 0.199908321347628 NA NA NA 0.113842417985224 74.2903804601825 a577 CDKN1A_mut 186 Bexarotene Retinioic acid X family agonist 3 16 2.07944154167984 NA 4.22768886197352 3.4141336691827 0.813555192790819 0.629834083957422 1.00721197590576 0.838317909312028 1.29169762880889 0.807729864469901 0.200297076906863 NA NA NA 0.135519184483563 74.2903804601825 a578 NRAS_mut 1049 PD-173074 FGFR1, FGFR3 3 12 0.693147180559945 NA 3.191426179939 2.43704550642404 0.754380673514953 0.569291594431695 0.911978932097942 0.868994139330385 1.32512174936998 0.827190899881376 0.201231078023454 NA NA NA 0.133062300175587 74.2903804601825 a579 TP53_mut 154 CHIR-99021 GSK3B 15 4 0.940007258491471 NA 2.60856582342726 3.16764758103344 -0.559081757606174 0.773786163031477 0.616083720729317 0.747060958812998 0.722527468591385 0.907476920416491 0.201875442435494 NA NA NA 0.180046352041948 74.2903804601825 a580 EP300_mut 306 TG101348 JAK2 4 15 2.32630161961136 NA 3.53807474711527 2.8540342977499 0.684040449365366 0.76246493579978 0.945324518045052 0.747003584755045 0.897143484569358 0.723603837949717 0.201908436815884 NA NA NA 0.183567301112449 74.2903804601825 a581 TP53_mut 1032 Afatinib ERBB2, EGFR 10 4 -0.693147180559945 NA 0.199132606465018 1.35798554309021 -1.15885293662519 1.48658806696316 1.34093854206546 0.798357458390194 0.779538705024402 0.864210327521946 0.202095585437807 NA NA NA 0.205388487263608 74.2903804601825 a582 CDKN1A_mut 197 Bryostatin 1 PRKC 3 16 -4.8283137373023 NA -3.66609331024103 -2.99254250126234 -0.673550808978694 1.25813195481904 0.725846437139097 0.834735177272893 0.535357842552828 0.927952214842405 0.202134985243722 NA NA NA 0.45383386017058 74.2903804601825 a583 RB1_mut 180 Thapsigargin sarco-endoplasmic reticulum Ca2+-ATPases 6 13 -0.669430653942629 NA -5.09240004745454 -4.02611580158331 -1.06628424587124 0.668088922090581 1.89319879366328 0.653620871905095 1.59602144357465 0.563218320992068 0.202923303635408 NA NA NA 0.0898601833500214 74.2903804601825 a584 EP300_mut 1129 PF-4708671 RPS6KB1 (p70S6KA) 4 15 2.30258509299405 NA 3.18201851410399 3.81737238463121 -0.635353870527227 1.0655106923127 0.802250639235571 0.743433055552543 0.596290469078433 0.791964305734461 0.203970199979612 NA NA NA 0.329286689856214 74.2903804601825 a585 gain_cnaBLCA15_(ASXL1) 226 GSK1070916 AURKB 6 13 0.940007258491471 2.32630161961136 2.9734664807077 1.65297237583231 1.32049410487539 0.837559936393598 2.35242299270801 0.651145499628943 1.57659654849446 0.56133361600725 0.204558153048559 NA NA NA 0.09137183254958 74.2903804601825 a586 gain_cnaBLCA9 1066 AZD6482 PI3Kbeta 3 15 1.6094379124341 NA 2.7407724822434 1.86344745205974 0.877325030183657 0.414155236366468 1.11025899766508 0.836484720070511 2.11834827414171 0.790198532080089 0.204563186357646 NA NA NA 0.0427850614395178 74.2903804601825 a587 NRAS_mut 303 PIK-93 PI4K, PI3K 3 16 2.99573227355399 NA 4.44499809017759 3.13193987337338 1.3130582168042 1.29412232759431 1.61717207488521 0.82968808794012 1.01463222510433 0.81194712498199 0.204746793285677 NA NA NA 0.211622155903976 74.2903804601825 a588 TP53_mut 269 NSC-207895 MDM4 15 4 2.99573227355399 NA 3.40657884119145 4.34641558176734 -0.939836740575883 1.18779994595139 1.58885255551115 0.741297725122035 0.791241609144127 0.591519167285808 0.205211180961893 NA NA NA 0.332514504183713 74.2903804601825 a589 MLL2_mut 1058 GDC0941 PI3K (class 1) 3 12 1.38629436111989 0.693147180559945 0.240116905869088 1.32167526763279 -1.0815583617637 1.38742384740947 1.23285688574427 0.859830947627646 0.779544307086207 0.877278112544883 0.205727838158629 NA NA NA 0.309305056071267 74.2903804601825 a590 EP300_mut 1375 Temozolomide DNA akylating agent 3 15 3.40119738166216 NA 4.84003008761533 5.40413676494327 -0.564106677327934 0.896877843763265 0.638946817205762 0.833753193940392 0.628967123282881 0.882869531763038 0.205971527347471 NA NA NA 0.391598645357424 74.2903804601825 a591 NRAS_mut 1236 UNC0638 G9a(EHMT2), GLP(EHMT1) 3 16 2.99573227355399 NA 2.77021289307608 3.79327920150512 -1.02306630842904 0.516492948902382 1.3047496055863 0.82616197077021 1.98079433727643 0.784109306528066 0.206587336885531 NA NA NA 0.0489158251369027 74.2903804601825 a592 gain_cnaBLCA23_(MYC) 309 Y-39983 ROCK 4 15 2.99573227355399 NA 3.49018434479558 4.58841875933122 -1.09823441453563 2.66127701768253 1.08066430295599 0.738488270464792 0.412671964338379 1.01625862123102 0.206853043109732 NA NA NA 0.473866539409889 74.2903804601825 a593 TP53_mut 1203 QL-XII-61 BTK 3 3 2.30258509299405 NA 2.62046459328216 4.26935046120066 -1.6488858679185 1.58462845636717 1.04615480166137 1.2280713897722 1.04055045919007 1.57613946358604 0.207001184450379 NA NA NA 0.217612300396873 74.2903804601825 a594 loss_cnaBLCA5_(FAT1,IRF2) 135 Gemcitabine DNA replication 5 14 0.0237165266173161 NA -3.75792284478482 -1.84305685273338 -1.91486599205144 2.21447985358195 2.96137587136097 0.683003957040337 0.864702376476405 0.646613626648958 0.207298785372245 NA NA NA 0.163309056393387 74.2903804601825 a595 RB1_mut 1030 KU-55933 ATM 5 10 2.30258509299405 NA 3.05216550384387 3.71828684474475 -0.666121340900875 0.755261916431345 0.979827836682864 0.726723251527266 0.881973956860337 0.679835085269653 0.207406719718201 NA NA NA 0.175874159338525 74.2903804601825 a596 TP53_mut 309 Y-39983 ROCK 15 4 2.99573227355399 NA 4.12653573903596 5.22224567090278 -1.09570993186682 1.59705098164643 0.797154376017022 0.736619407449497 0.686083252481539 1.37452664732461 0.207950961956032 NA NA NA 0.0842043873640668 74.2903804601825 a597 gain_cnaBLCA9 249 XL-184 VEGFR, MET, RET, KIT, FLT1, FLT3, FLT4, Tie2,AXL 4 15 1.63315443905142 NA 3.61440289708667 2.92224534860543 0.692157548481233 0.831750004928674 0.962575825662743 0.735702477726932 0.832170176591208 0.719068077576824 0.208491321176152 NA NA NA 0.208508383755298 74.2903804601825 a598 loss_cnaBLCA18_(CHD9,CNOT1,CYLD,MMP2,NUP93) 229 LY317615 PRKCB (PKCbeta) 3 16 2.99573227355399 2.32630161961136 2.6788449626597 4.00940992708367 -1.33056496442396 0.643463995269362 1.70632390968266 0.822383956273815 2.06781571961454 0.779784516218507 0.208573867025663 NA NA NA 0.0439876891974168 74.2903804601825 a599 EP300_mut 260 NG-25 MAP3K7 (TAK1) 4 15 2.32630161961136 NA 3.93778944570195 2.88222060351244 1.05556884218951 1.04301901968146 1.50685059514608 0.735113373891609 1.01203220868579 0.700513272908237 0.208839072978259 NA NA NA 0.149915461400661 74.2903804601825 a600 EP300_mut 223 ZSTK474 PI3K 4 15 1.63315443905142 2.32630161961136 2.54980937458516 1.4794172446859 1.07039212989927 1.32175194610073 1.48350077926778 0.735026703834878 0.809828298764384 0.721531221862642 0.20889027350562 NA NA NA 0.217607904596895 74.2903804601825 a601 gain_cnaBLCA23_(MYC) 133 Doxorubicin DNA intercalating 4 15 0.0237165266173161 NA -3.05617798290188 -1.81425104388659 -1.24192693901529 1.23836235682504 1.7725541993769 0.734609325802778 1.00287846458721 0.700642575246422 0.209136979322965 NA NA NA 0.152420682198875 74.2903804601825 a602 RB1_mut 308 XL-880 MET 6 13 1.63315443905142 NA 1.27592447319637 0.370330137434705 0.905594335761666 2.09970236284611 0.983023598444812 0.643771310026532 0.431296526491567 0.92123356671636 0.209490315192314 NA NA NA 0.352683384600499 74.2903804601825 a603 EP300_mut 1091 BMS-536924 IGF1R 4 15 1.38629436111989 NA 2.9620495771033 2.24165783259568 0.720391744507616 0.9873132818767 0.981370313609395 0.733281599399606 0.729648590504409 0.734067185971907 0.209923308227196 NA NA NA 0.254021201058328 74.2903804601825 a604 TP53_mut 1058 GDC0941 PI3K (class 1) 11 4 1.38629436111989 0.693147180559945 0.846896273122407 1.81614873121356 -0.969252458091151 0.91506710834573 2.02051414743922 0.769581589723841 1.05921461852495 0.479705850770495 0.210236995947517 NA NA NA 0.414639075405048 74.2903804601825 a605 gain_cnaBLCA9 294 MPS-1-IN-1 MPS1 4 15 2.99573227355399 NA 5.03059181247471 4.19508399837145 0.835507814103261 1.52907359805357 1.03842611049733 0.732609821428775 0.546414387879576 0.804590529511163 0.2103220478614 NA NA NA 0.363963465654205 74.2903804601825 a606 MLL2_mut 221 TAK-715 p38a 3 16 2.99573227355399 2.32630161961136 5.12313669106851 4.5015023795358 0.621634311532719 0.308336279368029 0.800283958788337 0.818867809218864 2.0160920174779 0.776767177082868 0.210436231967463 NA NA NA 0.0471874085185813 74.2903804601825 a607 loss_cnaBLCA18_(CHD9,CNOT1,CYLD,MMP2,NUP93) 1050 ZM-447439 AURKB 3 12 1.38629436111989 0.693147180559945 1.35678103208089 2.41853443207358 -1.06175339999269 1.23812137082428 1.25056088636252 0.850317538544138 0.857551953316034 0.849021756214519 0.210482493404377 NA NA NA 0.273775916538639 74.2903804601825 a608 ARID1A_mut 153 Midostaurin KIT 5 14 -0.669430653942629 NA 0.267634630661071 -0.522422898502109 0.79005752916318 1.82612481327317 0.866598137963467 0.677735144726964 0.432641582558133 0.911676929077922 0.210662152367845 NA NA NA 0.397660085910784 74.2903804601825 a609 NRAS_mut 1248 FK866 NAMPT 3 16 0 NA -3.94684970858158 -1.64176281440109 -2.30508689418048 3.09663490808416 2.78800202379727 0.815653408209956 0.744384456870507 0.826788099328904 0.21215022550884 NA NA NA 0.326074787201745 74.2903804601825 a610 gain_cnaBLCA23_(MYC) 1030 KU-55933 ATM 3 12 2.30258509299405 NA 2.8743840529714 3.65171198397939 -0.777327931007992 0.320082931763785 0.988397476275198 0.846927926125467 2.42852040477324 0.786452767906058 0.212197911591559 NA NA NA 0.0425107394273332 74.2903804601825 a611 NRAS_mut 301 PHA-793887 CDK-pan 3 16 2.32630161961136 NA 2.33113274903588 3.40482716931812 -1.07369442028223 1.58652688621637 1.27640685928788 0.815450790043409 0.676757784321468 0.841185091156012 0.212258633549835 NA NA NA 0.363031558312939 74.2903804601825 a612 TP53_mut 1062 AZD6244 MAP2K1 (MEK1), MAP2K2 (MEK2) 11 3 1.38629436111989 0.693147180559945 2.33090912054226 1.00268184473659 1.32822727580567 1.45610267052889 1.94235216907169 0.858144861039173 0.912179685326189 0.683824126723872 0.21226917511915 NA NA NA 0.360127489267076 74.2903804601825 a613 gain_cnaBLCA23_(MYC) 140 Vinorelbine Microtubules 4 15 -2.74887219562247 NA -4.72017555200284 -3.79421015552223 -0.925965396480615 1.10459557915011 1.30238822764774 0.72926480596367 0.838284539571547 0.710974943433734 0.212316408602433 NA NA NA 0.206661394533553 74.2903804601825 a614 RB1_mut 283 GSK2126458 PI3K, MTOR 6 13 -2.05572501506252 0.0237165266173161 -1.5399744528662 -2.5310156572865 0.991041204420301 1.65959798647362 1.50350228226403 0.638950906145394 0.59715739142713 0.659155104791697 0.212764821762007 NA NA NA 0.244431202730473 74.3260324151904 a615 CDKN1A_mut 154 CHIR-99021 GSK3B 3 16 0.940007258491471 NA 2.2126868948989 2.82256356192787 -0.609876667028971 1.11009531971919 0.688180854900004 0.812913193534933 0.549391260548008 0.886215683982649 0.21362003563132 NA NA NA 0.444106260653361 74.3553176730141 a616 MLL2_mut 258 STF-62247 stimulates autophagy 3 16 2.32630161961136 NA 4.03277145251854 4.63459470550284 -0.601823252984302 0.295460658979019 0.781355977285345 0.812265264643287 2.03689809351924 0.770229281505222 0.2139687431212 NA NA NA 0.0464104263494615 74.3553176730141 a617 loss_cnaBLCA18_(CHD9,CNOT1,CYLD,MMP2,NUP93) 1037 BX-795 TBK1, PDPK1, IKK, AURKB, AURKC 3 12 1.6094379124341 NA 1.15133436702159 2.14624049824022 -0.99490613121863 0.859071992736418 1.23027293310427 0.842580167137486 1.15811729358041 0.808687328191676 0.214414743303946 NA NA NA 0.172220063737697 74.3553176730141 a618 gain_cnaBLCA15_(ASXL1) 134 Etoposide TOP2 6 13 2.77258872223978 NA 1.79551347975499 0.866472464175615 0.92904101557937 1.56981615356693 1.41320065670297 0.635890502361431 0.59181517113861 0.657402054812828 0.214864579300962 NA NA NA 0.247771060802994 74.3553176730141 a619 gain_cnaBLCA23_(MYC) 173 FH535 unknown 4 15 3.46573590279973 NA 1.0508254019243 1.92466798206208 -0.873842580137776 0.374464150943477 1.31964197415322 0.723473657945806 2.33358140675441 0.662181559281256 0.215804362824707 NA NA NA 0.0384632546514955 74.3553176730141 a620 RB1_mut 159 HG-6-64-1 BRAFV600E, TAK, MAP4K5 6 13 1.63315443905142 NA -0.154508688729901 0.549741354289598 -0.7042500430195 0.676227317600215 1.25183566189376 0.632262361383191 1.04143980092187 0.562573878071278 0.217374913143455 NA NA NA 0.131549036320872 74.3553176730141 a621 ARID1A_mut 1230 IOX2 EGLN1 5 14 -2.30258509299405 NA 0.181146853161843 -0.269658111569915 0.450804964731759 0.36305856301584 0.746857674150423 0.666442149891215 1.24168663310688 0.603602239535887 0.218015872222035 NA NA NA 0.100432791063027 74.3553176730141 a622 NRAS_mut 1192 GSK269962A ROCK1, ROCK2 3 16 1.6094379124341 NA 2.45676929987015 1.70412407101732 0.752645228852829 0.932114296222093 0.935860536719532 0.80460623160669 0.807460235191477 0.804227979834552 0.218124717229476 NA NA NA 0.295076817350777 74.3553176730141 a623 NRAS_mut 1218 JQ1 BRD2, BRD3, BRD4 3 16 0 NA 2.44507052286869 1.88588139266497 0.559189130203724 0.525194934172111 0.714662983462872 0.804520971421372 1.06472681631098 0.782451509513189 0.218171334975754 NA NA NA 0.195682144608953 74.3553176730141 a624 gain_cnaBLCA15_(ASXL1) 263 FR-180204 ERK 6 13 2.99573227355399 NA 5.31915577194686 4.90876939910423 0.41038637284263 0.767295241523196 0.596103051639017 0.630255650213681 0.534848061911542 0.688448703146629 0.218773212117266 NA NA NA 0.280356722656379 74.3553176730141 a625 MLL2_mut 261 TL-1-85 MAP3K7 (TAK1) 3 16 2.32630161961136 NA 4.32370017080404 3.3945729017887 0.92912726901534 0.530184045627191 1.21606738831142 0.803270057387436 1.7524617662084 0.764042583450487 0.218856195230891 NA NA NA 0.0683263556832213 74.3553176730141 a626 EP300_mut 222 BX-912 PDPK1 (PDK1) 4 15 2.32630161961136 NA 4.1336251881566 3.08262613875056 1.05099904940604 0.558588340203176 1.59163405280239 0.718228576466971 1.88152700971838 0.660327069250336 0.219002097082554 NA NA NA 0.0515672113358397 74.3553176730141 a627 EP300_mut 1003 Camptothecin TOP1 3 11 -2.30258509299405 NA -5.55156121637877 -3.90689010548537 -1.6446711108934 1.67829501737735 1.99847719683711 0.843953373853013 0.979965437461349 0.822962160136895 0.219441056580717 NA NA NA 0.227762182182776 74.3553176730141 a628 EP300_mut 228 KIN001-102 AKT1 4 15 2.32630161961136 NA 4.05861233623836 3.15825452866784 0.900357807570518 0.869839110939301 1.32491347511333 0.716480959973704 1.03508544999576 0.67955970294098 0.220075755816605 NA NA NA 0.146171049891251 74.3553176730141 a629 gain_cnaBLCA9 208 SB-715992 KIF11 4 15 -2.05572501506252 NA -0.306252693568302 -1.395947043207 1.0896943496387 1.76589728921857 1.46486159668106 0.71581286221982 0.61707685735273 0.74388894630566 0.220487291661294 NA NA NA 0.317551775729284 74.3553176730141 a630 RB1_mut 279 BIX02189 MAP2K5 (MEK5) 6 13 2.99573227355399 NA 5.14304621876702 4.4792821153817 0.663764103385328 0.695694826491476 1.17578027459007 0.627701616085123 0.954102399658223 0.564530735657004 0.220563064500528 NA NA NA 0.144853515509078 74.3553176730141 a631 gain_cnaBLCA15_(ASXL1) 133 Doxorubicin DNA intercalating 6 13 0.0237165266173161 NA -1.34814712186355 -2.41150729682501 1.06336017496146 2.32886164512996 1.34470058949665 0.627510509149878 0.456600836372192 0.790778395776189 0.220697450152434 NA NA NA 0.334456925468262 74.3553176730141 a632 gain_cnaBLCA15_(ASXL1) 1529 MLN4924 NEDD8-activating enzyme 5 11 0 NA 0.509297183339739 -0.5691241481495 1.07842133148924 1.66537921125637 1.51907569277017 0.690288883940786 0.647553016274099 0.709919417855106 0.221407188589421 NA NA NA 0.256238975961658 74.3553176730141 a633 gain_cnaBLCA23_(MYC) 295 NVP-BHG712 EPHB4 4 15 2.32630161961136 NA 2.83483728291186 3.85076747198288 -1.01593018907102 1.79549861822228 1.32903479719284 0.714181146065378 0.565820646566074 0.764412031360542 0.221494927141565 NA NA NA 0.351188670383563 74.3553176730141 a634 NRAS_mut 205 BMS-708163 g-secretase 3 16 2.32630161961136 0.940007258491471 4.48845786108779 4.77253461761883 -0.284076756531034 0.368323690539682 0.354355868589639 0.797906589870104 0.771269304222039 0.801670810932747 0.221811717122018 NA NA NA 0.312653358231672 74.3553176730141 a635 CDKN1A_mut 1218 JQ1 BRD2, BRD3, BRD4 3 16 0 NA 2.44141457578126 1.88656688274386 0.5548476930374 0.164672444518666 0.738051113307249 0.797681671173185 3.36940217690463 0.751774075038103 0.221936335603545 NA NA NA 0.0168555299394903 74.3553176730141 a636 loss_cnaBLCA5_(FAT1,IRF2) 328 SNX-2112 HSP90 5 13 0.940007258491471 NA -1.42867852626152 -0.0867201699916374 -1.34195835626988 1.47398312493957 2.1572341472268 0.668195184592585 0.910429932042059 0.622073574162087 0.222325478493892 NA NA NA 0.160247715969425 74.3553176730141 a637 TP53_mut 258 STF-62247 stimulates autophagy 15 4 2.32630161961136 NA 4.42824050494729 4.95705551784795 -0.528815012900657 0.766699703742371 0.614999265783209 0.712510492451153 0.689728990789269 0.859862836140471 0.222530330219916 NA NA NA 0.200062013176532 74.3553176730141 a638 gain_cnaBLCA23_(MYC) 1248 FK866 NAMPT 4 15 0 NA -3.59688606575807 -1.58141399287533 -2.01547207288274 1.69007169310946 3.02134332881601 0.711614225392181 1.1925364356435 0.667078134967385 0.223087354554691 NA NA NA 0.11395253821317 74.3553176730141 a639 loss_cnaBLCA18_(CHD9,CNOT1,CYLD,MMP2,NUP93) 1219 PFI-1 BRD2, BRD3, BRD4 3 16 2.30258509299405 NA 1.71292231209535 2.41554998465473 -0.70262767255938 1.06218942993918 0.857178724116793 0.795035038924361 0.661489987336454 0.819697984551988 0.223406837217395 NA NA NA 0.372172862990025 74.3553176730141 a640 ARID1A_mut 1023 GW 441756 NTRK1 3 11 0.693147180559945 NA 3.02562499245879 2.28282132237495 0.742803670083845 0.765526468617656 0.911100028644574 0.836023983741629 0.970317422760256 0.815282237658251 0.223533042085179 NA NA NA 0.231494894016749 74.3553176730141 a641 loss_cnaBLCA18_(CHD9,CNOT1,CYLD,MMP2,NUP93) 1011 ABT-263 BCL2, BCL2L1, BCL2L2 3 12 0.693147180559945 NA 1.73042901432928 2.38112018134854 -0.650691167019259 0.600226378976503 0.818705004528252 0.824661491582326 1.08407625824244 0.79478098145277 0.223748661079751 NA NA NA 0.193556876953771 74.3553176730141 a642 CDKN1A_mut 1219 PFI-1 BRD2, BRD3, BRD4 3 16 2.30258509299405 NA 2.89537126327421 2.1938408063087 0.701530456965514 1.24989033695504 0.822891800979278 0.793677201964782 0.561273606350593 0.852518467349731 0.224164211230463 NA NA NA 0.436070960547134 74.3553176730141 a643 EP300_mut 1371 PLX4720 (rescreen) BRAF 3 15 2.30258509299405 NA 4.52447040917249 3.8094016856881 0.715068723484393 0.438022710169379 0.94150636382886 0.799664609008374 1.6324923500151 0.759494307161553 0.224202178854696 NA NA NA 0.083349483874922 74.3553176730141 a644 RB1_mut 151 QS11 ARFGAP 6 13 2.32630161961136 NA 2.36190329876417 3.36900221243536 -1.00709891367119 1.61027344631061 1.62091951096979 0.622513079651475 0.625421052541488 0.621313339037203 0.224234378735122 NA NA NA 0.235075089684384 74.3553176730141 a645 CDKN1A_mut 269 NSC-207895 MDM4 3 16 2.99573227355399 NA 2.75563401315706 3.76359018159187 -1.00795616843481 1.11069999334592 1.29308111823335 0.791807421290775 0.90749633066837 0.779499564429421 0.225210409275595 NA NA NA 0.251780069158426 74.3553176730141 a646 ARID1A_mut 1043 JNK Inhibitor VIII JNK 5 9 2.30258509299405 NA 4.26551226820821 3.6976503543741 0.567861913834106 0.79338303142992 0.79869307900336 0.712564535757662 0.715747490604437 0.710988900195186 0.225582731213995 NA NA NA 0.234571443900155 74.3553176730141 a647 MLL2_mut 1057 NVP-BEZ235 PI3K (Class 1) and MTORC1/2 3 12 -1.38629436111989 0.693147180559945 -3.32280689269757 -2.32035019566471 -1.00245669703286 0.220866453354534 1.32389759651399 0.821089450808387 4.5387458430535 0.757201085395478 0.225647687029108 NA NA NA 0.0275420924251793 74.3553176730141 a648 EP300_mut 263 FR-180204 ERK 4 15 2.99573227355399 NA 5.40254567309936 4.94125027517591 0.461295397923451 0.241936290256082 0.709707853182461 0.707487484687653 1.90668128967004 0.649979277888666 0.225666135550039 NA NA NA 0.0526173899121744 74.3553176730141 a649 NRAS_mut 260 NG-25 MAP3K7 (TAK1) 3 16 2.32630161961136 NA 4.06163285945702 2.92497301607021 1.13665984338681 1.84115064785199 1.37905752475826 0.78872684327548 0.617363845111161 0.82422946322421 0.226942368674318 NA NA NA 0.399167117531388 74.3553176730141 a650 ARID1A_mut 147 NSC-87877 PTPN6 (SHP-1), PTPN11 (SHP-2) 5 14 2.77258872223978 NA 5.38948655414369 4.94832776302153 0.44115879112216 0.428503934435927 0.735247314895943 0.65287400522195 1.02953264992279 0.600014147871585 0.22711529788997 NA NA NA 0.132825590826826 74.3553176730141 a651 NRAS_mut 165 DMOG Prolyl-4-Hydroxylase 3 16 8.29404964010203 NA 6.37411581182774 5.62173952677377 0.752376285053975 0.591910003558531 0.992843559269256 0.788277000687012 1.27109912069526 0.757799431773252 0.227196142797676 NA NA NA 0.14144346441131 74.3553176730141 a652 CDKN1A_mut 222 BX-912 PDPK1 (PDK1) 3 16 2.32630161961136 NA 2.3311586954227 3.48627604672605 -1.15511735130335 1.22154721582479 1.4952200973757 0.788111289235603 0.945618258827118 0.772540011554637 0.227289682788103 NA NA NA 0.23700004096596 74.3553176730141 a653 TP53_mut 1033 Vismodegib SMO 10 4 2.30258509299405 NA 4.34069780257094 4.90847575725465 -0.567777954683712 0.772456662823361 0.703110486379455 0.751310366029328 0.735028878653801 0.807523093002617 0.228177084369893 NA NA NA 0.232080761468941 74.3553176730141 a654 RB1_mut 177 GSK-650394 SGK3 6 13 2.77258872223978 NA 2.07449545833315 3.33169618289013 -1.25720072455697 1.34581930594633 2.2651097424833 0.616808607355343 0.934152689742373 0.55502861560194 0.228325517276574 NA NA NA 0.152019585081657 74.3553176730141 a655 TP53_mut 345 KIN001-270 CDK9 15 4 2.99573227355399 NA 4.79262227488828 5.4232201415959 -0.630597866707619 0.950840896655777 0.583955113491851 0.702955353782163 0.663200193560782 1.0798738672513 0.228524903337247 NA NA NA 0.137419910482783 74.3553176730141 a656 MLL2_mut 333 T0901317 LXR 3 16 2.32630161961136 NA 4.05471778836481 4.54732970980523 -0.492611921440418 0.242334271399617 0.661381868418915 0.785920852713369 2.03277860203308 0.744822235024443 0.228528943079984 NA NA NA 0.0486578497325859 74.3553176730141 a657 RB1_mut 231 FMK RSK 6 8 2.99573227355399 2.32630161961136 5.42378224976405 5.14016211552621 0.283620134237841 0.453526865440323 0.384646088216117 0.683852075098858 0.625365674781974 0.737353486560058 0.229453249690257 NA NA NA 0.24573675049401 74.3553176730141 a658 MLL2_mut 1218 JQ1 BRD2, BRD3, BRD4 3 16 0 NA 1.51413677778796 2.06043146986761 -0.546294692079647 1.27626485655812 0.576837052167015 0.784251867054278 0.428041788718462 0.947052014130111 0.229476703013373 NA NA NA 0.537714696039804 74.3553176730141 a659 ARID1A_mut 269 NSC-207895 MDM4 5 14 2.99573227355399 NA 4.21403744309768 3.38672555210377 0.827311890993915 1.49607538701236 1.19744151361761 0.649370392822105 0.55298810352468 0.690899623560327 0.229512319858109 NA NA NA 0.307701301173334 74.3553176730141 a660 MLL2_mut 292 Masitinib KIT 3 16 2.99573227355399 NA 4.85980753616698 4.1625076441071 0.697299892059887 0.504590916831201 0.928881559761356 0.783895340384794 1.3819113043867 0.750687625060653 0.229679556928944 NA NA NA 0.119286837189867 74.3553176730141 a661 gain_cnaBLCA23_(MYC) 223 ZSTK474 PI3K 4 15 1.63315443905142 2.32630161961136 0.896113657818068 1.92040276915712 -1.02428911133905 2.16916905476765 1.26041395646443 0.70041212215934 0.472203450020529 0.812660877075873 0.230141387086047 NA NA NA 0.422721790333113 74.3553176730141 a662 EP300_mut 159 HG-6-64-1 BRAFV600E, TAK, MAP4K5 4 15 1.63315443905142 NA 0.944246508066964 0.162839962741168 0.781406545325796 1.3408776423624 1.06252898562306 0.699744727447582 0.582757531812588 0.735421391697455 0.230567049379688 NA NA NA 0.340535476376137 74.3553176730141 a663 loss_cnaBLCA5_(FAT1,IRF2) 1072 BMS-708163 g-secretase 5 13 1.6094379124341 NA 3.73267684259944 3.32581862113033 0.406858221469106 0.542077456575441 0.645199481535281 0.655138383021131 0.750553664488138 0.630592914459524 0.231074961360792 NA NA NA 0.211054038059987 74.3553176730141 a664 NRAS_mut 1067 CCT007093 PPM1D 3 15 1.88706964903238 NA 4.12605480289049 3.73072708656618 0.395327716324314 0.272823418432686 0.527248258275811 0.786659965911769 1.44902412921658 0.74979425748527 0.231481837391175 NA NA NA 0.109318722483734 74.3553176730141 a665 RB1_mut 192 LFM-A13 BTK 6 13 2.77258872223978 NA 4.65879812682101 4.26467279267742 0.394125334143594 0.564679932458436 0.674620325214301 0.611772202966405 0.697962352633462 0.584217995534594 0.231985485394457 NA NA NA 0.209785530352912 74.3553176730141 a666 gain_cnaBLCA23_(MYC) 175 PAC-1 CASP3 agonist 4 15 0.940007258491471 NA 2.11521981321679 2.74978305324974 -0.634563240032944 0.909175282554437 0.910975210160562 0.696818515222475 0.697954786287263 0.696575749762828 0.232440580719539 NA NA NA 0.272803361384449 74.3553176730141 a667 EP300_mut 1236 UNC0638 G9a(EHMT2), GLP(EHMT1) 4 15 2.99573227355399 NA 2.94702803447444 3.81433291769416 -0.867304883219718 1.21493418203813 1.25099071341437 0.696796262884119 0.713869850764063 0.693294421708817 0.232454872949269 NA NA NA 0.264657711468454 74.3553176730141 a668 loss_cnaBLCA18_(CHD9,CNOT1,CYLD,MMP2,NUP93) 281 CH5424802 ALK 3 16 1.63315443905142 NA 3.86364875480117 4.13911646075874 -0.27546770595757 0.366650028084973 0.352002368591038 0.778691659810351 0.751309654594459 0.782573444207736 0.23265615144194 NA NA NA 0.323008345734643 74.3553176730141 a669 gain_cnaBLCA15_(ASXL1) 1039 SL 0101-1 RSK, AURKB, PIM3 4 11 2.30258509299405 NA 4.63317134090582 4.08040284137211 0.552768499533713 0.632994266889262 0.79176520524147 0.729166258668888 0.873259883142695 0.698146995945763 0.233744203309842 NA NA NA 0.207503749806831 74.3553176730141 a670 gain_cnaBLCA15_(ASXL1) 222 BX-912 PDPK1 (PDK1) 6 13 2.32630161961136 NA 3.91531560529551 3.02169224631629 0.893623358979224 1.04027623609589 1.61248442597369 0.608928615308288 0.859025062740022 0.55419038136732 0.234071890697081 NA NA NA 0.168344142193458 74.3553176730141 a671 gain_cnaBLCA15_(ASXL1) 306 TG101348 JAK2 6 13 2.32630161961136 NA 3.38197938298411 2.82084131975423 0.561138063229887 0.9654627168713 0.902744494885676 0.60885118111357 0.581211530413441 0.621591232523606 0.234128908021282 NA NA NA 0.259420726647854 74.3553176730141 a672 TP53_mut 228 KIN001-102 AKT1 15 4 2.32630161961136 NA 3.16368625677574 4.03824335583373 -0.874557099057992 1.27391137801713 1.19305075464913 0.694082480624574 0.686513296096987 0.733042660297548 0.234202980998385 NA NA NA 0.255442056126341 74.3553176730141 a673 ARID1A_mut 1239 YK 4-279 RNA helicase A 4 13 2.30258509299405 NA 1.75829767016708 1.07409980676428 0.684197863402796 1.0177815885847 0.953014359033635 0.708048367134036 0.672244291974496 0.717930277668197 0.234620790092606 NA NA NA 0.28897416522855 74.3553176730141 a674 gain_cnaBLCA23_(MYC) 294 MPS-1-IN-1 MPS1 4 15 2.99573227355399 NA 3.7443188464919 4.53809012263353 -0.793771276141624 1.7716173720554 0.960269872976918 0.692658005881023 0.448048934641402 0.826612703865077 0.235124624041095 NA NA NA 0.443508755798967 74.3553176730141 a675 gain_cnaBLCA9 167 OSU-03012 PDPK1 (PDK1) 4 15 2.77258872223978 NA 0.870645876892967 2.14274037490836 -1.27209449801539 0.912254915615502 1.98031243531642 0.692292444064615 1.39445069162177 0.642370605430317 0.235361595252667 NA NA NA 0.0893567400432581 74.3553176730141 a676 MLL2_mut 1248 FK866 NAMPT 3 16 0 NA -3.8552625165522 -1.6589354129066 -2.1963271036456 4.99155542235611 2.41078395705849 0.773653038323472 0.440008558015548 0.911042690994777 0.235566671506847 NA NA NA 0.527853260581824 74.3553176730141 a677 gain_cnaBLCA15_(ASXL1) 299 OSI-027 MTORC1/2 6 13 2.99573227355399 NA 2.63527857799274 1.55264278798728 1.08263579000546 2.46453759789371 1.40645993550846 0.606846679120865 0.439285564533778 0.769759424120437 0.235608623270792 NA NA NA 0.351324197798328 74.3553176730141 a678 gain_cnaBLCA9 182 Obatoclax Mesylate BCL2, BCL2L1, MCL1 4 15 2.77258872223978 NA -1.58745517534379 -0.67343658357131 -0.914018591772485 1.26327075453967 1.33621246403459 0.690538033064427 0.723533406031825 0.684036870164102 0.236501436284249 NA NA NA 0.260385281724313 74.3553176730141 a679 CDKN1A_mut 302 PI-103 PI3Ka, PRKDC (DNAPK) 3 16 2.32630161961136 NA 0.745524364905696 2.48550472894008 -1.73998036403438 1.84192163289028 2.30566268437656 0.771248081829256 0.944654936976917 0.75465521293496 0.236965741575535 NA NA NA 0.237710846776549 74.3553176730141 a680 TP53_mut 190 Bleomycin DNA damage 15 4 4.15888308335967 NA 0.934539755867437 2.56912181585822 -1.63458205999078 1.7045271025292 4.27844507608093 0.689322674092504 0.958965133241569 0.382050495197209 0.237293546282901 NA NA NA 0.504566805297974 74.3553176730141 a681 gain_cnaBLCA9 1378 Bleomycin (50 uM) DNA damage 4 14 3.91202300542815 NA 1.69102901523687 0.614615261867838 1.07641375336903 1.80894472689842 1.47998493383128 0.695806125466864 0.595050659847756 0.727313994057011 0.237467029242414 NA NA NA 0.333828100020269 74.3553176730141 a682 gain_cnaBLCA9 1053 MK-2206 AKT1, AKT2 3 12 1.38629436111989 0.693147180559945 2.63095211692466 1.77647192776429 0.85448018916037 0.614265227237941 1.13221915144857 0.799330071935939 1.39106065469889 0.754695050041455 0.237494769891683 NA NA NA 0.126436024578368 74.3553176730141 a683 gain_cnaBLCA9 269 NSC-207895 MDM4 4 15 2.99573227355399 NA 4.29805942429135 3.41947381651838 0.878585607772965 1.4870894525978 1.22599644142889 0.688568420498746 0.590808848948639 0.716629818883471 0.237786157425709 NA NA NA 0.335933387523206 74.3553176730141 a684 RB1_mut 276 CAY10603 HDAC6 6 13 2.99573227355399 NA 1.73444211238024 1.02684877132063 0.707593341059606 1.55562295228176 0.967865224676594 0.603877347464468 0.454861725986827 0.731086646176429 0.237813813285332 NA NA NA 0.339609556164145 74.3553176730141 a685 loss_cnaBLCA18_(CHD9,CNOT1,CYLD,MMP2,NUP93) 176 IPA-3 PAK1, PAK2, PAK3 3 16 3.46573590279973 NA 2.67958209965402 3.90439390636783 -1.22481180671381 0.989323367484221 1.65515283244887 0.769670428607886 1.2380297958881 0.739999221039697 0.237887003873953 NA NA NA 0.149673314896945 74.3553176730141 a686 EP300_mut 208 SB-715992 KIF11 4 15 -2.05572501506252 NA -0.336951097280159 -1.38776080221717 1.05080970493702 0.928746672004613 1.62726285874735 0.687978644244664 1.13142769348389 0.645752896828186 0.238171894783317 NA NA NA 0.128921848198835 74.3553176730141 a687 gain_cnaBLCA9 1199 Tamoxifen ER 4 15 1.6094379124341 NA 3.22121083375715 3.61272408298618 -0.391513249229038 0.827540323101314 0.497520222601938 0.68708070378775 0.47310473979297 0.786929317529038 0.238760108288011 NA NA NA 0.422545666654535 74.3553176730141 a688 TP53_mut 260 NG-25 MAP3K7 (TAK1) 15 4 2.32630161961136 NA 2.89554064264141 3.8878392989683 -0.992298656326883 1.29252726545094 2.0060274950452 0.687052729467253 0.767719709170458 0.494658552177283 0.238778451346461 NA NA NA 0.405138234095753 74.3553176730141 a689 MLL2_mut 235 QL-XII-47 BTK, BMX 3 16 2.32630161961136 NA 2.93715538129764 1.64559105700246 1.29156432429518 0.763808234531385 1.77102802285549 0.766919572124238 1.690953652899 0.72927379331511 0.239499942356943 NA NA NA 0.0770029470493787 74.3553176730141 a690 NRAS_mut 156 AZD6482 PI3Kbeta 3 16 1.63315443905142 NA 2.87696216597778 1.83527745015724 1.04168471582055 1.1736933592673 1.38402798275101 0.765398184472327 0.887527144629021 0.752647149337262 0.240395596565134 NA NA NA 0.260421431084873 74.3553176730141 a691 MLL2_mut 305 TPCA-1 IKK 3 16 2.99573227355399 NA 4.5384838317479 3.37772807289746 1.16075575885045 0.966399288571806 1.57583141215557 0.765217997493322 1.20111404527819 0.736598947004523 0.240501844375535 NA NA NA 0.158719502387837 74.3553176730141 a692 loss_cnaBLCA18_(CHD9,CNOT1,CYLD,MMP2,NUP93) 1264 SGC0946 Q8TEK3 (DOT1L) 3 15 -0.693147180559945 NA 1.30779859218868 1.64034210546064 -0.332543513271959 0.633039671300697 0.394239100238718 0.770882786406699 0.525312280332585 0.843507184017514 0.24055885561338 NA NA NA 0.461973379938095 74.3553176730141 a693 NRAS_mut 1028 VX-702 p38 3 11 0.693147180559945 NA 2.45197904704136 3.02306930282168 -0.571090255780319 1.43784314241616 0.437745863770601 0.804232813654466 0.397185366701863 1.30461599536574 0.240559809851246 NA NA NA 0.56397487395423 74.3553176730141 a694 gain_cnaBLCA15_(ASXL1) 277 ABT-869 VEGFR and PDGFR family 6 13 0.0237165266173161 NA 2.51685134356567 2.24811688871311 0.268734454852557 0.371074708247453 0.476075088093552 0.600180607390169 0.724205797053002 0.56447913695444 0.240581376964227 NA NA NA 0.204995093102866 74.3553176730141 a695 CDKN1A_mut 226 GSK1070916 AURKB 3 16 0.940007258491471 2.32630161961136 0.755321129267811 2.31646727389143 -1.56114614462362 2.63077362397612 1.95061713110111 0.764358837319209 0.593417134182804 0.800334478628492 0.241008946754165 NA NA NA 0.414891511674674 74.380288383236 a696 loss_cnaBLCA18_(CHD9,CNOT1,CYLD,MMP2,NUP93) 201 Epothilone B Microtubules 3 16 -3.44201937618241 NA -6.75507280197935 -4.95614619631057 -1.79892660566878 1.31476982326465 2.46164822607547 0.763590004709109 1.36824451994338 0.730781346665748 0.241463430517064 NA NA NA 0.122825351413079 74.4134816066552 a697 gain_cnaBLCA15_(ASXL1) 1166 QL-VIII-58 MTOR, ATR 3 4 2.30258509299405 NA -2.00941491280336 -1.15667840210846 -0.852736510694899 1.17556477561864 0.517951065214852 1.00935355872431 0.725384537186516 1.64636501006359 0.243554365316939 NA NA NA 0.337093247512208 74.5027178980206 a698 EP300_mut 1072 BMS-708163 g-secretase 4 14 1.6094379124341 NA 3.77108768218975 3.34390539706661 0.427182285123143 0.339898400206914 0.671062168073042 0.686197291801778 1.25679404452358 0.636576319523121 0.243726616936181 NA NA NA 0.113287945204234 74.5027178980206 a699 MLL2_mut 196 Phenformin AAPK1 (AMPK) agonist 3 16 8.29404964010203 NA 8.20984131126187 9.14292193690345 -0.933080625641576 0.922950280566464 1.26496698979253 0.758801355731374 1.01097604636828 0.737632391335851 0.244308979242692 NA NA NA 0.21428869710244 74.5027178980206 a700 gain_cnaBLCA23_(MYC) 1378 Bleomycin (50 uM) DNA damage 3 15 3.91202300542815 NA 1.84043050210303 0.656495881385873 1.18393462071716 1.76864488835583 1.51506108597513 0.764306620595997 0.66940211034549 0.781443488765439 0.244422507152825 NA NA NA 0.36834671624927 74.5027178980206 a701 RB1_mut 1170 CCT018159 HSP90 6 13 2.30258509299405 NA 2.99795975327815 2.46696689956188 0.530992853716266 0.793809697064222 0.93113207988626 0.594658100998856 0.668917066244035 0.570265878693738 0.244761771911705 NA NA NA 0.225409400467391 74.5027178980206 a702 loss_cnaBLCA18_(CHD9,CNOT1,CYLD,MMP2,NUP93) 1003 Camptothecin TOP1 3 11 -2.30258509299405 NA -5.48616823871944 -3.92472455393791 -1.56144368478153 1.35514875476515 2.06224574864451 0.795773059548978 1.15223046864116 0.757156942041388 0.245260589063158 NA NA NA 0.179763428908477 74.5027178980206 a703 gain_cnaBLCA15_(ASXL1) 176 IPA-3 PAK1, PAK2, PAK3 6 13 3.46573590279973 NA 4.35835499655339 3.41222452473285 0.946130471820541 2.22802108540514 1.23642980329251 0.593754801249752 0.424650591512916 0.765211635388498 0.245450805063553 NA NA NA 0.365384886924686 74.5027178980206 a704 MLL2_mut 219 AT-7519 CDK9 3 16 2.32630161961136 NA 2.87570982549134 1.55950236112258 1.31620746436876 1.85302480922264 1.72489749274259 0.756240741097835 0.710302127536502 0.763064164628118 0.245841063116361 NA NA NA 0.345077156389123 74.5027178980206 a705 gain_cnaBLCA23_(MYC) 1069 EHT 1864 Rac GTPases 3 15 2.30258509299405 NA 2.8886501834739 3.6082147253367 -0.719564541862798 0.306966116894193 1.00638965038952 0.759333429757365 2.34411715906359 0.714995967599922 0.247375942789997 NA NA NA 0.0411825958783383 74.5027178980206 a706 RB1_mut 175 PAC-1 CASP3 agonist 6 13 0.940007258491471 NA 2.2469582493438 2.78660581196542 -0.539647562621617 1.00357416640181 0.872654648894733 0.590998856542774 0.537725641699665 0.61839762534367 0.247562191070731 NA NA NA 0.287189150579661 74.5027178980206 a707 TP53_mut 1012 Vorinostat HDAC inhibitor Class I, IIa, IIb, IV 10 4 2.30258509299405 NA 1.39370137039582 1.78289686062864 -0.38919549023282 0.566596394895115 0.457685340285679 0.718833570450364 0.686900752880479 0.850356032792947 0.247713419770471 NA NA NA 0.222754915744683 74.5027178980206 a708 loss_cnaBLCA18_(CHD9,CNOT1,CYLD,MMP2,NUP93) 180 Thapsigargin sarco-endoplasmic reticulum Ca2+-ATPases 3 16 -0.669430653942629 NA -5.40589825737425 -4.16726318332422 -1.23863507405003 0.694089900607643 1.73340175906344 0.752713445246602 1.78454559411635 0.71456894950843 0.247963547050497 NA NA NA 0.0692627794666324 74.5027178980206 a709 loss_cnaBLCA18_(CHD9,CNOT1,CYLD,MMP2,NUP93) 308 XL-880 MET 3 16 1.63315443905142 NA -0.241838382039217 0.82470961074669 -1.06654799278591 0.262506913088932 1.50543325922832 0.752695231654979 4.06293297283406 0.708465809591995 0.247974542904955 NA NA NA 0.0176483228126671 74.5027178980206 a710 gain_cnaBLCA9 1062 AZD6244 MAP2K1 (MEK1), MAP2K2 (MEK2) 3 11 1.38629436111989 0.693147180559945 3.01602712557724 1.78181495304027 1.23421217253698 0.708472647652398 1.68261110709358 0.78964256103594 1.74207455520926 0.733510059058663 0.248712312519198 NA NA NA 0.0917187587751016 74.5027178980206 a711 EP300_mut 1017 Olaparib PARP1, PARP2 3 11 1.6094379124341 NA 3.08987891947432 3.74162619878199 -0.651747279307675 0.916755780188029 0.806862216307312 0.788855477342826 0.710927919291657 0.807755359137355 0.249158237816499 NA NA NA 0.34702781816773 74.5027178980206 a712 RB1_mut 204 Tipifarnib Farnesyl-transferase (FNTA) 6 13 2.77258872223978 NA 0.785832671465716 1.52254307806119 -0.73671040659547 0.858901878750293 1.38262845813191 0.588637487607529 0.857735237076658 0.532833244001683 0.249382285145279 NA NA NA 0.176546789338368 74.5027178980206 a713 ARID1A_mut 1498 AZD6244 MAP2K1 (MEK1), MAP2K2 (MEK2) 5 14 1.38629436111989 NA 0.82016390091741 1.56701272476931 -0.746848823851896 1.22513794041192 1.19530013868973 0.621138258249485 0.609603865178469 0.624821163888244 0.249547735718724 NA NA NA 0.277792459299032 74.5027178980206 a714 NRAS_mut 140 Vinorelbine Microtubules 3 16 -2.74887219562247 NA -3.18198771216296 -4.14049321277224 0.95850550060928 2.00070212219304 1.14857578370779 0.749623931177333 0.479084562352854 0.834516550153156 0.249834062312455 NA NA NA 0.496806896112463 74.5027178980206 a715 MLL2_mut 1526 RDEA119 (rescreen) MAP2K1 (MEK1), MAP2K2 (MEK2) 3 16 1.6094379124341 NA 0.847104144495327 1.55099532974059 -0.703891185245258 1.38696041942585 0.863081201048734 0.748826496601277 0.507506324900493 0.815556154380326 0.25031860154836 NA NA NA 0.475168454446747 74.5027178980206 a716 EP300_mut 1012 Vorinostat HDAC inhibitor Class I, IIa, IIb, IV 3 11 2.30258509299405 NA 1.17005329123103 1.59622193388906 -0.426168642658027 0.490152536053128 0.551533193092315 0.786599271004528 0.869461262181115 0.772698085982099 0.25043999540415 NA NA NA 0.272369848419143 74.5027178980206 a717 RB1_mut 201 Epothilone B Microtubules 6 13 -3.44201937618241 NA -6.18778718909832 -4.8028334163321 -1.38495377276622 1.3698104113472 2.66571171659282 0.586934926504708 1.01105507834776 0.519543716653801 0.250700896108143 NA NA NA 0.153928761691758 74.5027178980206 a718 TP53_mut 205 BMS-708163 g-secretase 15 4 2.32630161961136 0.940007258491471 4.77805280029694 4.53878386517761 0.239268935119337 0.279183822292951 0.601863719872995 0.668480569779978 0.857030085605279 0.397546699059759 0.251196912996436 NA NA NA 0.490269351613598 74.5027178980206 a719 gain_cnaBLCA9 328 SNX-2112 HSP90 4 14 0.940007258491471 NA 0.60005976162023 -0.762213849119985 1.36227361074021 2.33326961665241 1.94009286443763 0.674508984650746 0.583847490670493 0.70216928050766 0.251511134554834 NA NA NA 0.342600462206933 74.5027178980206 a720 loss_cnaBLCA5_(FAT1,IRF2) 1039 SL 0101-1 RSK, AURKB, PIM3 3 12 2.30258509299405 NA 3.75618056881291 4.34571457602315 -0.589534007210232 0.902846671055393 0.732546642442851 0.774448733212294 0.652972454914287 0.804773338724604 0.251637795080116 NA NA NA 0.379275813773855 74.5027178980206 a721 RB1_mut 190 Bleomycin DNA damage 6 13 4.15888308335967 NA 0.3263854843425 1.71817466887611 -1.39178918453361 1.64676954635285 2.62229290022351 0.585449992837327 0.845163300242009 0.530752756267229 0.251855282971764 NA NA NA 0.18032585415735 74.5027178980206 a722 NRAS_mut 1021 Axitinib PDGFR, KIT, VEGFR 3 11 0.693147180559945 NA 2.73958104626463 1.81940456111304 0.920176485151589 1.35573221046706 1.13706664228139 0.782238828719488 0.678730266971071 0.809254665412896 0.252931891131474 NA NA NA 0.364942795529404 74.5027178980206 a723 RB1_mut 1230 IOX2 EGLN1 6 13 -2.30258509299405 NA -0.423020463967967 -0.0254889624893688 -0.397531501478598 1.16913326900994 0.29498589634272 0.583945746638008 0.340022401223123 1.34762884058951 0.253028798332951 NA NA NA 0.447061316131592 74.5027178980206 a724 MLL2_mut 155 AP-24534 ABL 3 16 -0.669430653942629 NA 0.831259697197646 0.0951917023727803 0.736067994824865 0.671839311881101 1.02386423797565 0.744273847994721 1.09560125733627 0.71891171458454 0.253098598212448 NA NA NA 0.188055770416142 74.5027178980206 a725 EP300_mut 1219 PFI-1 BRD2, BRD3, BRD4 4 15 2.30258509299405 NA 1.83772070792501 2.42911225727079 -0.591391549345777 0.637255535515498 0.933591016745401 0.66560108625851 0.928028893256109 0.633458911598605 0.253165572627944 NA NA NA 0.182787254815558 74.5027178980206 a726 gain_cnaBLCA15_(ASXL1) 163 JQ1 BRD4 6 13 0.940007258491471 NA 0.286738948795573 -0.499229300509864 0.785968249305437 1.89300347316418 1.03778127102763 0.583530951956767 0.41519641165353 0.757354436091489 0.253353123463078 NA NA NA 0.374989659968939 74.5027178980206 a727 loss_cnaBLCA5_(FAT1,IRF2) 1091 BMS-536924 IGF1R 5 14 1.38629436111989 NA 2.84268725516073 2.23283068011034 0.609856575050384 1.5703276440848 0.723902828809364 0.615749338863371 0.388362630784492 0.842456405445248 0.253519441792869 NA NA NA 0.443590763754855 74.5027178980206 a728 gain_cnaBLCA23_(MYC) 1072 BMS-708163 g-secretase 3 15 1.6094379124341 NA 3.04953663111288 3.51669442629019 -0.467157795177308 0.631114305502906 0.622571800053086 0.749075254064405 0.740211069696878 0.75036774093763 0.253554331992227 NA NA NA 0.32975434593686 74.5027178980206 a729 gain_cnaBLCA15_(ASXL1) 282 EKB-569 EGFR 6 13 0.916290731874155 2.99573227355399 2.53021481655453 1.63446833862033 0.895746477934204 1.24441346118481 1.64313450663106 0.582925001719024 0.719814198314251 0.545144949679599 0.25382747886247 NA NA NA 0.212360027025256 74.5027178980206 a730 RB1_mut 328 SNX-2112 HSP90 5 13 0.940007258491471 NA 0.449255094968865 -0.809002332003322 1.25825742697219 2.12866872939561 1.98316701074774 0.622737873102779 0.591100629983625 0.634468716024965 0.25394213089211 NA NA NA 0.290785843830855 74.5027178980206 a731 gain_cnaBLCA15_(ASXL1) 341 EX-527 SIRT1 6 13 2.99573227355399 NA 5.5257246082433 5.247220739205 0.2785038690383 0.259126797887133 0.544755088712324 0.581701147885634 1.07477833751339 0.511246016437623 0.254787601497182 NA NA NA 0.149516146577511 74.5027178980206 a732 TP53_mut 1011 ABT-263 BCL2, BCL2L1, BCL2L2 11 4 0.693147180559945 NA 2.10355667363584 2.65640145229401 -0.552844778658175 0.741757552254346 0.95064519154734 0.695533609282976 0.745317357373675 0.581546915267435 0.254855528917035 NA NA NA 0.346814752189412 74.5027178980206 a733 loss_cnaBLCA5_(FAT1,IRF2) 1043 JNK Inhibitor VIII JNK 3 11 2.30258509299405 NA 4.39149672739719 3.76653857711058 0.624958150286608 1.10232562018599 0.728473335564514 0.778315878870311 0.566945137482298 0.857901202111003 0.255190389355973 NA NA NA 0.433987090921034 74.5027178980206 a734 gain_cnaBLCA23_(MYC) 1019 Bosutinib SRC, ABL, TEC 4 10 0.693147180559945 NA 0.949748408193904 1.63050876641311 -0.680760358219201 0.524317960925807 1.0707354997178 0.706453927407976 1.29837314178053 0.635787604313689 0.255500025644844 NA NA NA 0.140001761720167 74.5027178980206 a735 gain_cnaBLCA15_(ASXL1) 1161 ZG-10 IRAK1 3 4 2.30258509299405 NA 1.27178065076831 2.45353891703376 -1.18175826626545 0.767828329428845 1.42578093836198 0.979529085233324 1.53909177477798 0.828849814490524 0.255902669263677 NA NA NA 0.221638276969069 74.5027178980206 a736 gain_cnaBLCA9 223 ZSTK474 PI3K 4 15 1.63315443905142 2.32630161961136 2.47160677087938 1.50027127234077 0.971335498538615 1.60992055355142 1.43713677623407 0.661174814148527 0.603343746618979 0.675882431374376 0.256214555899554 NA NA NA 0.329848164315207 74.5027178980206 a737 TP53_mut 1526 RDEA119 (rescreen) MAP2K1 (MEK1), MAP2K2 (MEK2) 15 4 1.6094379124341 NA 1.57075774665098 0.948967877392659 0.621789869258322 0.82825733850773 1.34754030647456 0.660807223697504 0.750720627937448 0.461425803941293 0.256469011404433 NA NA NA 0.433477777139997 74.5027178980206 a738 gain_cnaBLCA23_(MYC) 1037 BX-795 TBK1, PDPK1, IKK, AURKB, AURKC 3 12 1.6094379124341 NA 1.21648499515246 2.1299528412075 -0.913467846055039 0.992243928743411 1.22582792164594 0.76577139025446 0.920608148453844 0.745184401435817 0.256722052954025 NA NA NA 0.251407596794871 74.5027178980206 a739 TP53_mut 310 YM201636 FYV1 15 4 1.63315443905142 NA 2.63231277368012 3.40990471671162 -0.777591943031501 1.11941291668477 1.41721979736833 0.660401611529049 0.69464263940638 0.548674203165545 0.256750008442603 NA NA NA 0.366300691694649 74.5027178980206 a740 EP300_mut 1053 MK-2206 AKT1, AKT2 4 11 1.38629436111989 0.693147180559945 1.4035355609902 2.14512520363497 -0.741589642644772 0.882002202602717 1.12521587213366 0.690499982107866 0.840802483776572 0.659064328019609 0.258139262891739 NA NA NA 0.22503651290935 74.5027178980206 a741 NRAS_mut 1019 Bosutinib SRC, ABL, TEC 3 11 0.693147180559945 NA 2.02144578544512 1.27634035823376 0.74510542721136 0.849817896498661 0.9855999786475 0.772691854796969 0.876782461608861 0.755991724181892 0.258455779485805 NA NA NA 0.27015369631491 74.5027178980206 a742 loss_cnaBLCA5_(FAT1,IRF2) 287 KIN001-244 PDPK1 (PDK1) 5 14 2.99573227355399 NA 3.16768664492264 3.86892765882638 -0.701241013903738 0.945764976789812 1.20806411802266 0.60885700215821 0.741453776691905 0.580466718150288 0.258668866751531 NA NA NA 0.219857526251265 74.5027178980206 a743 gain_cnaBLCA15_(ASXL1) 298 OSI-930 KIT, VEGFR, PDGFR 6 13 2.32630161961136 NA 4.6241307829778 4.189484559149 0.434646223828802 0.225960986161422 0.885008001060186 0.576770561030119 1.92354543681403 0.491121236540372 0.258683577338365 NA NA NA 0.118282718822 74.5027178980206 a744 gain_cnaBLCA9 258 STF-62247 stimulates autophagy 4 15 2.32630161961136 NA 4.92734305846851 4.43616382744847 0.491179231020036 0.612462832320901 0.772757787687246 0.657558537014948 0.801973940457307 0.63561861018582 0.258726154694582 NA NA NA 0.22867246843654 74.5027178980206 a745 gain_cnaBLCA9 235 QL-XII-47 BTK, BMX 4 15 2.32630161961136 NA 2.72655744995654 1.61564621707374 1.1109112328828 2.27934851775704 1.53403371976303 0.657491399491119 0.487381032004693 0.724176540952703 0.258772958721005 NA NA NA 0.412421480081343 74.5027178980206 a746 gain_cnaBLCA9 257 NPK76-II-72-1 PLK3 4 15 2.32630161961136 NA 4.15110607368776 3.27237644240528 0.878729631282478 1.70679457771255 1.24802526540152 0.65555170472131 0.514842057009669 0.704096027254518 0.260127953639696 NA NA NA 0.391254952021007 74.6815562375596 a747 NRAS_mut 310 YM201636 FYV1 3 16 1.63315443905142 NA 3.5229062019152 2.65972449164392 0.863181710271285 0.692199209025689 1.22848293393362 0.732671033254038 1.24701343055024 0.70264037572534 0.260289544588596 NA NA NA 0.149459881915192 74.6815562375596 a748 loss_cnaBLCA18_(CHD9,CNOT1,CYLD,MMP2,NUP93) 133 Doxorubicin DNA intercalating 3 16 0.0237165266173161 NA -3.12830775145433 -1.87834714597147 -1.24996060548287 1.51284073515736 1.73078189049841 0.732433002274244 0.826234101471926 0.722194178448976 0.260438664429595 NA NA NA 0.287782000619494 74.6815562375596 a749 TP53_mut 1069 EHT 1864 Rac GTPases 14 4 2.30258509299405 NA 3.34895385277435 3.9759543729078 -0.627000520133451 0.97175813485416 0.849160495750694 0.660016522772572 0.645222815888802 0.738376930239973 0.261425367451461 NA NA NA 0.258677225642877 74.8644101335285 a750 MLL2_mut 208 SB-715992 KIF11 3 16 -2.05572501506252 NA -0.225455045044339 -1.34299070545283 1.11753566040849 1.10420439826802 1.58225216144266 0.728622782501701 1.01207318333579 0.706294285854882 0.262834437753111 NA NA NA 0.214950965177215 74.8741179957849 a751 gain_cnaBLCA15_(ASXL1) 1009 ATRA Retinoic acid and retinoid X receptor agonist 4 10 2.30258509299405 NA 3.81242310296685 4.10207837498272 -0.289655272015869 0.311893846620011 0.446597129781057 0.694582627958686 0.928698257932495 0.648582923400945 0.263145966898454 NA NA NA 0.205361076911898 74.8741179957849 a752 gain_cnaBLCA15_(ASXL1) 1219 PFI-1 BRD2, BRD3, BRD4 6 13 2.30258509299405 NA 1.95687174133624 2.46510278790341 -0.508231046567179 0.761574428945139 0.938290400211984 0.571068500409993 0.66734258301074 0.541656449274506 0.263245061925431 NA NA NA 0.233885144823379 74.8741179957849 a753 loss_cnaBLCA5_(FAT1,IRF2) 333 T0901317 LXR 5 14 2.32630161961136 NA 4.18954217899837 4.56955127335616 -0.380009094357789 0.580888744610001 0.645108295073775 0.602628042174554 0.654185673046429 0.58906248339952 0.263390289714975 NA NA NA 0.25835287203404 74.8741179957849 a754 ARID1A_mut 201 Epothilone B Microtubules 5 14 -3.44201937618241 NA -4.19038510666639 -5.61511657239823 1.42473146573184 1.86999327811163 2.49711360980479 0.602533826566028 0.761891223037211 0.570551319786853 0.263462197816187 NA NA NA 0.213969401150622 74.8741179957849 a755 EP300_mut 150 Bicalutamide ANDR (androgen receptor) 4 15 0.0237165266173161 NA 2.11749817501881 2.43335125349393 -0.315853078475115 0.535220577966653 0.474066988678587 0.650681403477015 0.590136275542817 0.666262545205948 0.263553733916584 NA NA NA 0.339072307960461 74.8741179957849 a756 gain_cnaBLCA15_(ASXL1) 1242 (5Z)-7-Oxozeaenol MAP3K7 (TAK1) 6 13 2.30258509299405 NA 0.157821793406308 0.723242840975258 -0.56542104756895 1.22668333986845 0.876423346824703 0.569775102171676 0.460934806230912 0.645146035437646 0.264288115874553 NA NA NA 0.341561340638129 74.9626995269968 a757 gain_cnaBLCA15_(ASXL1) 211 TL-2-105 CRAF 6 13 2.32630161961136 1.63315443905142 4.70164080472413 4.23101620759231 0.470624597131823 0.613916441760678 0.90129023366728 0.568938390411793 0.766593896364949 0.522167643176259 0.264964530244505 NA NA NA 0.204805141117127 74.9626995269968 a758 loss_cnaBLCA18_(CHD9,CNOT1,CYLD,MMP2,NUP93) 272 AR-42 HDAC 3 16 1.63315443905142 NA -0.794256138206488 0.216968807412765 -1.01122494561925 0.99696500511612 1.43970669226237 0.724927672494932 1.01430335110055 0.702382611023502 0.265173637388697 NA NA NA 0.214352435717535 74.9626995269968 a759 gain_cnaBLCA15_(ASXL1) 1129 PF-4708671 RPS6KB1 (p70S6KA) 6 13 2.30258509299405 NA 4.01972286889431 3.5284863548091 0.491236514085204 0.79374708494417 0.892111690574172 0.568334676961572 0.618882920520906 0.550644632589714 0.26545339114236 NA NA NA 0.253590102415164 74.9626995269968 a760 gain_cnaBLCA9 1043 JNK Inhibitor VIII JNK 3 11 2.30258509299405 NA 4.38144747079837 3.76927928345571 0.612168187342653 0.766248350813777 0.812403907050433 0.760556450462687 0.79891615648179 0.753526887340105 0.265612991054768 NA NA NA 0.304458986913164 74.9626995269968 a761 MLL2_mut 165 DMOG Prolyl-4-Hydroxylase 3 16 8.29404964010203 NA 6.32521578183491 5.63090828239743 0.694307499437484 1.00706173323293 0.954661261901592 0.72250368371067 0.689438866084778 0.727281526071867 0.266716620642574 NA NA NA 0.357324423239191 75.0710433757948 a762 ARID1A_mut 333 T0901317 LXR 5 14 2.32630161961136 NA 4.74746653042667 4.37029257641748 0.377173954009194 0.706842990386663 0.605695348166259 0.597782407739202 0.533603585433973 0.622712317588516 0.267107788725791 NA NA NA 0.327585235549463 75.0710433757948 a763 loss_cnaBLCA18_(CHD9,CNOT1,CYLD,MMP2,NUP93) 1033 Vismodegib SMO 3 11 2.30258509299405 NA 4.0485187925839 4.62684769790693 -0.578328905323031 0.883010524483952 0.736652134456467 0.757969777145116 0.654951316306243 0.785077349636333 0.267158306404057 NA NA NA 0.379402896349372 75.0710433757948 a764 TP53_mut 1498 AZD6244 MAP2K1 (MEK1), MAP2K2 (MEK2) 15 4 1.38629436111989 NA 1.53428887647724 0.756166126049663 0.778122750427582 1.05460661727331 1.74639972321002 0.645274098933457 0.737832228323602 0.445558219052697 0.267396866020786 NA NA NA 0.447734622259863 75.0710433757948 a765 gain_cnaBLCA15_(ASXL1) 190 Bleomycin DNA damage 6 13 4.15888308335967 NA 2.20048391423499 0.853206162771883 1.34727775146311 3.12382761696613 1.9955222434053 0.565256006483437 0.431290684590205 0.675150455433672 0.267956897481409 NA NA NA 0.364960424707278 75.097188896189 a766 gain_cnaBLCA15_(ASXL1) 1023 GW 441756 NTRK1 4 10 0.693147180559945 NA 2.88278791800773 2.26567578514699 0.617112132860743 0.393259168217918 1.01223780522873 0.686897193223392 1.5692250371612 0.60965133852247 0.26819022979536 NA NA NA 0.126447863897556 75.097188896189 a767 EP300_mut 265 Tubastatin A HDAC6 4 15 2.99573227355399 NA 5.30285946023132 4.71640912750093 0.586450332730387 0.314985243415772 0.995752707198263 0.642145246761463 1.86183430807992 0.588951783400595 0.269639735474581 NA NA NA 0.0695805757850155 75.1426509338874 a768 CDKN1A_mut 293 MP470 PDGFR 3 16 2.99573227355399 NA 4.82754101707663 3.81238835628826 1.01515266078837 0.169447540936472 1.50501524530715 0.717468082594757 5.99095540235053 0.674513207725805 0.269943518609902 NA NA NA 0.0185472489451047 75.1426509338874 a769 EP300_mut 1058 GDC0941 PI3K (class 1) 4 11 1.38629436111989 0.693147180559945 0.475392291328736 1.33444406944416 -0.859051778115424 1.22666810897912 1.2921987279222 0.672513539667538 0.700313126123706 0.664798501618045 0.270141088813428 NA NA NA 0.284582006726027 75.1426509338874 a770 gain_cnaBLCA9 1026 17-AAG HSP90 3 12 0 NA -2.55834804327107 -1.32584278013386 -1.2325052631372 0.382219105166758 1.79490582643349 0.74342893272421 3.2246040202503 0.686668484210235 0.270179636072978 NA NA NA 0.0474913899538719 75.1426509338874 a771 MLL2_mut 1062 AZD6244 MAP2K1 (MEK1), MAP2K2 (MEK2) 3 11 1.38629436111989 0.693147180559945 1.1172697729201 2.2996578674013 -1.1823880944812 1.14078810791627 1.64341344145419 0.752705465779184 1.03646600650573 0.719470867559024 0.270324814248135 NA NA NA 0.21561722278312 75.1426509338874 a772 MLL2_mut 1192 GSK269962A ROCK1, ROCK2 3 16 1.6094379124341 NA 1.25353815418762 1.9297299108328 -0.676191756645175 0.715502137364617 0.97047360482734 0.716260860604839 0.945059031040449 0.696764706718096 0.270721447905893 NA NA NA 0.239214274158959 75.1426509338874 a773 TP53_mut 303 PIK-93 PI4K, PI3K 15 4 2.99573227355399 NA 3.12335182628093 4.14893871257323 -1.0255868862923 1.33471054741916 2.49479253158919 0.640313149424879 0.768396479877539 0.41109105198379 0.270959561514335 NA NA NA 0.478690268402902 75.1426509338874 a774 loss_cnaBLCA5_(FAT1,IRF2) 186 Bexarotene Retinioic acid X family agonist 5 14 2.07944154167984 NA 3.9718619642186 3.3892782479822 0.582583716236403 0.879532503076201 1.0129118166921 0.59256385168663 0.662378836710176 0.575157389454656 0.271155223701679 NA NA NA 0.256655950379545 75.1426509338874 a775 gain_cnaBLCA9 203 BMS-345541 IKBKB 4 15 2.77258872223978 NA 3.90133502371512 3.40631796520571 0.495017058509414 1.11442416664111 0.680683753989795 0.638674648756018 0.444190886492889 0.727235012746955 0.272144004538982 NA NA NA 0.449242524741106 75.2517690104188 a776 gain_cnaBLCA15_(ASXL1) 292 Masitinib KIT 6 13 2.99573227355399 NA 4.61567184496576 4.11427029572461 0.501401549241159 1.20166851743736 0.731880446538297 0.559600927718841 0.417254460747986 0.685086685417987 0.272601478910295 NA NA NA 0.37740814587803 75.2517690104188 a777 loss_cnaBLCA5_(FAT1,IRF2) 294 MPS-1-IN-1 MPS1 5 14 2.99573227355399 NA 3.86929021780296 4.55015543831827 -0.680865220515305 1.37983808346723 1.07386841278931 0.590419930708913 0.493438490119393 0.634030401124101 0.272831230292853 NA NA NA 0.356766992049652 75.2517690104188 a778 RB1_mut 303 PIK-93 PI4K, PI3K 6 13 2.99573227355399 NA 3.95205212225227 3.0564399623841 0.895612159868174 1.37451854494684 1.6880570637245 0.558981409254433 0.651582449113345 0.530557988301717 0.273113925240092 NA NA NA 0.243953652807186 75.2517690104188 a779 MLL2_mut 179 5-Fluorouracil DNA antimetabolite 3 16 3.46573590279973 NA 4.9716802115934 4.13373145780751 0.83794875378589 0.771599621664555 1.22036678158426 0.712245143713095 1.08598906772168 0.68663680987619 0.273321210413481 NA NA NA 0.192384015747073 75.2517690104188 a780 loss_cnaBLCA5_(FAT1,IRF2) 256 JW-7-24-1 LCK 5 14 2.32630161961136 NA 1.64390128238204 2.3472567403818 -0.703355457999767 0.915676598494552 1.2685036064569 0.588633528180065 0.768126497014493 0.55447651423265 0.274233637308926 NA NA NA 0.215491677440092 75.2517690104188 a781 MLL2_mut 1219 PFI-1 BRD2, BRD3, BRD4 3 16 2.30258509299405 NA 1.77116431678026 2.40462960877631 -0.633465291996056 0.76325841436858 0.907235604468169 0.710557362113657 0.829948651820762 0.69823680736979 0.274419412609037 NA NA NA 0.286744199807956 75.2517690104188 a782 gain_cnaBLCA15_(ASXL1) 1373 Dabrafenib BRAF 5 12 2.30258509299405 NA 3.00904265339818 3.78374790805118 -0.774705254652993 1.80615884203172 1.02940219984641 0.603653846149128 0.428924210110744 0.752577811441033 0.274565652214695 NA NA NA 0.408380304049833 75.2517690104188 a783 EP300_mut 154 CHIR-99021 GSK3B 4 15 0.940007258491471 NA 3.10642760857292 2.62489114941673 0.481536459156195 0.442953993771232 0.810084191864535 0.635001130876944 1.08710264706382 0.594427670595402 0.274813555209329 NA NA NA 0.147763062070404 75.2517690104188 a784 MLL2_mut 306 TG101348 JAK2 3 16 2.32630161961136 NA 3.55243071323477 2.89409508218783 0.658335631046932 0.933162689409997 0.927221878149536 0.709472438278673 0.70548859112999 0.710008733142468 0.275127081295719 NA NA NA 0.348724651409102 75.2517690104188 a785 gain_cnaBLCA15_(ASXL1) 1262 UNC1215 LMBL3 6 12 0 NA 2.22705864269327 2.4468934662158 -0.219834823522532 0.543632360362724 0.29348163157897 0.564662893308763 0.404381415734437 0.749058202858529 0.275408203828897 NA NA NA 0.387823208415837 75.2517690104188 a786 loss_cnaBLCA5_(FAT1,IRF2) 304 SB52334 ALK5 5 14 2.99573227355399 NA 4.31182433498716 4.89622470446664 -0.584400369479486 1.14587850935421 0.947344348881111 0.585795061917738 0.510002033120284 0.616882731363426 0.276472991332902 NA NA NA 0.345531380695034 75.3816481151059 a787 TP53_mut 1038 NU-7441 PRKDC (DNAPK) 11 4 0.693147180559945 NA 2.00961580835671 2.72232523488279 -0.712709426526083 0.971607180077998 1.36508821952268 0.66282057620351 0.73353659909025 0.522097704993228 0.276784143127103 NA NA NA 0.389614732092052 75.3816481151059 a788 NRAS_mut 1241 CHIR-99021 GSK3B 3 16 2.30258509299405 NA 3.09366037980987 3.71182722971864 -0.618166849908777 0.836071167521846 0.879795546314603 0.706666234918482 0.739371089354812 0.702625573064368 0.276963793600483 NA NA NA 0.330714790308461 75.3816481151059 a789 ARID1A_mut 231 FMK RSK 3 11 2.99573227355399 2.32630161961136 5.50581917618137 5.19513935402272 0.310679822158657 0.705434435576769 0.334231275588511 0.740487191298235 0.440409209545665 0.929535458977068 0.277785954297728 NA NA NA 0.528555978969132 75.3816481151059 a790 loss_cnaBLCA18_(CHD9,CNOT1,CYLD,MMP2,NUP93) 140 Vinorelbine Microtubules 3 16 -2.74887219562247 NA -4.75163342047169 -3.84618464246436 -0.905448778007329 0.936053990271337 1.32391992589372 0.70496815803693 0.967304009616863 0.683915061853988 0.278079631160071 NA NA NA 0.231524762319199 75.3816481151059 a791 loss_cnaBLCA18_(CHD9,CNOT1,CYLD,MMP2,NUP93) 305 TPCA-1 IKK 3 16 2.99573227355399 NA 2.65522232817412 3.73083960481754 -1.07561727664342 0.382913393763104 1.61872982111986 0.70477117502965 2.80903539589653 0.664482276541554 0.278209287959622 NA NA NA 0.0338474723372158 75.3816481151059 a792 loss_cnaBLCA18_(CHD9,CNOT1,CYLD,MMP2,NUP93) 223 ZSTK474 PI3K 3 16 1.63315443905142 2.32630161961136 0.830281859355406 1.86872816191018 -1.03844630255477 0.761304351032371 1.5445944239554 0.704411236851671 1.36403568578924 0.672310016434941 0.278446319835042 NA NA NA 0.127818164470231 75.3816481151059 a793 TP53_mut 1218 JQ1 BRD2, BRD3, BRD4 15 4 0 NA 1.88114351676342 2.32304027494859 -0.441896758185168 0.689893949808797 0.75779615850553 0.629165405709991 0.640528530954126 0.583134070060007 0.279094375772613 NA NA NA 0.345387606051972 75.3816481151059 a794 gain_cnaBLCA23_(MYC) 1046 681640 WEE1, CHEK1 3 12 0.693147180559945 NA 1.11386929135957 1.76886260256892 -0.654993311209354 0.684661322336011 0.932294345433477 0.728864031010878 0.956667610453835 0.702560639156092 0.279239880667408 NA NA NA 0.240651191650077 75.3816481151059 a795 gain_cnaBLCA15_(ASXL1) 230 GSK429286A ROCK2 6 13 2.99573227355399 2.32630161961136 4.17035831536326 5.08790481660219 -0.917546501238929 2.73941137888889 0.891716993558391 0.551453787255315 0.334942940045422 1.02896603728215 0.279397978427925 NA NA NA 0.456308665471939 75.3816481151059 a796 CDKN1A_mut 159 HG-6-64-1 BRAFV600E, TAK, MAP4K5 3 16 1.63315443905142 NA -0.337321661875801 0.451971903688298 -0.789293565564099 0.224167455443144 1.19591665342059 0.70097347600162 3.52099979902876 0.659990446078782 0.28071775571273 NA NA NA 0.0270548511148442 75.6425764789587 a797 CDKN1A_mut 223 ZSTK474 PI3K 3 16 1.63315443905142 2.32630161961136 0.835756157958648 1.86770173092207 -1.03194557296342 0.756560948890256 1.54563860672105 0.699679694896828 1.3639952927482 0.667649972300197 0.281576140562784 NA NA NA 0.128260430565203 75.7098245136876 a798 loss_cnaBLCA5_(FAT1,IRF2) 197 Bryostatin 1 PRKC 5 14 -4.8283137373023 NA -3.44805979363126 -2.97419007019745 -0.473869723433809 0.897724693092502 0.792453152323768 0.578989981112033 0.527856398604134 0.597978217443197 0.281897004536182 NA NA NA 0.334412271275264 75.7098245136876 a799 loss_cnaBLCA18_(CHD9,CNOT1,CYLD,MMP2,NUP93) 204 Tipifarnib Farnesyl-transferase (FNTA) 3 16 2.77258872223978 NA 0.549427611083253 1.42873582564625 -0.879308214562994 0.482905663336236 1.32757672117999 0.698976949488234 1.82086954310733 0.662340790204154 0.282043203877714 NA NA NA 0.0723638660934127 75.7098245136876 a800 EP300_mut 203 BMS-345541 IKBKB 4 15 2.77258872223978 NA 3.89338642649671 3.40843759113062 0.484948835366093 0.921368959316982 0.741467850663917 0.624732273316705 0.526335113053504 0.654038924185136 0.28237921650157 NA NA NA 0.384813143226113 75.7098245136876 a801 ARID1A_mut 298 OSI-930 KIT, VEGFR, PDGFR 5 14 2.32630161961136 NA 4.64883545642181 4.21170762033534 0.437127836086471 0.445341072208269 0.828920558509939 0.577925286438382 0.981557425006699 0.527345873616946 0.282752696473223 NA NA NA 0.16500298327486 75.7153155826416 a802 loss_cnaBLCA18_(CHD9,CNOT1,CYLD,MMP2,NUP93) 134 Etoposide TOP2 3 16 2.77258872223978 NA 0.292769639955257 1.3224321245592 -1.02966248460394 1.24855252783269 1.50630654634917 0.696509954648315 0.824684954497897 0.683567688860895 0.283687368217887 NA NA NA 0.289602541679019 75.7853114481752 a803 TP53_mut 294 MPS-1-IN-1 MPS1 15 4 2.99573227355399 NA 4.21950283488408 4.93902117555232 -0.719518340668242 1.1832625627225 1.01305413991467 0.622932750590604 0.608080035096135 0.710246681118985 0.283720742259001 NA NA NA 0.274096869032571 75.7853114481752 a804 loss_cnaBLCA18_(CHD9,CNOT1,CYLD,MMP2,NUP93) 309 Y-39983 ROCK 3 16 2.99573227355399 NA 3.47519561345223 4.52258949554962 -1.04739388209738 0.886734171262459 1.57186996792849 0.694781750982464 1.18118136871413 0.666336213215974 0.284843361566993 NA NA NA 0.167618548467057 75.9857405336833 a805 loss_cnaBLCA5_(FAT1,IRF2) 165 DMOG Prolyl-4-Hydroxylase 5 14 8.29404964010203 NA 5.33237822909018 5.88630633702947 -0.553928107939294 0.583873503779253 1.05330172787964 0.57482566151091 0.948712528234059 0.525896894761945 0.285254776935494 NA NA NA 0.172405199852762 75.9857405336833 a806 EP300_mut 333 T0901317 LXR 4 15 2.32630161961136 NA 4.15960594285341 4.55220033003763 -0.392594387184223 0.288369033019527 0.684298187517267 0.620510561558182 1.36143046662586 0.573718291741518 0.28553387846466 NA NA NA 0.109483561039317 75.9857405336833 a807 loss_cnaBLCA5_(FAT1,IRF2) 331 QL-X-138 MNK2, PRKDC (DNAPK), MTOR, BTK, JAK3 5 14 2.32630161961136 NA 1.48197774646333 2.26954201405831 -0.787564267594988 1.13497344832238 1.43872147885692 0.573479350916376 0.693905455461623 0.547405650898268 0.286346616190677 NA NA NA 0.247472810160099 76.1075984731041 a808 ARID1A_mut 1050 ZM-447439 AURKB 5 10 1.38629436111989 0.693147180559945 2.72042282227824 1.94906421697345 0.771358605304786 1.42901514773438 1.19362821036856 0.607030757537035 0.539783365157277 0.64623020686367 0.287823934793049 NA NA NA 0.333705114643381 76.3508152067305 a809 TP53_mut 185 OSI-906 IGF1R 15 4 0.940007258491471 NA 2.11542033835736 2.86828296251469 -0.752862624157332 1.22879476448473 1.17613322911985 0.617269104325954 0.61268378244843 0.64011678738193 0.287973617761933 NA NA NA 0.311883132919463 76.3508152067305 a810 CDKN1A_mut 1199 Tamoxifen ER 3 16 1.6094379124341 NA 3.86366476140671 3.46779439347507 0.395870367931635 0.526978509757232 0.580377374516202 0.689245886326999 0.751207801839973 0.682091317328883 0.288569666107179 NA NA NA 0.325157498735246 76.4143909044207 a811 EP300_mut 1059 AZD8055 MTORC1/2 4 11 0.693147180559945 NA -0.101509537790048 0.359367003704246 -0.460876541494294 0.531801939121764 0.760387514478922 0.645340102665614 0.866631931157306 0.606107455367837 0.289077829958313 NA NA NA 0.226491618267441 76.4545663520361 a812 gain_cnaBLCA9 1047 Nutlin-3a MDM2 3 12 2.07944154167984 1.38629436111989 4.38586628886674 3.56675184733429 0.819114441532457 0.25602807930238 1.24538971182359 0.712282715384461 3.19931487110462 0.657717366504537 0.289833594182833 NA NA NA 0.0550978445798675 76.5600469136909 a813 loss_cnaBLCA5_(FAT1,IRF2) 291 KIN001-266 MAP3K8 (COT) 5 14 2.99573227355399 NA 3.18325799457261 3.82410295402599 -0.640844959453376 0.494247340442886 1.26090229767569 0.567928556903513 1.29660780547474 0.508243153045793 0.290880723054465 NA NA NA 0.130661505614446 76.7421378005176 a814 loss_cnaBLCA5_(FAT1,IRF2) 221 TAK-715 p38a 5 14 2.99573227355399 2.32630161961136 4.92113668136319 4.48484033849731 0.436296342865883 0.943176666329452 0.707844291441175 0.566826883886918 0.462581781803203 0.616373329758132 0.291786841740281 NA NA NA 0.38354095453422 76.8178072777438 a815 gain_cnaBLCA9 228 KIN001-102 AKT1 4 15 2.32630161961136 NA 3.96234177558781 3.18392667817465 0.778415097413157 1.58938081901158 1.19264028045284 0.61211581840166 0.489759966964524 0.6526822128778 0.291883817308562 NA NA NA 0.413348130397508 76.8178072777438 a816 ARID1A_mut 1059 AZD8055 MTORC1/2 5 10 0.693147180559945 NA 0.522456990803812 0.093471393556745 0.428985597247067 1.02490330205168 0.520497282143692 0.600249115068552 0.41856202081534 0.824184125381539 0.293009926494644 NA NA NA 0.418256484345574 76.8920311785829 a817 gain_cnaBLCA23_(MYC) 1527 GDC0941 (rescreen) PI3K 4 15 1.38629436111989 NA 0.292172212592745 0.992007815047193 -0.699835602454448 0.664882754437338 1.22593938363856 0.610119316855914 1.05256994227003 0.570856611505009 0.293409127278602 NA NA NA 0.160717135369693 76.8920311785829 a818 RB1_mut 1047 Nutlin-3a MDM2 5 10 2.07944154167984 1.38629436111989 4.19037177357296 3.50067621667469 0.689695556898277 0.861333995909937 1.2582679045029 0.599313132277699 0.800729519760408 0.548130930170035 0.293731160410721 NA NA NA 0.23809737161926 76.8920311785829 a819 gain_cnaBLCA9 253 XMD14-99 EPHB3, CAMK1 4 15 2.32630161961136 NA 4.94819550076455 4.66332110248109 0.284874398283465 0.581108157737348 0.439398387751644 0.609308049564012 0.490226121403417 0.648328273895446 0.294030591627758 NA NA NA 0.413182656073327 76.8920311785829 a820 NRAS_mut 171 AKT inhibitor VIII AKT1, AKT2, AKT3 3 16 0.940007258491471 NA 2.63153314076856 1.91640934664662 0.71512379412194 1.0950647109451 1.04395441442357 0.681007682731546 0.65304249783079 0.68501438783302 0.294181080012137 NA NA NA 0.379418287706713 76.8920311785829 a821 TP53_mut 157 JNK-9L JNK 15 4 1.63315443905142 NA -0.545016755021133 0.0478045391883683 -0.592821294209501 1.02994784896403 0.64835726194786 0.608934904201671 0.575583797573621 0.914343571056007 0.294316759283716 NA NA NA 0.196770114654886 76.8920311785829 a822 NRAS_mut 1129 PF-4708671 RPS6KB1 (p70S6KA) 3 16 2.30258509299405 NA 3.18775643750091 3.77658690708634 -0.588830469585433 0.337642949986269 0.916051416853074 0.678189482188844 1.74394421565556 0.642791942408923 0.296118882309688 NA NA NA 0.0817940114526919 77.2632894277237 a823 gain_cnaBLCA9 331 QL-X-138 MNK2, PRKDC (DNAPK), MTOR, BTK, JAK3 4 15 2.32630161961136 NA 2.72040089473885 1.88679155667851 0.833609338060341 1.8990229495562 1.23443080031186 0.606150915036628 0.438967490232361 0.675298556913633 0.296458243790391 NA NA NA 0.455525468014126 77.2632894277237 a824 ARID1A_mut 1033 Vismodegib SMO 3 11 2.30258509299405 NA 4.93137013865705 4.3860700580688 0.545300080588253 0.917246973096839 0.7342188674033 0.710248477645904 0.594496462329216 0.742694181255252 0.29692989844516 NA NA NA 0.418072872268101 77.292297301287 a825 gain_cnaBLCA23_(MYC) 1067 CCT007093 PPM1D 3 15 1.88706964903238 NA 3.50851982015043 3.85423408311419 -0.345714262963754 0.331243543525167 0.52869144094498 0.680241307270411 1.04368604225334 0.653905541473919 0.298077838478337 NA NA NA 0.208937253076554 77.4873522376858 a826 MLL2_mut 1527 GDC0941 (rescreen) PI3K 3 16 1.38629436111989 NA 1.49671122923538 0.722417024273296 0.774294204962085 0.895447624543604 1.17744280283667 0.674549712869589 0.864700719214852 0.657606639657289 0.2986353541832 NA NA NA 0.27299731708443 77.4873522376858 a827 loss_cnaBLCA5_(FAT1,IRF2) 206 Ruxolitinib JAK1, JAK2, TYK2 5 14 1.65632149833295 0.0237165266173161 3.93638541875525 4.19767139391476 -0.261285975159515 0.652225864073266 0.395188991275605 0.557670724890252 0.400606583626933 0.661167140097013 0.299397769950967 NA NA NA 0.437407734443724 77.4873522376858 a828 gain_cnaBLCA15_(ASXL1) 330 XMD13-2 RIPK 6 13 2.32630161961136 NA 4.12197399880827 3.62857141672781 0.493402582080458 0.871538634310179 0.958917566189609 0.5282305212674 0.566128181421338 0.514541186309749 0.299458185549492 NA NA NA 0.290913778281776 77.4873522376858 a829 EP300_mut 1057 NVP-BEZ235 PI3K (Class 1) and MTORC1/2 4 11 -1.38629436111989 0.693147180559945 -3.09429612022569 -2.31231259501513 -0.781983525210562 0.491314582883904 1.38820840320955 0.630527855147515 1.59161472598777 0.563304128834408 0.299813416100022 NA NA NA 0.131212284878711 77.4873522376858 a830 NRAS_mut 1194 SB-505124 TGFR1 (ALK5) 3 16 2.30258509299405 NA 4.65693402011397 3.97387319071371 0.68306082940026 0.329425896005103 1.07409367518511 0.672805465145094 2.07348856809265 0.635941580498128 0.29984679831832 NA NA NA 0.0606246143835672 77.4873522376858 a831 gain_cnaBLCA15_(ASXL1) 200 LAQ824 HDAC 6 13 0.0237165266173161 NA -2.39766375559708 -2.92364115595529 0.525977400358216 1.39582609680375 0.77312184355393 0.527308813181825 0.376821583693435 0.68032924531064 0.300275473720693 NA NA NA 0.418557881775994 77.5016664648214 a832 TP53_mut 306 TG101348 JAK2 15 4 2.32630161961136 NA 2.88047080980808 3.43893782689712 -0.55846701708904 0.94572491478689 0.861427383052886 0.599597336402434 0.590517399253339 0.648304230949614 0.301544147821168 NA NA NA 0.309360729597801 77.5016664648214 a833 CDKN1A_mut 288 KIN001-055 JAK3, MNK1 3 16 2.32630161961136 NA 4.59088640567277 4.04360701162649 0.547279394046273 0.427337714038148 0.855768328960084 0.669775688233866 1.28067188096911 0.639518168090327 0.30195957364057 NA NA NA 0.147307423494488 77.5016664648214 a834 gain_cnaBLCA15_(ASXL1) 1268 XAV 939 TNKS1 (tankyrase-1) 6 12 1.6094379124341 NA 2.94088841021796 3.33815527669781 -0.397266866479849 0.709865192742335 0.76075920302583 0.533080767189341 0.559637055798069 0.522197910849802 0.302175211182915 NA NA NA 0.298412369915538 77.5016664648214 a835 RB1_mut 1001 AICAR AAPK1 (AMPK) agonist 5 9 7.60090245954208 NA 7.72583587871082 8.10554866767021 -0.379712788959398 0.491746400399414 0.691435077741324 0.6008847289371 0.772171974519755 0.549166221360632 0.302530539011343 NA NA NA 0.25839291308582 77.5016664648214 a836 gain_cnaBLCA9 136 Mitomycin C DNA crosslinker 4 15 2.77258872223978 NA -1.96440530663494 -1.0173621910927 -0.947043115542242 1.87514057677149 1.51645689034016 0.597254580035341 0.505051795728728 0.624510410796978 0.303377527053117 NA NA NA 0.402726543307724 77.5016664648214 a837 gain_cnaBLCA15_(ASXL1) 1012 Vorinostat HDAC inhibitor Class I, IIa, IIb, IV 4 10 2.30258509299405 NA 1.75322635934889 1.40556957090772 0.347656788441167 0.436491197716279 0.580573307972261 0.634276973383163 0.796480639839031 0.598816348714704 0.304752964489651 NA NA NA 0.259806150286895 77.5016664648214 a838 gain_cnaBLCA9 184 BMS-754807 IGF1R 4 15 0.940007258491471 NA 0.110899180681217 1.11221855081854 -1.00131937013732 1.2945675206559 1.75698040167235 0.594386525708343 0.773477902203195 0.569909242689463 0.30563296768497 NA NA NA 0.249751744687466 77.5016664648214 a839 gain_cnaBLCA15_(ASXL1) 286 KIN001-236 TIE2 6 13 2.32630161961136 NA 4.62099658151756 4.19498687029988 0.426009711217684 0.811379936254722 0.820028018067572 0.521116645864713 0.525043437953516 0.519506287384659 0.30580815743321 NA NA NA 0.314199910304618 77.5016664648214 a840 RB1_mut 255 CP724714 ERBB2 6 13 2.32630161961136 NA 4.62270832454593 4.13708552729752 0.485622797248411 0.534428803421088 1.05499295658431 0.52074453889864 0.908676317855155 0.46030904208184 0.306142966932876 NA NA NA 0.201257440183342 77.5016664648214 a841 gain_cnaBLCA15_(ASXL1) 249 XL-184 VEGFR, MET, RET, KIT, FLT1, FLT3, FLT4, Tie2,AXL 6 13 1.63315443905142 NA 3.40822286733238 2.91091958564876 0.497303281683612 0.933983875010436 0.965364428076622 0.520060201077671 0.532453819588753 0.515145645747929 0.306759402669269 NA NA NA 0.310600556626218 77.5016664648214 a842 CDKN1A_mut 1067 CCT007093 PPM1D 3 15 1.88706964903238 NA 4.07967186006267 3.74000367513174 0.339668184930934 0.319093915227742 0.530455825708144 0.667508671874988 1.06447716086503 0.640332650654721 0.306908552634163 NA NA NA 0.203699571235625 77.5016664648214 a843 gain_cnaBLCA9 279 BIX02189 MAP2K5 (MEK5) 4 15 2.99573227355399 NA 5.19044540527126 4.55514421276528 0.635301192505979 0.886755452454879 1.10791373287366 0.592518023945024 0.716433364742469 0.573421173197447 0.307108865922651 NA NA NA 0.275391990817488 77.5016664648214 a844 gain_cnaBLCA15_(ASXL1) 1526 RDEA119 (rescreen) MAP2K1 (MEK1), MAP2K2 (MEK2) 6 13 1.6094379124341 NA 1.10294645645233 1.5953506900478 -0.492404233595464 1.27953597973667 0.768722948466333 0.519425422398536 0.384830314577635 0.640548372567584 0.307331997513259 NA NA NA 0.412869091928286 77.5016664648214 a845 gain_cnaBLCA23_(MYC) 1013 Nilotinib ABL 4 10 0.693147180559945 NA 2.64652694472864 3.01939949359684 -0.372872548868207 0.428355655494629 0.636515077766945 0.630507726370401 0.870474205453516 0.585803167736949 0.307509521437051 NA NA NA 0.238427691812446 77.5016664648214 a846 MLL2_mut 1133 JNJ-26854165 MDM2 3 16 2.30258509299405 NA 1.62874862227126 2.44547115723754 -0.816722534966283 1.62522015190828 1.17280037602976 0.661495375433265 0.502530401193534 0.69638665851311 0.307788761325284 NA NA NA 0.480402325098326 77.5016664648214 a847 EP300_mut 1043 JNK Inhibitor VIII JNK 4 10 2.30258509299405 NA 3.5350907465983 4.04660515440147 -0.511514407803168 1.17585541386369 0.646541438722081 0.630026576884452 0.435014715051068 0.791154869847476 0.307862736673603 NA NA NA 0.460225055330913 77.5016664648214 a848 gain_cnaBLCA15_(ASXL1) 167 OSU-03012 PDPK1 (PDK1) 6 13 2.77258872223978 NA 2.53444546769939 1.57053971730777 0.963905750391619 2.44676159684824 1.54817801465285 0.5187483477632 0.393951642707348 0.622606535726936 0.307943594682867 NA NA NA 0.405080110608213 77.5016664648214 a849 gain_cnaBLCA23_(MYC) 283 GSK2126458 PI3K, MTOR 4 15 -2.05572501506252 0.0237165266173161 -2.95346646206803 -2.02194562757664 -0.931520834491394 2.61976061289405 1.24211664354152 0.591310257137515 0.355574791798378 0.749946343070846 0.308065594344464 NA NA NA 0.534344278535337 77.5016664648214 a850 ARID1A_mut 1066 AZD6482 PI3Kbeta 4 14 1.6094379124341 NA 2.50551690418063 1.8679972579217 0.637519646258934 0.249675710964291 1.17908963952105 0.596759954120312 2.55339073150817 0.540688023107301 0.308168654873336 NA NA NA 0.0786447242463623 77.5016664648214 a851 ARID1A_mut 344 THZ-2-49 CDK9 5 14 2.99573227355399 NA 5.0279412185577 3.96977091524425 1.05817030331345 1.85090982846843 1.95963531145944 0.546970357847775 0.571702784780743 0.539983280116226 0.308474002366715 NA NA NA 0.313631220258865 77.5016664648214 a852 CDKN1A_mut 157 JNK-9L JNK 3 16 1.63315443905142 NA -0.962184069851744 -0.318592559938018 -0.643591509913727 0.0758920178623992 1.03807688240289 0.659788778110029 8.48035838341564 0.619984435472616 0.309000202950525 NA NA NA 0.026607519171429 77.5016664648214 a853 loss_cnaBLCA5_(FAT1,IRF2) 312 AV-951 VEGFR 5 14 -2.05572501506252 NA 0.258174090177205 0.463198413817328 -0.205024323640123 0.378776355086668 0.374268860329556 0.546244545631864 0.541280681559998 0.547799577714247 0.309096762730428 NA NA NA 0.331906088083555 77.5016664648214 a854 NRAS_mut 1061 SB590885 BRAF 3 12 1.6094379124341 NA 3.33156459957831 3.88323561532687 -0.551671015748567 1.40906934769838 0.641264259681411 0.682474179777298 0.391514453599947 0.860286547113423 0.309633739338246 NA NA NA 0.570705449965755 77.5016664648214 a855 MLL2_mut 287 KIN001-244 PDPK1 (PDK1) 3 16 2.99573227355399 NA 4.32643406282674 3.5640073912314 0.762426671595338 1.07612986031301 1.17124882185444 0.657002085522806 0.708489467408302 0.650951921888114 0.310985736976684 NA NA NA 0.34875137543356 77.5016664648214 a856 EP300_mut 1022 AZD7762 CHEK1, CHEK2 3 11 0.693147180559945 NA -0.320628754840948 0.304564044424395 -0.625192799265343 0.66453867781634 0.948913434824364 0.688746424467191 0.940792191840079 0.658851246405907 0.311137638518355 NA NA NA 0.253446110803763 77.5016664648214 a857 ARID1A_mut 1069 EHT 1864 Rac GTPases 4 14 2.30258509299405 NA 3.92933367506233 3.36227405215877 0.567059622903552 0.673496621813541 1.01151750267824 0.592369260004764 0.841963574184851 0.560602877757552 0.311626025421018 NA NA NA 0.228373190478231 77.5016664648214 a858 MLL2_mut 331 QL-X-138 MNK2, PRKDC (DNAPK), MTOR, BTK, JAK3 3 16 2.32630161961136 NA 2.82292651316865 1.91966858685169 0.903257926316956 0.662814221168608 1.44699616386927 0.655438152785464 1.36276183803724 0.624229662020417 0.312104059668057 NA NA NA 0.133427873227519 77.5016664648214 a859 EP300_mut 308 XL-880 MET 4 15 1.63315443905142 NA 1.31822808333661 0.47979508616553 0.83843299717108 1.18264173093668 1.47819089067959 0.586120385326129 0.708949274525446 0.567202113379022 0.312201188219145 NA NA NA 0.27995990241851 77.5016664648214 a860 MLL2_mut 1052 RO-3306 CDK1 3 12 1.6094379124341 NA 2.09971676513177 2.96713049273597 -0.867413727604196 0.678268292820042 1.35991411562037 0.67824157694523 1.27886521718086 0.637844491531362 0.312524579680957 NA NA NA 0.16301558802613 77.5016664648214 a861 loss_cnaBLCA18_(CHD9,CNOT1,CYLD,MMP2,NUP93) 1498 AZD6244 MAP2K1 (MEK1), MAP2K2 (MEK2) 3 16 1.38629436111989 NA 2.03880101590081 1.24516216272843 0.793638853172376 1.1874039571422 1.21713887902099 0.653911951217132 0.668381512794078 0.652052832139207 0.313198184382186 NA NA NA 0.371306149238936 77.5016664648214 a862 gain_cnaBLCA23_(MYC) 186 Bexarotene Retinioic acid X family agonist 4 15 2.07944154167984 NA 3.08611237306152 3.66431705337318 -0.578204680311655 0.67299882777035 1.04430727322153 0.584656544576246 0.859146638081453 0.553672941995298 0.313374842577511 NA NA NA 0.219480952987285 77.5016664648214 a863 RB1_mut 1039 SL 0101-1 RSK, AURKB, PIM3 5 10 2.30258509299405 NA 4.52244159651493 4.08049086361419 0.441950732900738 0.6478153909373 0.819046069705518 0.573646243595366 0.682217093146391 0.53959203181286 0.314030181412036 NA NA NA 0.281724602594714 77.5016664648214 a864 RB1_mut 199 Pazopanib VEGFR, PDGFRA, PDGFRB, KIT 6 13 2.07944154167984 NA 2.38789272855945 3.08447235997449 -0.696579631415033 1.41093796128866 1.33931193933528 0.511901140706528 0.493699688098845 0.520102607134793 0.314177976882421 NA NA NA 0.335057917855133 77.5016664648214 a865 loss_cnaBLCA5_(FAT1,IRF2) 302 PI-103 PI3Ka, PRKDC (DNAPK) 5 14 2.32630161961136 NA 1.30303499537468 2.53496241292035 -1.23192741754567 2.70304320737503 2.1368194060726 0.539675361617616 0.455755725318952 0.576523881262346 0.314774452848159 NA NA NA 0.39296890036259 77.5016664648214 a866 MLL2_mut 1059 AZD8055 MTORC1/2 3 12 0.693147180559945 NA -0.15086056983565 0.333298383257788 -0.484158953093439 0.640005318334704 0.730603446353261 0.674870319079797 0.756492077836512 0.662683642556127 0.314841318583302 NA NA NA 0.327963549768795 77.5016664648214 a867 gain_cnaBLCA15_(ASXL1) 245 UNC0638 G9a(EHMT2), GLP(EHMT1) 6 13 3.68887945411394 NA 4.41017204211275 3.81320112886459 0.59697091324816 1.71875204126583 0.83747985904434 0.511158077921542 0.34732811884168 0.712818232941592 0.314859943303456 NA NA NA 0.44949847767095 77.5016664648214 a868 CDKN1A_mut 1378 Bleomycin (50 uM) DNA damage 3 15 3.91202300542815 NA 1.71039681165183 0.682502619476114 1.02789419217571 0.568235952657014 1.66065829019907 0.656239076951727 1.80892143020762 0.618967910642529 0.314881686131582 NA NA NA 0.0850675573502068 77.5016664648214 a869 gain_cnaBLCA15_(ASXL1) 201 Epothilone B Microtubules 6 13 -3.44201937618241 NA -4.4094931998707 -5.6235844882833 1.2140912884126 3.46506900196471 1.74269132661999 0.509639962099002 0.350380118757867 0.69667603772802 0.31625653121373 NA NA NA 0.446755473700082 77.5016664648214 a870 RB1_mut 1241 CHIR-99021 GSK3B 6 13 2.30258509299405 NA 3.91995451541758 3.47311459403249 0.44683992138508 0.700219688946995 0.944404377950098 0.507974605150408 0.63814246933994 0.473144695024583 0.317793664820001 NA NA NA 0.269751888429006 77.5016664648214 a871 loss_cnaBLCA18_(CHD9,CNOT1,CYLD,MMP2,NUP93) 179 5-Fluorouracil DNA antimetabolite 3 16 3.46573590279973 NA 3.62095236534647 4.38699292897881 -0.766040563632335 0.530017371916673 1.24524981514004 0.64712962245921 1.44531218073503 0.615170188598812 0.31809367389027 NA NA NA 0.121260865794806 77.5016664648214 a872 gain_cnaBLCA15_(ASXL1) 1036 PLX4720 BRAF 4 11 2.30258509299405 NA 3.46128360676914 3.86294167388513 -0.401658067115998 0.515481440963568 0.701051547612622 0.605951718824502 0.779190161269814 0.572936567195115 0.318276569860646 NA NA NA 0.265377160940431 77.5016664648214 a873 loss_cnaBLCA5_(FAT1,IRF2) 154 CHIR-99021 GSK3B 5 14 0.940007258491471 NA 3.02702249531545 2.61885465706896 0.408167838246499 0.867597094591138 0.727666799181423 0.535018535961563 0.470457820561111 0.560926840012022 0.318844326372032 NA NA NA 0.382479006787411 77.5016664648214 a874 EP300_mut 1023 GW 441756 NTRK1 3 11 0.693147180559945 NA 1.95918537210213 2.57366849156313 -0.614483119461002 1.17808599760921 0.84308121154576 0.677083584706474 0.521594451260795 0.728854007236586 0.319052900480855 NA NA NA 0.468452469542679 77.5016664648214 a875 EP300_mut 164 JQ12 HDAC 4 15 1.63315443905142 NA 1.89829953739162 1.05380449798869 0.844495039402931 0.499160280757394 1.59440197718619 0.577625357926061 1.69183140557888 0.529662564075153 0.319056292760188 NA NA NA 0.0984600878936574 77.5016664648214 a876 NRAS_mut 1375 Temozolomide DNA akylating agent 3 15 3.40119738166216 NA 4.9362042711766 5.38490192823101 -0.448697657054416 0.815680749393861 0.670067637649165 0.65033174610061 0.550089796023564 0.669630395266674 0.319120201658966 NA NA NA 0.446900934058341 77.5016664648214 a877 NRAS_mut 287 KIN001-244 PDPK1 (PDK1) 3 16 2.99573227355399 NA 4.31586398080939 3.56598928160965 0.749874699199745 1.34670261209799 1.1347307343053 0.64551000944344 0.556822785122203 0.660839330890983 0.319270755464754 NA NA NA 0.441910983154806 77.5016664648214 a878 ARID1A_mut 151 QS11 ARFGAP 5 14 2.32630161961136 NA 3.69728740263585 2.82014368150468 0.87714372113117 0.803591370128981 1.8237666246349 0.534262981454871 1.09152954316867 0.480951734329914 0.3195081761631 NA NA NA 0.167051797395672 77.5016664648214 a879 NRAS_mut 180 Thapsigargin sarco-endoplasmic reticulum Ca2+-ATPases 3 16 -0.669430653942629 NA -3.45966881169912 -4.53218120438831 1.07251239268919 2.44425541298842 1.52872312665276 0.645001650745971 0.438789001750803 0.701573995964543 0.319640853839522 NA NA NA 0.530661307644134 77.5016664648214 a880 NRAS_mut 176 IPA-3 PAK1, PAK2, PAK3 3 16 3.46573590279973 NA 2.83621344223864 3.87502552963321 -1.03881208739457 1.56880779439316 1.6164123337354 0.644870493147266 0.662166577134072 0.642665281447068 0.319736389618386 NA NA NA 0.375242308647881 77.5016664648214 a881 gain_cnaBLCA15_(ASXL1) 135 Gemcitabine DNA replication 6 13 0.0237165266173161 NA -1.35957633631991 -2.80268862648246 1.44311229016255 3.62598645952611 2.46378662288334 0.505442143733405 0.397991637936549 0.585729412100504 0.32014135679141 NA NA NA 0.404598197781378 77.5016664648214 a882 gain_cnaBLCA23_(MYC) 167 OSU-03012 PDPK1 (PDK1) 4 15 2.77258872223978 NA 1.02852343668856 2.1006396922962 -1.07211625560764 0.934462780771562 2.00464248507469 0.576079805477929 1.1473076056838 0.534816688556662 0.320314951618781 NA NA NA 0.151793849533491 77.5016664648214 a883 NRAS_mut 326 GSK690693 AKT 3 16 2.32630161961136 NA 4.77225815083549 4.16657219411982 0.60568595671567 0.506206195228646 0.984345998595604 0.643803849954174 1.19652023705891 0.615318147866523 0.32051409335012 NA NA NA 0.168699760573599 77.5016664648214 a884 gain_cnaBLCA23_(MYC) 224 AS605240 PI3Kgamma 4 15 2.99573227355399 2.32630161961136 2.70276013731824 3.5093371709109 -0.806577033592667 0.575878959665996 1.52383044321412 0.574544504976943 1.4006016716785 0.529308911752285 0.32156876092668 NA NA NA 0.120118963241599 77.5016664648214 a885 gain_cnaBLCA23_(MYC) 153 Midostaurin KIT 4 15 -0.669430653942629 NA -0.852357913761188 -0.171087718045295 -0.681270195715894 1.0010398276472 1.22268923030765 0.574142648255594 0.680562527983647 0.55718998648943 0.32189751493446 NA NA NA 0.29585488967825 77.5016664648214 a886 gain_cnaBLCA23_(MYC) 1047 Nutlin-3a MDM2 3 12 2.07944154167984 1.38629436111989 4.34543155761117 3.57686053014818 0.768571027462994 0.37948542344604 1.24669111742078 0.664619038161369 2.02529789018966 0.616488733033611 0.321963506624635 NA NA NA 0.0936025808149181 77.5016664648214 a887 TP53_mut 1373 Dabrafenib BRAF 13 4 2.30258509299405 NA 3.7338250305166 2.97761569172231 0.756209338794287 1.07664579832675 1.92909715225205 0.584889416722331 0.702375228668088 0.39200168737561 0.322550693456899 NA NA NA 0.499912279481913 77.5016664648214 a888 NRAS_mut 268 YM155 BIRC5 (Survivin) 3 16 1.63315443905142 NA -4.98387026773005 -3.63243416519621 -1.35143610253384 1.24746777928467 2.20187374844768 0.639855728971533 1.08334349389673 0.61376639032397 0.323404442513854 NA NA NA 0.198564857349826 77.5016664648214 a889 gain_cnaBLCA15_(ASXL1) 1192 GSK269962A ROCK1, ROCK2 6 13 1.6094379124341 NA 1.4965266074809 1.97362564546171 -0.47709903798081 1.00549246263026 0.927216390665571 0.501730032884742 0.474492903440341 0.514549831931186 0.323604926117191 NA NA NA 0.350085547075368 77.5016664648214 a890 RB1_mut 152 CP466722 ATM 6 13 2.77258872223978 NA 3.50777730003573 2.894401915209 0.613375384826724 1.56225159292865 1.04968418436585 0.501555129477916 0.392622665646875 0.584342789919508 0.323768773335085 NA NA NA 0.409978899463787 77.5016664648214 a891 EP300_mut 1192 GSK269962A ROCK1, ROCK2 4 15 1.6094379124341 NA 1.39372080104052 1.93742732211503 -0.543706521074508 0.647997096416052 1.00402992383164 0.571758981009816 0.839057032942965 0.541524219716066 0.3238524793025 NA NA NA 0.229199265503612 77.5016664648214 a892 gain_cnaBLCA23_(MYC) 1498 AZD6244 MAP2K1 (MEK1), MAP2K2 (MEK2) 4 15 1.38629436111989 NA 0.822194363270419 1.51668134655171 -0.694486983281291 0.490400975239042 1.31984640800724 0.57143965912078 1.41616150527182 0.52618772841141 0.324115010287699 NA NA NA 0.11981806289293 77.5016664648214 a893 loss_cnaBLCA18_(CHD9,CNOT1,CYLD,MMP2,NUP93) 221 TAK-715 p38a 3 16 2.99573227355399 2.32630161961136 4.18381979016545 4.67762429845512 -0.493804508289666 1.04232636013071 0.729579255214369 0.638841329316775 0.47375229791535 0.676834634154412 0.324150048197525 NA NA NA 0.502852201049067 77.5016664648214 a894 ARID1A_mut 1129 PF-4708671 RPS6KB1 (p70S6KA) 5 14 2.30258509299405 NA 4.02323951297175 3.56231873293038 0.460920780041369 0.93981468492247 0.849229354249421 0.528948201755937 0.490437942113443 0.542751822855614 0.324205730932674 NA NA NA 0.369073596742924 77.5016664648214 a895 CDKN1A_mut 221 TAK-715 p38a 3 16 2.99573227355399 2.32630161961136 5.01517087382363 4.52174597026921 0.493424903554424 0.970060626174051 0.742791507048539 0.638320481364845 0.508653676111469 0.664284525162429 0.324533356545056 NA NA NA 0.476405320626517 77.5016664648214 a896 CDKN1A_mut 194 AUY922 HSP90 3 16 -1.36257783450257 NA -3.97997188176018 -2.57413226100029 -1.40583962075989 1.01626103424561 2.31652368740338 0.637934244510602 1.38334500033594 0.606874701262265 0.324817808000181 NA NA NA 0.132413612391997 77.5016664648214 a897 loss_cnaBLCA5_(FAT1,IRF2) 1527 GDC0941 (rescreen) PI3K 5 14 1.38629436111989 NA 0.396529930383711 1.00472545886859 -0.608195528484883 0.432181599288425 1.29507684040248 0.528061413749672 1.40726844800024 0.469621191199643 0.324994283743371 NA NA NA 0.143387023037794 77.5016664648214 a898 RB1_mut 134 Etoposide TOP2 6 13 2.77258872223978 NA 0.651525233387978 1.39446703942193 -0.742941806033949 1.03781432013249 1.63756236441485 0.499792534800439 0.715871607879822 0.453687640958592 0.325423237579605 NA NA NA 0.250335010272152 77.5016664648214 a899 CDKN1A_mut 1170 CCT018159 HSP90 3 16 2.30258509299405 NA 3.11924420285602 2.54378722533783 0.575456977518184 0.91229375507783 0.902259918602505 0.636957692514508 0.630780353713032 0.637795124945259 0.325537797073274 NA NA NA 0.394258614145558 77.5016664648214 a900 gain_cnaBLCA9 276 CAY10603 HDAC6 4 15 2.99573227355399 NA 1.783495669121 1.10811360166438 0.675382067456617 1.95988180140639 0.942359245110844 0.568940677006403 0.344603468929591 0.716692780338963 0.326174770156331 NA NA NA 0.546453568646068 77.5016664648214 a901 loss_cnaBLCA18_(CHD9,CNOT1,CYLD,MMP2,NUP93) 1046 681640 WEE1, CHEK1 3 12 0.693147180559945 NA 1.16093675957621 1.75709573551476 -0.596158975938555 0.825828490397095 0.920034721915469 0.657882036106278 0.721891994367856 0.64797443154904 0.326707749903876 NA NA NA 0.346470632361361 77.5016664648214 a902 EP300_mut 1039 SL 0101-1 RSK, AURKB, PIM3 4 11 2.30258509299405 NA 3.89200884308515 4.34991647694326 -0.457907633858111 0.896531808163113 0.730813795949985 0.592976101751383 0.510754475958092 0.626572235493826 0.328354843305364 NA NA NA 0.40529546005178 77.5016664648214 a903 TP53_mut 1001 AICAR AAPK1 (AMPK) agonist 10 4 7.60090245954208 NA 7.86064834625814 8.24315848500114 -0.382510138742993 0.646078737851142 0.600155449990053 0.602464131770315 0.592048795809659 0.637351770694297 0.328604210438725 NA NA NA 0.332627773243873 77.5016664648214 a904 gain_cnaBLCA9 1061 SB590885 BRAF 3 12 1.6094379124341 NA 4.19783840220941 3.6666671646691 0.531171237540314 0.849360683231099 0.803674478056066 0.655062820245088 0.625377708230685 0.660928338579464 0.328708071385865 NA NA NA 0.400413559115693 77.5016664648214 a905 gain_cnaBLCA15_(ASXL1) 253 XMD14-99 EPHB3, CAMK1 6 13 2.32630161961136 NA 4.88271195367695 4.64971744755483 0.232994506122123 0.411252395623702 0.491920086477564 0.496118436684777 0.566548690297028 0.473643001225058 0.328891185454204 NA NA NA 0.303254621131444 77.5016664648214 a906 gain_cnaBLCA9 164 JQ12 HDAC 4 15 1.63315443905142 NA 0.578468166249404 1.40575953029329 -0.827291364043882 1.34938063556994 1.4872186352966 0.56515238065108 0.613089696292003 0.556267481061314 0.329314889135095 NA NA NA 0.334027682346997 77.5016664648214 a907 TP53_mut 1242 (5Z)-7-Oxozeaenol MAP3K7 (TAK1) 15 4 2.30258509299405 NA 0.663815985689351 0.097961976943984 0.565854008745367 0.826057236857989 1.58001210116907 0.565147972592561 0.685005812548369 0.35813270564617 0.329318555373578 NA NA NA 0.53294126515065 77.5016664648214 a908 CDKN1A_mut 182 Obatoclax Mesylate BCL2, BCL2L1, MCL1 3 16 2.77258872223978 NA -1.57975295912231 -0.732006911098619 -0.847746048023689 0.671520198637962 1.40723788144077 0.631803891261776 1.26242821845592 0.602418439131089 0.329356310878111 NA NA NA 0.155714868481422 77.5016664648214 a909 loss_cnaBLCA18_(CHD9,CNOT1,CYLD,MMP2,NUP93) 211 TL-2-105 CRAF 3 16 2.32630161961136 1.63315443905142 3.93567172864094 4.46287752132012 -0.527205792679182 0.217795302767135 0.884856738201471 0.631740951074992 2.42064813143774 0.595809208336665 0.329403138818596 NA NA NA 0.0562647411665809 77.5016664648214 a910 gain_cnaBLCA15_(ASXL1) 1371 PLX4720 (rescreen) BRAF 6 12 2.30258509299405 NA 3.62368075261312 4.08102933309669 -0.457348580483566 1.24792756460682 0.703809654182588 0.502849547366759 0.366486480028719 0.649818566377489 0.329528558997569 NA NA NA 0.433334773214178 77.5016664648214 a911 NRAS_mut 1042 BIRB 0796 p38, JNK2 3 12 2.30258509299405 NA 3.50254282007878 4.10977704499949 -0.60723422492071 1.59176772427155 0.747522222736164 0.653800220305694 0.381484192487068 0.812329328080767 0.329606799662152 NA NA NA 0.580051187203699 77.5016664648214 a912 MLL2_mut 229 LY317615 PRKCB (PKCbeta) 3 16 2.99573227355399 2.32630161961136 4.67531893682963 3.6350710569268 1.04024787990283 0.225685200981346 1.75381821536826 0.630742633760831 4.60928707500325 0.593133239686647 0.330146522701931 NA NA NA 0.0363780413961712 77.5016664648214 a913 MLL2_mut 164 JQ12 HDAC 3 16 1.63315443905142 NA 2.00916250122565 1.0857986322325 0.923363868993156 0.547720638946817 1.54564586755215 0.630719248229331 1.68582997122154 0.597396783038984 0.330163950612526 NA NA NA 0.0954533943721801 77.5016664648214 a914 loss_cnaBLCA5_(FAT1,IRF2) 204 Tipifarnib Farnesyl-transferase (FNTA) 5 14 2.77258872223978 NA 0.802857632514174 1.46384056292992 -0.660982930415744 1.13710246851099 1.30310178398018 0.52210225677085 0.581287042038774 0.507238144051068 0.330328586750039 NA NA NA 0.31450042593295 77.5016664648214 a915 EP300_mut 1133 JNJ-26854165 MDM2 4 15 2.30258509299405 NA 1.76576136750131 2.46338259417395 -0.697621226672637 1.35498474685181 1.21169639445468 0.563421050329233 0.514855409474902 0.575739293989232 0.330757076850429 NA NA NA 0.398555154098741 77.5016664648214 a916 MLL2_mut 1047 Nutlin-3a MDM2 3 12 2.07944154167984 1.38629436111989 3.12686672793261 3.88150173756782 -0.754635009635204 1.23517590692373 1.14353007352087 0.65161383575149 0.610953472622911 0.659917064805931 0.33116729280614 NA NA NA 0.409395455880395 77.5016664648214 a917 ARID1A_mut 1016 Temsirolimus MTOR 3 11 -1.6094379124341 NA -1.92841619730229 -2.86204330592036 0.933627108618065 0.676678378299812 1.52120777558079 0.659398099355057 1.37972061552173 0.613740689210986 0.331337719624489 NA NA NA 0.158925748653016 77.5016664648214 a918 MLL2_mut 279 BIX02189 MAP2K5 (MEK5) 3 16 2.99573227355399 NA 5.25819923428764 4.58214669435633 0.676052539931305 0.398279386152225 1.13567242043675 0.628599686194369 1.69743291628182 0.595288331182078 0.331746236462052 NA NA NA 0.0948074879035135 77.5126921772593 a919 gain_cnaBLCA9 1262 UNC1215 LMBL3 4 14 0 NA 2.54664804914959 2.32417723243934 0.222470816710248 0.264936493162567 0.416383992786866 0.566855544237183 0.839713751981077 0.534292433340788 0.33227043908596 NA NA NA 0.235205490338391 77.5506945303716 a920 NRAS_mut 1004 Vinblastine Microtubules 3 11 -2.30258509299405 NA -3.66308854566637 -4.57533093491534 0.912242389248971 2.01936677695887 1.22367410041587 0.657079708167167 0.451746755298604 0.745494563412713 0.332973433676648 NA NA NA 0.521523451919251 77.6302982970169 a921 NRAS_mut 179 5-Fluorouracil DNA antimetabolite 3 16 3.46573590279973 NA 4.89136103737562 4.14879130297334 0.742569734402275 1.21696848784108 1.18177751416657 0.626127633918339 0.610179919875825 0.628349859005364 0.333598401971519 NA NA NA 0.407443685461452 77.6612441218688 a922 gain_cnaBLCA9 151 QS11 ARFGAP 4 15 2.32630161961136 NA 2.32528271487096 3.24448784631739 -0.919205131446428 0.899194037135773 1.76399190566027 0.558868904665587 1.0222544784376 0.521093735462671 0.334570216613524 NA NA NA 0.181311172198494 77.6612441218688 a923 gain_cnaBLCA23_(MYC) 245 UNC0638 G9a(EHMT2), GLP(EHMT1) 4 15 3.68887945411394 NA 4.51732352023378 3.86422352313207 0.653099997101709 1.57307254985136 1.06500785764617 0.557824651229652 0.415174746494318 0.613234909407295 0.335449283084834 NA NA NA 0.479494757450098 77.6612441218688 a924 loss_cnaBLCA5_(FAT1,IRF2) 147 NSC-87877 PTPN6 (SHP-1), PTPN11 (SHP-2) 5 14 2.77258872223978 NA 5.32572365138384 4.9711002282929 0.354623423090936 0.156459611099457 0.780429021569506 0.516437609897069 2.26654930687199 0.454395484137378 0.33545625847092 NA NA NA 0.127212199412091 77.6612441218688 a925 gain_cnaBLCA15_(ASXL1) 1054 PD-0332991 CDK4, CDK6 4 11 1.38629436111989 0.693147180559945 1.21789374481839 2.2138938962354 -0.996000151417016 1.69391266705144 1.71128714325356 0.583379625943044 0.587987899724922 0.582018134912991 0.335956104751643 NA NA NA 0.357975718206349 77.6612441218688 a926 TP53_mut 1494 SN-38 TOP1 14 4 -2.99573227355399 NA -5.10914924089502 -4.15568263726304 -0.953466603631983 1.49239309693389 2.38261613467344 0.56241769754049 0.638884356669077 0.40017633967826 0.335958169843393 NA NA NA 0.493352135338512 77.6612441218688 a927 ARID1A_mut 1242 (5Z)-7-Oxozeaenol MAP3K7 (TAK1) 5 14 2.30258509299405 NA 0.164067459536961 0.6806250282451 -0.51655756870814 1.40833294064389 0.838357383301056 0.515488779512938 0.366786541591485 0.616154374014313 0.336320582032505 NA NA NA 0.474272490516876 77.6612441218688 a928 gain_cnaBLCA9 192 LFM-A13 BTK 4 15 2.77258872223978 NA 4.67648840238508 4.31250543041281 0.363982971972262 0.593144037150834 0.666522395534511 0.556402864235403 0.613650225197665 0.546092636062692 0.336648766957522 NA NA NA 0.334963678190824 77.6612441218688 a929 gain_cnaBLCA23_(MYC) 1017 Olaparib PARP1, PARP2 4 10 1.6094379124341 NA 3.95740423331637 3.45979080117594 0.497613432140431 0.301859540271285 0.955194112324156 0.591778046879438 1.64849330815657 0.520955296646091 0.336915559398373 NA NA NA 0.166650108632033 77.6612441218688 a930 TP53_mut 1017 Olaparib PARP1, PARP2 10 4 1.6094379124341 NA 3.45994448834361 3.95702001539719 -0.497075527053584 0.860482312659018 0.779439989527607 0.591085107836035 0.577670824537401 0.637734185738719 0.337459735477976 NA NA NA 0.335009200799748 77.6612441218688 a931 gain_cnaBLCA23_(MYC) 200 LAQ824 HDAC 4 15 0.0237165266173161 NA -3.19687525517219 -2.64038776935417 -0.556487485818018 1.0575114325862 0.989843726450729 0.555311800435486 0.526223612029516 0.562197315543342 0.337571274856979 NA NA NA 0.391281462609077 77.6612441218688 a932 gain_cnaBLCA23_(MYC) 310 YM201636 FYV1 4 15 1.63315443905142 NA 2.27494333572305 2.93496914194374 -0.66002580622069 1.95990799362003 0.947882746829932 0.55431250333616 0.336763668687118 0.69631587707241 0.338417745219508 NA NA NA 0.555175300199802 77.6612441218688 a933 CDKN1A_mut 287 KIN001-244 PDPK1 (PDK1) 3 16 2.99573227355399 NA 3.07691345671883 3.79829250487663 -0.721379048157799 0.452821080003599 1.22847449263726 0.619551772648706 1.59307744275524 0.587215324763611 0.338560665847683 NA NA NA 0.107183005003882 77.6612441218688 a934 TP53_mut 1036 PLX4720 BRAF 11 4 2.30258509299405 NA 3.65304159951778 4.03850881127937 -0.385467211761591 0.646790927760827 0.722471247148657 0.579632089226715 0.595968797979385 0.53353986512667 0.338958645403473 NA NA NA 0.391856496742451 77.6612441218688 a935 loss_cnaBLCA18_(CHD9,CNOT1,CYLD,MMP2,NUP93) 170 Shikonin unknown 3 16 2.77258872223978 NA 0.568105141879959 -0.3395048873511 0.907610029231058 1.80711216829432 1.41711414017865 0.618101959458051 0.502243327865877 0.640463603811506 0.339661638300026 NA NA NA 0.481702706566529 77.6612441218688 a936 RB1_mut 256 JW-7-24-1 LCK 6 13 2.32630161961136 NA 2.56194206326531 1.97764987674335 0.584292186521956 1.45614801982423 1.08364443682512 0.484803044323576 0.401258785897662 0.539191792682315 0.339735322616708 NA NA NA 0.407026381150936 77.6612441218688 a937 EP300_mut 1170 CCT018159 HSP90 4 15 2.30258509299405 NA 2.23986046299038 2.73992575746746 -0.500065294477075 0.869310658142035 0.912432485777465 0.552575389370935 0.575243487231432 0.548057310838708 0.339892728137538 NA NA NA 0.358826471740634 77.6612441218688 a938 loss_cnaBLCA5_(FAT1,IRF2) 1230 IOX2 EGLN1 5 14 -2.30258509299405 NA 0.108628417432969 -0.243758670238174 0.352387087671143 0.251492100263249 0.77543224380757 0.511460675029577 1.40118551358982 0.454439559981195 0.340007306863947 NA NA NA 0.153390873301973 77.6612441218688 a939 gain_cnaBLCA9 272 AR-42 HDAC 4 15 1.63315443905142 NA 0.671603972952496 -0.106512225855014 0.77811619880751 2.08464673913751 1.2163560396213 0.552240683657568 0.37326045904998 0.639710885186025 0.340177442153479 NA NA NA 0.518759863289439 77.6612441218688 a940 loss_cnaBLCA5_(FAT1,IRF2) 271 VNLG/124 HDAC, RAR 5 14 1.63315443905142 NA 4.12393268459516 3.88060854893764 0.243324135657516 0.325560378348032 0.513604310938629 0.51109040877103 0.747400948764706 0.473757969851993 0.340347605545622 NA NA NA 0.248392444752448 77.6612441218688 a941 ARID1A_mut 204 Tipifarnib Farnesyl-transferase (FNTA) 5 14 2.77258872223978 NA 1.76654187305076 1.11966761988114 0.646874253169619 0.725424308266754 1.39256247779803 0.510321753720981 0.891718468485274 0.464520812159523 0.341054808706659 NA NA NA 0.211225324529942 77.739913215456 a942 loss_cnaBLCA18_(CHD9,CNOT1,CYLD,MMP2,NUP93) 269 NSC-207895 MDM4 3 16 2.99573227355399 NA 2.93403136560049 3.73014067800873 -0.796109312408237 0.931150691605 1.33615440526684 0.614710008628942 0.854973657417366 0.595821343154761 0.342247216967949 NA NA NA 0.280769559142263 77.8410954394532 a943 RB1_mut 1006 Cytarabine DNA synthesis 4 9 0.693147180559945 NA -0.227567583496787 0.3775698914364 -0.605137474933187 0.437988329180874 1.16044784754497 0.595770452205414 1.38162922300901 0.5214689106567 0.342787266822477 NA NA NA 0.200750292404826 77.8410954394532 a944 loss_cnaBLCA18_(CHD9,CNOT1,CYLD,MMP2,NUP93) 268 YM155 BIRC5 (Survivin) 3 16 1.63315443905142 NA -4.94005945954964 -3.64064869173004 -1.2994107678196 0.883534941992277 2.23044406678832 0.613815245623611 1.47069539195537 0.582579400742678 0.342931548772557 NA NA NA 0.123420315721879 77.8410954394532 a945 RB1_mut 1495 AZD-2281 PARP1, PARP2 6 11 2.30258509299405 NA 3.07876767622203 3.43266005024707 -0.353892374025033 0.506349072382802 0.795856439906585 0.496659161910195 0.69890988910016 0.444668606396616 0.343297178411119 NA NA NA 0.282083262243212 77.8410954394532 a946 CDKN1A_mut 294 MPS-1-IN-1 MPS1 3 16 2.99573227355399 NA 3.76986932141606 4.4836887038264 -0.713819382410338 0.770437646517474 1.20667147522903 0.613316699041488 0.926511555655333 0.591560666729819 0.34331326000497 NA NA NA 0.252532381998339 77.8410954394532 a947 loss_cnaBLCA5_(FAT1,IRF2) 172 Embelin XIAP 5 14 3.46573590279973 NA 2.44742112917739 2.82435869298476 -0.376937563807369 0.151141277348817 0.847930910667348 0.505881981459332 2.49394189608071 0.444538062081859 0.345159696338985 NA NA NA 0.131763235894987 77.9670752714886 a948 loss_cnaBLCA5_(FAT1,IRF2) 1373 Dabrafenib BRAF 4 13 2.30258509299405 NA 4.10854940792395 3.38584542553148 0.722703982392471 0.854442498267622 1.38550817901808 0.55729289899925 0.845819331151891 0.521616539936024 0.345177892412653 NA NA NA 0.24218666788644 77.9670752714886 a949 NRAS_mut 291 KIN001-266 MAP3K8 (COT) 3 16 2.99573227355399 NA 4.23890323492542 3.54606385152816 0.692839383397262 1.36012678026989 1.10290354621822 0.609790971832743 0.509393237047934 0.628195807124709 0.346021169659657 NA NA NA 0.476663907297473 77.9670752714886 a950 RB1_mut 1378 Bleomycin (50 uM) DNA damage 6 12 3.91202300542815 NA 1.36267185562431 0.599391549445943 0.76328030617837 1.55473911286853 1.58055651643904 0.48538235262227 0.490937868521299 0.482918705050815 0.346113047832218 NA NA NA 0.351311734333419 77.9670752714886 a951 MLL2_mut 294 MPS-1-IN-1 MPS1 3 16 2.99573227355399 NA 4.96868234115474 4.25891126262539 0.70977107852935 0.537509152540796 1.22378419588272 0.609645684632947 1.32048184700535 0.579980588830363 0.346133073887199 NA NA NA 0.147971971057444 77.9670752714886 a952 gain_cnaBLCA15_(ASXL1) 1143 HG-5-88-01 EGFR, ADCK4 3 4 2.30258509299405 NA 3.36218257478265 3.92216785090774 -0.559985276125089 0.376182919067121 0.857938890651583 0.793335542911576 1.48859835931352 0.652709979961154 0.346533306635118 NA NA NA 0.304541955188701 77.9670752714886 a953 gain_cnaBLCA9 1242 (5Z)-7-Oxozeaenol MAP3K7 (TAK1) 4 15 2.30258509299405 NA 0.975554770612906 0.429791240710972 0.545763529901933 0.614429626608969 1.06839185825812 0.543958223301534 0.888244163801144 0.510827114305919 0.347275911603545 NA NA NA 0.220342430559827 77.9670752714886 a954 gain_cnaBLCA9 1248 FK866 NAMPT 4 15 0 NA -0.767146503225724 -2.33601120955062 1.5688647063249 1.2867600074575 3.12199707510589 0.54393794513477 1.21923645219966 0.502519595176649 0.347293416223857 NA NA NA 0.152232440219353 77.9670752714886 a955 gain_cnaBLCA9 205 BMS-708163 g-secretase 4 15 2.32630161961136 0.940007258491471 4.88325435326801 4.68619400347284 0.197060349795173 0.319836307147835 0.371214508891566 0.543349399557626 0.616128767720193 0.530853038001096 0.34780173010721 NA NA NA 0.335558984941492 77.9670752714886 a956 CDKN1A_mut 275 I-BET BRD2, BRD3, BRD4 3 16 2.99573227355399 NA 5.20836413821423 4.53374839297627 0.674615745237957 0.379769491110061 1.17433149539078 0.60734791013099 1.77638215030403 0.574467897596042 0.34790622500006 NA NA NA 0.0929148974024932 77.9670752714886 a957 MLL2_mut 238 CAL-101 PI3Kdelta 3 16 2.99573227355399 2.32630161961136 5.26838412479562 4.74331644697416 0.525067677821461 0.432646573851547 0.906972237946553 0.607169317374636 1.21361801885348 0.57892364931726 0.348044305080466 NA NA NA 0.169792017738785 77.9670752714886 a958 gain_cnaBLCA9 1219 PFI-1 BRD2, BRD3, BRD4 4 15 2.30258509299405 NA 2.69033664325609 2.20174800784916 0.488588635406925 0.419224454677724 0.972622840005122 0.542853001090506 1.16545833611382 0.502341313930435 0.348230859323437 NA NA NA 0.160387413349328 77.9670752714886 a959 loss_cnaBLCA18_(CHD9,CNOT1,CYLD,MMP2,NUP93) 1029 AMG-706 VEGFR, RET, c-KIT, PDGFR 3 12 0.693147180559945 NA 2.23436466290657 2.71163745606765 -0.47727279316108 1.00930011867484 0.707641871620702 0.626453107636963 0.47287499954693 0.674455275050342 0.349510107345869 NA NA NA 0.505628321881371 78.1173616613155 a960 NRAS_mut 1091 BMS-536924 IGF1R 3 16 1.38629436111989 NA 1.88213712881295 2.48916590068185 -0.607028771868903 1.03014165505688 0.999771118386825 0.604976789902438 0.589267280756049 0.607167741401023 0.349742566158098 NA NA NA 0.421646016303064 78.1173616613155 a961 CDKN1A_mut 262 VX-11e ERK 3 16 1.63315443905142 NA 3.58546716852513 2.70915021879776 0.876316949727371 0.412264594870912 1.53658403823987 0.604240035172208 2.12561777225076 0.570301999707857 0.350314517551299 NA NA NA 0.0734470097082562 78.1173616613155 a962 NRAS_mut 249 XL-184 VEGFR, MET, RET, KIT, FLT1, FLT3, FLT4, Tie2,AXL 3 16 1.63315443905142 NA 3.55703151352001 2.97626232980426 0.580769183715749 0.799880439496401 0.980758902526508 0.604182912320091 0.72606999126194 0.59216305069436 0.350358889696906 NA NA NA 0.341988258004734 78.1173616613155 a963 gain_cnaBLCA23_(MYC) 1372 Trametinib MAP2K1 (MEK1), MAP2K2 (MEK2) 4 11 0 NA -2.39865852032531 -1.19740146484612 -1.20125705547918 2.22973916868343 2.09850079261059 0.564101657611218 0.538743307894832 0.572435835959246 0.351606632973739 NA NA NA 0.391047320799289 78.1975535872102 a964 ARID1A_mut 159 HG-6-64-1 BRAFV600E, TAK, MAP4K5 5 14 1.63315443905142 NA 0.744866712533329 0.178232279337052 0.566634433196277 1.42552324335579 1.03091574158502 0.49872667033956 0.397492244224919 0.549641847863421 0.351847309186289 NA NA NA 0.448018541930858 78.1975535872102 a965 ARID1A_mut 182 Obatoclax Mesylate BCL2, BCL2L1, MCL1 5 14 2.77258872223978 NA -0.37169490461715 -1.04234963798993 0.670654733372784 1.15767879470523 1.39791863617667 0.498532822543328 0.579309853855921 0.479752337523044 0.352029723321456 NA NA NA 0.322340657156579 78.1975535872102 a966 loss_cnaBLCA18_(CHD9,CNOT1,CYLD,MMP2,NUP93) 135 Gemcitabine DNA replication 3 16 0.0237165266173161 NA -3.79856836395299 -2.07479406689578 -1.72377429705721 2.65952736719752 2.89227099890216 0.60148364248255 0.648150614397941 0.595993355294685 0.352460070925223 NA NA NA 0.38535687946923 78.1975535872102 a967 gain_cnaBLCA9 1049 PD-173074 FGFR1, FGFR3 3 12 0.693147180559945 NA 3.03343492166135 2.47654332099345 0.556891600667893 0.729430642101952 0.922167293234721 0.622072018738753 0.763460661678724 0.603894331054035 0.352776555582337 NA NA NA 0.329196270298219 78.1975535872102 a968 CDKN1A_mut 252 WZ3105 CLK2, CNSK1E, FLT3, ULK1 3 16 0.246860077931526 2.32630161961136 -0.138533358938239 0.822736670797718 -0.961270029735956 0.493658882040139 1.69342739145078 0.600912228902862 1.94723535766909 0.567647620788999 0.352905986877141 NA NA NA 0.0831597009416832 78.1975535872102 a969 gain_cnaBLCA23_(MYC) 154 CHIR-99021 GSK3B 4 15 0.940007258491471 NA 2.40156174037285 2.81285538093675 -0.411293640563904 0.84150305977758 0.748789459008887 0.536960302143519 0.48876071903127 0.549278085602728 0.353353031623948 NA NA NA 0.420719044084806 78.2158091235762 a970 NRAS_mut 1038 NU-7441 PRKDC (DNAPK) 3 12 0.693147180559945 NA 1.65901395235402 2.33483608119941 -0.675822128845386 1.74188685647788 0.92225505422177 0.620439460210718 0.387982793676914 0.732793087716573 0.35399926670693 NA NA NA 0.575116497909957 78.2780729743771 a971 RB1_mut 341 EX-527 SIRT1 6 13 2.99573227355399 NA 5.17917550149992 5.40716648077887 -0.227990979278948 0.482547312553416 0.486278589882728 0.469906089763733 0.472473834892014 0.46884848319958 0.354389260056297 NA NA NA 0.362375487211087 78.2836054894399 a972 gain_cnaBLCA15_(ASXL1) 1149 TW 37 BCL2, BCL2L1 6 13 1.6094379124341 NA -0.0924443339988534 -0.789962900416801 0.697518566417947 1.21634224235806 1.58618979539827 0.469080550197912 0.573455843369956 0.439744706744131 0.355213889763537 NA NA NA 0.312704530507459 78.3200126176196 a973 ARID1A_mut 1037 BX-795 TBK1, PDPK1, IKK, AURKB, AURKC 5 10 1.6094379124341 NA 2.37184787143358 1.73496497227795 0.636882899155633 1.4327652904761 1.10240020305759 0.524759141858143 0.444513070905006 0.577723858712282 0.355504923771388 NA NA NA 0.413848403753732 78.3200126176196 a974 gain_cnaBLCA9 308 XL-880 MET 4 15 1.63315443905142 NA 1.26271425394087 0.494598774004395 0.768115479936472 2.41002748590728 1.12499669539525 0.534231436818161 0.318716481213618 0.682771321089623 0.355742584249234 NA NA NA 0.57501711782877 78.3200126176196 a975 ARID1A_mut 1149 TW 37 BCL2, BCL2L1 5 14 1.6094379124341 NA -1.11085577370489 -0.376421774349079 -0.734433999355807 2.31354735877578 1.11595139034255 0.4938397749173 0.317449304234011 0.658123647420133 0.356465879936489 NA NA NA 0.527460629818167 78.3200126176196 a976 loss_cnaBLCA18_(CHD9,CNOT1,CYLD,MMP2,NUP93) 245 UNC0638 G9a(EHMT2), GLP(EHMT1) 3 16 3.68887945411394 NA 3.41372409274447 4.11196716560517 -0.698243072860697 1.0215809020205 1.19250659242789 0.594912497544423 0.683492684211012 0.585525545346549 0.357611496261692 NA NA NA 0.365456545436882 78.3200126176196 a977 EP300_mut 312 AV-951 VEGFR 4 15 -2.05572501506252 NA 0.250819737363829 0.451491286324887 -0.200671548961058 0.299343230006935 0.392225385575605 0.531582083241021 0.670372765592222 0.51162305230847 0.358073119035051 NA NA NA 0.308644357017656 78.3200126176196 a978 loss_cnaBLCA5_(FAT1,IRF2) 1052 RO-3306 CDK1 3 12 1.6094379124341 NA 3.42656228475909 2.63541911282914 0.791143171929948 1.26377206923201 1.29237217493029 0.614235157660695 0.626017294725245 0.61216357584658 0.358673301440749 NA NA NA 0.40259558191876 78.3200126176196 a979 gain_cnaBLCA23_(MYC) 263 FR-180204 ERK 4 15 2.99573227355399 NA 4.75986578692311 5.11263157815625 -0.35276579123314 0.921703225933191 0.595073914544812 0.530885776366257 0.382732512274737 0.592810040250176 0.35868736775999 NA NA NA 0.511058254814785 78.3200126176196 a980 CDKN1A_mut 346 THZ-2-102-1 CDK7 3 16 0.916290731874155 2.99573227355399 -1.53352746795422 -0.0976214043830797 -1.43590606357114 0.718451524554227 2.56337434215205 0.593239788342721 1.99861231342236 0.560162454604912 0.358931022933397 NA NA NA 0.0824911943335958 78.3200126176196 a981 ARID1A_mut 1005 Cisplatin DNA crosslinker 3 11 1.79175946922805 2.30258509299405 3.01326640990881 2.37365244454381 0.639613965364996 0.719211207960889 1.08138907197944 0.621039247392468 0.889327027005645 0.591474411882312 0.359158921316497 NA NA NA 0.281324315849136 78.3200126176196 a982 loss_cnaBLCA18_(CHD9,CNOT1,CYLD,MMP2,NUP93) 287 KIN001-244 PDPK1 (PDK1) 3 16 2.99573227355399 NA 3.10220333464211 3.79355065276601 -0.691347318123901 0.184985483780325 1.24059344187919 0.592383354295081 3.73730578203041 0.557271459598146 0.359607916050089 NA NA NA 0.0502332474991815 78.3200126176196 a983 ARID1A_mut 1012 Vorinostat HDAC inhibitor Class I, IIa, IIb, IV 3 11 2.30258509299405 NA 1.77391632443989 1.43153201574119 0.342384308698698 0.575570009099539 0.548781264566783 0.618763698868843 0.594861273669119 0.623899412763266 0.360860132589535 NA NA NA 0.422840266323142 78.3200126176196 a984 CDKN1A_mut 192 LFM-A13 BTK 3 16 2.77258872223978 NA 4.71521266249816 4.32799356738988 0.387219095108283 0.640767243009203 0.657946331778493 0.590319251087667 0.604305384416665 0.588526869754851 0.361242895327717 NA NA NA 0.412674021436964 78.3200126176196 a985 MLL2_mut 263 FR-180204 ERK 3 16 2.99573227355399 NA 5.36834954249343 4.97649301203474 0.391856530458689 0.284224384463761 0.699985020624306 0.589515692995668 1.37868723402461 0.55980702288343 0.361880767194629 NA NA NA 0.142029873871345 78.3200126176196 a986 EP300_mut 303 PIK-93 PI4K, PI3K 4 15 2.99573227355399 NA 4.01372872813254 3.15940782213178 0.854320906000754 1.07228596902853 1.71505181882906 0.527274503048791 0.79672860661858 0.498131249809138 0.361884641098072 NA NA NA 0.255364552655455 78.3200126176196 a987 gain_cnaBLCA15_(ASXL1) 1058 GDC0941 PI3K (class 1) 4 11 1.38629436111989 0.693147180559945 0.580549187500422 1.296205198109 -0.71565601060858 1.08584609388868 1.3541454791903 0.551707726447667 0.65907683845474 0.528492707472243 0.361937569467532 NA NA NA 0.328568063405449 78.3200126176196 a988 TP53_mut 1133 JNJ-26854165 MDM2 15 4 2.30258509299405 NA 2.17862557962758 2.83360017205018 -0.654974592422596 0.785344458693101 2.42282900661114 0.527139337538412 0.833996579682431 0.270334633866186 0.362004688057997 NA NA NA 0.628996709611678 78.3200126176196 a989 loss_cnaBLCA5_(FAT1,IRF2) 140 Vinorelbine Microtubules 5 14 -2.74887219562247 NA -4.45522357378175 -3.82269547656686 -0.632528097214888 0.698500137106236 1.43283983560921 0.487315467515137 0.905551858350868 0.441450664264893 0.362696617206902 NA NA NA 0.220293139544248 78.3200126176196 a990 TP53_mut 1059 AZD8055 MTORC1/2 11 4 0.693147180559945 NA 0.13044079588718 0.528037533706883 -0.397596737819703 0.595032551649193 1.04068002034676 0.55016095934401 0.668193255507994 0.382054743096944 0.363241675942798 NA NA NA 0.512639878329319 78.3200126176196 a991 RB1_mut 274 PXD101, Belinostat HDAC 6 13 2.99573227355399 NA 0.898998185176714 0.24556455679715 0.653433628379564 1.65572799383065 1.30529216369655 0.461013752547879 0.394650347650279 0.500603348854145 0.363341216710621 NA NA NA 0.418883135116131 78.3200126176196 a992 loss_cnaBLCA18_(CHD9,CNOT1,CYLD,MMP2,NUP93) 1018 ABT-888 PARP1, PARP2 3 11 1.6094379124341 NA 3.7063017655737 4.0577387571629 -0.351436991589196 0.1478849467021 0.622339792770089 0.615137139747048 2.37642166715678 0.564702748678369 0.36358314386968 NA NA NA 0.113979046480172 78.3200126176196 a993 ARID1A_mut 1008 Methotrexate Dihydrofolate reductase (DHFR) 3 11 -1.6094379124341 NA 0.236676776977283 -0.403584344934447 0.640261121911729 1.11969530470095 1.02512981519401 0.614756604556101 0.571817278525369 0.624565896359725 0.363869708878625 NA NA NA 0.437652377774562 78.3200126176196 a994 loss_cnaBLCA5_(FAT1,IRF2) 1241 CHIR-99021 GSK3B 5 14 2.30258509299405 NA 3.93075748394569 3.50117352822853 0.42958395571716 0.808138013230167 0.906462845982858 0.485783418924035 0.531572514452193 0.473912370066719 0.364170448313554 NA NA NA 0.35271187766603 78.3200126176196 a995 gain_cnaBLCA9 179 5-Fluorouracil DNA antimetabolite 4 15 3.46573590279973 NA 4.75881901993455 4.13463119199748 0.624187827937074 1.43205914343712 1.1314119611953 0.524527776779935 0.435867352823812 0.551689260274073 0.364329479606058 NA NA NA 0.464237807082997 78.3200126176196 a996 ARID1A_mut 276 CAY10603 HDAC6 5 14 2.99573227355399 NA 1.67661997783818 1.09804191516134 0.578578062676836 1.27111820628367 1.16685518876631 0.485299488880902 0.455172508596513 0.495843930118314 0.364636836300093 NA NA NA 0.403633158092179 78.3200126176196 a997 CDKN1A_mut 1194 SB-505124 TGFR1 (ALK5) 3 16 2.30258509299405 NA 4.5862463513412 3.98712712860861 0.599119222732599 0.483348595964636 1.07476671620906 0.58559808900074 1.23951787123104 0.557441176486956 0.365001611418763 NA NA NA 0.168033443114507 78.3200126176196 a998 loss_cnaBLCA18_(CHD9,CNOT1,CYLD,MMP2,NUP93) 164 JQ12 HDAC 3 16 1.63315443905142 NA 0.507224327758164 1.36741203975765 -0.860187711999487 0.7350540614745 1.54141415835843 0.585283819532926 1.17023734318803 0.558050999684321 0.365252756873015 NA NA NA 0.183302832193416 78.3200126176196 a999 RB1_mut 147 NSC-87877 PTPN6 (SHP-1), PTPN11 (SHP-2) 6 13 2.77258872223978 NA 4.84815788580353 5.16423647216912 -0.316078586365597 1.14654441076019 0.353102911235823 0.45878548150098 0.275679322492208 0.895145795483121 0.365608406669132 NA NA NA 0.535589381464465 78.3200126176196 a1000 gain_cnaBLCA9 298 OSI-930 KIT, VEGFR, PDGFR 4 15 2.32630161961136 NA 4.6422703431733 4.2426001729407 0.3996701702326 0.569941747346988 0.799588561232842 0.523063795577172 0.701247403077626 0.499844782191944 0.365637145462237 NA NA NA 0.295686912223438 78.3200126176196 a1001 TP53_mut 1161 ZG-10 IRAK1 4 3 2.30258509299405 NA 1.5338481326856 2.49803502989919 -0.964186897213588 0.732796404089889 1.79820693500705 0.758564428260739 1.31576368529139 0.536193515019343 0.366217943724742 NA NA NA 0.457024488903219 78.3200126176196 a1002 NRAS_mut 290 KIN001-260 IKK 3 16 2.99573227355399 NA 5.58471800274367 4.90336444498711 0.681353557756565 0.549530278682645 1.22627872615851 0.583746564965671 1.23988355908237 0.555626990195776 0.366482933856136 NA NA NA 0.168315645105626 78.3200126176196 a1003 gain_cnaBLCA9 300 CX-5461 RNA Pol I 4 15 2.32630161961136 NA 4.57806390840166 3.90328980376235 0.674774104639307 1.22812885529357 1.30599933741066 0.522029191150025 0.54943266069423 0.51667262402839 0.366563204767846 NA NA NA 0.379813763250107 78.3200126176196 a1004 gain_cnaBLCA15_(ASXL1) 1158 XMD11-85h BRSK2, FLT4, MARK4, PRKCD, RET, SPRK1 3 4 2.30258509299405 NA 3.33732728848766 4.08811686634139 -0.750789577853733 1.17660070132392 0.84416895550801 0.75789849937082 0.63810056972509 0.889383070717067 0.366603801375533 NA NA NA 0.408079387145788 78.3200126176196 a1005 EP300_mut 184 BMS-754807 IGF1R 4 15 0.940007258491471 NA 1.59924362736933 0.715326698368373 0.88391692900096 1.47054748414668 1.74144538527305 0.520936160689806 0.60108016812111 0.507576600722603 0.367543290998895 NA NA NA 0.348068637141153 78.442591973603 a1006 TP53_mut 1024 CEP-701 FLT3, JAK2, NTRK1, RET 10 4 0.693147180559945 NA -0.385858690012502 0.351847207261037 -0.73770589727354 1.24596984424919 1.56627580668133 0.553301546172586 0.59207363699727 0.470993610529304 0.368098927148665 NA NA NA 0.441503771099863 78.4640435093023 a1007 loss_cnaBLCA5_(FAT1,IRF2) 201 Epothilone B Microtubules 5 14 -3.44201937618241 NA -6.08886254827836 -4.93708891467967 -1.15177363359869 0.64127626725835 2.71740929810498 0.480590800304281 1.79606464858409 0.42384989055638 0.369196067747553 NA NA NA 0.15948565616161 78.4640435093023 a1008 loss_cnaBLCA5_(FAT1,IRF2) 345 KIN001-270 CDK9 5 14 2.99573227355399 NA 4.60147018729383 5.0410616966599 -0.439591509366072 1.03343781701456 0.874960333812297 0.480573555588814 0.425368127746655 0.502413072202627 0.369212835853373 NA NA NA 0.427666325621787 78.4640435093023 a1009 loss_cnaBLCA18_(CHD9,CNOT1,CYLD,MMP2,NUP93) 1047 Nutlin-3a MDM2 3 12 2.07944154167984 1.38629436111989 4.28979174976355 3.59077048211009 0.699021267653466 0.41482519123255 1.25355691459308 0.600261737870494 1.68509840392407 0.557630259556567 0.369358604435398 NA NA NA 0.135341626188735 78.4640435093023 a1010 CDKN1A_mut 207 AS601245 JNK 3 16 2.07944154167984 NA 1.62487229426211 2.33094083459822 -0.706068540336108 1.06223879239825 1.2365148102386 0.580024831986451 0.664698507895755 0.571015029087975 0.369472875956692 NA NA NA 0.376947248463424 78.4640435093023 a1011 loss_cnaBLCA18_(CHD9,CNOT1,CYLD,MMP2,NUP93) 194 AUY922 HSP90 3 16 -1.36257783450257 NA -3.87550528519784 -2.59371974785573 -1.28178553734211 0.437472463498019 2.3525778731799 0.578697124226163 2.92997992854906 0.544842979250486 0.370543511835625 NA NA NA 0.0616730157140888 78.6135765862717 a1012 gain_cnaBLCA23_(MYC) 202 GSK-1904529A IGF1R 4 15 0.0237165266173161 NA 1.85749310190245 2.137276205204 -0.279783103301553 0.556899710252625 0.537970215126725 0.516816382379783 0.502394054352508 0.520071735264464 0.371253346424861 NA NA NA 0.413013823454746 78.629126259241 a1013 CDKN1A_mut 1373 Dabrafenib BRAF 3 14 2.30258509299405 NA 4.18350182555499 3.42140590621001 0.762095919344982 0.573501286156277 1.37926225502473 0.585782463370164 1.32884779466268 0.55253880584974 0.371758198523467 NA NA NA 0.162075983425188 78.629126259241 a1014 loss_cnaBLCA5_(FAT1,IRF2) 1194 SB-505124 TGFR1 (ALK5) 5 14 2.30258509299405 NA 4.442012059617 3.95305091526259 0.488961144354414 0.603532009373743 1.12191710888021 0.477577672889008 0.810166050449895 0.435826444292706 0.372133752966367 NA NA NA 0.246155528995702 78.629126259241 a1015 gain_cnaBLCA15_(ASXL1) 1022 AZD7762 CHEK1, CHEK2 4 10 0.693147180559945 NA 0.529458682381347 0.0270483494620114 0.502410332919336 0.811927725300646 0.949271568082125 0.547964588439764 0.618787014242308 0.529258802024786 0.372580152454795 NA NA NA 0.355145262110942 78.629126259241 a1016 RB1_mut 1019 Bosutinib SRC, ABL, TEC 5 9 0.693147180559945 NA 1.10926251101258 1.61752986020486 -0.508267349192282 1.04313721356008 0.95421380464393 0.516139744438391 0.487248793912393 0.532655623633473 0.373015194478476 NA NA NA 0.39514027423169 78.629126259241 a1017 NRAS_mut 282 EKB-569 EGFR 3 16 0.916290731874155 2.99573227355399 2.67142868079769 1.7759432036874 0.895485477110288 0.711412290119669 1.64108438874859 0.573763043234681 1.25874333287053 0.545666928068909 0.374540636732989 NA NA NA 0.166574658049444 78.629126259241 a1018 MLL2_mut 140 Vinorelbine Microtubules 3 16 -2.74887219562247 NA -3.36165918061525 -4.10680481243744 0.745145631822191 1.77293285113793 1.22272165380051 0.573365540309662 0.420289821661282 0.609415584901192 0.374863916754285 NA NA NA 0.547615698647245 78.629126259241 a1019 TP53_mut 164 JQ12 HDAC 15 4 1.63315443905142 NA 1.07292368712772 1.82660257812027 -0.753678890992545 1.50921994688606 1.27893695926375 0.512287373879312 0.499383070405075 0.589301048447623 0.375361068784629 NA NA NA 0.356550153259506 78.629126259241 a1020 gain_cnaBLCA15_(ASXL1) 224 AS605240 PI3Kgamma 6 13 2.99573227355399 2.32630161961136 2.9054781194438 3.53986379971336 -0.634385680269565 1.50802055375212 1.37038273229218 0.449199693207173 0.420674425617836 0.462925915016788 0.37547116143223 NA NA NA 0.403404702772254 78.629126259241 a1021 gain_cnaBLCA15_(ASXL1) 326 GSK690693 AKT 6 13 2.32630161961136 NA 4.55289185831598 4.12804449296367 0.424847365352305 0.798119126911842 1.00197249391379 0.448821684818244 0.532310717819988 0.42401100622315 0.375863733314483 NA NA NA 0.34039485289439 78.629126259241 a1022 CDKN1A_mut 330 XMD13-2 RIPK 3 16 2.32630161961136 NA 3.33079499332308 3.86943046439637 -0.53863547107329 0.727258507889024 0.96749910681648 0.571545319158506 0.740638253427601 0.556729683033662 0.376346661783404 NA NA NA 0.336855789492593 78.629126259241 a1023 loss_cnaBLCA18_(CHD9,CNOT1,CYLD,MMP2,NUP93) 300 CX-5461 RNA Pol I 3 16 2.32630161961136 NA 3.4227062611822 4.16209274415596 -0.739386482973765 1.36722570926109 1.28379396840233 0.571445185644058 0.540793285238442 0.575938586075402 0.376428344507937 NA NA NA 0.455639222720747 78.629126259241 a1024 EP300_mut 175 PAC-1 CASP3 agonist 4 15 0.940007258491471 NA 2.99065554853949 2.51633352383035 0.474322024709144 0.577737857813595 0.987704452622117 0.510790544747614 0.820998690485993 0.48022667453805 0.376725369957652 NA NA NA 0.251679705556259 78.629126259241 a1025 EP300_mut 196 Phenformin AAPK1 (AMPK) agonist 4 15 8.29404964010203 NA 8.49108903954801 9.13012791773659 -0.639038878188581 0.940368342156192 1.30829325613361 0.51071977090423 0.679562305046673 0.488452321520887 0.376789960014268 NA NA NA 0.308725739751348 78.629126259241 a1026 MLL2_mut 1241 CHIR-99021 GSK3B 3 16 2.30258509299405 NA 3.18858312342344 3.6940292152911 -0.505446091867662 0.89903181368995 0.883632122155442 0.570830274898129 0.562211574908711 0.572009639752263 0.376930212095041 NA NA NA 0.441030996733626 78.629126259241 a1027 gain_cnaBLCA9 193 GW-2580 CSF1R (cFMS) 4 15 2.99573227355399 NA 5.48832124960155 5.24894809679873 0.239373152802811 0.777732815688217 0.370934943873565 0.51028366050456 0.307783274633962 0.64532381420609 0.377188130048265 NA NA NA 0.587820097275334 78.629126259241 a1028 gain_cnaBLCA23_(MYC) 1526 RDEA119 (rescreen) MAP2K1 (MEK1), MAP2K2 (MEK2) 4 15 1.6094379124341 NA 1.05504433692269 1.54247069077631 -0.487426353853616 0.71135050625152 1.00015448759459 0.510098735817363 0.685212633673549 0.487351064159991 0.377357052168551 NA NA NA 0.306196421043409 78.629126259241 a1029 gain_cnaBLCA9 231 FMK RSK 3 11 2.99573227355399 2.32630161961136 5.46184869029538 5.20713130471889 0.25471738557649 0.624529696340791 0.375085140763441 0.596662114425532 0.407854721831349 0.679092179066447 0.377679939770292 NA NA NA 0.559227191612583 78.629126259241 a1030 EP300_mut 1527 GDC0941 (rescreen) PI3K 4 15 1.38629436111989 NA 1.31066654822859 0.720409325544302 0.590257222684283 0.820366661229926 1.2187407407494 0.509528829297212 0.719504156591818 0.484317298132937 0.377877961195295 NA NA NA 0.290870449808552 78.629126259241 a1031 EP300_mut 326 GSK690693 AKT 4 15 2.32630161961136 NA 4.64300029670687 4.16066189143974 0.482338405267122 0.147390587820053 1.0410667830195 0.509451704347888 3.2725183636285 0.46331168483558 0.377948492441606 NA NA NA 0.103052511914943 78.629126259241 a1032 RB1_mut 292 Masitinib KIT 6 13 2.99573227355399 NA 4.54982904281662 4.14465928133191 0.405169761484712 1.01465193624842 0.859184613423085 0.446380148773541 0.399318965460007 0.471574740928461 0.378405986039717 NA NA NA 0.41983546818166 78.6480208608089 a1033 NRAS_mut 238 CAL-101 PI3Kdelta 3 16 2.99573227355399 2.32630161961136 5.24148623660395 4.7483598010101 0.493126435593847 1.0662957899061 0.837517526699587 0.56839989247579 0.46246683168211 0.588795362333628 0.378918201433721 NA NA NA 0.513623697448095 78.6782412658323 a1034 EP300_mut 286 KIN001-236 TIE2 4 15 2.32630161961136 NA 4.65952522872985 4.24151385920563 0.418011369524223 0.210613369254539 0.903217072623391 0.507038503631574 1.98473331015863 0.462802777088912 0.380159844854967 NA NA NA 0.120730587330609 78.7607335982717 a1035 RB1_mut 254 AC220 FLT3 6 13 0.0237165266173161 NA 2.53827041645202 2.30891402958293 0.229356386869082 0.446787221271357 0.542269798703407 0.444468475659023 0.513345896994179 0.422956224774981 0.380404557294758 NA NA NA 0.351380270534195 78.7607335982717 a1036 EP300_mut 261 TL-1-85 MAP3K7 (TAK1) 4 15 2.32630161961136 NA 4.01455487833796 3.41506982851196 0.599485049825998 0.754771485665799 1.25588524932172 0.506758397576953 0.794260330724047 0.477340624989239 0.380417082349856 NA NA NA 0.262215545678152 78.7607335982717 a1037 loss_cnaBLCA5_(FAT1,IRF2) 166 FTI-277 Farnesyl transferase (FNTA) 5 14 0.0237165266173161 NA 1.2355400700604 1.6086321842729 -0.373092114212501 0.797671398055357 0.795756748261668 0.46858643675617 0.467726579042525 0.468851963904197 0.380993497943104 NA NA NA 0.39855119372725 78.8040077969417 a1038 loss_cnaBLCA5_(FAT1,IRF2) 153 Midostaurin KIT 5 14 -0.669430653942629 NA -0.726111440466264 -0.167513587385204 -0.558597853081061 1.22473845469743 1.18490347704869 0.467682309390153 0.456095626734495 0.47142899307916 0.381892158879387 NA NA NA 0.407056035918754 78.8193382722346 a1039 RB1_mut 1072 BMS-708163 g-secretase 5 13 1.6094379124341 NA 3.65550043196455 3.3555018559899 0.299998575974652 0.505943703668967 0.672038413743264 0.472733953565635 0.592948531228165 0.446400934588926 0.382328105375395 NA NA NA 0.330805449264582 78.8193382722346 a1040 ARID1A_mut 1259 BMN-673 PARP1 4 14 2.30258509299405 NA 2.54224966662604 1.71731376745347 0.824935899172572 1.99341416542081 1.52206173876329 0.508932309293315 0.413830659720645 0.541985832876168 0.382669708468075 NA NA NA 0.485661416904383 78.8193382722346 a1041 RB1_mut 287 KIN001-244 PDPK1 (PDK1) 6 13 2.99573227355399 NA 4.03831399330997 3.52104126833252 0.517272724977448 1.14316748980907 1.18072689743336 0.442187061233631 0.45249075886845 0.438096841955479 0.382798914108775 NA NA NA 0.385358436663913 78.8193382722346 a1042 loss_cnaBLCA18_(CHD9,CNOT1,CYLD,MMP2,NUP93) 295 NVP-BHG712 EPHB4 3 16 2.32630161961136 NA 2.94665015477699 3.76630692169123 -0.819656766914246 1.2804031269061 1.47610490352106 0.563551574547911 0.640155236807976 0.555283547232353 0.382904972057579 NA NA NA 0.392260439002719 78.8193382722346 a1043 MLL2_mut 302 PI-103 PI3Ka, PRKDC (DNAPK) 3 16 2.32630161961136 NA 3.300673946317 2.00641418242546 1.29425976389154 1.50784192270589 2.38601523747889 0.562680326286893 0.858352420371047 0.54243566577516 0.383624359595896 NA NA NA 0.284381644466942 78.8230567667781 a1044 RB1_mut 1061 SB590885 BRAF 5 10 1.6094379124341 NA 4.04175834916753 3.63847294368198 0.40328540548555 0.596842350818314 0.898008650870192 0.493466652492291 0.67569837316775 0.449088552871687 0.384006069206731 NA NA NA 0.321885668116873 78.8230567667781 a1045 MLL2_mut 153 Midostaurin KIT 3 16 -0.669430653942629 NA 0.25106358391317 -0.42055863609148 0.67162222000465 1.37778012407073 1.16805709773733 0.562194977266587 0.487466910191959 0.574990915517458 0.384025502089878 NA NA NA 0.494631982344508 78.8230567667781 a1046 NRAS_mut 1011 ABT-263 BCL2, BCL2L1, BCL2L2 3 12 0.693147180559945 NA 2.62782190953851 2.15677195754623 0.471049951992278 0.478419158328534 0.859146331536479 0.579916149878343 0.984596757450095 0.54827674250772 0.385308908493768 NA NA NA 0.252734335605358 78.9108591314061 a1047 CDKN1A_mut 286 KIN001-236 TIE2 3 16 2.32630161961136 NA 4.71862904923727 4.25655760345575 0.462071445781515 0.262470770152146 0.872884244564236 0.560181975828303 1.76046820571169 0.529361652085027 0.385692240096672 NA NA NA 0.107536581781969 78.9108591314061 a1048 gain_cnaBLCA15_(ASXL1) 1013 Nilotinib ABL 4 10 0.693147180559945 NA 3.14059034555278 2.82177413326719 0.318816212285591 0.473484366073926 0.63518111118079 0.532368264584142 0.673340526381421 0.501929617669073 0.385893613572599 NA NA NA 0.336180905676151 78.9108591314061 a1049 loss_cnaBLCA18_(CHD9,CNOT1,CYLD,MMP2,NUP93) 302 PI-103 PI3Ka, PRKDC (DNAPK) 3 16 2.32630161961136 NA 1.12601044141114 2.41416358959531 -1.28815314818416 0.457458420753777 2.4435562652205 0.559901483051572 2.81589121490344 0.52716328513431 0.385924866213052 NA NA NA 0.0700007835114717 78.9108591314061 a1050 RB1_mut 1059 AZD8055 MTORC1/2 5 10 0.693147180559945 NA 0.47289495504884 0.118252411434231 0.354642543614608 0.37383979948755 0.835006995822515 0.489125268537062 0.948648442730665 0.424718050733541 0.388080872694177 NA NA NA 0.277015019027201 78.9141812708904 a1051 loss_cnaBLCA5_(FAT1,IRF2) 300 CX-5461 RNA Pol I 5 14 2.32630161961136 NA 3.60487434272827 4.20265935545719 -0.597785012728923 1.76273121920069 1.11273078695105 0.461483257707238 0.339124312440548 0.537223396475703 0.388091863166443 NA NA NA 0.508628274211655 78.9141812708904 a1052 EP300_mut 1526 RDEA119 (rescreen) MAP2K1 (MEK1), MAP2K2 (MEK2) 4 15 1.6094379124341 NA 1.06367041496958 1.54017040329714 -0.476499988327562 1.21245340861596 0.892248941329653 0.498130752474799 0.393004782650987 0.534043769911869 0.388397399749794 NA NA NA 0.504109523692805 78.9141812708904 a1053 EP300_mut 329 QL-XI-92 DDR1 4 15 2.32630161961136 NA 4.60767710274276 4.14650688057564 0.461170222167116 0.22740042889805 1.01525775640907 0.4978785668108 2.02800946507393 0.454239545825541 0.388632325487136 NA NA NA 0.124979721846868 78.9141812708904 a1054 gain_cnaBLCA15_(ASXL1) 1024 CEP-701 FLT3, JAK2, NTRK1, RET 4 10 0.693147180559945 NA -0.6803405578096 0.0270164160157525 -0.707356973825352 1.36239454194971 1.32868246640769 0.5289875673276 0.519201268094526 0.532374733398724 0.388822268235248 NA NA NA 0.414060698933659 78.9141812708904 a1055 loss_cnaBLCA18_(CHD9,CNOT1,CYLD,MMP2,NUP93) 1375 Temozolomide DNA akylating agent 3 15 3.40119738166216 NA 4.98554885714014 5.37503301103831 -0.389484153898163 0.972656494462347 0.646335660641757 0.559966386091191 0.400433406979364 0.602603534998267 0.389061973935509 NA NA NA 0.565114479203235 78.9141812708904 a1056 MLL2_mut 329 QL-XI-92 DDR1 3 16 2.32630161961136 NA 4.67654303201166 4.16241765772317 0.514125374288499 0.221610774354732 0.98289480774388 0.554975682946264 2.31994755573363 0.52307263222665 0.39002528490132 NA NA NA 0.0824476433313703 78.9141812708904 a1057 gain_cnaBLCA23_(MYC) 332 XMD15-27 CAMK2B, CLK2, DYRK1A, MAST1, STK39 4 15 2.32630161961136 NA 4.56496137877231 4.81232677696209 -0.247365398189776 0.702203155876279 0.442684579009936 0.496319063820101 0.352270416502313 0.558784764409477 0.390087188513384 NA NA NA 0.542770938910599 78.9141812708904 a1058 TP53_mut 163 JQ1 BRD4 15 4 0.940007258491471 NA -0.394196569713785 0.285850332962994 -0.680046902676779 1.3766040877818 1.3399309974629 0.496310809183383 0.494003256791556 0.50752382321509 0.390094898870598 NA NA NA 0.412234428144881 78.9141812708904 a1059 CDKN1A_mut 173 FH535 unknown 3 16 3.46573590279973 NA 1.1627376321952 1.84906927762767 -0.686331645432474 0.608274948608934 1.29826524648808 0.554734175617551 1.12832469428841 0.528652867577763 0.390227064732384 NA NA NA 0.199193861964137 78.9141812708904 a1060 MLL2_mut 262 VX-11e ERK 3 16 1.63315443905142 NA 2.16838035269978 2.97485399676501 -0.806473644065231 2.27285110816391 1.30949098390914 0.55378693739801 0.354829069607084 0.615868038783832 0.391019151625002 NA NA NA 0.605374159541487 78.9141812708904 a1061 NRAS_mut 328 SNX-2112 HSP90 3 15 0.940007258491471 NA 0.496661211717444 -0.650715898423413 1.14737711014086 1.84831144107792 2.08590159592617 0.557600764137386 0.620770441950906 0.550062913984879 0.391021859238458 NA NA NA 0.405453541804163 78.9141812708904 a1062 TP53_mut 147 NSC-87877 PTPN6 (SHP-1), PTPN11 (SHP-2) 15 4 2.77258872223978 NA 4.99245363383832 5.33430423636125 -0.341850602522932 0.739195607731491 0.391731232335616 0.49493440992969 0.462462978604585 0.87266619126772 0.391381955872997 NA NA NA 0.241042031882262 78.9141812708904 a1063 MLL2_mut 1243 piperlongumine Increases ROS levels 3 16 2.30258509299405 NA 0.884784896230891 1.37302834459013 -0.488243448359237 0.614494264536358 0.912445147141504 0.553170103333078 0.794545167525073 0.535093479195763 0.391535524255171 NA NA NA 0.312882019547614 78.9141812708904 a1064 NRAS_mut 1033 Vismodegib SMO 3 11 2.30258509299405 NA 4.14896203868433 4.59945408533409 -0.450492046649762 1.17525325414136 0.673316624640195 0.577744129076164 0.383314868571788 0.669064196789281 0.392504103949484 NA NA NA 0.580730217938847 78.9141812708904 a1065 CDKN1A_mut 1377 Afatinib (rescreen) ERBB2, EGFR 3 15 2.30258509299405 NA 3.97066955706765 3.22369222837445 0.7469773286932 0.926375631055486 1.39351234420959 0.555774773011021 0.806343888647108 0.53603926208267 0.392539153897476 NA NA NA 0.30954205308236 78.9141812708904 a1066 loss_cnaBLCA18_(CHD9,CNOT1,CYLD,MMP2,NUP93) 265 Tubastatin A HDAC6 3 16 2.99573227355399 NA 4.40959007378151 4.92055028325592 -0.510960209474415 0.816591733943245 0.940632260330336 0.551256377438591 0.625722975429883 0.543209318905321 0.393140438715895 NA NA NA 0.401701374066856 78.9141812708904 a1067 NRAS_mut 261 TL-1-85 MAP3K7 (TAK1) 3 16 2.32630161961136 NA 4.09073780709035 3.43825334498501 0.652484462105341 1.05212817885267 1.20099706496448 0.550873331557233 0.620156816650292 0.543285642521234 0.39346219502262 NA NA NA 0.405098287787831 78.9141812708904 a1068 gain_cnaBLCA23_(MYC) 176 IPA-3 PAK1, PAK2, PAK3 4 15 3.46573590279973 NA 3.07951550834318 3.87939911783164 -0.79988360948846 2.29989618148451 1.43803787212221 0.492624238856291 0.3477911811533 0.556232645186193 0.393548482590525 NA NA NA 0.547454684341493 78.9141812708904 a1069 loss_cnaBLCA18_(CHD9,CNOT1,CYLD,MMP2,NUP93) 263 FR-180204 ERK 3 16 2.99573227355399 NA 4.72927910620069 5.09631871883963 -0.367039612638941 0.461550506445234 0.68957832397389 0.550440093967248 0.795231740651317 0.532266748936903 0.393826321548488 NA NA NA 0.312874389725924 78.9141812708904 a1070 gain_cnaBLCA9 1494 SN-38 TOP1 4 14 -2.99573227355399 NA -4.23815357031671 -5.0855861171654 0.847432546848691 1.94718084040467 1.64560509371738 0.496673763838196 0.435209986285905 0.514967138886501 0.393965271856541 NA NA NA 0.469048070534615 78.9141812708904 a1071 ARID1A_mut 293 MP470 PDGFR 5 14 2.99573227355399 NA 3.49065280753712 4.14482662243975 -0.654173814902629 2.24435468892273 1.07100957170348 0.455522394122674 0.291475237016404 0.610801091032398 0.394116059710844 NA NA NA 0.560178272295179 78.9141812708904 a1072 CDKN1A_mut 133 Doxorubicin DNA intercalating 3 16 0.0237165266173161 NA -2.87882699977527 -1.92512478691129 -0.953702212863977 1.29580210563044 1.78517173109021 0.549754359081828 0.735993720584347 0.534235556307821 0.394403120869802 NA NA NA 0.341124560142057 78.9141812708904 a1073 CDKN1A_mut 208 SB-715992 KIF11 3 16 -2.05572501506252 NA -1.88666597455155 -1.03151365617022 -0.855152318381327 1.46217118049898 1.571052648099 0.548653616956363 0.584851028242465 0.544318052877524 0.39533016398522 NA NA NA 0.427341444899219 78.9541169475097 a1074 NRAS_mut 279 BIX02189 MAP2K5 (MEK5) 3 16 2.99573227355399 NA 5.18910005619749 4.59510279024823 0.593997265949254 0.701746065806052 1.12374118456724 0.548643236238858 0.846456139753297 0.528589032872374 0.395338913436521 NA NA NA 0.290990177849818 78.9541169475097 a1075 NRAS_mut 1377 Afatinib (rescreen) ERBB2, EGFR 3 15 2.30258509299405 NA 3.96586547813134 3.22465304416171 0.741212433969626 1.06622935275575 1.37970946336151 0.551280998667611 0.695171664570956 0.537223563114327 0.396289859386206 NA NA NA 0.363772426810536 79.070410370505 a1076 NRAS_mut 333 T0901317 LXR 3 16 2.32630161961136 NA 4.17443092723844 4.52488349626642 -0.350452569027984 1.09275329330287 0.553377484514929 0.546859337913725 0.320706028685334 0.633297484691086 0.396844377650533 NA NA NA 0.637470796423112 79.1074632354578 a1077 TP53_mut 1047 Nutlin-3a MDM2 11 4 2.07944154167984 1.38629436111989 3.88967622155002 3.29304564939036 0.596630572159661 0.899794834242624 1.79460744107474 0.510479443208793 0.663074013602065 0.332457426902429 0.397820944043096 NA NA NA 0.563027677114587 79.1697702754551 a1078 TP53_mut 1164 XMD8-92 MAP2K5 (ERK5) 4 3 2.30258509299405 NA 2.20803975530581 2.72474430558922 -0.516704550283411 0.190303730915573 1.13462025459714 0.705320949919126 2.7151572268052 0.455398665932393 0.398132432484894 NA NA NA 0.513875877564351 79.1697702754551 a1079 CDKN1A_mut 178 BAY 61-3606 SYK 3 16 2.07944154167984 NA 1.53705381601916 2.34410112383804 -0.807047307818882 1.73496530242635 1.44326640440135 0.54509237403226 0.465166252426044 0.559181108461842 0.398339263173907 NA NA NA 0.512368654292486 79.1697702754551 a1080 loss_cnaBLCA18_(CHD9,CNOT1,CYLD,MMP2,NUP93) 157 JNK-9L JNK 3 16 1.63315443905142 NA -0.872074858133912 -0.335488037135111 -0.5365868209988 1.96798069681314 0.763706408450988 0.54474526025811 0.272658579358895 0.702608770937447 0.398633362185158 NA NA NA 0.685007121183956 79.1697702754551 a1081 NRAS_mut 345 KIN001-270 CDK9 3 16 2.99573227355399 NA 5.34541738946559 4.84662265758194 0.498794731883658 0.837226124218039 0.927566853249366 0.543704510865426 0.595770625707036 0.537745317371278 0.3995160118249 NA NA NA 0.420692373871873 79.1961711653921 a1082 loss_cnaBLCA18_(CHD9,CNOT1,CYLD,MMP2,NUP93) 230 GSK429286A ROCK2 3 16 2.99573227355399 2.32630161961136 4.02579328384282 4.94297079102997 -0.917177507187154 0.928269686075192 1.76392417585004 0.543598840118835 0.988050693613688 0.519964247751843 0.399605701803346 NA NA NA 0.240496559742367 79.1961711653921 a1083 gain_cnaBLCA15_(ASXL1) 184 BMS-754807 IGF1R 6 13 0.940007258491471 NA 1.39738928287458 0.672503022135036 0.724886260739539 1.7123334473695 1.69789303287757 0.425864355481723 0.423332419192718 0.42693282009115 0.40022241356802 NA NA NA 0.410464324488161 79.1961711653921 a1084 MLL2_mut 303 PIK-93 PI4K, PI3K 3 16 2.99573227355399 NA 4.08240643612697 3.19992580850787 0.882480627619102 1.30245768975847 1.66480525608969 0.542606994053598 0.677550322408364 0.530080394923718 0.400448192766749 NA NA NA 0.372480662514562 79.1961711653921 a1085 CDKN1A_mut 309 Y-39983 ROCK 3 16 2.99573227355399 NA 3.66020007190493 4.48790115958974 -0.827701087684813 1.6830489225117 1.50575824441291 0.541801153707028 0.491786707215612 0.549690556738428 0.401133543470836 NA NA NA 0.492251382580198 79.1961711653921 a1086 gain_cnaBLCA15_(ASXL1) 1372 Trametinib MAP2K1 (MEK1), MAP2K2 (MEK2) 4 11 0 NA -2.31419417828576 -1.22811577104232 -1.08607840724344 3.11242786795892 1.75109786953055 0.506704266552347 0.348948940608114 0.620227130728338 0.401223179338335 NA NA NA 0.547393304419531 79.1961711653921 a1087 NRAS_mut 288 KIN001-055 JAK3, MNK1 3 16 2.32630161961136 NA 4.50675106664668 4.05938238769388 0.447368678952796 0.346252745846712 0.870310280567921 0.541545782541294 1.29202925989459 0.514033545209722 0.401350891548538 NA NA NA 0.168278204388225 79.1961711653921 a1088 EP300_mut 1373 Dabrafenib BRAF 3 14 2.30258509299405 NA 2.96576087477498 3.68235039566286 -0.716589520887887 2.34758308318234 1.05730050258978 0.549009589892304 0.305245648608309 0.677753882772829 0.401758063758168 NA NA NA 0.652587276792902 79.2036515775667 a1089 CDKN1A_mut 1262 UNC1215 LMBL3 3 15 0 NA 2.55277388257582 2.33778345353478 0.214990429041038 0.0761182120045142 0.42184087112082 0.543574095900205 2.8244282594064 0.509648172472747 0.402777399412941 NA NA NA 0.0859080434973364 79.2111353313259 a1090 TP53_mut 193 GW-2580 CSF1R (cFMS) 15 4 2.99573227355399 NA 5.2515618228255 5.47851977700118 -0.226957954175687 0.504152441457475 0.258721601398935 0.482639598465732 0.450177239089758 0.877228468548822 0.403003109216629 NA NA NA 0.244556138736657 79.2111353313259 a1091 ARID1A_mut 1036 PLX4720 BRAF 5 10 2.30258509299405 NA 3.54415307469146 3.86167274663557 -0.317519671944109 0.742211699869552 0.636444385037829 0.473368173442404 0.427802030067587 0.498896179161414 0.403116997521208 NA NA NA 0.440108829174836 79.2111353313259 a1092 gain_cnaBLCA23_(MYC) 306 TG101348 JAK2 4 15 2.32630161961136 NA 2.63976503648581 3.09358355391776 -0.453818517431944 1.1015062540884 0.904050048458409 0.481807731638594 0.411998130512225 0.501983842825735 0.403797466018756 NA NA NA 0.488898376085748 79.2111353313259 a1093 gain_cnaBLCA15_(ASXL1) 136 Mitomycin C DNA crosslinker 6 13 2.77258872223978 NA -0.753308174901305 -1.43063115719404 0.677322982292733 2.32101572753194 1.1816935913441 0.422491023741284 0.291821797783752 0.573179872730224 0.403887147388124 NA NA NA 0.523596605175307 79.2111353313259 a1094 CDKN1A_mut 150 Bicalutamide ANDR (androgen receptor) 3 16 0.0237165266173161 NA 2.5906681886069 2.32489105854147 0.265777130065432 0.140477604658596 0.522995055124195 0.538418490232507 1.89195374388218 0.508182873741163 0.404018798710001 NA NA NA 0.106677857637991 79.2111353313259 a1095 TP53_mut 273 CUDC-101 HDAC, EGFR 15 4 1.63315443905142 NA -0.200501346250793 0.491068463188097 -0.69156980943889 1.36553220405017 1.7366613406698 0.480923910582347 0.506447088825656 0.398218002119034 0.404642553208829 NA NA NA 0.501060705061213 79.2111353313259 a1096 gain_cnaBLCA9 302 PI-103 PI3Ka, PRKDC (DNAPK) 4 15 2.32630161961136 NA 3.08560431688589 1.97748209934765 1.10812221753824 1.82143477679106 2.39559856722698 0.480811199636414 0.608378752650418 0.462565904278756 0.404750407402564 NA NA NA 0.352235189036297 79.2111353313259 a1097 gain_cnaBLCA23_(MYC) 290 KIN001-260 IKK 4 15 2.99573227355399 NA 4.56691425612022 5.12935520690293 -0.562440950782707 1.2972335634245 1.1428589070574 0.480070248591266 0.433569533382985 0.49213507223815 0.40545989712469 NA NA NA 0.470916561845325 79.2776514417261 a1098 ARID1A_mut 1013 Nilotinib ABL 3 11 0.693147180559945 NA 3.17717646923347 2.84077939156205 0.336397077671423 0.681945914615017 0.582857334104931 0.560186929041687 0.493289966934301 0.577151659570372 0.406613929395765 NA NA NA 0.494820208437977 79.316743502048 a1099 TP53_mut 1495 AZD-2281 PARP1, PARP2 14 3 2.30258509299405 NA 3.23898842998269 3.62867619676412 -0.38968776678143 0.737849099345302 0.56982232537535 0.542950889835153 0.528140194420787 0.683875919611849 0.406850884267914 NA NA NA 0.372605233379024 79.316743502048 a1100 gain_cnaBLCA9 1230 IOX2 EGLN1 4 15 -2.30258509299405 NA 0.110977227905561 -0.220892547186123 0.331869775091684 0.675553846009777 0.697464869841646 0.478440836665555 0.491255844448084 0.475822925916014 0.407022970713747 NA NA NA 0.42664264130509 79.316743502048 a1101 gain_cnaBLCA9 207 AS601245 JNK 4 15 2.07944154167984 NA 1.75841172207102 2.34240155653825 -0.58398983446723 0.729536093061213 1.30321132756157 0.478010901465859 0.800494780205795 0.448115990182443 0.40743605450559 NA NA NA 0.269809150831594 79.316743502048 a1102 loss_cnaBLCA5_(FAT1,IRF2) 1175 AG-014699 PARP1, PARP2 5 14 1.6094379124341 NA 3.41765410957746 3.0338589793943 0.383795130183153 0.452236781432597 0.959627925172574 0.442482048687426 0.848659697619832 0.39994160248529 0.407508781595274 NA NA NA 0.258110991282776 79.316743502048 a1103 loss_cnaBLCA5_(FAT1,IRF2) 207 AS601245 JNK 5 14 2.07944154167984 NA 2.61696743245509 2.07748807672017 0.53947935573492 0.810168111130273 1.32296148676306 0.441536707522062 0.665885694985313 0.407781602966299 0.408491050500089 NA NA NA 0.307698198929316 79.3451789644557 a1104 MLL2_mut 1072 BMS-708163 g-secretase 3 15 1.6094379124341 NA 3.7233127566706 3.38193920117865 0.341373555491951 0.399501843105467 0.663217126052166 0.536532686698395 0.854498073997193 0.51472367356373 0.408765388561283 NA NA NA 0.292266481651904 79.3451789644557 a1105 gain_cnaBLCA15_(ASXL1) 1005 Cisplatin DNA crosslinker 4 10 1.79175946922805 2.30258509299405 2.88523105391164 2.36090519040618 0.524325863505465 0.620519128679993 1.14271913828589 0.50555987702884 0.844979371741276 0.458840537397463 0.409535618052615 NA NA NA 0.295949514292648 79.3451789644557 a1106 loss_cnaBLCA18_(CHD9,CNOT1,CYLD,MMP2,NUP93) 1133 JNJ-26854165 MDM2 3 16 2.30258509299405 NA 1.75794186907449 2.42124742346193 -0.66330555438744 0.44366157016283 1.31895285838332 0.531387948363226 1.49507101582857 0.502903155462642 0.410058718808369 NA NA NA 0.142241237256158 79.3451789644557 a1107 TP53_mut 235 QL-XII-47 BTK, BMX 15 4 2.32630161961136 NA 1.67747223688929 2.49470987564821 -0.817237638758919 1.56100456415649 2.32420412242712 0.475009408518059 0.523533151359184 0.351620423900416 0.410327489376301 NA NA NA 0.545007252773185 79.3451789644557 a1108 gain_cnaBLCA15_(ASXL1) 302 PI-103 PI3Ka, PRKDC (DNAPK) 6 13 2.32630161961136 NA 2.86721516917396 1.90779674943959 0.95941841973437 2.73363880775283 2.10222747689025 0.416061330493978 0.350967515171858 0.456381828456359 0.410932694275173 NA NA NA 0.468329384888412 79.3451789644557 a1109 NRAS_mut 134 Etoposide TOP2 3 16 2.77258872223978 NA 1.82891997943662 1.03440393590644 0.794516043530183 2.24073126386328 1.37098664387541 0.529775578283599 0.354578907494844 0.579521359365178 0.411452112332744 NA NA NA 0.606155806197905 79.3451789644557 a1110 loss_cnaBLCA18_(CHD9,CNOT1,CYLD,MMP2,NUP93) 152 CP466722 ATM 3 16 2.77258872223978 NA 2.53769135672154 3.19130091423542 -0.653609557513887 0.794998967758009 1.28131210827427 0.529630506616746 0.822151454305838 0.510109561357534 0.411577631821593 NA NA NA 0.303721881275945 79.3451789644557 a1111 gain_cnaBLCA15_(ASXL1) 186 Bexarotene Retinioic acid X family agonist 6 13 2.07944154167984 NA 3.25854599874888 3.67368686925773 -0.41514087050885 0.973212141105685 1.0099257746272 0.415445109710822 0.426567706026767 0.411060773908947 0.411612094830899 NA NA NA 0.412796322165003 79.3451789644557 a1112 gain_cnaBLCA15_(ASXL1) 1060 PD-0325901 MAP2K1 (MEK1), MAP2K2 (MEK2) 4 11 -1.38629436111989 0.693147180559945 -1.60696596268654 -0.892977440437847 -0.713988522248693 0.722830634161735 1.59568522372367 0.495157512526918 0.987767380773373 0.447449479153877 0.411750135019958 NA NA NA 0.25861657650275 79.3451789644557 a1113 EP300_mut 219 AT-7519 CDK9 4 15 2.32630161961136 NA 2.43029935175185 1.59053132316186 0.839768028589985 1.7557607817877 1.78081039438688 0.472731750409682 0.478292964110373 0.471565098247932 0.412530480485326 NA NA NA 0.437022672584858 79.3451789644557 a1114 gain_cnaBLCA23_(MYC) 1014 RDEA119 MAP2K1 (MEK1), MAP2K2 (MEK2) 3 12 1.6094379124341 NA 0.530436232489057 1.225021890142 -0.694585657652945 0.657852614048812 1.35307781293219 0.546437808869898 1.05583780138541 0.513337556062456 0.412565322939969 NA NA NA 0.242825706189298 79.3451789644557 a1115 gain_cnaBLCA23_(MYC) 1061 SB590885 BRAF 3 12 1.6094379124341 NA 3.41463259295414 3.86246861698292 -0.447836024028779 1.42927945410112 0.650717983048188 0.546071144207509 0.313329924909909 0.688218299932269 0.412870779871536 NA NA NA 0.645049283958469 79.3451789644557 a1116 loss_cnaBLCA18_(CHD9,CNOT1,CYLD,MMP2,NUP93) 154 CHIR-99021 GSK3B 3 16 0.940007258491471 NA 2.38380110278563 2.79047964794911 -0.406678545163481 0.827476457101268 0.762492540689066 0.527864482101496 0.491468417830419 0.53335412933478 0.413107624171082 NA NA NA 0.493152704873558 79.3451789644557 a1117 NRAS_mut 1261 rTRAIL TR10A (DR4), TR10B (DR5) 3 15 -2.30258509299405 NA -0.435391796518754 -1.21007529491003 0.774683498391279 1.25923077965952 1.48415053728977 0.531356894207754 0.615203750499765 0.52197097189746 0.41320371691865 NA NA NA 0.410885066161442 79.3451789644557 a1118 gain_cnaBLCA15_(ASXL1) 288 KIN001-055 JAK3, MNK1 6 13 2.32630161961136 NA 4.36401639567582 4.02202100222979 0.34199539344603 0.970154751423302 0.759431753988887 0.413536515293719 0.352516330971211 0.450330647421196 0.413720979950654 NA NA NA 0.467811729664393 79.3734465800764 a1119 ARID1A_mut 1060 PD-0325901 MAP2K1 (MEK1), MAP2K2 (MEK2) 5 10 -1.38629436111989 0.693147180559945 -0.639735882867268 -1.30519362812261 0.665457745255346 1.09324892958955 1.5729672234442 0.46133681384538 0.608697367309738 0.423058875822121 0.414857540419639 NA NA NA 0.360130220313413 79.4766638056979 a1120 EP300_mut 1243 piperlongumine Increases ROS levels 4 15 2.30258509299405 NA 0.967766079250092 1.38344959234229 -0.415683513092198 0.528468517863759 0.943484333316834 0.469958565893074 0.786581412214536 0.440583376335308 0.41522305087225 NA NA NA 0.277557514747403 79.4766638056979 a1121 NRAS_mut 1013 Nilotinib ABL 3 11 0.693147180559945 NA 3.17205847382738 2.84217520849099 0.329883265336389 0.690002730565847 0.581837580682677 0.548691583290571 0.478089796928576 0.566967958565573 0.416035203742835 NA NA NA 0.506654944517657 79.4766638056979 a1122 TP53_mut 196 Phenformin AAPK1 (AMPK) agonist 15 4 8.29404964010203 NA 9.1195107619247 8.53090337384256 0.58860738808214 1.1220548702358 1.74977399524424 0.468696623909765 0.524579861195598 0.336390522251406 0.416452049350007 NA NA NA 0.56055945536419 79.4766638056979 a1123 gain_cnaBLCA23_(MYC) 1042 BIRB 0796 p38, JNK2 3 12 2.30258509299405 NA 3.58131533363378 4.09008391661074 -0.508768582976955 1.84810886696663 0.649954645621181 0.541453817410533 0.275291457159673 0.782775515806508 0.416730151837606 NA NA NA 0.68243522917072 79.4766638056979 a1124 gain_cnaBLCA15_(ASXL1) 170 Shikonin unknown 6 13 2.77258872223978 NA -0.612050337680182 -0.00426621122281764 -0.607784126457364 1.87736080782599 1.27791024753554 0.410762734842806 0.323743908961851 0.475607835236848 0.416798250169418 NA NA NA 0.494272501433213 79.4766638056979 a1125 NRAS_mut 1264 SGC0946 Q8TEK3 (DOT1L) 3 15 -0.693147180559945 NA 1.39098706506547 1.62370441088528 -0.232717345819808 0.682580954387567 0.395208538932186 0.527128538028317 0.340937355963307 0.5888469577317 0.41685273302936 NA NA NA 0.618997389740248 79.4766638056979 a1126 gain_cnaBLCA9 178 BAY 61-3606 SYK 4 15 2.07944154167984 NA 1.66907035447079 2.36269986743887 -0.693629512968071 1.1557399700949 1.54421488351977 0.46769745283097 0.600160529977273 0.449179398780992 0.417426794788182 NA NA NA 0.359950151090468 79.5154333767646 a1127 loss_cnaBLCA18_(CHD9,CNOT1,CYLD,MMP2,NUP93) 163 JQ1 BRD4 3 16 0.940007258491471 NA -0.853771372337115 -0.138014568552716 -0.715756803784399 0.81338859837491 1.43200901512896 0.52101809073909 0.879969064250996 0.499827023588913 0.419073632577378 NA NA NA 0.281907676317576 79.6519412817333 a1128 gain_cnaBLCA9 299 OSI-027 MTORC1/2 4 15 2.99573227355399 NA 2.56596409312449 1.7154780892862 0.850486003838286 2.21110118728953 1.73139019908718 0.465961101843547 0.384643637626033 0.4912156741367 0.419124182986777 NA NA NA 0.514779451019137 79.6519412817333 a1129 NRAS_mut 190 Bleomycin DNA damage 3 16 4.15888308335967 NA 2.34235165622966 1.07922053954722 1.26313111668244 2.2589512856702 2.4466581633862 0.520808123067083 0.559167045653085 0.516267918250686 0.419257469929769 NA NA NA 0.445955421596304 79.6519412817333 a1130 loss_cnaBLCA18_(CHD9,CNOT1,CYLD,MMP2,NUP93) 1017 Olaparib PARP1, PARP2 3 11 1.6094379124341 NA 3.23826715973468 3.70115667871098 -0.462889518976303 1.23113967774287 0.752059562063708 0.544031967017835 0.37598456726287 0.61549582283895 0.419895245240279 NA NA NA 0.588357843112117 79.6705676941445 a1131 NRAS_mut 1017 Olaparib PARP1, PARP2 3 11 1.6094379124341 NA 3.96545047952624 3.50283395513147 0.462616524394769 0.6767412805287 0.881588548639059 0.543692481918324 0.683594362728032 0.524753327511941 0.420177401972692 NA NA NA 0.381722895641805 79.6705676941445 a1132 TP53_mut 295 NVP-BHG712 EPHB4 15 4 2.32630161961136 NA 3.77962889348886 3.10160695226444 0.678021941224425 1.28050407622335 2.10174731305909 0.464587766682808 0.529496120952731 0.322599171180842 0.420469831609388 NA NA NA 0.57486136414986 79.6705676941445 a1133 RB1_mut 1052 RO-3306 CDK1 5 10 1.6094379124341 NA 2.40015036273242 2.99039643945648 -0.590246076724058 1.12523570111418 1.36800661893248 0.454681599091881 0.524553279050434 0.431464342756365 0.421448144087831 NA NA NA 0.39521091729688 79.7644449839788 a1134 loss_cnaBLCA5_(FAT1,IRF2) 223 ZSTK474 PI3K 5 14 1.63315443905142 2.32630161961136 1.23166990248872 1.8737247611561 -0.642054858667382 1.55427552634472 1.48033791663785 0.428589927405409 0.413089473381429 0.433721822194232 0.422097827557989 NA NA NA 0.44928176232354 79.7644449839788 a1135 EP300_mut 287 KIN001-244 PDPK1 (PDK1) 4 15 2.99573227355399 NA 4.11285926348159 3.57013222628375 0.542727037197847 0.976981966994687 1.21209245802959 0.462277512100908 0.555513873881767 0.447760427517321 0.422739743614877 NA NA NA 0.387069442939423 79.7644449839788 a1136 gain_cnaBLCA15_(ASXL1) 1029 AMG-706 VEGFR, RET, c-KIT, PDGFR 4 11 0.693147180559945 NA 2.88856073086525 2.51713641255187 0.371424318313375 0.415595545997499 0.846732841581892 0.482995538197725 0.893715829946866 0.438655854684305 0.423034447592174 NA NA NA 0.282721990917244 79.7644449839788 a1137 RB1_mut 1239 YK 4-279 RNA helicase A 5 12 2.30258509299405 NA 1.54213534231818 1.10715095475109 0.434984387567087 1.16043241901235 0.923637715475303 0.438349412309382 0.37484680748346 0.470946974424106 0.4231157230588 NA NA NA 0.483105349561372 79.7644449839788 a1138 loss_cnaBLCA18_(CHD9,CNOT1,CYLD,MMP2,NUP93) 238 CAL-101 PI3Kdelta 3 16 2.99573227355399 2.32630161961136 4.44790815881373 4.89715569059577 -0.44924753178204 0.549454789068781 0.9053975338323 0.515722149676025 0.817624198968995 0.496188154920744 0.423726279151073 NA NA NA 0.307715111509584 79.7644449839788 a1139 gain_cnaBLCA23_(MYC) 1062 AZD6244 MAP2K1 (MEK1), MAP2K2 (MEK2) 3 11 1.38629436111989 0.693147180559945 1.36403672666945 2.23235778910603 -0.86832106243658 0.770404006120225 1.73037480042887 0.539123515242921 1.12709832183956 0.501810973103265 0.423987039742068 NA NA NA 0.240161992595297 79.7644449839788 a1140 gain_cnaBLCA23_(MYC) 1058 GDC0941 PI3K (class 1) 3 12 1.38629436111989 0.693147180559945 0.54861810513567 1.24454996781614 -0.695931862680471 0.954037241841616 1.36161289562496 0.532380899938921 0.729459849321067 0.511108454478207 0.424382801375628 NA NA NA 0.357482479272235 79.7644449839788 a1141 CDKN1A_mut 180 Thapsigargin sarco-endoplasmic reticulum Ca2+-ATPases 3 16 -0.669430653942629 NA -5.08930137471304 -4.2266250988232 -0.862676275889845 0.433270159147605 1.78239737922783 0.513237104529948 1.99108167889299 0.483997724605931 0.425920783736001 NA NA NA 0.112234721752634 79.7644449839788 a1142 gain_cnaBLCA23_(MYC) 330 XMD13-2 RIPK 4 15 2.32630161961136 NA 3.4413629905442 3.87585469654229 -0.43449170599809 1.4344152422447 0.804575524308885 0.458964028452068 0.302905109484307 0.540026004856797 0.426008996554133 NA NA NA 0.595852069580328 79.7644449839788 a1143 CDKN1A_mut 166 FTI-277 Farnesyl transferase (FNTA) 3 16 0.0237165266173161 NA 1.16578461899761 1.57507481707061 -0.409290198073001 0.534378149801778 0.828476603343479 0.511925215007037 0.765918663075619 0.49402746730714 0.427082203952296 NA NA NA 0.331156133320769 79.7644449839788 a1144 gain_cnaBLCA23_(MYC) 341 EX-527 SIRT1 4 15 2.99573227355399 NA 5.15863435544417 5.38224532248988 -0.22361096704571 0.719652577990486 0.422885744238535 0.45771610501649 0.310720719809144 0.528773953939623 0.427244420683447 NA NA NA 0.587671198486954 79.7644449839788 a1145 CDKN1A_mut 1268 XAV 939 TNKS1 (tankyrase-1) 3 15 1.6094379124341 NA 3.52997667617888 3.14088425020965 0.389092425969225 0.885849110065908 0.735293306178087 0.514839513217539 0.439231040081168 0.529166283304894 0.427575735832218 NA NA NA 0.534708970364217 79.7644449839788 a1146 gain_cnaBLCA15_(ASXL1) 175 PAC-1 CASP3 agonist 6 13 0.940007258491471 NA 2.36019804464975 2.73434129105498 -0.37414324640523 1.16633471864903 0.816154636979918 0.401056094107994 0.320785483294711 0.458422006630633 0.427682342913106 NA NA NA 0.499783294389318 79.7644449839788 a1147 gain_cnaBLCA15_(ASXL1) 333 T0901317 LXR 6 13 2.32630161961136 NA 4.64579661014618 4.38820377393084 0.257592836215338 0.642009054531771 0.64282025827349 0.400871680678974 0.401229288585665 0.400722959334216 0.427890859946319 NA NA NA 0.435688426128746 79.7644449839788 a1148 NRAS_mut 157 JNK-9L JNK 3 16 1.63315443905142 NA -0.844984851629235 -0.340567413354738 -0.504417438274497 1.78339652599072 0.825356663078806 0.510778523076301 0.282840877462337 0.611150864636971 0.42809902047111 NA NA NA 0.675204330971283 79.7644449839788 a1149 loss_cnaBLCA5_(FAT1,IRF2) 1067 CCT007093 PPM1D 5 13 1.88706964903238 NA 3.95590041186006 3.73535143445106 0.220548977409001 0.423433219738192 0.543032496648591 0.42763646100029 0.520858938619333 0.40614323962222 0.428354219941474 NA NA NA 0.384782774955111 79.7644449839788 a1150 TP53_mut 304 SB52334 ALK5 15 4 2.99573227355399 NA 4.64495449719629 5.1079875198811 -0.463033022684814 1.00482643571182 1.0590680263184 0.456365875882071 0.460808957874202 0.43720800853033 0.428583686149132 NA NA NA 0.471146520131831 79.7644449839788 a1151 gain_cnaBLCA23_(MYC) 287 KIN001-244 PDPK1 (PDK1) 4 15 2.99573227355399 NA 3.26124418994267 3.79722957922746 -0.535985389284793 1.99281288576814 0.907936853914713 0.456311635277531 0.268959214943151 0.590333333175989 0.428637541899005 NA NA NA 0.633331267377843 79.7644449839788 a1152 gain_cnaBLCA9 306 TG101348 JAK2 4 15 2.32630161961136 NA 3.33781915825686 2.90743578811215 0.430383370144709 1.33846809387563 0.835514573468616 0.455939222315353 0.321549218927217 0.515111745278104 0.429007428340478 NA NA NA 0.576564805737364 79.7644449839788 a1153 EP300_mut 257 NPK76-II-72-1 PLK3 4 15 2.32630161961136 NA 3.94857479574619 3.3263847831897 0.622190012556481 1.1407521737414 1.41060696670376 0.455195814667118 0.545420843263304 0.44107963964646 0.429746397348275 NA NA NA 0.394882100547444 79.7644449839788 a1154 CDKN1A_mut 200 LAQ824 HDAC 3 16 0.0237165266173161 NA -3.19072542532165 -2.67632133031477 -0.514404095006888 1.25386818638626 0.974239122580984 0.508727559583712 0.410253725704167 0.528005992660316 0.429921516751186 NA NA NA 0.558118868019151 79.7644449839788 a1155 CDKN1A_mut 147 NSC-87877 PTPN6 (SHP-1), PTPN11 (SHP-2) 3 16 2.77258872223978 NA 5.36123607945861 5.00876957591525 0.352466503543368 0.0849736005334337 0.737149808481926 0.508576795031715 4.14795302694848 0.478147724502881 0.430055680461108 NA NA NA 0.0824907155103012 79.7644449839788 a1156 loss_cnaBLCA5_(FAT1,IRF2) 299 OSI-027 MTORC1/2 5 14 2.99573227355399 NA 1.32846562588384 2.09669282731227 -0.768227201428432 2.17618754537825 1.7052311329353 0.420485799194799 0.353015163173772 0.450512066423537 0.430760863779358 NA NA NA 0.502162905404797 79.7644449839788 a1157 loss_cnaBLCA18_(CHD9,CNOT1,CYLD,MMP2,NUP93) 203 BMS-345541 IKBKB 3 16 2.77258872223978 NA 3.17341076643119 3.57374232960328 -0.400331563172089 0.868202630380088 0.777767439725514 0.507426384982839 0.461103835860102 0.514718851323182 0.431080290129187 NA NA NA 0.517211882391381 79.7644449839788 a1158 gain_cnaBLCA9 1057 NVP-BEZ235 PI3K (Class 1) and MTORC1/2 3 12 -1.38629436111989 0.693147180559945 -1.99088434165633 -2.65333083342502 0.662446491768694 1.25866884442957 1.26373992387303 0.52451853079714 0.526307213132709 0.524195270921304 0.431088274263689 NA NA NA 0.473159620767264 79.7644449839788 a1159 CDKN1A_mut 255 CP724714 ERBB2 3 16 2.32630161961136 NA 4.6940026677355 4.21477211243356 0.47923055530194 0.164529921617057 1.0039254891298 0.507277497351276 2.91272584701856 0.477356696777702 0.431213009229838 NA NA NA 0.0919913476686578 79.7644449839788 a1160 RB1_mut 1057 NVP-BEZ235 PI3K (Class 1) and MTORC1/2 5 10 -1.38629436111989 0.693147180559945 -2.14658628933148 -2.70796915794118 0.561382868609698 0.953445581588496 1.37850110193151 0.44446839910061 0.588793822584401 0.407241508783059 0.431695025558413 NA NA NA 0.376544655844474 79.7644449839788 a1161 loss_cnaBLCA5_(FAT1,IRF2) 173 FH535 unknown 5 14 3.46573590279973 NA 1.35681270055694 1.87780413113169 -0.520991430574746 0.549561898031619 1.38687042458512 0.419567333088056 0.948012284768642 0.37565977422195 0.43174972510819 NA NA NA 0.258004723319712 79.7644449839788 a1162 TP53_mut 203 BMS-345541 IKBKB 15 4 2.77258872223978 NA 3.58562455255369 3.2289353211602 0.356689231393491 0.833004506263781 0.538499193955047 0.4520426190761 0.428196040611264 0.662376537230745 0.432889717008502 NA NA NA 0.333260960518434 79.8387141485588 a1163 EP300_mut 302 PI-103 PI3Ka, PRKDC (DNAPK) 4 15 2.32630161961136 NA 3.03470947934726 1.99105405602462 1.04365542332264 1.34114623861143 2.46894145429473 0.451744790271849 0.778181672718403 0.422713718669674 0.433187361144786 NA NA NA 0.287718358129252 79.8387141485588 a1164 ARID1A_mut 167 OSU-03012 PDPK1 (PDK1) 5 14 2.77258872223978 NA 2.45487886465669 1.66780677199384 0.787072092662847 1.485943062841 1.98833755865133 0.418159352561995 0.529678500034873 0.395844301807944 0.433268401065499 NA NA NA 0.377742952587125 79.8387141485588 a1165 CDKN1A_mut 140 Vinorelbine Microtubules 3 16 -2.74887219562247 NA -4.54359946792787 -3.88519100856632 -0.658408459361552 1.02019177226167 1.3401063987762 0.503932313133804 0.645377150907541 0.491310585460095 0.434201726820666 NA NA NA 0.394226646151498 79.8656988071356 a1166 loss_cnaBLCA5_(FAT1,IRF2) 1502 Bicalutamide ANDR (androgen receptor) 4 13 2.30258509299405 NA 4.5086601797065 4.22718486832778 0.281475311378713 0.758004547543411 0.571278925469992 0.459034478835373 0.371337233122065 0.492710826234564 0.434611140688946 NA NA NA 0.529918428383382 79.8656988071356 a1167 EP300_mut 309 Y-39983 ROCK 4 15 2.99573227355399 NA 4.90167425598648 4.21202144968031 0.689652806306173 0.677756770270772 1.65886478711056 0.45014071626593 1.01755207259774 0.415737805555221 0.434792658997643 NA NA NA 0.228727663355735 79.8656988071356 a1168 gain_cnaBLCA9 1039 SL 0101-1 RSK, AURKB, PIM3 3 12 2.30258509299405 NA 4.55350913961402 4.14638243332287 0.407126706291155 0.717435133833256 0.794299231163068 0.519980532780797 0.56747528395477 0.512560871669248 0.434989666556103 NA NA NA 0.446886738680472 79.8656988071356 a1169 NRAS_mut 1022 AZD7762 CHEK1, CHEK2 3 11 0.693147180559945 NA 0.552411633361197 0.0664621203692648 0.485949512991932 0.596643040406439 0.976745595296271 0.525740495617651 0.81447277531453 0.497519021669641 0.435276588898233 NA NA NA 0.329058173581023 79.8656988071356 a1170 gain_cnaBLCA23_(MYC) 1259 BMN-673 PARP1 4 14 2.30258509299405 NA 2.47408609987173 1.73678907224042 0.737297027631315 1.63027107965882 1.62883708810554 0.452577672374564 0.452254251965025 0.452652406440994 0.436401652159438 NA NA NA 0.462109297592648 79.9715792661052 a1171 gain_cnaBLCA9 265 Tubastatin A HDAC6 4 15 2.99573227355399 NA 5.16907870837221 4.75208399466336 0.416994713708853 1.18020012307156 0.867563295540193 0.448188776126382 0.353325428083834 0.480650479166721 0.436751131848771 NA NA NA 0.54572986140986 79.9715792661052 a1172 MLL2_mut 152 CP466722 ATM 3 16 2.77258872223978 NA 3.60969683038307 2.99029988792389 0.619396942459185 0.355898757624089 1.31014396104882 0.500844358641109 1.74037399454317 0.472770138911553 0.436972178174953 NA NA NA 0.132341386096353 79.9715792661052 a1173 ARID1A_mut 184 BMS-754807 IGF1R 5 14 0.940007258491471 NA 1.42207699219043 0.715463573146484 0.706613419043947 1.4530356434834 1.77865299510667 0.413797184718059 0.486301504173679 0.397274466120116 0.43799486697111 NA NA NA 0.403821474821829 80.0904080617533 a1174 TP53_mut 1057 NVP-BEZ235 PI3K (Class 1) and MTORC1/2 11 4 -1.38629436111989 0.693147180559945 -2.67774511948009 -2.08935667794707 -0.588388441533021 1.02856752377932 1.84337458640571 0.465457373842835 0.572046489831871 0.319190926180818 0.439660049151376 NA NA NA 0.580247719392318 80.2323947585076 a1175 gain_cnaBLCA15_(ASXL1) 1261 rTRAIL TR10A (DR4), TR10B (DR5) 6 12 -2.30258509299405 NA -0.695067854023949 -1.27390814075526 0.578840286731307 1.41603192961931 1.48150855621831 0.396096362820822 0.408776295663703 0.390710053142623 0.439836543322809 NA NA NA 0.438631548426232 80.2323947585076 a1176 RB1_mut 1038 NU-7441 PRKDC (DNAPK) 5 10 0.693147180559945 NA 1.87942039229594 2.35979728699752 -0.48037689470158 1.05878084508286 1.11889474971024 0.436409556731908 0.453707579743745 0.429331619284106 0.43989353489795 NA NA NA 0.438484828556138 80.2323947585076 a1177 CDKN1A_mut 206 Ruxolitinib JAK1, JAK2, TYK2 3 16 1.65632149833295 0.0237165266173161 3.93000896496936 4.16620623210468 -0.236197267135321 0.705152542538654 0.435734007030458 0.496816102696227 0.33495910868445 0.542067553425572 0.440602888110815 NA NA NA 0.625099765793067 80.2934972509846 a1178 loss_cnaBLCA5_(FAT1,IRF2) 1062 AZD6244 MAP2K1 (MEK1), MAP2K2 (MEK2) 3 11 1.38629436111989 0.693147180559945 2.70249672589597 1.86732324386243 0.835173482033539 1.89103202750777 1.55274305788454 0.517437793340518 0.441649570120837 0.537869725317839 0.442378122718869 NA NA NA 0.536246916682801 80.4014320742497 a1179 CDKN1A_mut 172 Embelin XIAP 3 16 3.46573590279973 NA 2.41185825906529 2.78390953565486 -0.372051276589572 0.25367388820607 0.795121135510857 0.494790286505288 1.46665184667071 0.467917729731248 0.442435884129399 NA NA NA 0.159715187357 80.4014320742497 a1180 TP53_mut 155 AP-24534 ABL 15 4 -0.669430653942629 NA 0.305530974648345 -0.14152957254194 0.447060547190285 0.985192777960061 1.12195361486717 0.442339603881562 0.453779764926788 0.398466158730825 0.442652969926526 NA NA NA 0.505329333716921 80.4014320742497 a1181 loss_cnaBLCA5_(FAT1,IRF2) 192 LFM-A13 BTK 5 14 2.77258872223978 NA 4.58852143620511 4.31792342033621 0.270598015868898 0.612140877576904 0.675091017030308 0.409488896402071 0.442051863845512 0.400831901243843 0.442694558985696 NA NA NA 0.43376593723606 80.4014320742497 a1182 NRAS_mut 1015 CI-1040 MAP2K1 (MEK1), MAP2K2 (MEK2) 3 11 2.30258509299405 NA 1.84420140996629 2.40696291665824 -0.56276150669195 1.19983084337632 1.0660453647763 0.516539293784019 0.469034039088661 0.527896396613515 0.443151101273233 NA NA NA 0.515788577226826 80.4162568418026 a1183 TP53_mut 257 NPK76-II-72-1 PLK3 15 4 2.32630161961136 NA 3.3304278287555 3.93341337487445 -0.602985546118955 1.21810629627624 1.92029989772687 0.440630678584856 0.495018823859859 0.314005925237371 0.444386629648722 NA NA NA 0.585491956170019 80.5119859001923 a1184 gain_cnaBLCA23_(MYC) 1262 UNC1215 LMBL3 4 14 0 NA 2.23666979248888 2.41274244862812 -0.176072656139239 0.381204472704713 0.400579998035597 0.443486591435326 0.461885074143995 0.439544303266965 0.445498415599324 NA NA NA 0.456642529553214 80.5119859001923 a1185 CDKN1A_mut 235 QL-XII-47 BTK, BMX 3 16 2.32630161961136 NA 1.13646398620354 1.9832206935826 -0.846756707379058 0.758371544503438 1.81599447227686 0.490717448674296 1.1165459905718 0.466277139223563 0.446135426619919 NA NA NA 0.218838480036458 80.5119859001923 a1186 MLL2_mut 265 Tubastatin A HDAC6 3 16 2.99573227355399 NA 5.22430063585075 4.76779205286794 0.456508582982813 0.334357027780481 0.983699736000862 0.490281810124189 1.36533269844272 0.46407309697846 0.446532271014377 NA NA NA 0.174395360742856 80.5119859001923 a1187 NRAS_mut 309 Y-39983 ROCK 3 16 2.99573227355399 NA 4.99002304118663 4.23855935284942 0.751463688337217 0.999665574039394 1.59123452964191 0.490022592400159 0.751715081375408 0.472251999525379 0.446768508990999 NA NA NA 0.341088507130404 80.5119859001923 a1188 EP300_mut 299 OSI-027 MTORC1/2 4 15 2.99573227355399 NA 2.52725828638457 1.72579963775018 0.801458648634381 2.01758101091038 1.78643167230351 0.438112048791242 0.397237406726356 0.448636609538466 0.446949401363512 NA NA NA 0.506956404465306 80.5119859001923 a1189 EP300_mut 269 NSC-207895 MDM4 4 15 2.99573227355399 NA 3.15244275763501 3.72497159429341 -0.572528836658399 1.6759641998187 1.2145891108912 0.437750400955668 0.341611614806767 0.471376559796677 0.447318138813987 NA NA NA 0.55804907102192 80.5119859001923 a1190 loss_cnaBLCA5_(FAT1,IRF2) 330 XMD13-2 RIPK 5 14 2.32630161961136 NA 3.50121099810811 3.88551552998362 -0.384304531875501 0.676834937046363 1.01735100956302 0.405258627752966 0.567796534783748 0.37775018480649 0.447339611267388 NA NA NA 0.365407200285023 80.5119859001923 a1191 RB1_mut 273 CUDC-101 HDAC, EGFR 6 13 1.63315443905142 NA 0.3241041416511 -0.229836245455086 0.553940387106186 1.97900108578844 1.14825479455371 0.383849288468904 0.279909087005627 0.48241939831959 0.447414905235713 NA NA NA 0.545018862821783 80.5119859001923 a1192 gain_cnaBLCA23_(MYC) 257 NPK76-II-72-1 PLK3 4 15 2.32630161961136 NA 2.98492118339491 3.58335907981671 -0.598437896421799 1.74329738990544 1.27435173015187 0.437189037671491 0.343279293531358 0.469601823627201 0.447890880285437 NA NA NA 0.556482959334094 80.5119859001923 a1193 loss_cnaBLCA18_(CHD9,CNOT1,CYLD,MMP2,NUP93) 167 OSU-03012 PDPK1 (PDK1) 3 16 2.77258872223978 NA 1.09979554809631 2.02026890543177 -0.920473357335463 1.28483995440577 1.95051497807994 0.4884586059662 0.716410907194411 0.471912991020229 0.448195491721954 NA NA NA 0.358322045885472 80.5119859001923 a1194 MLL2_mut 1067 CCT007093 PPM1D 3 15 1.88706964903238 NA 4.00828255387612 3.75428153636905 0.254001017507065 0.4378897257286 0.526895170480568 0.491669958196423 0.580057038525933 0.482071257695144 0.448266334017955 NA NA NA 0.43625129794483 80.5119859001923 a1195 TP53_mut 1043 JNK Inhibitor VIII JNK 11 3 2.30258509299405 NA 3.8098682118763 4.23262139992286 -0.422753188046554 0.883352385805876 0.465418963387382 0.510282031546953 0.478578192394736 0.908328240365839 0.448558351145348 NA NA NA 0.302913220013375 80.5119859001923 a1196 ARID1A_mut 202 GSK-1904529A IGF1R 5 14 0.0237165266173161 NA 2.24008737567997 2.02061990051928 0.21946747516069 0.658530672885921 0.505148154519066 0.402593117930835 0.333268417397938 0.434461599428464 0.450281939194373 NA NA NA 0.52431224397816 80.6908419766156 a1197 EP300_mut 226 GSK1070916 AURKB 4 15 0.940007258491471 2.32630161961136 2.78785117723102 1.87853567074281 0.909315506488203 0.467264602458063 2.2960602648734 0.434483358784641 1.94603978496277 0.396032944082302 0.450657765207712 NA NA NA 0.171902489344616 80.6908419766156 a1198 gain_cnaBLCA23_(MYC) 197 Bryostatin 1 PRKC 4 15 -4.8283137373023 NA -2.81316821613933 -3.17508580575755 0.361917589618216 0.664594921131265 0.865035475260966 0.434383666468526 0.544568696074541 0.41838467897404 0.450759913913815 NA NA NA 0.400550094464024 80.6908419766156 a1199 loss_cnaBLCA18_(CHD9,CNOT1,CYLD,MMP2,NUP93) 277 ABT-869 VEGFR and PDGFR family 3 16 0.0237165266173161 NA 2.14568483074326 2.36809832015217 -0.222413489408905 0.505272369355817 0.452338759241503 0.484684235009343 0.440185339428841 0.491696731409565 0.451650836153247 NA NA NA 0.53480871112338 80.6908419766156 a1200 RB1_mut 1008 Methotrexate Dihydrofolate reductase (DHFR) 5 9 -1.6094379124341 NA 0.0271276945686541 -0.429448437354482 0.456576131923136 1.07954949460916 1.03988317443789 0.433483891764786 0.422932097326796 0.439064832614431 0.452108453468461 NA NA NA 0.464142781729246 80.6908419766156 a1201 gain_cnaBLCA23_(MYC) 279 BIX02189 MAP2K5 (MEK5) 4 15 2.99573227355399 NA 4.31729884794772 4.78798329471822 -0.470684446770504 1.32458282740448 1.03008337490358 0.432669042999082 0.355345424259208 0.456938203487228 0.452519020903347 NA NA NA 0.545415812150486 80.6908419766156 a1202 NRAS_mut 1058 GDC0941 PI3K (class 1) 3 12 1.38629436111989 0.693147180559945 0.581331456758318 1.23637162991048 -0.655040173152162 1.56013491760174 1.26054833371603 0.49961043800135 0.419861234923898 0.519647010457057 0.452781442560173 NA NA NA 0.553448311168351 80.6908419766156 a1203 EP300_mut 1218 JQ1 BRD2, BRD3, BRD4 4 15 0 NA 1.73047059775916 2.03916209734727 -0.308691499588111 1.12831848756318 0.59055313547753 0.431462779682282 0.273585430878466 0.522715876088776 0.453759109260938 NA NA NA 0.62946642193491 80.6908419766156 a1204 loss_cnaBLCA5_(FAT1,IRF2) 170 Shikonin unknown 5 14 2.77258872223978 NA -0.632838366725714 -0.0402550670249395 -0.592583299700774 0.565921591507868 1.66781215407004 0.399296318838814 1.04711201797738 0.355305780842685 0.453937607394624 NA NA NA 0.26364484126733 80.6908419766156 a1205 gain_cnaBLCA23_(MYC) 1114 Cetuximab EGFR 4 14 4.18661983833127 NA 6.0045679645388 5.75567296144218 0.248895003096623 0.2845374347626 0.62187417567749 0.433667392448274 0.87473552752131 0.400233701335916 0.455455743727976 NA NA NA 0.277961196211182 80.6908419766156 a1206 NRAS_mut 1016 Temsirolimus MTOR 3 11 -1.6094379124341 NA -2.09388484240582 -2.81691549361939 0.723030651213572 0.39749046770671 1.56725542337919 0.502148079204341 1.81898865496081 0.461335555409744 0.455650273876103 NA NA NA 0.193955972619253 80.6908419766156 a1207 RB1_mut 223 ZSTK474 PI3K 6 13 1.63315443905142 2.32630161961136 2.09152441205281 1.52625766894709 0.56526674310572 1.51157185856456 1.49816734945678 0.376312071704046 0.373959557332933 0.377305474792707 0.456233650880797 NA NA NA 0.465377557248094 80.6908419766156 a1208 loss_cnaBLCA18_(CHD9,CNOT1,CYLD,MMP2,NUP93) 271 VNLG/124 HDAC, RAR 3 16 1.63315443905142 NA 3.75036129210414 3.9810687019869 -0.230707409882764 0.494787413816958 0.479392349436056 0.479412844005759 0.46627582561773 0.481249669825064 0.456504064742843 NA NA NA 0.514838425549734 80.6908419766156 a1209 gain_cnaBLCA15_(ASXL1) 1020 Lenalidomide TNFA 4 10 1.6094379124341 NA 4.05757094980494 3.6453697505258 0.412201199279142 0.462482432512466 1.01105285963554 0.455160273994706 0.891279690430255 0.407695003629908 0.456556110015454 NA NA NA 0.317708236502946 80.6908419766156 a1210 NRAS_mut 346 THZ-2-102-1 CDK7 3 16 0.916290731874155 2.99573227355399 0.661135593755813 -0.509120728453712 1.17025632220952 3.38281195544448 2.28703398937986 0.479297247556281 0.345941878420422 0.511691705345771 0.456610848363773 NA NA NA 0.615482840121471 80.6908419766156 a1211 CDKN1A_mut 1129 PF-4708671 RPS6KB1 (p70S6KA) 3 16 2.30258509299405 NA 3.32794651090507 3.75030126832306 -0.422354757417985 1.28779421275472 0.813375887804079 0.478574020222233 0.327967584599194 0.519261467853739 0.457279285738693 NA NA NA 0.632146117097102 80.6908419766156 a1212 gain_cnaBLCA9 273 CUDC-101 HDAC, EGFR 4 15 1.63315443905142 NA 0.433107672216618 -0.185045135325066 0.618152807541684 2.49664807716762 1.09405432133236 0.42802443292367 0.247593088186847 0.565011074394264 0.457305321002244 NA NA NA 0.659252084812491 80.6908419766156 a1213 loss_cnaBLCA5_(FAT1,IRF2) 1262 UNC1215 LMBL3 4 14 0 NA 2.50704894093821 2.33549126335688 0.171557677581331 0.213125080793464 0.428826935399368 0.431696677716472 0.804962404906184 0.400062737247508 0.45747061637886 NA NA NA 0.297112948688059 80.6908419766156 a1214 loss_cnaBLCA18_(CHD9,CNOT1,CYLD,MMP2,NUP93) 1091 BMS-536924 IGF1R 3 16 1.38629436111989 NA 1.98528196592218 2.46982624372387 -0.484544277801694 1.05956627964869 1.00690704528404 0.478210709284202 0.457304358498789 0.481220466249702 0.457615299078171 NA NA NA 0.521784583919384 80.6908419766156 a1215 NRAS_mut 1003 Camptothecin TOP1 3 11 -2.30258509299405 NA -3.46143094704155 -4.47692563348643 1.01549468644488 3.27077286080967 1.67695352493586 0.499905946547204 0.3104754532522 0.605559230679168 0.457617636984862 NA NA NA 0.649260126345525 80.6908419766156 a1216 MLL2_mut 1054 PD-0332991 CDK4, CDK6 3 12 1.38629436111989 0.693147180559945 1.26319062139451 2.11956966447329 -0.856379043078773 0.549473643820957 1.86934614224222 0.494159290152628 1.55854435005043 0.458116891102669 0.457619679961341 NA NA NA 0.196319538050487 80.6908419766156 a1217 loss_cnaBLCA5_(FAT1,IRF2) 1372 Trametinib MAP2K1 (MEK1), MAP2K2 (MEK2) 3 12 0 NA -0.666128728822521 -1.73063866734508 1.06450993852256 0.74585276387283 2.32286837336716 0.493591447868926 1.42723871263158 0.458273895640277 0.458125537536682 NA NA NA 0.207813516014706 80.6908419766156 a1218 NRAS_mut 230 GSK429286A ROCK2 3 16 2.99573227355399 2.32630161961136 5.47955909645839 4.67038970116455 0.80916939529384 0.582481206581476 1.79234080617167 0.47726674048518 1.38917682862727 0.451459561991549 0.458489048218663 NA NA NA 0.176910181640121 80.6908419766156 a1219 TP53_mut 1029 AMG-706 VEGFR, RET, c-KIT, PDGFR 11 4 0.693147180559945 NA 2.52438311480341 2.86863229967352 -0.344249184870119 0.852014766409212 0.402277434347089 0.446005536142355 0.404041336420665 0.85575067224153 0.458583532253745 NA NA NA 0.312944624944248 80.6908419766156 a1220 loss_cnaBLCA18_(CHD9,CNOT1,CYLD,MMP2,NUP93) 1062 AZD6244 MAP2K1 (MEK1), MAP2K2 (MEK2) 3 11 1.38629436111989 0.693147180559945 2.67847283020192 1.87387521541535 0.804597614786565 1.66737198135547 1.60686143513261 0.497554719767508 0.482554357266145 0.500726196543613 0.459686498225601 NA NA NA 0.507864949854308 80.8186171102833 a1221 TP53_mut 224 AS605240 PI3Kgamma 15 4 2.99573227355399 2.32630161961136 3.21214945174227 3.8172140842006 -0.605064632458331 1.09324651717844 2.42689188775303 0.425337922490213 0.553456720831769 0.249316681765555 0.460087884994408 NA NA NA 0.657377951932907 80.822937598656 a1222 gain_cnaBLCA15_(ASXL1) 1015 CI-1040 MAP2K1 (MEK1), MAP2K2 (MEK2) 4 10 2.30258509299405 NA 1.93511833241221 2.42687229834907 -0.491753965936858 1.20200362796962 1.05223917838782 0.450485740090369 0.409111881606805 0.46734048307372 0.461085579596959 NA NA NA 0.506334915632152 80.9101912784358 a1223 MLL2_mut 282 EKB-569 EGFR 3 16 0.916290731874155 2.99573227355399 2.54454410794874 1.79973406109658 0.744810046852159 0.688339189191699 1.65501958437435 0.473663355116987 1.08203928898305 0.450030956663102 0.461833749948416 NA NA NA 0.232648096191942 80.9101912784358 a1224 MLL2_mut 226 GSK1070916 AURKB 3 16 0.940007258491471 2.32630161961136 2.90500842941368 1.91340090511408 0.991607524299603 0.495125623081138 2.22258466138398 0.473399972712145 2.00273926065245 0.446150619829319 0.462078805690684 NA NA NA 0.13243119594884 80.9101912784358 a1225 loss_cnaBLCA18_(CHD9,CNOT1,CYLD,MMP2,NUP93) 1114 Cetuximab EGFR 3 15 4.18661983833127 NA 5.58299379444939 5.8565807956665 -0.273587001217112 0.510897555549519 0.582722314822445 0.476436743819611 0.535502662413099 0.469498068390385 0.462203797655128 NA NA NA 0.466678653653949 80.9101912784358 a1226 TP53_mut 254 AC220 FLT3 15 4 0.0237165266173161 NA 2.33509740148803 2.55476096524244 -0.219663563754406 0.505964546519668 0.579180606094311 0.422726505866656 0.434148134025173 0.379266089787954 0.462802547154704 NA NA NA 0.524766497451069 80.9101912784358 a1227 NRAS_mut 331 QL-X-138 MNK2, PRKDC (DNAPK), MTOR, BTK, JAK3 3 16 2.32630161961136 NA 2.61878804216305 1.95794455016524 0.660843491997806 1.77929036645917 1.33944628502729 0.472573917937109 0.37140845836922 0.493370655758952 0.462847895032984 NA NA NA 0.592895364039919 80.9101912784358 a1228 gain_cnaBLCA9 309 Y-39983 ROCK 4 15 2.99573227355399 NA 4.86878644971957 4.22079153135149 0.647994918368083 1.10121277267713 1.61337438199142 0.42202085165344 0.588437524923324 0.401639523721859 0.463537768525765 NA NA NA 0.37951711806612 80.9428529936085 a1229 loss_cnaBLCA5_(FAT1,IRF2) 1042 BIRB 0796 p38, JNK2 3 12 2.30258509299405 NA 4.35640859345854 3.89631060165455 0.460097991803991 0.928611713514001 0.947071924689709 0.487260120677564 0.495468649714652 0.485811034842717 0.463789479684505 NA NA NA 0.497966639945821 80.9428529936085 a1230 loss_cnaBLCA5_(FAT1,IRF2) 262 VX-11e ERK 5 14 1.63315443905142 NA 3.26871623069111 2.69708741806314 0.57162881262797 1.26782165632753 1.52070280327385 0.390154798371125 0.450874781776323 0.375897783181129 0.464169209509745 NA NA NA 0.434979530093496 80.943264258979 a1231 gain_cnaBLCA23_(MYC) 1261 rTRAIL TR10A (DR4), TR10B (DR5) 4 14 -2.30258509299405 NA -1.5634033099984 -0.943120826658082 -0.620282483340323 1.63484557316463 1.42219599430165 0.423568187012687 0.379413501508659 0.43614416425417 0.46583901708001 NA NA NA 0.526048209316987 81.1684598566077 a1232 EP300_mut 305 TPCA-1 IKK 4 15 2.99573227355399 NA 4.07633201035443 3.42358484134568 0.652747169008748 1.21530062702085 1.62005262749702 0.419424140612476 0.537107571983135 0.402917262025767 0.466249384198862 NA NA NA 0.409156994165387 81.1740212849334 a1233 RB1_mut 1046 681640 WEE1, CHEK1 5 10 0.693147180559945 NA 1.89022222603558 1.51168479747279 0.378537428562791 0.54755428949198 1.04621876575959 0.410573571423062 0.691324012663653 0.361814795290889 0.466844085806034 NA NA NA 0.3746668038429 81.1765645981205 a1234 MLL2_mut 1236 UNC0638 G9a(EHMT2), GLP(EHMT1) 3 16 2.99573227355399 NA 3.12768902231431 3.72625242727295 -0.598563404958642 1.42065732844459 1.25887913587095 0.468002639661987 0.421328488562389 0.475473290408082 0.467117980392987 NA NA NA 0.550879532279722 81.1765645981205 a1235 EP300_mut 268 YM155 BIRC5 (Survivin) 4 15 1.63315443905142 NA -4.55227655108832 -3.65743008279841 -0.894846468289908 0.826210649348711 2.32799003266567 0.417969527384077 1.08307302622558 0.384385867522492 0.467772551504096 NA NA NA 0.23893334591744 81.1765645981205 a1236 gain_cnaBLCA9 1114 Cetuximab EGFR 4 14 4.18661983833127 NA 5.62281802930317 5.8647443715095 -0.24192634220633 0.620399337728448 0.563389273731596 0.421100501521519 0.389952611961399 0.429412403619147 0.468397875470708 NA NA NA 0.517359568340638 81.1765645981205 a1237 EP300_mut 155 AP-24534 ABL 4 15 -0.669430653942629 NA 0.54484909065898 0.122496664461433 0.422352426197547 0.793118013167418 1.05375298806432 0.417078524536043 0.532521540534465 0.400807808833248 0.468707029053303 NA NA NA 0.41258880618733 81.1765645981205 a1238 NRAS_mut 274 PXD101, Belinostat HDAC 3 16 2.99573227355399 NA -0.108464778230763 0.55698266775722 -0.665447445987984 0.176890382053224 1.52149466024252 0.4651908540903 3.76191988656431 0.437364299314672 0.469756296149409 NA NA NA 0.10979942275784 81.1765645981205 a1239 gain_cnaBLCA9 282 EKB-569 EGFR 4 15 0.916290731874155 2.99573227355399 2.43373096074971 1.77963023055951 0.654100730190203 1.50781398048582 1.58708662406515 0.415727654625021 0.433807312211981 0.412139274739017 0.470125958370833 NA NA NA 0.480667275118797 81.1765645981205 a1240 loss_cnaBLCA5_(FAT1,IRF2) 283 GSK2126458 PI3K, MTOR 5 14 -2.05572501506252 0.0237165266173161 -2.67161791534816 -2.05606862037006 -0.615549294978093 1.78147694409471 1.54020482492734 0.384658025017073 0.345527511326226 0.399654179116814 0.470388313203255 NA NA NA 0.516970640468591 81.1765645981205 a1241 TP53_mut 1529 MLN4924 NEDD8-activating enzyme 13 3 0 NA -0.376387786379785 0.393053836663799 -0.769441623043585 1.66149746437806 1.3412053970076 0.475074208905059 0.463101292382415 0.573694099919599 0.470523973691273 NA NA NA 0.446344419724587 81.1765645981205 a1242 gain_cnaBLCA23_(MYC) 1028 VX-702 p38 4 10 0.693147180559945 NA 3.13271855959466 2.80788252337839 0.324836036216266 0.494996286965076 0.80161109625608 0.440745698246591 0.656239339102729 0.405228966681488 0.470614007081663 NA NA NA 0.382567000337249 81.1765645981205 a1243 gain_cnaBLCA9 1194 SB-505124 TGFR1 (ALK5) 4 15 2.30258509299405 NA 4.42018937742153 3.99146770680501 0.428721670616514 0.509173540640823 1.11299814964251 0.415255153761636 0.841995187096613 0.385195312996897 0.470622874845469 NA NA NA 0.286898573706659 81.1765645981205 a1244 EP300_mut 194 AUY922 HSP90 4 15 -1.36257783450257 NA -3.52815690305829 -2.6008936139368 -0.927263289121484 1.2294779509099 2.39497562313511 0.415081553521609 0.754192694903754 0.387170240967907 0.470805524940005 NA NA NA 0.312692010139898 81.1765645981205 a1245 CDKN1A_mut 341 EX-527 SIRT1 3 16 2.99573227355399 NA 5.14386736638515 5.37103844749809 -0.227171081112935 0.350416047309353 0.505918005730369 0.463434058501409 0.64828960561953 0.449027467968805 0.471409256838638 NA NA NA 0.397700355060465 81.1919953349351 a1246 gain_cnaBLCA23_(MYC) 156 AZD6482 PI3Kbeta 4 15 1.63315443905142 NA 1.54288719547002 2.1215851279046 -0.578697932434589 1.68247582438036 1.32771853090158 0.414277466370211 0.343956165104315 0.435858895515773 0.471652085635489 NA NA NA 0.558284485407037 81.1919953349351 a1247 gain_cnaBLCA15_(ASXL1) 1042 BIRB 0796 p38, JNK2 4 11 2.30258509299405 NA 4.28789459635246 3.8793976922564 0.408496904096066 0.782054101620064 0.988675021747954 0.432266571911143 0.522338420385296 0.413176114608269 0.472252743197842 NA NA NA 0.434246124427688 81.1961561695214 a1248 RB1_mut 1264 SGC0946 Q8TEK3 (DOT1L) 6 12 -0.693147180559945 NA 1.69371591633208 1.53051932170693 0.163196594625151 0.257519366494514 0.505943793234705 0.367958180033591 0.633725520711964 0.322558744286136 0.472433361067845 NA NA NA 0.377983664978229 81.1961561695214 a1249 gain_cnaBLCA9 304 SB52334 ALK5 4 15 2.99573227355399 NA 5.07439821079319 4.6539116462864 0.420486564506795 1.38530236382934 0.920475843870541 0.413033573529378 0.303534142065896 0.456814339351565 0.472963484375395 NA NA NA 0.598610619420849 81.2221854994748 a1250 gain_cnaBLCA23_(MYC) 262 VX-11e ERK 4 15 1.63315443905142 NA 2.36989439191499 2.97488182924531 -0.604987437330322 1.78531665027757 1.38817536867319 0.412651646968896 0.338868422717204 0.435814848024976 0.473366576680718 NA NA NA 0.563340042111129 81.2263755558777 a1251 NRAS_mut 200 LAQ824 HDAC 3 16 0.0237165266173161 NA -3.15030776938894 -2.68389964080215 -0.466408128586793 0.426386769130749 1.06885652034803 0.459691284891066 1.09386163538243 0.436361775137907 0.47494245367339 NA NA NA 0.23513937880952 81.2287252956509 a1252 NRAS_mut 229 LY317615 PRKCB (PKCbeta) 3 16 2.99573227355399 2.32630161961136 4.44538975900104 3.67818277776966 0.767206981231379 1.4261788321082 1.70134907875071 0.459040013048712 0.537945847995289 0.450940368918726 0.475558872878302 NA NA NA 0.465331459934676 81.2287252956509 a1253 gain_cnaBLCA9 147 NSC-87877 PTPN6 (SHP-1), PTPN11 (SHP-2) 4 15 2.77258872223978 NA 5.28975634601721 5.0043330712634 0.285423274753809 0.560795885651976 0.721031055479623 0.410419849351371 0.508961071320947 0.395854343006 0.475726172611092 NA NA NA 0.429060098562637 81.2287252956509 a1254 gain_cnaBLCA23_(MYC) 205 BMS-708163 g-secretase 4 15 2.32630161961136 0.940007258491471 4.60893413445128 4.75934606182396 -0.150411927372684 0.246994828822197 0.387690583369119 0.410060114739113 0.60896792086672 0.387968998538914 0.476107163676882 NA NA NA 0.373398750210351 81.2287252956509 a1255 RB1_mut 1050 ZM-447439 AURKB 5 10 1.38629436111989 0.693147180559945 2.55465938806788 2.03194593407863 0.522713453989247 1.19056980531772 1.34964173061225 0.401233290712804 0.439044776420946 0.387297934061452 0.476834960318311 NA NA NA 0.463035646473287 81.2287252956509 a1256 gain_cnaBLCA9 293 MP470 PDGFR 4 15 2.99573227355399 NA 3.50559429278633 4.09723063871312 -0.591636345926788 2.33243078789766 1.17141171312427 0.409234343106393 0.253656549637669 0.505062685730565 0.476982418860456 NA NA NA 0.653242150861459 81.2287252956509 a1257 TP53_mut 300 CX-5461 RNA Pol I 15 4 2.32630161961136 NA 3.9330082394661 4.46661977451261 -0.533611535046514 1.29701729715713 1.3405094830426 0.408961113895487 0.411414355241146 0.39806621422428 0.477272232398592 NA NA NA 0.51065890131145 81.2287252956509 a1258 RB1_mut 310 YM201636 FYV1 6 13 1.63315443905142 NA 3.09170192306724 2.65954607181884 0.432155851248401 0.971162039046098 1.29085489493952 0.35843936642085 0.444988409630257 0.334782672275995 0.477566531609971 NA NA NA 0.433191831284442 81.2287252956509 a1259 gain_cnaBLCA9 185 OSI-906 IGF1R 4 15 0.940007258491471 NA 1.87314273419679 2.3807910659088 -0.507648331712006 0.763000695064222 1.32337664406917 0.408411665108596 0.665331414500582 0.383600794216128 0.477855349308977 NA NA NA 0.348762949009069 81.2287252956509 a1260 TP53_mut 1170 CCT018159 HSP90 15 4 2.30258509299405 NA 2.55599568160547 2.92959824747281 -0.373602565867337 0.749244028819752 1.46200062920659 0.407755619104938 0.498639363807617 0.255542000737774 0.478552151349257 NA NA NA 0.651179565721535 81.2287252956509 a1261 gain_cnaBLCA9 288 KIN001-055 JAK3, MNK1 4 15 2.32630161961136 NA 4.39747413177412 4.05869832506305 0.338775806711073 1.05206155241867 0.775705496428482 0.407585145924135 0.322011393660601 0.436732507724737 0.478733313982901 NA NA NA 0.580372286456461 81.2287252956509 a1262 NRAS_mut 167 OSU-03012 PDPK1 (PDK1) 3 16 2.77258872223978 NA 2.59958665738549 1.73905807244005 0.860528584945435 2.25421046372341 1.83441256524815 0.45563161251293 0.381742787017344 0.469103080325351 0.478792667064241 NA NA NA 0.584656181390427 81.2287252956509 a1263 ARID1A_mut 1133 JNJ-26854165 MDM2 5 14 2.30258509299405 NA 2.66475266626177 2.19214436080754 0.472608305454231 1.91476157531781 0.965225642357158 0.376570410943548 0.246823579262493 0.489635049790102 0.479629363968901 NA NA NA 0.62094287509584 81.2287252956509 a1264 CDKN1A_mut 256 JW-7-24-1 LCK 3 16 2.32630161961136 NA 1.69490122122768 2.24977481959827 -0.554873598370597 0.577706377193399 1.28191214321029 0.454687122304784 0.960476844770647 0.432848383026491 0.479691084901874 NA NA NA 0.271329756359015 81.2287252956509 a1265 TP53_mut 211 TL-2-105 CRAF 15 4 2.32630161961136 1.63315443905142 4.30723816403198 4.65112076664128 -0.343882602609305 0.851363880669691 0.820710366168428 0.406463732434835 0.403919652239421 0.419006042551597 0.479926062738299 NA NA NA 0.494042843164534 81.2287252956509 a1266 ARID1A_mut 155 AP-24534 ABL 5 14 -0.669430653942629 NA 0.492414005585709 0.111055450116348 0.381358555469361 0.71807722442513 1.08831568728154 0.376299859092351 0.531082928823797 0.35041170491803 0.479940358275212 NA NA NA 0.3976198968645 81.2287252956509 a1267 NRAS_mut 265 Tubastatin A HDAC6 3 16 2.99573227355399 NA 5.19664643150466 4.77297721618283 0.423669215321831 0.506498436499949 0.976336940504548 0.453889930356211 0.836466975593267 0.433937504303472 0.480450169406943 NA NA NA 0.313011984866136 81.2287252956509 a1268 loss_cnaBLCA5_(FAT1,IRF2) 346 THZ-2-102-1 CDK7 5 14 0.916290731874155 2.99573227355399 -1.00167939499248 -0.082437707073538 -0.919241687918945 1.74780477542757 2.62344497702591 0.375848002452339 0.525940711939107 0.350394880002801 0.480460026284766 NA NA NA 0.400277351822901 81.2287252956509 a1269 gain_cnaBLCA15_(ASXL1) 1069 EHT 1864 Rac GTPases 5 13 2.30258509299405 NA 3.22180106191579 3.59078200929947 -0.368980947383683 0.66536140212531 1.05672079679397 0.378931495226913 0.554557186823698 0.349175438302293 0.481863096403349 NA NA NA 0.394608241789936 81.2287252956509 a1270 RB1_mut 265 Tubastatin A HDAC6 6 13 2.99573227355399 NA 5.0660203964513 4.73549633651781 0.330524059933488 0.886353388656513 0.952560381810657 0.354041151404681 0.372903250738939 0.346984890664062 0.482906227970443 NA NA NA 0.476836718555163 81.2287252956509 a1271 loss_cnaBLCA5_(FAT1,IRF2) 1375 Temozolomide DNA akylating agent 4 14 3.40119738166216 NA 5.08813995886551 5.37354156439521 -0.285401605529708 0.942790101777335 0.632448895748934 0.407030542569551 0.302720197201554 0.451264295736877 0.483149707821014 NA NA NA 0.600681016956614 81.2287252956509 a1272 NRAS_mut 272 AR-42 HDAC 3 16 1.63315443905142 NA -0.484419713549564 0.158874477789592 -0.643294191339156 0.3550256552912 1.51360526093526 0.450805027792254 1.81196536574663 0.425007898652297 0.483394322633039 NA NA NA 0.155369649521897 81.2287252956509 a1273 gain_cnaBLCA23_(MYC) 1377 Afatinib (rescreen) ERBB2, EGFR 4 14 2.30258509299405 NA 2.91991961133483 3.47055097510574 -0.550631363770909 0.587356828925293 1.47594343857226 0.406523081063018 0.937473332485839 0.373070775871708 0.483686886702475 NA NA NA 0.282421378255438 81.2287252956509 a1274 loss_cnaBLCA5_(FAT1,IRF2) 225 Genentech Cpd 10 AURKA, AURKB 5 14 2.32630161961136 NA 2.59254191594307 3.17450212800385 -0.581960212060781 0.482737982161292 1.76449923922759 0.3728897001163 1.20554054904745 0.329816074228253 0.483870537060084 NA NA NA 0.277760234570566 81.2287252956509 a1275 NRAS_mut 166 FTI-277 Farnesyl transferase (FNTA) 3 16 0.0237165266173161 NA 1.81492014721945 1.45336190552902 0.361558241690431 0.694840017788353 0.816254473139454 0.450301997215521 0.520347464789458 0.442947945264932 0.483875413055548 NA NA NA 0.478131928168095 81.2287252956509 a1276 TP53_mut 159 HG-6-64-1 BRAFV600E, TAK, MAP4K5 15 4 1.63315443905142 NA 0.229926824192036 0.692670777626208 -0.462743953434173 1.07549335448985 1.44427574625945 0.402664639446906 0.430262029516371 0.320398618222759 0.483979929925918 NA NA NA 0.582497189214967 81.2287252956509 a1277 CDKN1A_mut 1175 AG-014699 PARP1, PARP2 3 16 1.6094379124341 NA 3.46549561473589 3.07286308844999 0.392632526285895 0.641908156888788 0.898840619934644 0.449983368948935 0.6116646471497 0.436821075481039 0.484180290486469 NA NA NA 0.420419326905592 81.2287252956509 a1278 loss_cnaBLCA18_(CHD9,CNOT1,CYLD,MMP2,NUP93) 175 PAC-1 CASP3 agonist 3 16 0.940007258491471 NA 2.26179380754684 2.68264022681079 -0.420846419263949 1.09315037565909 0.914048001269071 0.449191467682659 0.384984928546732 0.460420479755596 0.484938507834411 NA NA NA 0.58219965505973 81.2287252956509 a1279 NRAS_mut 253 XMD14-99 EPHB3, CAMK1 3 16 2.32630161961136 NA 4.54325126093681 4.7570527973415 -0.213801536404691 0.745810928896119 0.427736577390717 0.448868470619527 0.286669889272258 0.499843940653672 0.485247967289492 NA NA NA 0.672683383016181 81.2287252956509 a1280 MLL2_mut 281 CH5424802 ALK 3 16 1.63315443905142 NA 3.95810435102727 4.12140603646634 -0.163301685439076 0.283013711588865 0.373415644209928 0.448695733117671 0.577009801123365 0.437318810743963 0.485413512767546 NA NA NA 0.44139892615483 81.2287252956509 a1281 TP53_mut 208 SB-715992 KIF11 15 4 -2.05572501506252 NA -1.29912119535555 -0.669349623011248 -0.629771572344302 1.58189209983484 1.51224196048772 0.40117298785332 0.398112850054725 0.416448947191751 0.485577135756585 NA NA NA 0.497097229795909 81.2287252956509 a1282 ARID1A_mut 1054 PD-0332991 CDK4, CDK6 5 10 1.38629436111989 0.693147180559945 2.40350433674615 1.72068861541323 0.68281572133292 1.50663423255027 1.83087897879984 0.392972115185656 0.453206031418204 0.372944213811724 0.485779866995624 NA NA NA 0.460369585747541 81.2287252956509 a1283 MLL2_mut 1061 SB590885 BRAF 3 12 1.6094379124341 NA 3.46733332541366 3.84929343386804 -0.381960108454371 0.211360641524939 0.893679742020019 0.462289671914714 1.80714869948624 0.427401551691226 0.486549336975921 NA NA NA 0.203853289202033 81.2287252956509 a1284 loss_cnaBLCA5_(FAT1,IRF2) 230 GSK429286A ROCK2 5 14 2.99573227355399 2.32630161961136 5.26199793455004 4.6324944882327 0.629503446317333 0.720937142304597 1.90103230869147 0.370560181610124 0.873173830807245 0.331137689474956 0.486566197289676 NA NA NA 0.310357173785852 81.2287252956509 a1285 CDKN1A_mut 306 TG101348 JAK2 3 16 2.32630161961136 NA 2.64110370215422 3.06496889676544 -0.423865194611215 0.889603509127033 0.955543136956498 0.447104047590622 0.476465290730647 0.443585619756811 0.486940495298741 NA NA NA 0.509612680252818 81.2287252956509 a1286 gain_cnaBLCA23_(MYC) 1243 piperlongumine Increases ROS levels 4 15 2.30258509299405 NA 1.01560965650833 1.37069130507343 -0.355081648565096 0.44310776715475 0.958368618107278 0.399236267839817 0.801343769812746 0.370506339477561 0.48765553827277 NA NA NA 0.307221765648362 81.2287252956509 a1287 gain_cnaBLCA9 166 FTI-277 Farnesyl transferase (FNTA) 4 15 0.0237165266173161 NA 1.25738106246974 1.57793511201624 -0.3205540495465 0.80563868712212 0.802597415461623 0.399128503401634 0.397888103774626 0.399395815848883 0.487771339882836 NA NA NA 0.512522424950401 81.2287252956509 a1288 EP300_mut 294 MPS-1-IN-1 MPS1 4 15 2.99573227355399 NA 4.74132721352316 4.27222122475853 0.469105988764629 0.631958971994953 1.26553769344181 0.397972066506973 0.742304500059184 0.370677215855049 0.489015042766431 NA NA NA 0.325643686817168 81.2287252956509 a1289 loss_cnaBLCA18_(CHD9,CNOT1,CYLD,MMP2,NUP93) 173 FH535 unknown 3 16 3.46573590279973 NA 1.27441849549263 1.8281291157594 -0.553710620266773 0.708266989518394 1.30216663795856 0.44401149924346 0.781782334149561 0.425222551496818 0.48991540390984 NA NA NA 0.337293698596435 81.2287252956509 a1290 MLL2_mut 1049 PD-173074 FGFR1, FGFR3 3 12 0.693147180559945 NA 2.25452128889951 2.67127172918391 -0.416750440284408 1.24748250570791 0.833039570380205 0.458380097064386 0.334073174074624 0.500276883718981 0.490173159704116 NA NA NA 0.628829587081752 81.2287252956509 a1291 MLL2_mut 182 Obatoclax Mesylate BCL2, BCL2L1, MCL1 3 16 2.77258872223978 NA -0.357565767583513 -0.961167009512143 0.603601241928631 1.45103518103498 1.34884694832918 0.443411253001924 0.415979743163841 0.447494241415837 0.490494050330623 NA NA NA 0.556708078128978 81.2287252956509 a1292 MLL2_mut 268 YM155 BIRC5 (Survivin) 3 16 1.63315443905142 NA -4.64600373365215 -3.69578414033582 -0.950219593316331 0.985508674308711 2.25427851556057 0.443129928781548 0.964192013817501 0.421518275917224 0.490765388941424 NA NA NA 0.274352902334566 81.2287252956509 a1293 ARID1A_mut 1039 SL 0101-1 RSK, AURKB, PIM3 5 10 2.30258509299405 NA 4.43128048660117 4.12607141857107 0.305209068030103 1.10404051416463 0.594523624206146 0.387694150963439 0.276447344200081 0.513367435041193 0.491547500928438 NA NA NA 0.587606978106087 81.2287252956509 a1294 CDKN1A_mut 1091 BMS-536924 IGF1R 3 16 1.38629436111989 NA 2.01561196811504 2.46413936831271 -0.448527400197668 1.83171429791399 0.84962085776857 0.441591872888156 0.244867554240563 0.527914770566807 0.492250405368785 NA NA NA 0.715182397339226 81.2287252956509 a1295 gain_cnaBLCA15_(ASXL1) 279 BIX02189 MAP2K5 (MEK5) 6 13 2.99573227355399 NA 4.94723363615652 4.56965715350962 0.377576482646899 1.12748310278149 1.07536126911285 0.346098876578582 0.334884382493558 0.35111593981657 0.49263766189793 NA NA NA 0.507842166589525 81.2287252956509 a1296 gain_cnaBLCA15_(ASXL1) 1019 Bosutinib SRC, ABL, TEC 4 10 0.693147180559945 NA 1.13761134670557 1.55536359100844 -0.417752244302872 0.447853991083614 1.12382077434628 0.418302014119123 0.932786695262202 0.371724970599404 0.493032100119896 NA NA NA 0.339714608494291 81.2287252956509 a1297 gain_cnaBLCA9 222 BX-912 PDPK1 (PDK1) 4 15 2.32630161961136 NA 3.77391774845325 3.17854812267146 0.595369625781792 2.35243262828241 1.25837975888528 0.394236758962936 0.253086791359671 0.473123968800321 0.493044919269534 NA NA NA 0.654807989227127 81.2287252956509 a1298 TP53_mut 1219 PFI-1 BRD2, BRD3, BRD4 15 4 2.30258509299405 NA 2.38016852275282 2.02125971236739 0.358908810385423 0.887859414037675 1.01359466664508 0.393838574491486 0.404240586641112 0.354095006807191 0.493475646487043 NA NA NA 0.55148661818548 81.2287252956509 a1299 gain_cnaBLCA23_(MYC) 1011 ABT-263 BCL2, BCL2L1, BCL2L2 3 12 0.693147180559945 NA 2.54987917932832 2.17625764009878 0.37362153922954 0.747393614450632 0.834350044681298 0.454764538047827 0.499899292696217 0.447799507666179 0.493538870674976 NA NA NA 0.498847713658768 81.2287252956509 a1300 EP300_mut 235 QL-XII-47 BTK, BMX 4 15 2.32630161961136 NA 2.38735220482265 1.70610094910944 0.681251255713207 1.26414772773593 1.81598766074748 0.393461167593781 0.538901617877618 0.375140905656152 0.493884100722438 NA NA NA 0.416307891360389 81.2287252956509 a1301 gain_cnaBLCA23_(MYC) 272 AR-42 HDAC 4 15 1.63315443905142 NA 0.500817477883541 -0.0609691605032926 0.561786638386834 1.53422717586472 1.40418645608712 0.393409227035718 0.366169135330432 0.400079801333719 0.493940329602749 NA NA NA 0.540681355228958 81.2287252956509 a1302 gain_cnaBLCA15_(ASXL1) 1059 AZD8055 MTORC1/2 4 11 0.693147180559945 NA 0.0156750326099918 0.316754432649686 -0.301079400039694 0.681152969208973 0.748036191999987 0.41066920026468 0.442014369238292 0.402493092258963 0.494241251762809 NA NA NA 0.489486567734386 81.2287252956509 a1303 RB1_mut 1010 Gefitinib EGFR 5 9 -0.693147180559945 NA 0.327742010163697 0.724164100958034 -0.396422090794337 0.468510657674571 1.18934061775346 0.393251859519727 0.84613249304073 0.333312496753989 0.494244073388288 NA NA NA 0.395041248654024 81.2287252956509 a1304 CDKN1A_mut 164 JQ12 HDAC 3 16 1.63315443905142 NA 0.682063902302789 1.33462961953053 -0.652565717227744 1.35269916800515 1.50230601587526 0.439293994548849 0.482417475121312 0.434376026143749 0.494473929912484 NA NA NA 0.505965654259537 81.2287252956509 a1305 EP300_mut 281 CH5424802 ALK 4 15 1.63315443905142 NA 3.98272385381256 4.12572761475287 -0.143003760940309 0.236267476181376 0.386107535055969 0.392680860821947 0.6052621514039 0.370372883087039 0.494729224547356 NA NA NA 0.382181881527208 81.2287252956509 a1306 MLL2_mut 178 BAY 61-3606 SYK 3 16 2.07944154167984 NA 2.7676620218106 2.11336208525215 0.654299936558455 2.00715895491314 1.40882978099398 0.438618196003141 0.325983119053355 0.464427956723646 0.495128973977074 NA NA NA 0.635331185542301 81.2287252956509 a1307 loss_cnaBLCA5_(FAT1,IRF2) 1236 UNC0638 G9a(EHMT2), GLP(EHMT1) 5 14 2.99573227355399 NA 3.28889121443301 3.75418927365323 -0.465298059220215 1.08266354773437 1.33667287850517 0.363104545929207 0.429771612976088 0.34810166848045 0.495252904192033 NA NA NA 0.459742873976291 81.2287252956509 a1308 gain_cnaBLCA23_(MYC) 1236 UNC0638 G9a(EHMT2), GLP(EHMT1) 4 15 2.99573227355399 NA 4.02841647006096 3.52596266820443 0.502453801856531 1.38508037414081 1.2581370565426 0.392096966544283 0.362761476689188 0.399363327901088 0.495362171566617 NA NA NA 0.543920216327622 81.2287252956509 a1309 MLL2_mut 326 GSK690693 AKT 3 16 2.32630161961136 NA 4.61405142007 4.19623595613835 0.417815463931652 0.166005280987363 1.01578226121203 0.437110070479805 2.51688055612796 0.411323843589389 0.496592604339935 NA NA NA 0.142142663677499 81.2287252956509 a1310 gain_cnaBLCA15_(ASXL1) 1091 BMS-536924 IGF1R 6 13 1.38629436111989 NA 2.15503889432062 2.50329480241729 -0.348255908096661 0.758256324931858 1.10580913964966 0.34276982943647 0.459285200328475 0.314933106998007 0.496750516552782 NA NA NA 0.437521401572515 81.2287252956509 a1311 NRAS_mut 1062 AZD6244 MAP2K1 (MEK1), MAP2K2 (MEK2) 3 11 1.38629436111989 0.693147180559945 1.46436697694882 2.20499499357529 -0.740628016626475 1.49826181068947 1.64692792949513 0.456305697717822 0.494324831175969 0.449702748591747 0.496933440738064 NA NA NA 0.504972967666655 81.2287252956509 a1312 loss_cnaBLCA5_(FAT1,IRF2) 1170 CCT018159 HSP90 5 14 2.30258509299405 NA 2.3903092654441 2.72191299191092 -0.331603726466815 0.74888532430544 0.963319941341985 0.361466174662617 0.442796401137069 0.344230106982799 0.497173845382633 NA NA NA 0.452324751305201 81.2287252956509 a1313 TP53_mut 1061 SB590885 BRAF 11 4 1.6094379124341 NA 3.68297381839094 4.02020229508928 -0.337228476698344 0.876597302707558 0.634290544166041 0.407770387023236 0.384701704712919 0.531662468879666 0.497238635990495 NA NA NA 0.439106475207717 81.2287252956509 a1314 gain_cnaBLCA9 260 NG-25 MAP3K7 (TAK1) 4 15 2.32630161961136 NA 3.5610863504775 2.98267476223896 0.578411588238544 1.6328636081023 1.45197942001994 0.389371258369026 0.354231416125911 0.398360734500355 0.498323094957116 NA NA NA 0.552022228023159 81.3439293974952 a1315 TP53_mut 226 GSK1070916 AURKB 15 4 0.940007258491471 2.32630161961136 1.89870698282398 2.71220875692663 -0.813501774102651 2.20160881431882 1.54095641973137 0.387348785186128 0.369503323574923 0.527920039584549 0.50052671550438 NA NA NA 0.424732003178571 81.537419259897 a1316 gain_cnaBLCA23_(MYC) 1054 PD-0332991 CDK4, CDK6 3 12 1.38629436111989 0.693147180559945 1.3263374420038 2.10378295932097 -0.777445517317165 2.03185969199369 1.68132665228579 0.446844326792897 0.382627560544953 0.462400043596653 0.500959948435547 NA NA NA 0.587503554499402 81.537419259897 a1317 loss_cnaBLCA5_(FAT1,IRF2) 167 OSU-03012 PDPK1 (PDK1) 5 14 2.77258872223978 NA 1.37596360038134 2.05313365209219 -0.677170051710849 0.633924622762768 2.13420606018506 0.358012271243543 1.06821856636458 0.31729365985032 0.501237587233238 NA NA NA 0.302705381024626 81.537419259897 a1318 EP300_mut 1114 Cetuximab EGFR 3 15 4.18661983833127 NA 6.01973476951707 5.76923260065297 0.2505021688641 0.635438562389689 0.566860320074593 0.434990686606113 0.394219337148878 0.441911631477638 0.501440786401288 NA NA NA 0.575943299803494 81.537419259897 a1319 ARID1A_mut 262 VX-11e ERK 5 14 1.63315443905142 NA 3.23437323496515 2.70935277367956 0.525020461285585 2.13454242257134 1.19149853633418 0.357422108795088 0.245963938563061 0.440638779885445 0.501933866373264 NA NA NA 0.624480291938822 81.537419259897 a1320 gain_cnaBLCA15_(ASXL1) 266 Zibotentan, ZD4054 Endothelin A Receptor 6 13 2.99573227355399 NA 5.54900734058031 5.41963987366108 0.12936746691923 0.365996149388024 0.389130815448631 0.338240544715612 0.353466743121595 0.332452383063216 0.502378113096577 NA NA NA 0.498169425239884 81.537419259897 a1321 ARID1A_mut 1015 CI-1040 MAP2K1 (MEK1), MAP2K2 (MEK2) 3 11 2.30258509299405 NA 2.67411622826501 2.18062251166768 0.493493716597328 1.36423821690658 1.03411230407527 0.4502432769608 0.361735736824854 0.477214819563162 0.502557544577612 NA NA NA 0.605806776594555 81.537419259897 a1322 NRAS_mut 277 ABT-869 VEGFR and PDGFR family 3 16 0.0237165266173161 NA 2.50005818315536 2.3016533165749 0.198404866580461 0.4990852084993 0.455126911893154 0.430831353063423 0.397537060208707 0.435933058221437 0.502713029148455 NA NA NA 0.572683594914118 81.537419259897 a1323 gain_cnaBLCA9 158 PF-562271 FAK 4 15 0.940007258491471 NA 1.99706584846322 1.61607517734133 0.380990671121892 1.16709051759394 0.946745527594717 0.385149168301185 0.326444834722277 0.402421411052059 0.502929728748999 NA NA NA 0.578638636397997 81.537419259897 a1324 loss_cnaBLCA18_(CHD9,CNOT1,CYLD,MMP2,NUP93) 1060 PD-0325901 MAP2K1 (MEK1), MAP2K2 (MEK2) 3 12 -1.38629436111989 0.693147180559945 -0.566254857696033 -1.2126542602062 0.646399402510165 1.47072995320709 1.45214664895714 0.444254325275048 0.439509239001095 0.445133694296217 0.503401019695886 NA NA NA 0.54295088246059 81.5521853821331 a1325 RB1_mut 1016 Temsirolimus MTOR 5 9 -1.6094379124341 NA -2.30508537433194 -2.86025534281901 0.555169968487073 1.38786510079631 1.47545668111999 0.383709733488578 0.400017240990161 0.376269920758131 0.504576911128026 NA NA NA 0.501276313447962 81.6246140490242 a1326 TP53_mut 268 YM155 BIRC5 (Survivin) 15 4 1.63315443905142 NA -4.01915327913259 -3.19581456483516 -0.823338714297431 2.11868904800442 2.27050527798988 0.383615442079807 0.388607622752818 0.362623563256522 0.504609203397135 NA NA NA 0.545404168861869 81.6246140490242 a1327 gain_cnaBLCA23_(MYC) 1049 PD-173074 FGFR1, FGFR3 3 12 0.693147180559945 NA 2.91005325051458 2.50738873878015 0.402664511734434 0.825452737275171 0.9249514126933 0.442317364093431 0.487810499076706 0.435335852465962 0.505231187163493 NA NA NA 0.508758858695767 81.6249388584093 a1328 RB1_mut 224 AS605240 PI3Kgamma 6 13 2.99573227355399 2.32630161961136 3.01163604018627 3.49086783629376 -0.479231796107481 0.759245356980956 1.62616789525128 0.335842640602841 0.631194898593896 0.294700072180081 0.505372314274934 NA NA NA 0.393442736060467 81.6249388584093 a1329 MLL2_mut 286 KIN001-236 TIE2 3 16 2.32630161961136 NA 4.62918601878599 4.27332817166537 0.355857847120628 0.247010487637708 0.881821268301982 0.427380643699277 1.44065885835004 0.403548723434468 0.506095177838942 NA NA NA 0.198313689985381 81.6801856161966 a1330 gain_cnaBLCA23_(MYC) 1199 Tamoxifen ER 4 15 1.6094379124341 NA 3.35394221608602 3.57732904769848 -0.223386831612461 0.433423044677341 0.614278770450763 0.380926617339359 0.515401371375534 0.363657092444425 0.50756130951089 NA NA NA 0.434296233694495 81.8295912786372 a1331 EP300_mut 140 Vinorelbine Microtubules 4 15 -2.74887219562247 NA -3.59437876951837 -4.09442263085142 0.500043861333046 1.52057913024381 1.26459838963914 0.380724228465687 0.32885093014059 0.395417126441015 0.507783915150035 NA NA NA 0.576912185755711 81.8295912786372 a1332 gain_cnaBLCA9 283 GSK2126458 PI3K, MTOR 4 15 -2.05572501506252 0.0237165266173161 -1.73642368904202 -2.34649036705024 0.61006667800822 2.01273873037939 1.50240121697171 0.380269485596514 0.303102766792402 0.406061091482533 0.508284286323608 NA NA NA 0.602302210913188 81.8459468523464 a1333 NRAS_mut 1032 Afatinib ERBB2, EGFR 3 11 -0.693147180559945 NA 1.06294039885703 0.384949730949086 0.677990667907941 1.5024966468311 1.53369859059364 0.443553691723048 0.451242716140422 0.44206252262742 0.508807357657753 NA NA NA 0.536476896715938 81.8459468523464 a1334 RB1_mut 1053 MK-2206 AKT1, AKT2 5 10 1.38629436111989 0.693147180559945 2.22277575234935 1.80966407221988 0.413111680129478 0.770463828062538 1.2321960635216 0.371918256378449 0.536185691115853 0.335264567352059 0.509030153213191 NA NA NA 0.442454485769989 81.8459468523464 a1335 loss_cnaBLCA5_(FAT1,IRF2) 1061 SB590885 BRAF 3 12 1.6094379124341 NA 4.06205585464213 3.70061280156092 0.36144305308121 0.6062677210261 0.862139500519361 0.436558275093844 0.596177300136436 0.419239639134355 0.510695849347106 NA NA NA 0.443987551797794 82.0522623812852 a1336 NRAS_mut 178 BAY 61-3606 SYK 3 16 2.07944154167984 NA 2.74554277493397 2.11750944404151 0.628033330892459 1.83472137509215 1.44180632327951 0.420537337594691 0.342304471631785 0.435587860000464 0.512840966187018 NA NA NA 0.621154563211492 82.2006489023114 a1337 loss_cnaBLCA18_(CHD9,CNOT1,CYLD,MMP2,NUP93) 1054 PD-0332991 CDK4, CDK6 3 12 1.38629436111989 0.693147180559945 2.55310008883045 1.7970922976143 0.756007791216144 2.16967192656034 1.65189435364048 0.434087855978197 0.348443366926295 0.45766110256993 0.51305052964914 NA NA NA 0.617484450364419 82.2006489023114 a1338 gain_cnaBLCA9 344 THZ-2-49 CDK9 4 15 2.99573227355399 NA 4.83226676274876 4.0924954570142 0.739771305734561 1.57940675102051 2.0448404553002 0.375383345006137 0.468385553788831 0.361774584328613 0.513678445380822 NA NA NA 0.465607819034026 82.2006489023114 a1339 MLL2_mut 231 FMK RSK 3 11 2.99573227355399 2.32630161961136 5.11248327568169 5.30241278143172 -0.189929505750032 0.412158890624902 0.437620536845403 0.43814975395321 0.460816229056875 0.434005010640368 0.513889468294891 NA NA NA 0.530467103942197 82.2006489023114 a1340 gain_cnaBLCA15_(ASXL1) 1033 Vismodegib SMO 4 10 2.30258509299405 NA 4.72743916968785 4.41311243759765 0.314326732090193 0.741069313879575 0.805847961755619 0.397805733458114 0.424152945214611 0.390057116239894 0.514059313221304 NA NA NA 0.510509052573265 82.2006489023114 a1341 RB1_mut 176 IPA-3 PAK1, PAK2, PAK3 6 13 3.46573590279973 NA 3.34265602082298 3.88100866737765 -0.538352646554675 1.51756635964883 1.6866024161928 0.328524835856246 0.354747351331149 0.319193570094551 0.514572910970069 NA NA NA 0.502576903298864 82.2006489023114 a1342 loss_cnaBLCA5_(FAT1,IRF2) 1242 (5Z)-7-Oxozeaenol MAP3K7 (TAK1) 5 14 2.30258509299405 NA 0.28499800637488 0.637435547231557 -0.352437540856677 0.278554342390799 1.15311074913129 0.346417287219731 1.26523800645773 0.305640669052987 0.515019153548458 NA NA NA 0.304588549314823 82.2006489023114 a1343 gain_cnaBLCA15_(ASXL1) 202 GSK-1904529A IGF1R 6 13 0.0237165266173161 NA 2.2013154907017 2.0216325031892 0.179682987512504 0.447658556664512 0.584154758432959 0.328156679369435 0.401384012072315 0.307594836673962 0.515038287043837 NA NA NA 0.475293780951531 82.2006489023114 a1344 CDKN1A_mut 228 KIN001-102 AKT1 3 16 2.32630161961136 NA 2.89044445523285 3.43355836932953 -0.543113914096682 0.826203172649223 1.34894802589939 0.418288836320217 0.657361206148828 0.402620340939058 0.51506853132799 NA NA NA 0.40113984882499 82.2006489023114 a1345 NRAS_mut 295 NVP-BHG712 EPHB4 3 16 2.32630161961136 NA 3.11987773032443 3.73382675127609 -0.613949020951654 1.7777371822571 1.4232936172642 0.417812396624365 0.345354210441926 0.431357952782618 0.515541237484266 NA NA NA 0.618546734730201 82.2149170555986 a1346 TP53_mut 170 Shikonin unknown 15 4 2.77258872223978 NA -0.313118260072639 0.242252782277967 -0.555371042350607 1.53586700587852 1.25659961468342 0.37263425288321 0.361600998149532 0.441963403347473 0.516727591253576 NA NA NA 0.484582820954233 82.323257307038 a1347 MLL2_mut 1069 EHT 1864 Rac GTPases 3 15 2.30258509299405 NA 3.82806423903026 3.42033191422542 0.40773232480484 0.797187896663522 0.999133188942976 0.417682612832845 0.511463265450123 0.408086058312402 0.518383831568033 NA NA NA 0.48975309917222 82.323257307038 a1348 loss_cnaBLCA18_(CHD9,CNOT1,CYLD,MMP2,NUP93) 196 Phenformin AAPK1 (AMPK) agonist 3 16 8.29404964010203 NA 9.43744273881722 8.91274666923682 0.524696069580392 0.536956090639845 1.33249523889714 0.414733980439773 0.977167553784809 0.393769564245995 0.518601439494103 NA NA NA 0.282657223676791 82.323257307038 a1349 EP300_mut 272 AR-42 HDAC 4 15 1.63315443905142 NA 0.475783769059269 -0.0542935048168201 0.53007727387609 0.962383103008944 1.51178001593331 0.370619728123595 0.550796530216266 0.350631221665437 0.518968471387935 NA NA NA 0.418599877389363 82.323257307038 a1350 gain_cnaBLCA9 238 CAL-101 PI3Kdelta 4 15 2.99573227355399 2.32630161961136 5.08279219640562 4.7578031160234 0.324989080382225 0.793760817074123 0.893873677757147 0.370553237434666 0.409429482271706 0.363573834277867 0.519042526272117 NA NA NA 0.509245109390836 82.323257307038 a1351 CDKN1A_mut 176 IPA-3 PAK1, PAK2, PAK3 3 16 3.46573590279973 NA 3.13920837906089 3.81821397897904 -0.679005599918153 0.400171461974086 1.73887596008144 0.414243400706173 1.69678666381793 0.390485356923532 0.519090060534174 NA NA NA 0.187475990483521 82.323257307038 a1352 TP53_mut 1129 PF-4708671 RPS6KB1 (p70S6KA) 15 4 2.30258509299405 NA 3.61458672277967 3.94246474604727 -0.327878023267594 0.877853894562226 0.924286264373414 0.369971687331443 0.373499537108168 0.354736444655344 0.519690488905058 NA NA NA 0.554722598706743 82.323257307038 a1353 NRAS_mut 257 NPK76-II-72-1 PLK3 3 16 2.32630161961136 NA 3.93612899027883 3.36760524749961 0.568523742779214 1.76782283605333 1.31445429070636 0.413300684284405 0.32159542867341 0.43251693634299 0.520029740193606 NA NA NA 0.640457490892242 82.323257307038 a1354 MLL2_mut 194 AUY922 HSP90 3 16 -1.36257783450257 NA -3.5753792192076 -2.6499933852289 -0.925385833978703 1.50134751633504 2.32208676704933 0.412900438756445 0.616370176731419 0.39851475281201 0.520428985460344 NA NA NA 0.424181789284521 82.323257307038 a1355 TP53_mut 1239 YK 4-279 RNA helicase A 14 3 2.30258509299405 NA 1.16129482290068 1.5794535493315 -0.418158726430817 1.05021169170676 0.577976124213779 0.418069651318654 0.398166131393227 0.723487889745685 0.521055692831413 NA NA NA 0.378408385425698 82.323257307038 a1356 loss_cnaBLCA5_(FAT1,IRF2) 260 NG-25 MAP3K7 (TAK1) 5 14 2.32630161961136 NA 2.73086875854639 3.23786593162589 -0.506997173079492 1.20402511109181 1.56463161564508 0.34079999177099 0.421085215257467 0.324036129661398 0.521772233847731 NA NA NA 0.475557185176613 82.323257307038 a1357 gain_cnaBLCA9 310 YM201636 FYV1 4 15 1.63315443905142 NA 3.14713178399064 2.70238555573905 0.444746228251594 1.24459148505715 1.20138299486399 0.367826307344241 0.357343139167607 0.370195208482991 0.522084799891227 NA NA NA 0.552803211103655 82.323257307038 a1358 NRAS_mut 173 FH535 unknown 3 16 3.46573590279973 NA 2.17341352185067 1.65956754831727 0.513845973533396 0.896516889400442 1.28938959314164 0.411209409662103 0.573158163118419 0.398518784598992 0.522117687800173 NA NA NA 0.44945887216036 82.323257307038 a1359 gain_cnaBLCA9 173 FH535 unknown 4 15 3.46573590279973 NA 1.3779745200314 1.83742821723352 -0.459453697202116 0.555377723217341 1.3527868832043 0.367678652578594 0.827281466279326 0.3396349439121 0.522249814383624 NA NA NA 0.321922282818994 82.323257307038 a1360 loss_cnaBLCA18_(CHD9,CNOT1,CYLD,MMP2,NUP93) 326 GSK690693 AKT 3 16 2.32630161961136 NA 3.93112094034105 4.32428542108753 -0.393164480746477 1.14048871375634 0.930282940845879 0.41065361487424 0.344733337563281 0.422628926624178 0.522673387808109 NA NA NA 0.619481608641427 82.323257307038 a1361 RB1_mut 1014 RDEA119 MAP2K1 (MEK1), MAP2K2 (MEK2) 5 10 1.6094379124341 NA 1.39389520351658 0.932209536158831 0.461685667357744 0.247172994511102 1.5350549535676 0.359405708323208 1.86786452246104 0.300761654352991 0.523152194412857 NA NA NA 0.3758037868631 82.323257307038 a1362 CDKN1A_mut 253 XMD14-99 EPHB3, CAMK1 3 16 2.32630161961136 NA 4.88818523049469 4.6923776780494 0.195807552445285 0.10767814884827 0.506772639313905 0.410102002478645 1.81845206794184 0.386381460353463 0.523225233481248 NA NA NA 0.184206818354911 82.323257307038 a1363 TP53_mut 261 TL-1-85 MAP3K7 (TAK1) 15 4 2.32630161961136 NA 3.44897957240172 3.88739333875134 -0.438413766349619 1.11741736926898 1.50971628513449 0.366556445089204 0.392345580448987 0.29039480508125 0.523504914102529 NA NA NA 0.616814370015111 82.323257307038 a1364 CDKN1A_mut 1498 AZD6244 MAP2K1 (MEK1), MAP2K2 (MEK2) 3 16 1.38629436111989 NA 1.79713376106687 1.29047477300979 0.50665898805708 0.673018033121847 1.2930087331671 0.409814549426543 0.752816363191492 0.391844985312719 0.523512937271397 NA NA NA 0.359063015977217 82.323257307038 a1365 loss_cnaBLCA5_(FAT1,IRF2) 133 Doxorubicin DNA intercalating 5 14 0.0237165266173161 NA -2.51327937663901 -1.91943433619367 -0.593845040445341 1.27604606949189 1.87383122215236 0.339024867110361 0.465378997391375 0.316914903234042 0.52391656438547 NA NA NA 0.451248208676892 82.3263717469439 a1366 gain_cnaBLCA15_(ASXL1) 1006 Cytarabine DNA synthesis 4 9 0.693147180559945 NA 0.475559507686172 0.065068962021752 0.41049054566442 0.534952102671818 1.17460311620291 0.394727976686575 0.767340746235458 0.349471698143791 0.524770985012515 NA NA NA 0.405332533845906 82.4002658477824 a1367 NRAS_mut 1050 ZM-447439 AURKB 3 12 1.38629436111989 0.693147180559945 2.64701682554964 2.0959754837064 0.551041341843246 1.90001148484139 1.16874239097045 0.421243746826926 0.290020005794462 0.47148229250562 0.52539428686865 NA NA NA 0.671518663244614 82.410569051171 a1368 CDKN1A_mut 254 AC220 FLT3 3 16 0.0237165266173161 NA 2.5604961740201 2.34775102257687 0.212745151443231 0.166180045966398 0.552156578017635 0.407726929909697 1.28020876517418 0.385298590858111 0.525605029981384 NA NA NA 0.229708685880562 82.410569051171 a1369 TP53_mut 298 OSI-930 KIT, VEGFR, PDGFR 15 4 2.32630161961136 NA 4.26755902322938 4.54867465459076 -0.281115631361372 0.834738962061904 0.376436583503587 0.363272166700559 0.336770708134892 0.746780848835042 0.527187792131594 NA NA NA 0.345751846518592 82.5568760931107 a1370 ARID1A_mut 164 JQ12 HDAC 5 14 1.63315443905142 NA 1.59947274426937 1.10020727843215 0.499265465837217 0.759602771344253 1.64931029975806 0.335392208501014 0.657271780293373 0.302711664330511 0.528320088557617 NA NA NA 0.383466360170372 82.5568760931107 a1371 NRAS_mut 201 Epothilone B Microtubules 3 16 -3.44201937618241 NA -4.41320778239949 -5.39524588748179 0.982038105082307 3.38257615860545 2.26875008299242 0.404718460758103 0.290322540878777 0.432854245359199 0.528628127765488 NA NA NA 0.670484854549783 82.5568760931107 a1372 loss_cnaBLCA5_(FAT1,IRF2) 238 CAL-101 PI3Kdelta 5 14 2.99573227355399 2.32630161961136 4.60954472993566 4.90360656259251 -0.294061832656858 0.998631936152078 0.836760956922049 0.335098449411379 0.294464679138878 0.351428720740674 0.528677081081163 NA NA NA 0.577033844927333 82.5568760931107 a1373 TP53_mut 293 MP470 PDGFR 15 4 2.99573227355399 NA 4.08312453842046 3.5584921688838 0.524632369536661 1.32462615665883 1.93243252337282 0.361687599394069 0.396060705052035 0.271488066564405 0.528969814648573 NA NA NA 0.63715251834702 82.5568760931107 a1374 CDKN1A_mut 170 Shikonin unknown 3 16 2.77258872223978 NA -0.70407810058367 -0.100970529389169 -0.6031075711945 0.821389167403605 1.55921528375787 0.404368897293282 0.734253134967571 0.38680198781848 0.528980015999498 NA NA NA 0.368619154211387 82.5568760931107 a1375 loss_cnaBLCA5_(FAT1,IRF2) 1494 SN-38 TOP1 5 13 -2.99573227355399 NA -5.31880200528333 -4.73513922270507 -0.583662782578262 1.59427139169244 1.76578580972547 0.338451932494732 0.366100016358356 0.330539966605013 0.529232433494989 NA NA NA 0.518689126636151 82.5568760931107 a1376 loss_cnaBLCA5_(FAT1,IRF2) 1069 EHT 1864 Rac GTPases 5 13 2.30258509299405 NA 3.72664242486018 3.39661225432086 0.330030170539323 1.152725996187 0.910766170937196 0.337837332427407 0.286304092760119 0.362365424925385 0.529971215010043 NA NA NA 0.586141894340652 82.5720920554901 a1377 gain_cnaBLCA15_(ASXL1) 1057 NVP-BEZ235 PI3K (Class 1) and MTORC1/2 4 11 -1.38629436111989 0.693147180559945 -2.87283634272401 -2.39284342319756 -0.479992919526448 1.55679013561438 1.17654227621008 0.376641705925225 0.308322174290384 0.407969122089365 0.530099910223029 NA NA NA 0.602556283270949 82.5720920554901 a1378 loss_cnaBLCA5_(FAT1,IRF2) 178 BAY 61-3606 SYK 5 14 2.07944154167984 NA 2.58396281865457 2.08549752401381 0.498465294640766 0.8004973230553 1.65092842079514 0.333421166009383 0.622694517875772 0.301930288655815 0.530717972108667 NA NA NA 0.394310591182701 82.6083741666502 a1379 NRAS_mut 306 TG101348 JAK2 3 16 2.32630161961136 NA 3.3198775279585 2.93769880442713 0.382178723531371 1.22694353218938 0.907481323946925 0.402016836770163 0.311488437328003 0.421142246618536 0.531351093979811 NA NA NA 0.650403639547353 82.6192647169647 a1380 loss_cnaBLCA5_(FAT1,IRF2) 1059 AZD8055 MTORC1/2 3 12 0.693147180559945 NA -0.00761408101871924 0.297486761053556 -0.305100842072275 0.740066808836369 0.734512038965163 0.414894694842002 0.412261215378642 0.415378953491524 0.531558312877914 NA NA NA 0.566919340031151 82.6192647169647 a1381 TP53_mut 165 DMOG Prolyl-4-Hydroxylase 15 4 8.29404964010203 NA 5.6662561728054 6.01908431794564 -0.352828145140237 1.00942792057325 0.867662845569069 0.357876739098927 0.349532777872708 0.406641988811714 0.533269200179635 NA NA NA 0.514554086962549 82.7271833105575 a1382 ARID1A_mut 176 IPA-3 PAK1, PAK2, PAK3 5 14 3.46573590279973 NA 4.1108153794406 3.56821227883174 0.542603100608861 1.37816706662503 1.71325817865358 0.330738118148558 0.393713587959717 0.316708308980778 0.533991705360224 NA NA NA 0.49802519399097 82.7271833105575 a1383 EP300_mut 221 TAK-715 p38a 4 15 2.99573227355399 2.32630161961136 4.82147957857397 4.54050198876549 0.280977589808474 0.653734575234632 0.812482243128708 0.357114914999242 0.429803777332151 0.34582612996745 0.534130990131823 NA NA NA 0.497676099275868 82.7271833105575 a1384 loss_cnaBLCA18_(CHD9,CNOT1,CYLD,MMP2,NUP93) 1008 Methotrexate Dihydrofolate reductase (DHFR) 3 11 -1.6094379124341 NA -0.613812936571665 -0.171632604875643 -0.442180331696022 0.910061960568274 1.08928040513815 0.41655628991019 0.485879369597989 0.405938020743098 0.534491650158311 NA NA NA 0.517309303901445 82.7271833105575 a1385 gain_cnaBLCA23_(MYC) 299 OSI-027 MTORC1/2 4 15 2.99573227355399 NA 1.37629742140503 2.03272253507806 -0.656425113673025 3.06974692740059 1.44638233881815 0.356743033209534 0.213836882712959 0.453839276141463 0.534551948235816 NA NA NA 0.702851248790679 82.7271833105575 a1386 gain_cnaBLCA23_(MYC) 1032 Afatinib ERBB2, EGFR 4 10 -0.693147180559945 NA 0.944064552421743 0.364701002732405 0.579363549689338 0.682719562761489 1.72444723524316 0.378191463768219 0.848611320504583 0.335970586892237 0.534666498692258 NA NA NA 0.385640125510618 82.7271833105575 a1387 loss_cnaBLCA18_(CHD9,CNOT1,CYLD,MMP2,NUP93) 332 XMD15-27 CAMK2B, CLK2, DYRK1A, MAST1, STK39 3 16 2.32630161961136 NA 4.59133321736582 4.79192171983894 -0.200588502473127 0.346289934640338 0.521190402101723 0.398170459718446 0.579250167006619 0.384866071332559 0.535241197641587 NA NA NA 0.448309717621301 82.7271833105575 a1388 EP300_mut 1032 Afatinib ERBB2, EGFR 3 11 -0.693147180559945 NA 0.0300514881947761 0.666646706584245 -0.636595218389469 0.526343320101608 1.6616709101508 0.415522620428691 1.20946764987267 0.383105472028573 0.535489568218043 NA NA NA 0.300212614445136 82.7271833105575 a1389 gain_cnaBLCA15_(ASXL1) 1011 ABT-263 BCL2, BCL2L1, BCL2L2 4 11 0.693147180559945 NA 2.47552366698793 2.16933041374714 0.306193253240795 0.941047778512388 0.786004600901601 0.371424272670546 0.325374821802169 0.389556566067896 0.535726564113003 NA NA NA 0.588268775339552 82.7271833105575 a1390 NRAS_mut 223 ZSTK474 PI3K 3 16 1.63315443905142 2.32630161961136 2.20918978331565 1.61018292616763 0.599006857148019 1.47760130674579 1.51430899542191 0.396683626038831 0.405391396456767 0.395564484500157 0.536749119350728 NA NA NA 0.568865746724841 82.7271833105575 a1391 gain_cnaBLCA9 1239 YK 4-279 RNA helicase A 4 13 2.30258509299405 NA 1.51156154034686 1.15001861593974 0.361542924407119 1.21979020694226 0.93874464937393 0.361079083482989 0.296397628337602 0.385134471496845 0.537213511699647 NA NA NA 0.61354733134814 82.7271833105575 a1392 NRAS_mut 329 QL-XI-92 DDR1 3 16 2.32630161961136 NA 4.55593310556148 4.18503201893257 0.370901086628906 0.995958521489084 0.928289390689064 0.396048467800869 0.372406158114257 0.399553297009662 0.537393995619165 NA NA NA 0.596238013263876 82.7271833105575 a1393 CDKN1A_mut 201 Epothilone B Microtubules 3 16 -3.44201937618241 NA -6.04931507316755 -5.08847577046278 -0.960839302704771 0.938767541096208 2.56168601480416 0.395776329603741 1.0235114239067 0.375080824563203 0.537670427406288 NA NA NA 0.2812921929244 82.7271833105575 a1394 MLL2_mut 192 LFM-A13 BTK 3 16 2.77258872223978 NA 4.16761121520095 4.4306688387581 -0.263057623557151 0.891005201609668 0.628795590416459 0.395556591509696 0.295236911167205 0.418351571745159 0.537893689163945 NA NA NA 0.66610780555892 82.7271833105575 a1395 EP300_mut 274 PXD101, Belinostat HDAC 4 15 2.99573227355399 NA 0.853058975839912 0.344939496404239 0.508119479435673 0.989595653397456 1.51545027140868 0.353669558526906 0.513461713065542 0.335292743696139 0.538037997587406 NA NA NA 0.445932816702497 82.7271833105575 a1396 TP53_mut 344 THZ-2-49 CDK9 15 4 2.99573227355399 NA 4.39460692628887 3.69934875296872 0.695258173320149 1.78107134087673 2.69651003470548 0.352258259000694 0.390359531010088 0.257836301134361 0.539642905316278 NA NA NA 0.652809163101447 82.9093658352303 a1397 gain_cnaBLCA23_(MYC) 276 CAY10603 HDAC6 4 15 2.99573227355399 NA 1.58604413543728 1.16076734398004 0.425276791457246 1.55538939200515 1.12019073372823 0.351924072456492 0.273421429799643 0.379646767869465 0.540023319396347 NA NA NA 0.636122322854309 82.9093658352303 a1398 loss_cnaBLCA18_(CHD9,CNOT1,CYLD,MMP2,NUP93) 1262 UNC1215 LMBL3 3 15 0 NA 2.24197231235629 2.39994376757869 -0.157971455222401 0.288428232528861 0.413147078724057 0.395233764228295 0.547697615581353 0.382361302687345 0.540834425117437 NA NA NA 0.470390575370327 82.9093658352303 a1399 gain_cnaBLCA9 1014 RDEA119 MAP2K1 (MEK1), MAP2K2 (MEK2) 3 12 1.6094379124341 NA 1.50311787837503 0.981851478670509 0.521266399704517 0.305930719700256 1.39228789939134 0.405236061438338 1.70387073326681 0.374395554204268 0.541013625514029 NA NA NA 0.256344236640265 82.9093658352303 a1400 MLL2_mut 1194 SB-505124 TGFR1 (ALK5) 3 16 2.30258509299405 NA 3.73908542515509 4.1459698022685 -0.406884377113414 1.74785512194635 0.900839262001672 0.392351860632356 0.232790676987188 0.451672561661348 0.541155568015919 NA NA NA 0.728785214466841 82.9093658352303 a1401 NRAS_mut 1037 BX-795 TBK1, PDPK1, IKK, AURKB, AURKC 3 12 1.6094379124341 NA 2.34766055996183 1.84715895000516 0.500501609956676 2.21987166384953 0.95555993079661 0.404532909077314 0.225464209533962 0.523778356360578 0.541705633347495 NA NA NA 0.736543795344423 82.9344013900441 a1402 NRAS_mut 254 AC220 FLT3 3 16 0.0237165266173161 NA 2.55298938613526 2.34915854530528 0.203830840829986 0.460268788431677 0.530035951151993 0.390247315048884 0.442851755220077 0.38456040649125 0.54330348976706 NA NA NA 0.540374859381062 82.9647627885496 a1403 EP300_mut 252 WZ3105 CLK2, CNSK1E, FLT3, ULK1 4 15 0.246860077931526 2.32630161961136 0.223724882097249 0.790219141837318 -0.566494259740068 0.924487356605986 1.73739976875646 0.348871453691859 0.612765827128025 0.326058671082669 0.543504962615502 NA NA NA 0.40083435485326 82.9647627885496 a1404 gain_cnaBLCA9 171 AKT inhibitor VIII AKT1, AKT2, AKT3 4 15 0.940007258491471 NA 2.32480541827472 1.95052848637019 0.37427693190453 1.00286427879302 1.08819412758134 0.348609241186875 0.373207960258575 0.343943164567899 0.543804594524158 NA NA NA 0.54328783595587 82.9647627885496 a1405 TP53_mut 1072 BMS-708163 g-secretase 14 4 1.6094379124341 NA 3.38863866479454 3.614521245142 -0.225882580347461 0.620517907264469 0.731266118081068 0.351437813375705 0.364022661881357 0.308892446624226 0.544065891246474 NA NA NA 0.601625125279005 82.9647627885496 a1406 EP300_mut 230 GSK429286A ROCK2 4 15 2.99573227355399 2.32630161961136 5.26689792709513 4.67315471997517 0.593743207119958 0.393620297186237 1.86971930237604 0.348281276026961 1.50841613444297 0.317557403598192 0.54417948848791 NA NA NA 0.270667969581445 82.9647627885496 a1407 ARID1A_mut 165 DMOG Prolyl-4-Hydroxylase 5 14 8.29404964010203 NA 5.97385268380569 5.65720831748822 0.316644366317473 0.64346998053633 1.07027152534405 0.320944867405913 0.492088793409681 0.295854237751194 0.546034721645315 NA NA NA 0.450084552292376 82.9647627885496 a1408 RB1_mut 186 Bexarotene Retinioic acid X family agonist 6 13 2.07944154167984 NA 3.33297936860951 3.63933300624513 -0.306353637635622 0.828292473277801 1.0749801432303 0.303709214890001 0.369861670266409 0.284985392116205 0.546468117429698 NA NA NA 0.509062539096958 82.9647627885496 a1409 MLL2_mut 135 Gemcitabine DNA replication 3 16 0.0237165266173161 NA -1.39938717811496 -2.52464053924041 1.12525336112545 2.86950265456602 2.91506928605402 0.386718819418812 0.392142296622352 0.386012561179515 0.54691506791118 NA NA NA 0.580525653033101 82.9647627885496 a1410 TP53_mut 275 I-BET BRD2, BRD3, BRD4 15 4 2.99573227355399 NA 4.55813282563846 4.94826857942153 -0.390135753783077 1.1738012743508 0.885819181766043 0.345762494534715 0.332369509480088 0.440423691215706 0.547063347153073 NA NA NA 0.493877214164769 82.9647627885496 a1411 CDKN1A_mut 196 Phenformin AAPK1 (AMPK) agonist 3 16 8.29404964010203 NA 9.40765484678715 8.91833189899246 0.489322947794685 0.258474252724786 1.34577847855627 0.38613167672885 1.89312065954862 0.363598434357207 0.547517291050439 NA NA NA 0.201618640377415 82.9647627885496 a1412 CDKN1A_mut 333 T0901317 LXR 3 16 2.32630161961136 NA 4.25902580470249 4.50902195674191 -0.249996152039427 0.208074893694104 0.685439686660779 0.385914518117742 1.20147196810276 0.364723777896958 0.547740117821323 NA NA NA 0.255578592169884 82.9647627885496 a1413 MLL2_mut 1037 BX-795 TBK1, PDPK1, IKK, AURKB, AURKC 3 12 1.6094379124341 NA 1.55414087213251 2.04553887196249 -0.491397999829981 0.645098938661195 1.31733440922405 0.396958776769714 0.761740518206095 0.373024492785724 0.549190945918623 NA NA NA 0.386769202115147 82.9647627885496 a1414 CDKN1A_mut 177 GSK-650394 SGK3 3 16 2.77258872223978 NA 2.25284115551037 3.06253122881497 -0.809690073304599 2.03676286717835 2.11597651079566 0.384320068041302 0.397537723390603 0.382655511142765 0.549377681234002 NA NA NA 0.576356280406097 82.9647627885496 a1415 gain_cnaBLCA23_(MYC) 1219 PFI-1 BRD2, BRD3, BRD4 4 15 2.30258509299405 NA 2.05685043823748 2.37067766252079 -0.313827224283318 1.20231251813124 0.839955342073724 0.343207427990197 0.26101967629107 0.373623701836964 0.549997155572706 NA NA NA 0.650265547802923 82.9647627885496 a1416 RB1_mut 156 AZD6482 PI3Kbeta 6 13 1.63315443905142 NA 1.71083511851254 2.13310115302876 -0.422266034516219 1.48730381972486 1.36739015774872 0.30081870994367 0.283913769948049 0.308811667338194 0.550251688091987 NA NA NA 0.569671524749628 82.9647627885496 a1417 MLL2_mut 154 CHIR-99021 GSK3B 3 16 0.940007258491471 NA 2.97718023899341 2.67922105991015 0.297959179083262 0.440548596226895 0.812228497100702 0.383091444336906 0.676336689380356 0.366841572472333 0.550641319959716 NA NA NA 0.401253563150406 82.9647627885496 a1418 NRAS_mut 293 MP470 PDGFR 3 16 2.99573227355399 NA 4.44049239105598 3.88495997366713 0.555532417388841 1.17483405860069 1.48541380634322 0.3825121014361 0.472860327228274 0.373991688387795 0.551237714472111 NA NA NA 0.519536448716486 82.9647627885496 a1419 gain_cnaBLCA23_(MYC) 1371 PLX4720 (rescreen) BRAF 4 14 2.30258509299405 NA 3.67990548870939 3.99962961128581 -0.319724122576422 0.352879673681825 1.01452961237771 0.344841495014455 0.906042899100791 0.31514518519287 0.551563599720751 NA NA NA 0.338846882083978 82.9647627885496 a1420 gain_cnaBLCA23_(MYC) 346 THZ-2-102-1 CDK7 4 15 0.916290731874155 2.99573227355399 -0.987010532379573 -0.14763218296491 -0.839378349414663 3.41045012516387 2.19879944034761 0.341705346576168 0.246119520476591 0.381743934445409 0.551725830103649 NA NA NA 0.666690400433183 82.9647627885496 a1421 gain_cnaBLCA15_(ASXL1) 1046 681640 WEE1, CHEK1 4 11 0.693147180559945 NA 1.39528341759655 1.72607503950177 -0.330791621905222 0.246145948814947 1.05001540619052 0.356270452700121 1.34388407974129 0.315035017538783 0.552258025518093 NA NA NA 0.348871973179367 82.9647627885496 a1422 EP300_mut 1067 CCT007093 PPM1D 4 14 1.88706964903238 NA 3.93584349603035 3.75683548021733 0.179008015813019 0.385773607623399 0.54668860052928 0.344033401404268 0.464023490139249 0.327440549592055 0.552485934426712 NA NA NA 0.483822344303222 82.9647627885496 a1423 TP53_mut 1199 Tamoxifen ER 15 4 1.6094379124341 NA 3.57245884115868 3.37220549061026 0.20025335054842 0.546684005861659 0.751257814738958 0.340578380168528 0.36630548616982 0.266557427582969 0.553024711071925 NA NA NA 0.644644104135626 82.9647627885496 a1424 gain_cnaBLCA9 330 XMD13-2 RIPK 4 15 2.32630161961136 NA 4.04107665199211 3.71593105348952 0.325145598502588 1.34374523430616 0.848560872292101 0.340540111222565 0.241969675650962 0.383172980418383 0.553068846486119 NA NA NA 0.671419136889238 82.9647627885496 a1425 gain_cnaBLCA23_(MYC) 235 QL-XII-47 BTK, BMX 4 15 2.32630161961136 NA 1.38239993842183 1.97408822014966 -0.591688281727826 2.7495958405193 1.43035358277508 0.340532769895563 0.215191001167676 0.413665745905897 0.553077313422855 NA NA NA 0.70222953895498 82.9647627885496 a1426 loss_cnaBLCA5_(FAT1,IRF2) 1060 PD-0325901 MAP2K1 (MEK1), MAP2K2 (MEK2) 3 12 -1.38629436111989 0.693147180559945 -0.624181350394282 -1.19817263703164 0.573991286637353 1.06921652856973 1.52099706737125 0.392978823192255 0.536833533059176 0.377378299373966 0.553147005025439 NA NA NA 0.48774676512308 82.9647627885496 a1427 gain_cnaBLCA15_(ASXL1) 150 Bicalutamide ANDR (androgen receptor) 6 13 0.0237165266173161 NA 2.2649577537385 2.41388576769639 -0.148928013957891 0.586108588163438 0.457539490972578 0.298569053794234 0.254096283462684 0.325497616918965 0.553206116160208 NA NA NA 0.597523876323472 82.9647627885496 a1428 gain_cnaBLCA23_(MYC) 1194 SB-505124 TGFR1 (ALK5) 4 15 2.30258509299405 NA 3.80288654207862 4.15608179622979 -0.353195254151171 0.9436390937462 1.05680136954276 0.34035415766991 0.37429061226046 0.334211578760526 0.553283332733062 NA NA NA 0.544411651282187 82.9647627885496 a1429 loss_cnaBLCA18_(CHD9,CNOT1,CYLD,MMP2,NUP93) 190 Bleomycin DNA damage 3 16 4.15888308335967 NA 0.495677920686405 1.42547186496158 -0.929793944275171 1.99463017280116 2.50183080030903 0.379876537179055 0.466148540693845 0.371645414294332 0.553955214608144 NA NA NA 0.524680853190639 82.9647627885496 a1430 NRAS_mut 263 FR-180204 ERK 3 16 2.99573227355399 NA 5.25409012195807 4.99791665338512 0.256173468572951 0.834396973808821 0.650176715191482 0.379816518560341 0.30701629633624 0.394005910373929 0.554017182310768 NA NA NA 0.655681412461731 82.9647627885496 a1431 loss_cnaBLCA5_(FAT1,IRF2) 286 KIN001-236 TIE2 5 14 2.32630161961136 NA 4.52288666902941 4.26045538984691 0.262431279182501 0.628305758336136 0.888961121478019 0.314295296129806 0.417680843603065 0.295211199727355 0.554294849567002 NA NA NA 0.491775526651518 82.9647627885496 a1432 NRAS_mut 308 XL-880 MET 3 16 1.63315443905142 NA 1.12231274543686 0.568931274344926 0.553381471091932 1.02978123835372 1.50802233622772 0.379051055709546 0.53737769778813 0.366958404924029 0.5548078276508 NA NA NA 0.47740270840407 82.9647627885496 a1433 gain_cnaBLCA9 153 Midostaurin KIT 4 15 -0.669430653942629 NA -0.637770208655151 -0.228311106073571 -0.409459102581579 1.32995030281855 1.18218117201411 0.338516095129956 0.307875491071971 0.346359011862771 0.555405815667535 NA NA NA 0.60328004206643 82.9647627885496 a1434 CDKN1A_mut 175 PAC-1 CASP3 agonist 3 16 0.940007258491471 NA 2.31657648946367 2.67236847395139 -0.355791984487723 1.14414985554106 0.910373291092143 0.378141658265715 0.310966245168534 0.39081988451231 0.555747923934673 NA NA NA 0.652085712831734 82.9647627885496 a1435 NRAS_mut 228 KIN001-102 AKT1 3 16 2.32630161961136 NA 3.7620672568046 3.27012909403483 0.491938162769774 0.916222624928576 1.34449557014343 0.377993499189965 0.536919902854531 0.365890504732043 0.555901164749273 NA NA NA 0.477901518251096 82.9647627885496 a1436 EP300_mut 193 GW-2580 CSF1R (cFMS) 4 15 2.99573227355399 NA 5.17258640888725 5.33314405432255 -0.160557645435292 0.338072411428238 0.499825940743164 0.337804025007415 0.474920874959869 0.321227115976748 0.55622923487623 NA NA NA 0.474877983517945 82.9647627885496 a1437 RB1_mut 1494 SN-38 TOP1 6 12 -2.99573227355399 NA -5.24319988541676 -4.7243017174235 -0.51889816799326 1.92230753941503 1.63093994063564 0.300413438150913 0.269935042834595 0.318158967761269 0.556371744883131 NA NA NA 0.584994713526241 82.9647627885496 a1438 gain_cnaBLCA15_(ASXL1) 1241 CHIR-99021 GSK3B 6 13 2.30258509299405 NA 3.43248666900574 3.69809975391488 -0.265613084909138 1.29056363923781 0.668120162131592 0.296047399381778 0.205811690980234 0.397552865433243 0.556527803767821 NA NA NA 0.650484774364849 82.9647627885496 a1439 gain_cnaBLCA23_(MYC) 288 KIN001-055 JAK3, MNK1 4 15 2.32630161961136 NA 3.90758675843671 4.18933495795302 -0.281748199516313 1.20519193730535 0.731869054077678 0.337373325516979 0.233778695986189 0.38497077851089 0.556727599401429 NA NA NA 0.680923593263869 82.9647627885496 a1440 RB1_mut 294 MPS-1-IN-1 MPS1 6 13 2.99573227355399 NA 4.61043073809707 4.26046483052985 0.349965907567213 1.17930244489297 1.18528038849973 0.29569786665057 0.296756704849343 0.295260016923238 0.556989066546057 NA NA NA 0.561847629352286 82.9647627885496 a1441 EP300_mut 1016 Temsirolimus MTOR 3 11 -1.6094379124341 NA -3.1104085596158 -2.53968175256213 -0.570726807053672 1.32414316366444 1.47772271210211 0.39272346121813 0.431015937486882 0.386220501572853 0.557767027247008 NA NA NA 0.558657946269101 83.0229869167229 a1442 MLL2_mut 171 AKT inhibitor VIII AKT1, AKT2, AKT3 3 16 0.940007258491471 NA 2.36894952602554 1.96564377441094 0.4033057516146 0.733290837892688 1.1121018732179 0.375346206235278 0.549994259813214 0.362651804953465 0.558643042280939 NA NA NA 0.470483466103483 83.0431413597169 a1443 MLL2_mut 312 AV-951 VEGFR 3 16 -2.05572501506252 NA 0.28810480495321 0.431958364341812 -0.143853559388602 0.355061257300214 0.386896967606476 0.375313698397768 0.405151382841439 0.371813613010581 0.558676756068844 NA NA NA 0.571170234337796 83.0431413597169 a1444 CDKN1A_mut 1495 AZD-2281 PARP1, PARP2 3 14 2.30258509299405 NA 3.53490016300907 3.25908329435877 0.275816868650306 1.05358151700463 0.661817364347521 0.379722009462786 0.261789775350714 0.41675677234947 0.559508415028597 NA NA NA 0.700062730796196 83.1091665637272 a1445 loss_cnaBLCA5_(FAT1,IRF2) 224 AS605240 PI3Kgamma 5 14 2.99573227355399 2.32630161961136 3.66575903599286 3.22302163806944 0.442737397923417 1.18374072533167 1.49951338899039 0.30928336903742 0.374015515770456 0.295254047862492 0.560564480559287 NA NA NA 0.521642761186828 83.2045591338624 a1446 RB1_mut 1015 CI-1040 MAP2K1 (MEK1), MAP2K2 (MEK2) 5 9 2.30258509299405 NA 2.52228451452286 2.15530819339169 0.366976321131168 1.00507948427338 1.14654979787768 0.33318657559062 0.365121691242633 0.320070111050091 0.561375748685542 NA NA NA 0.548712660420477 83.2045591338624 a1447 gain_cnaBLCA23_(MYC) 1091 BMS-536924 IGF1R 4 15 1.38629436111989 NA 2.12497083789376 2.46487882971823 -0.339907991824469 1.30833955321434 0.94666001304629 0.333292413271496 0.25980105163784 0.359060261487825 0.561461388383184 NA NA NA 0.652657650051084 83.2045591338624 a1448 ARID1A_mut 186 Bexarotene Retinioic acid X family agonist 5 14 2.07944154167984 NA 3.31319919822923 3.62451495012126 -0.311315751892032 1.26195766197924 0.917999757042151 0.308377001647299 0.246692707110133 0.339124002488965 0.561702281665293 NA NA NA 0.63224648257982 83.2045591338624 a1449 gain_cnaBLCA23_(MYC) 1018 ABT-888 PARP1, PARP2 4 10 1.6094379124341 NA 4.12939451171079 3.92364535786698 0.205749153843808 0.439210721267876 0.624345453675602 0.35255529759156 0.468452029699705 0.329543768810257 0.562295945289418 NA NA NA 0.505579267717287 83.2350153584897 a1450 loss_cnaBLCA5_(FAT1,IRF2) 249 XL-184 VEGFR, MET, RET, KIT, FLT1, FLT3, FLT4, Tie2,AXL 5 14 1.63315443905142 NA 2.84661633504983 3.14701501015564 -0.300398675105811 0.937409736305107 0.988885821284827 0.307464885839079 0.320456107368654 0.303774883449651 0.562848526758587 NA NA NA 0.562418769730947 83.2415909860841 a1451 NRAS_mut 299 OSI-027 MTORC1/2 3 16 2.99573227355399 NA 2.47035849147027 1.78655951483626 0.683798976634007 1.17667976932799 1.91430848305253 0.371041743625076 0.581125803687887 0.357204171996162 0.563116544263997 NA NA NA 0.453448450496856 83.2415909860841 a1452 loss_cnaBLCA18_(CHD9,CNOT1,CYLD,MMP2,NUP93) 1192 GSK269962A ROCK1, ROCK2 3 16 1.6094379124341 NA 2.12511741919069 1.76630879864472 0.358808620545975 1.17618204871858 0.938588910373677 0.37007072799638 0.305062146575768 0.382285169343332 0.564128291413467 NA NA NA 0.658039988558402 83.2583869695089 a1453 RB1_mut 1042 BIRB 0796 p38, JNK2 5 10 2.30258509299405 NA 4.19394172812066 3.88552443596269 0.308417292157966 0.883711273438465 0.980829588829301 0.323966773223839 0.349002328507062 0.314445338589435 0.564343267400865 NA NA NA 0.554579336961779 83.2583869695089 a1454 gain_cnaBLCA23_(MYC) 190 Bleomycin DNA damage 4 15 4.15888308335967 NA 0.639148214180605 1.44919938298147 -0.810051168800863 1.21703330722938 2.63916700893964 0.330772795813987 0.665594905241317 0.306934410007771 0.564394667194221 NA NA NA 0.393576192057495 83.2583869695089 a1455 gain_cnaBLCA15_(ASXL1) 207 AS601245 JNK 6 13 2.07944154167984 NA 2.46421052681306 2.10649285195996 0.357717674853103 1.76061019329726 0.93214037772731 0.289669241884748 0.203178236849334 0.383759445895123 0.564976596282876 NA NA NA 0.655248187210844 83.2869507406062 a1456 loss_cnaBLCA18_(CHD9,CNOT1,CYLD,MMP2,NUP93) 1377 Afatinib (rescreen) ERBB2, EGFR 3 15 2.30258509299405 NA 2.92695763199583 3.43243461338881 -0.505476981392982 0.911651647108976 1.41412693140972 0.371265574316671 0.554462861988949 0.357448097596926 0.56538070778225 NA NA NA 0.47178295342568 83.2889993550749 a1457 gain_cnaBLCA23_(MYC) 1129 PF-4708671 RPS6KB1 (p70S6KA) 4 15 2.30258509299405 NA 3.91466833748702 3.62199909839574 0.292669239091286 0.999004191608993 0.862995925941629 0.329392741495307 0.292960972085526 0.339131657860319 0.566004696320555 NA NA NA 0.619205979908556 83.2889993550749 a1458 loss_cnaBLCA18_(CHD9,CNOT1,CYLD,MMP2,NUP93) 303 PIK-93 PI4K, PI3K 3 16 2.99573227355399 NA 2.82980337274039 3.43478888289286 -0.604985510152464 0.727342238257557 1.73111063419438 0.367745212308462 0.831775577342774 0.349478247202849 0.566555229968922 NA NA NA 0.347441316669431 83.2889993550749 a1459 RB1_mut 1066 AZD6482 PI3Kbeta 5 13 1.6094379124341 NA 2.25263123332204 1.91622100469355 0.336410228628497 0.745080566972284 1.18657389946405 0.307772533011358 0.451508526112199 0.283513929288726 0.566800307670982 NA NA NA 0.486482112311644 83.2889993550749 a1460 loss_cnaBLCA5_(FAT1,IRF2) 1192 GSK269962A ROCK1, ROCK2 5 14 1.6094379124341 NA 1.60558869437588 1.90059639742916 -0.295007703053277 0.692322491553795 1.04028160849649 0.304223364886683 0.426113128855867 0.283584464671685 0.566932041134525 NA NA NA 0.493279876705646 83.2889993550749 a1461 loss_cnaBLCA18_(CHD9,CNOT1,CYLD,MMP2,NUP93) 206 Ruxolitinib JAK1, JAK2, TYK2 3 16 1.65632149833295 0.0237165266173161 3.98080736828486 4.15668153148302 -0.175874163198162 0.313420792798427 0.497244045726816 0.366946416881451 0.561143891022167 0.353697876745992 0.567390121562821 NA NA NA 0.46586721076407 83.2992424937731 a1462 loss_cnaBLCA5_(FAT1,IRF2) 303 PIK-93 PI4K, PI3K 5 14 2.99573227355399 NA 2.97134928416252 3.47066327312102 -0.499313988958493 1.24860733464045 1.74926921585153 0.303491749404015 0.399896729024321 0.28544147718019 0.567855833338596 NA NA NA 0.508453617502735 83.310591221166 a1463 CDKN1A_mut 282 EKB-569 EGFR 3 16 0.916290731874155 2.99573227355399 2.40497928697611 1.82590246502895 0.579076821947158 1.75382171541126 1.55855685237538 0.365860587579544 0.330179981727144 0.371546806948104 0.568526046928888 NA NA NA 0.635313881655433 83.3425605301962 a1464 loss_cnaBLCA18_(CHD9,CNOT1,CYLD,MMP2,NUP93) 228 KIN001-102 AKT1 3 16 2.32630161961136 NA 2.946927764072 3.42296774892219 -0.476039984850189 0.690974495237004 1.36327886755449 0.365531032728336 0.688940023302752 0.349187533218446 0.568871040534105 NA NA NA 0.401694880576679 83.3425605301962 a1465 loss_cnaBLCA5_(FAT1,IRF2) 1030 KU-55933 ATM 3 12 2.30258509299405 NA 3.20632934488076 3.56872566100205 -0.362396316121294 0.944568295226572 0.967738282314445 0.375847948235776 0.383663434346339 0.374477606956486 0.570351750775098 NA NA NA 0.594022965799827 83.3425605301962 a1466 loss_cnaBLCA5_(FAT1,IRF2) 1057 NVP-BEZ235 PI3K (Class 1) and MTORC1/2 3 12 -1.38629436111989 0.693147180559945 -2.90388679334432 -2.42508022050302 -0.4788065728413 0.512723379791557 1.37222909653759 0.374598182441956 0.933849696957361 0.348926118859764 0.571618006815024 NA NA NA 0.356124699533716 83.3425605301962 a1467 gain_cnaBLCA23_(MYC) 273 CUDC-101 HDAC, EGFR 4 15 1.63315443905142 NA 0.317664001836895 -0.154260156557139 0.471924158394034 1.50301664022311 1.44378757236087 0.324476951616738 0.313984653106688 0.326865369551801 0.571759125113609 NA NA NA 0.600044999255276 83.3425605301962 a1468 MLL2_mut 1036 PLX4720 BRAF 3 12 2.30258509299405 NA 3.55184097834534 3.80683082539808 -0.254989847052747 0.69535678408213 0.678369617210815 0.374428597795531 0.366703615884518 0.375886302368852 0.571789944286772 NA NA NA 0.607646170684624 83.3425605301962 a1469 loss_cnaBLCA18_(CHD9,CNOT1,CYLD,MMP2,NUP93) 1005 Cisplatin DNA crosslinker 3 11 1.79175946922805 2.30258509299405 2.19749322140594 2.59613604140823 -0.398642820002289 1.6072613902491 0.902868086648146 0.378399364358903 0.248026128432355 0.441529417084871 0.572020062342848 NA NA NA 0.714724631514954 83.3425605301962 a1470 gain_cnaBLCA15_(ASXL1) 206 Ruxolitinib JAK1, JAK2, TYK2 6 13 1.65632149833295 0.0237165266173161 4.22215903535403 4.08587479972759 0.136284235626441 0.453849662374137 0.489662881655257 0.284276464982762 0.300284977438395 0.27832257810873 0.572172234984579 NA NA NA 0.565518776212664 83.3425605301962 a1471 gain_cnaBLCA15_(ASXL1) 166 FTI-277 Farnesyl transferase (FNTA) 6 13 0.0237165266173161 NA 1.35357117378974 1.58285568364494 -0.229284509855193 0.888055378317885 0.770870484354271 0.284082715166723 0.25818717554472 0.297435839753621 0.572431638782182 NA NA NA 0.599686374776848 83.3425605301962 a1472 CDKN1A_mut 1072 BMS-708163 g-secretase 3 15 1.6094379124341 NA 3.63381785489285 3.3998381815342 0.233979673358657 0.737017629371914 0.629358199360629 0.363434812458011 0.317468217901455 0.371775045747174 0.573525941175437 NA NA NA 0.647632780290929 83.3425605301962 a1473 NRAS_mut 204 Tipifarnib Farnesyl-transferase (FNTA) 3 16 2.77258872223978 NA 1.68206737674744 1.21636586958421 0.46570150716323 1.03455020873979 1.32081058349994 0.360887768099987 0.450148773089044 0.35258765562674 0.573743390546456 NA NA NA 0.539026862833206 83.3425605301962 a1474 loss_cnaBLCA5_(FAT1,IRF2) 1371 PLX4720 (rescreen) BRAF 4 14 2.30258509299405 NA 4.16339314966218 3.86149027958502 0.301902870077169 0.773481498229267 0.960517932312289 0.325213003989769 0.390316860543292 0.314312580661964 0.574199050428546 NA NA NA 0.539688619262404 83.3425605301962 a1475 RB1_mut 219 AT-7519 CDK9 6 13 2.32630161961136 NA 2.11467135233505 1.60701070310962 0.507660649225431 1.98132466116013 1.71237710730158 0.282714451745819 0.256222848873329 0.296465449731117 0.574265283050029 NA NA NA 0.602067657423138 83.3425605301962 a1476 gain_cnaBLCA9 201 Epothilone B Microtubules 4 15 -3.44201937618241 NA -5.85859115001661 -5.07527952978938 -0.783311620227233 1.27058971703282 2.61517025498803 0.322017797150778 0.616494537714727 0.299526051404564 0.574649156877035 NA NA NA 0.416688611897958 83.3425605301962 a1477 RB1_mut 1003 Camptothecin TOP1 5 9 -2.30258509299405 NA -4.68284351566094 -4.02402858124118 -0.658814934419756 2.52060556316174 1.77269102235851 0.320981055387172 0.261371689425841 0.371646793553014 0.575606858109589 NA NA NA 0.622479174544898 83.3425605301962 a1478 gain_cnaBLCA23_(MYC) 260 NG-25 MAP3K7 (TAK1) 4 15 2.32630161961136 NA 2.72644851545219 3.20524485157904 -0.478796336126853 1.86170155321919 1.40022759904827 0.320893671253532 0.257182111331935 0.341941793214395 0.575972750647543 NA NA NA 0.656916543510276 83.3425605301962 a1479 MLL2_mut 277 ABT-869 VEGFR and PDGFR family 3 16 0.0237165266173161 NA 2.1932953369251 2.35917135024307 -0.165876013317978 0.457003556781658 0.463142246589433 0.35870956912295 0.362964381472481 0.358153492883633 0.576036465062151 NA NA NA 0.607392965357189 83.3425605301962 a1480 NRAS_mut 194 AUY922 HSP90 3 16 -1.36257783450257 NA -3.47478359097272 -2.66885506552294 -0.805928525449778 1.16909916286291 2.35482901427341 0.358504304442109 0.689358568589003 0.342245029496739 0.576252798137475 NA NA NA 0.404280307898401 83.3425605301962 a1481 gain_cnaBLCA23_(MYC) 261 TL-1-85 MAP3K7 (TAK1) 4 15 2.32630161961136 NA 3.23765720695763 3.62224254088005 -0.384585333922423 1.50209396849952 1.12407009517303 0.320629729114861 0.256032806194273 0.342136433994559 0.576283754720868 NA NA NA 0.658168927550045 83.3425605301962 a1482 gain_cnaBLCA15_(ASXL1) 271 VNLG/124 HDAC, RAR 6 13 1.63315443905142 NA 4.03782541991863 3.90163312219931 0.136192297719324 0.495098867119014 0.480415595124825 0.280936080181977 0.275081012630524 0.283488502665983 0.57665304651313 NA NA NA 0.586704555537517 83.3425605301962 a1483 loss_cnaBLCA18_(CHD9,CNOT1,CYLD,MMP2,NUP93) 299 OSI-027 MTORC1/2 3 16 2.99573227355399 NA 1.33842602725877 1.99879685187592 -0.660370824617146 0.532815372414433 1.95362189959684 0.35808258573279 1.23939897158879 0.338023864675874 0.576697388103273 NA NA NA 0.272588312409772 83.3425605301962 a1484 gain_cnaBLCA23_(MYC) 1059 AZD8055 MTORC1/2 3 12 0.693147180559945 NA 0.0184484021262036 0.290971140267325 -0.272522738141121 0.882010403932544 0.70834398817977 0.369408306287164 0.308979051637087 0.384732196063981 0.576892315968645 NA NA NA 0.657238557604066 83.3425605301962 a1485 TP53_mut 1261 rTRAIL TR10A (DR4), TR10B (DR5) 14 4 -2.30258509299405 NA -0.975162207483856 -1.45125847710819 0.476096269624339 1.31779150991457 2.01898025137213 0.322803507245238 0.361283454964134 0.235810265752117 0.577010604897661 NA NA NA 0.680518454420099 83.3425605301962 a1486 gain_cnaBLCA15_(ASXL1) 153 Midostaurin KIT 6 13 -0.669430653942629 NA -0.0829961091330581 -0.42136698237891 0.338370873245851 1.30592766018609 1.16919529282093 0.279411123376239 0.259103841324285 0.289404922619437 0.578704615524504 NA NA NA 0.600992493423917 83.4486339197795 a1487 gain_cnaBLCA23_(MYC) 1038 NU-7441 PRKDC (DNAPK) 3 12 0.693147180559945 NA 1.87236291971907 2.28149883935815 -0.409135919639079 1.10100359567331 1.11577303326678 0.367427872667287 0.371602709788496 0.366683821387224 0.578911716992435 NA NA NA 0.604648861933808 83.4486339197795 a1488 loss_cnaBLCA5_(FAT1,IRF2) 231 FMK RSK 4 10 2.99573227355399 2.32630161961136 5.15679028227197 5.30368292937061 -0.146892647098642 0.454781433422934 0.429181217621491 0.33712446148659 0.322996139031112 0.34226252470394 0.579295435069806 NA NA NA 0.60172050552542 83.4486339197795 a1489 RB1_mut 150 Bicalutamide ANDR (androgen receptor) 6 13 0.0237165266173161 NA 2.46180531575909 2.32303304676381 0.138772268995278 0.32111175634435 0.557236934697563 0.277815300703166 0.432161907041682 0.249036379956752 0.580855519277419 NA NA NA 0.503407354261256 83.4486339197795 a1490 TP53_mut 1230 IOX2 EGLN1 15 4 -2.30258509299405 NA -0.19777875817969 0.0243005191314396 -0.22207927731113 0.764192458744451 0.255419099127796 0.31646728647601 0.290606475855572 0.869470129953025 0.58119976912867 NA NA NA 0.359226499715429 83.4486339197795 a1491 gain_cnaBLCA23_(MYC) 1012 Vorinostat HDAC inhibitor Class I, IIa, IIb, IV 4 10 2.30258509299405 NA 1.64042329561886 1.45069079639973 0.189732499219132 0.427642944046963 0.605438606842245 0.335069743096097 0.443670360660262 0.313380245453309 0.581579455879787 NA NA NA 0.527100560932801 83.4486339197795 a1492 loss_cnaBLCA18_(CHD9,CNOT1,CYLD,MMP2,NUP93) 197 Bryostatin 1 PRKC 3 16 -4.8283137373023 NA -3.34871749164522 -3.05205046724905 -0.296667024396163 0.582049671033573 0.868515790846147 0.353216862899093 0.509693655301545 0.341579309809827 0.581839711827134 NA NA NA 0.500278769391554 83.4486339197795 a1493 TP53_mut 286 KIN001-236 TIE2 15 4 2.32630161961136 NA 4.27390714556573 4.53805040487946 -0.264143259313727 0.771656824899641 1.08771748408183 0.315900811965905 0.342306645636265 0.242841788588786 0.5818704494412 NA NA NA 0.672925611139018 83.4486339197795 a1494 TP53_mut 1049 PD-173074 FGFR1, FGFR3 11 4 0.693147180559945 NA 2.66840703106689 2.36658681879243 0.301820212274464 0.744984078216232 1.33485798978164 0.32968213261436 0.405136460093394 0.226106608032392 0.581927209784023 NA NA NA 0.691957924015784 83.4486339197795 a1495 TP53_mut 249 XL-184 VEGFR, MET, RET, KIT, FLT1, FLT3, FLT4, Tie2,AXL 15 4 1.63315443905142 NA 3.1329792235861 2.82415086590916 0.308828357676944 0.765200211749126 1.63925012164293 0.315788681805244 0.403591573728151 0.188396116980258 0.582003253243533 NA NA NA 0.73603327913605 83.4486339197795 a1496 gain_cnaBLCA15_(ASXL1) 1061 SB590885 BRAF 4 11 1.6094379124341 NA 3.97380537206023 3.69984542676514 0.273959945295087 0.689431904410611 0.870556246926367 0.329174201281641 0.397370564870062 0.314695283920304 0.582502035652766 NA NA NA 0.547846996001212 83.4486339197795 a1497 TP53_mut 1378 Bleomycin (50 uM) DNA damage 14 4 3.91202300542815 NA 0.967021107907748 0.457608554097182 0.509412553810566 1.68088978359158 1.2053755730381 0.317883182600068 0.303061246955822 0.422617286433483 0.582773951787812 NA NA NA 0.520428260616508 83.4486339197795 a1498 loss_cnaBLCA5_(FAT1,IRF2) 219 AT-7519 CDK9 5 14 2.32630161961136 NA 2.15329690802497 1.62947733673647 0.523819571288504 2.08611633671564 1.69738809079719 0.291588035185397 0.251097967102449 0.308603302997424 0.582995779931328 NA NA NA 0.631571538851267 83.4486339197795 a1499 ARID1A_mut 1020 Lenalidomide TNFA 3 11 1.6094379124341 NA 4.0272125956805 3.69112213794875 0.336090457731753 0.566213818906639 0.970552736205426 0.367052264179421 0.593575159258291 0.346287682466145 0.583448202335858 NA NA NA 0.473919548163018 83.4486339197795 a1500 loss_cnaBLCA5_(FAT1,IRF2) 254 AC220 FLT3 5 14 0.0237165266173161 NA 2.49347950742586 2.34129338186864 0.152186125557221 0.386611023323007 0.558812360680025 0.290755417371463 0.393641454527466 0.27233850978533 0.584062402570756 NA NA NA 0.519826108685151 83.4486339197795 a1501 gain_cnaBLCA23_(MYC) 136 Mitomycin C DNA crosslinker 4 15 2.77258872223978 NA -1.61872660419471 -1.1095431784101 -0.509183425784613 1.01809046822918 1.72476621505162 0.313811109822604 0.500135736139702 0.295218807825136 0.584347967735003 NA NA NA 0.472339954084944 83.4486339197795 a1502 loss_cnaBLCA18_(CHD9,CNOT1,CYLD,MMP2,NUP93) 200 LAQ824 HDAC 3 16 0.0237165266173161 NA -3.05922880471099 -2.70097694667927 -0.35825185803172 0.742069686489159 1.05275568436057 0.350841183964338 0.482773874953257 0.340299143812571 0.584358904931825 NA NA NA 0.518249879796782 83.4486339197795 a1503 CDKN1A_mut 298 OSI-930 KIT, VEGFR, PDGFR 3 16 2.32630161961136 NA 4.5552560339886 4.28389474155237 0.271361292436229 0.493152783611218 0.806527025664342 0.349578093976187 0.550258056842196 0.336456539956248 0.585700547707983 NA NA NA 0.476724090852965 83.5082148172515 a1504 ARID1A_mut 272 AR-42 HDAC 5 14 1.63315443905142 NA 0.363222035758309 -0.0519555482004835 0.415177583958792 1.42434877451822 1.43881426674549 0.289236950341857 0.291485899652089 0.288555370595469 0.58601017720419 NA NA NA 0.593874532486117 83.5082148172515 a1505 NRAS_mut 164 JQ12 HDAC 3 16 1.63315443905142 NA 0.793016571204071 1.31382599411154 -0.520809422907472 0.689895686383641 1.56954549158556 0.348787351471905 0.754910391797778 0.331821808096398 0.5865412601007 NA NA NA 0.383046620978447 83.5082148172515 a1506 TP53_mut 1091 BMS-536924 IGF1R 15 4 1.38629436111989 NA 2.46018756690733 2.14256307343462 0.317624493472713 1.08571109168592 0.639030386501615 0.311035915371918 0.292549736209746 0.497041299102464 0.58764644684976 NA NA NA 0.475457369532778 83.5082148172515 a1507 NRAS_mut 1018 ABT-888 PARP1, PARP2 3 11 1.6094379124341 NA 4.14874972012367 3.93707113319473 0.211678586928944 0.539253736570933 0.59335709042542 0.362037051265486 0.392539861244152 0.356747379183043 0.588537296096578 NA NA NA 0.591802309560544 83.5082148172515 a1508 gain_cnaBLCA15_(ASXL1) 1037 BX-795 TBK1, PDPK1, IKK, AURKB, AURKC 4 11 1.6094379124341 NA 1.65259100125393 2.05441137044833 -0.401820369194407 0.584743872828965 1.37845988068869 0.323737122969831 0.687173287084511 0.291499502324038 0.588673689321981 NA NA NA 0.444070484715662 83.5082148172515 a1509 loss_cnaBLCA18_(CHD9,CNOT1,CYLD,MMP2,NUP93) 262 VX-11e ERK 3 16 1.63315443905142 NA 2.41651061584494 2.9283295724253 -0.511818956580353 1.49926951241695 1.47284103242292 0.346766724687077 0.341378886411994 0.347504547546707 0.588692343957476 NA NA NA 0.62698785686654 83.5082148172515 a1510 gain_cnaBLCA15_(ASXL1) 229 LY317615 PRKCB (PKCbeta) 6 13 2.99573227355399 2.32630161961136 4.11226475578883 3.65488501435268 0.457379741436149 1.63702346803952 1.70087658094769 0.271869899830252 0.279397180532728 0.268908247993694 0.588904666227659 NA NA NA 0.588177084416585 83.5082148172515 a1511 RB1_mut 193 GW-2580 CSF1R (cFMS) 6 13 2.99573227355399 NA 5.2107856955983 5.34021479052288 -0.129429094924574 0.600348245381923 0.41341948685076 0.271864478220245 0.215590027821661 0.313069652111721 0.588912031807287 NA NA NA 0.646443197260249 83.5082148172515 a1512 loss_cnaBLCA18_(CHD9,CNOT1,CYLD,MMP2,NUP93) 1243 piperlongumine Increases ROS levels 3 16 2.30258509299405 NA 1.5568978248468 1.24700717047465 0.309890654372156 0.153646483145574 0.950647280293515 0.346427934801526 2.01690691532813 0.325978584061668 0.589053395521638 NA NA NA 0.238535175568827 83.5082148172515 a1513 NRAS_mut 155 AP-24534 ABL 3 16 -0.669430653942629 NA 0.508886721354384 0.155636635343392 0.353250086010992 0.694061857775761 1.055691312152 0.34638329293974 0.508960522831556 0.334614940887315 0.589100979079962 NA NA NA 0.502340608483272 83.5082148172515 a1514 ARID1A_mut 1526 RDEA119 (rescreen) MAP2K1 (MEK1), MAP2K2 (MEK2) 5 14 1.6094379124341 NA 1.23508348123129 1.51298716451278 -0.277903683281489 1.14476339447803 0.909191742489137 0.286562983825362 0.242760805090386 0.305660148782983 0.589448106907471 NA NA NA 0.641518542317209 83.5082148172515 a1515 RB1_mut 245 UNC0638 G9a(EHMT2), GLP(EHMT1) 6 13 3.68887945411394 NA 4.22318471133955 3.89950297383683 0.323681737502715 1.52019386034127 1.02733346151331 0.271179182297062 0.212921355589511 0.315069789536415 0.589843420176722 NA NA NA 0.649556346710255 83.5090616861176 a1516 loss_cnaBLCA18_(CHD9,CNOT1,CYLD,MMP2,NUP93) 1242 (5Z)-7-Oxozeaenol MAP3K7 (TAK1) 3 16 2.30258509299405 NA 0.840960337353296 0.48913791756602 0.351822419787276 1.02192587769161 1.02151069087529 0.344397369160309 0.3442739120982 0.344413840138878 0.591219720301694 NA NA NA 0.624708023461944 83.6487023301761 a1517 MLL2_mut 1091 BMS-536924 IGF1R 3 16 1.38629436111989 NA 2.68866762537558 2.33794143257636 0.35072619279922 1.00685407367327 1.02333296256661 0.343375193000637 0.348338654001447 0.342729302806357 0.592311746119118 NA NA NA 0.621319906869431 83.7479648455141 a1518 NRAS_mut 1133 JNJ-26854165 MDM2 3 16 2.30258509299405 NA 1.95188313482464 2.38488343613378 -0.433000301309138 2.31423790275586 1.04609379796291 0.342782908096177 0.187102761040042 0.413921105499652 0.592944965792104 NA NA NA 0.778649323784502 83.7787740852447 a1519 MLL2_mut 134 Etoposide TOP2 3 16 2.77258872223978 NA 1.59746079058766 1.07780253381562 0.519658256772036 1.90526078672462 1.45804240177899 0.342440837436133 0.272749148249355 0.356408192339257 0.593310832121774 NA NA NA 0.690325626299417 83.7787740852447 a1520 RB1_mut 1175 AG-014699 PARP1, PARP2 6 13 1.6094379124341 NA 3.2956239579435 3.06065788551896 0.23496607242454 0.787611024096485 0.913051812127095 0.267609082863025 0.298327556669339 0.257341444706353 0.594707490197007 NA NA NA 0.577146361911179 83.9006460500651 a1521 gain_cnaBLCA23_(MYC) 1264 SGC0946 Q8TEK3 (DOT1L) 4 14 -0.693147180559945 NA 1.47842864296861 1.61534377047151 -0.1369151275029 0.621293418955655 0.395896968001737 0.306363961217047 0.220371121479194 0.345835251514984 0.596380889682804 NA NA NA 0.699441281554692 83.9006460500651 a1522 loss_cnaBLCA18_(CHD9,CNOT1,CYLD,MMP2,NUP93) 136 Mitomycin C DNA crosslinker 3 16 2.77258872223978 NA -1.68098965186125 -1.12969282108416 -0.551296830777086 1.48400691157982 1.64120590274653 0.33957259684948 0.371492091091542 0.335909607596769 0.596383024729562 NA NA NA 0.60238969132212 83.9006460500651 a1523 CDKN1A_mut 238 CAL-101 PI3Kdelta 3 16 2.99573227355399 2.32630161961136 4.57541463610668 4.87324822610334 -0.297833589996653 0.492338090001525 0.920179366610768 0.338178355173927 0.604937127646838 0.323669059320079 0.597879255427317 NA NA NA 0.451171083066757 83.9006460500651 a1524 NRAS_mut 1007 Docetaxel Microtubules 3 11 -4.38202663467388 NA -5.32548402720325 -5.90573490390651 0.580250876703257 2.14654038975722 1.52597288233533 0.352579214393869 0.270319104859185 0.380249795668223 0.598197033460152 NA NA NA 0.694822622475622 83.9006460500651 a1525 RB1_mut 166 FTI-277 Farnesyl transferase (FNTA) 6 13 0.0237165266173161 NA 1.36395294432406 1.57806409724448 -0.214111152920419 0.521919805991585 0.900912749720586 0.264952781210563 0.410237646593299 0.237660253988884 0.598339478653213 NA NA NA 0.523774689095682 83.9006460500651 a1526 TP53_mut 1241 CHIR-99021 GSK3B 15 4 2.30258509299405 NA 3.67121762208251 3.40048812092256 0.270729501159946 0.793007858156502 1.28303001491335 0.301110739808845 0.341395735711004 0.211007925000282 0.599519347904645 NA NA NA 0.710165741312776 83.9006460500651 a1527 CDKN1A_mut 1248 FK866 NAMPT 3 16 0 NA -2.83643136926985 -1.84996625302204 -0.986465116247805 1.46586755979287 3.08155900505165 0.335765021773643 0.672956509377418 0.320118847190878 0.600473510017949 NA NA NA 0.421161130996214 83.9006460500651 a1528 gain_cnaBLCA9 1261 rTRAIL TR10A (DR4), TR10B (DR5) 4 14 -2.30258509299405 NA -0.733098856538004 -1.18035067050391 0.447251813965907 1.48657397507413 1.47433074611843 0.302886015448998 0.300860785581561 0.303359212404283 0.600520161794842 NA NA NA 0.618482742317627 83.9006460500651 a1529 MLL2_mut 1026 17-AAG HSP90 3 12 0 NA -1.09598888033557 -1.69143257086774 0.595443690532172 2.31303102213963 1.59046455584871 0.345889831520107 0.257430049503343 0.374383502192811 0.601110396038753 NA NA NA 0.706909246152976 83.9006460500651 a1530 NRAS_mut 1170 CCT018159 HSP90 3 16 2.30258509299405 NA 2.37434104422375 2.68345656758138 -0.309115523357637 0.669671510948891 0.951277390604884 0.335041230846941 0.461592763472402 0.324947829529598 0.601252642044557 NA NA NA 0.535809473715073 83.9006460500651 a1531 ARID1A_mut 173 FH535 unknown 5 14 3.46573590279973 NA 1.99716872905587 1.64910554952493 0.348063179530944 0.672800443736749 1.38551390300959 0.277389611181063 0.517334943475652 0.251215941445905 0.601318814239629 NA NA NA 0.477063948554574 83.9006460500651 a1532 loss_cnaBLCA18_(CHD9,CNOT1,CYLD,MMP2,NUP93) 199 Pazopanib VEGFR, PDGFRA, PDGFRB, KIT 3 16 2.07944154167984 NA 2.47232104948681 2.93803336891029 -0.465712319423473 1.71004728415054 1.34348614289031 0.334652045752243 0.27233885503629 0.346644676529051 0.601671789878402 NA NA NA 0.691158956389171 83.9006460500651 a1533 MLL2_mut 266 Zibotentan, ZD4054 Endothelin A Receptor 3 16 2.99573227355399 NA 5.35231212111578 5.48077662735804 -0.128464506242261 0.22990753779922 0.400677574540399 0.334070168872084 0.558765960750925 0.320618158851584 0.602298732455949 NA NA NA 0.476665606766614 83.9006460500651 a1534 RB1_mut 1069 EHT 1864 Rac GTPases 5 13 2.30258509299405 NA 3.29019516928896 3.56447658338672 -0.274281414097755 0.759420564340228 1.04418340068549 0.279657904539783 0.361171960540792 0.262675516501884 0.60242023168653 NA NA NA 0.552405091736993 83.9006460500651 a1535 EP300_mut 290 KIN001-260 IKK 4 15 2.99573227355399 NA 5.29064228934444 4.9363610647098 0.354281224634637 0.212108678453798 1.30389113636211 0.298565329492372 1.67028160854723 0.271710739305346 0.602583266037073 NA NA NA 0.33030125391936 83.9006460500651 a1536 RB1_mut 329 QL-XI-92 DDR1 6 13 2.32630161961136 NA 4.07574289049875 4.32106571358563 -0.245322823086879 0.954082384806147 0.933576887952402 0.261077723113695 0.257129601168273 0.262777309777818 0.60365748983834 NA NA NA 0.611799693026226 83.9006460500651 a1537 loss_cnaBLCA5_(FAT1,IRF2) 1529 MLN4924 NEDD8-activating enzyme 4 12 0 NA -0.607853375005654 -0.106872184410266 -0.500981190595388 2.18674388817792 1.44816985657996 0.306453294438157 0.229099161224969 0.345940904873217 0.603881312495329 NA NA NA 0.69113593136176 83.9006460500651 a1538 gain_cnaBLCA15_(ASXL1) 1007 Docetaxel Microtubules 4 10 -4.38202663467388 NA -5.41082884875982 -5.92962206295421 0.518793214194385 1.96831183957982 1.52399651628514 0.315116126753415 0.263572673680169 0.340416273036492 0.604003914198871 NA NA NA 0.657857941135628 83.9006460500651 a1539 loss_cnaBLCA5_(FAT1,IRF2) 235 QL-XII-47 BTK, BMX 5 14 2.32630161961136 NA 1.49615987583316 1.97572311976903 -0.479563243935876 1.14897365628679 1.88723025317975 0.275309924075262 0.417384020348832 0.254109557181945 0.604026299216109 NA NA NA 0.517989532972684 83.9006460500651 a1540 ARID1A_mut 1031 Elesclomol HSP70 3 11 -1.6094379124341 NA -3.23026277318888 -3.76805658875795 0.537793815569069 1.57252624538977 1.54610822363279 0.346842360490875 0.341993538833287 0.34783710955592 0.604095729169744 NA NA NA 0.63310097577505 83.9006460500651 a1541 NRAS_mut 207 AS601245 JNK 3 16 2.07944154167984 NA 2.56559878760341 2.15455461709673 0.411044170506677 1.78315511144729 1.14497636257759 0.332221092837358 0.23051509533181 0.358997953094271 0.604293144682313 NA NA NA 0.732942490727714 83.9006460500651 a1542 gain_cnaBLCA9 290 KIN001-260 IKK 4 15 2.99573227355399 NA 5.28897005112353 4.93680699490204 0.352163056221483 0.919051620484337 1.23657295262704 0.296750984596635 0.383180931704243 0.28478955121356 0.604771882111349 NA NA NA 0.551301878725279 83.9006460500651 a1543 loss_cnaBLCA5_(FAT1,IRF2) 136 Mitomycin C DNA crosslinker 5 14 2.77258872223978 NA -1.54534060381479 -1.09938221956117 -0.445958384253621 0.558175530570236 1.83128312515483 0.27458158356274 0.798957245220023 0.243522357699832 0.604975914593914 NA NA NA 0.428234897628632 83.9006460500651 a1544 NRAS_mut 276 CAY10603 HDAC6 3 16 2.99573227355399 NA 0.911788302273217 1.31377011216438 -0.401981809891161 0.0698279212110263 1.29043792770209 0.331560933014308 5.75674891819184 0.311508055724134 0.605005974984138 NA NA NA 0.234778405066161 83.9006460500651 a1545 loss_cnaBLCA5_(FAT1,IRF2) 305 TPCA-1 IKK 5 14 2.99573227355399 NA 3.24367341217979 3.674338114336 -0.430664702156218 1.21347157454719 1.66287505926133 0.274525835242781 0.354902999946186 0.258988009807258 0.605048629697468 NA NA NA 0.553206244500049 83.9006460500651 a1546 NRAS_mut 1020 Lenalidomide TNFA 3 11 1.6094379124341 NA 4.01187907950107 3.69530400599768 0.316575073503388 0.59160882867614 0.969068794003492 0.345224344510313 0.535108771469481 0.326679669660529 0.605764711249178 NA NA NA 0.510364235417483 83.9006460500651 a1547 TP53_mut 1014 RDEA119 MAP2K1 (MEK1), MAP2K2 (MEK2) 11 4 1.6094379124341 NA 1.19245133698022 0.793651668097185 0.398799668883038 0.660236992740653 2.40394009128418 0.308700620430653 0.604025029296851 0.165894179446876 0.605915614748031 NA NA NA 0.76387680792795 83.9006460500651 a1548 gain_cnaBLCA15_(ASXL1) 1066 AZD6482 PI3Kbeta 5 13 1.6094379124341 NA 1.7906541749335 2.09390448868914 -0.303250313755635 1.21003157998292 1.05419643699256 0.276881273299773 0.250613553209839 0.287660158120773 0.605997404309204 NA NA NA 0.638228382678473 83.9006460500651 a1549 CDKN1A_mut 165 DMOG Prolyl-4-Hydroxylase 3 16 8.29404964010203 NA 5.46506998392667 5.79218561950522 -0.327115635578555 0.95217155287234 0.994426897855971 0.330570314297048 0.34354695284875 0.328948901406258 0.606076400145415 NA NA NA 0.626752581663876 83.9006460500651 a1550 gain_cnaBLCA9 1170 CCT018159 HSP90 4 15 2.30258509299405 NA 2.84968254538588 2.57730653549532 0.272376009890563 0.695642002668648 0.964595106158124 0.295147797166749 0.391546239079389 0.282373410513565 0.60670901172959 NA NA NA 0.546083527858866 83.9006460500651 a1551 ARID1A_mut 163 JQ1 BRD4 5 14 0.940007258491471 NA 0.0286674781655572 -0.350920328905899 0.379587807071456 1.44688511205991 1.37204081597191 0.273082034100911 0.262348270714488 0.276659267459596 0.606933332226998 NA NA NA 0.626011468319131 83.9006460500651 a1552 RB1_mut 288 KIN001-055 JAK3, MNK1 6 13 2.32630161961136 NA 4.27814119743026 4.06165570911236 0.216485488317899 0.780312228642881 0.859755892871372 0.258591085647929 0.277434442741479 0.251798783948885 0.607082234897279 NA NA NA 0.597500858230725 83.9006460500651 a1553 TP53_mut 150 Bicalutamide ANDR (androgen receptor) 15 4 0.0237165266173161 NA 2.39785288885318 2.2506170424216 0.147235846431588 0.397791980646761 0.824010799368759 0.294391358168812 0.370132766860208 0.178681937839139 0.607624064893143 NA NA NA 0.749253564064642 83.9214555316903 a1554 TP53_mut 1236 UNC0638 G9a(EHMT2), GLP(EHMT1) 15 4 2.99573227355399 NA 3.71140278786804 3.33301602132242 0.378386766545614 1.20110390339536 1.63951860259072 0.293471083954082 0.315032500915172 0.230791383487627 0.608738211457968 NA NA NA 0.688719138993815 83.9656132525953 a1555 loss_cnaBLCA18_(CHD9,CNOT1,CYLD,MMP2,NUP93) 151 QS11 ARFGAP 3 16 2.32630161961136 NA 2.58807533076939 3.13776391012104 -0.549688579351649 2.06792772441698 1.61949012457246 0.32749237327094 0.265816146696629 0.339420766456828 0.609408188093205 NA NA NA 0.697891520492507 83.9656132525953 a1556 EP300_mut 304 SB52334 ALK5 4 15 2.99573227355399 NA 4.50535815723838 4.80565566056768 -0.300297503329302 0.527724912991475 1.10379661796531 0.292711127444559 0.569041741135601 0.272058727524332 0.609659013456544 NA NA NA 0.455850280840849 83.9656132525953 a1557 gain_cnaBLCA15_(ASXL1) 1030 KU-55933 ATM 4 11 2.30258509299405 NA 3.27996750506174 3.57489326785636 -0.294925762794618 0.612019760985395 1.04987879895824 0.305115940660241 0.481889281352234 0.280914104644521 0.610063162644781 NA NA NA 0.518784099747051 83.9656132525953 a1558 NRAS_mut 1262 UNC1215 LMBL3 3 15 0 NA 2.48330770677239 2.35167668869547 0.13163101807692 0.506201676367697 0.383837686761923 0.328110056751446 0.260036709126393 0.342934064623426 0.611009823440006 NA NA NA 0.703940087865774 83.9656132525953 a1559 loss_cnaBLCA5_(FAT1,IRF2) 1243 piperlongumine Increases ROS levels 5 14 2.30258509299405 NA 1.11826294541557 1.35939239107549 -0.241129445659917 0.368414668203053 1.00340366644113 0.269278620940855 0.654505551681829 0.240311505453389 0.61191185312453 NA NA NA 0.454197588281902 83.9656132525953 a1560 gain_cnaBLCA9 1241 CHIR-99021 GSK3B 4 15 2.30258509299405 NA 3.82049356436679 3.55921617049738 0.26127739386941 0.776940423083747 0.923793770425158 0.290430168039631 0.336290127410769 0.282830867921054 0.612426784951343 NA NA NA 0.58909923851736 83.9656132525953 a1561 loss_cnaBLCA18_(CHD9,CNOT1,CYLD,MMP2,NUP93) 254 AC220 FLT3 3 16 0.0237165266173161 NA 2.23805078604169 2.40820953282282 -0.17015874678113 0.392675861040334 0.539208779646069 0.324668246688181 0.433331313848324 0.315571172436807 0.612473019404715 NA NA NA 0.557596617996494 83.9656132525953 a1562 gain_cnaBLCA23_(MYC) 1039 SL 0101-1 RSK, AURKB, PIM3 3 12 2.30258509299405 NA 4.01520178854416 4.28095927109034 -0.265757482546174 1.22621325399706 0.686926798132623 0.334664639289777 0.216730231613376 0.386878897822335 0.612848322706902 NA NA NA 0.74802015901136 83.9656132525953 a1563 loss_cnaBLCA18_(CHD9,CNOT1,CYLD,MMP2,NUP93) 1129 PF-4708671 RPS6KB1 (p70S6KA) 3 16 2.30258509299405 NA 3.4404100126632 3.72921436174341 -0.288804349080209 0.315680518687921 0.940962728352862 0.324321434916276 0.914862755169628 0.306924323756963 0.612849902241308 NA NA NA 0.353880170187643 83.9656132525953 a1564 RB1_mut 135 Gemcitabine DNA replication 6 13 0.0237165266173161 NA -2.85469659746212 -2.1126331213399 -0.742063476122216 1.77967396014026 3.27915817441563 0.254199787013576 0.416965968341602 0.226296944719496 0.613153192348181 NA NA NA 0.532671282409499 83.9656132525953 a1565 gain_cnaBLCA23_(MYC) 211 TL-2-105 CRAF 4 15 2.32630161961136 1.63315443905142 4.18472634992172 4.43161000849052 -0.2468836585688 1.31849348498168 0.713836054188397 0.289666594371068 0.187246779283274 0.345854845969494 0.613354675411039 NA NA NA 0.739140982075119 83.9656132525953 a1566 CDKN1A_mut 211 TL-2-105 CRAF 3 16 2.32630161961136 1.63315443905142 4.61199777318732 4.33606638796767 0.275931385219645 0.430673594182575 0.893618564554599 0.323746357782467 0.640697244843548 0.308779826387308 0.613475088736448 NA NA NA 0.440629604716141 83.9656132525953 a1567 NRAS_mut 154 CHIR-99021 GSK3B 3 16 0.940007258491471 NA 2.93854117366936 2.68646588465841 0.252075289010945 0.782131321317923 0.779922763247252 0.323097677685739 0.322292794240983 0.32320545173142 0.614180659606676 NA NA NA 0.645944770346385 83.9656132525953 a1568 loss_cnaBLCA18_(CHD9,CNOT1,CYLD,MMP2,NUP93) 1261 rTRAIL TR10A (DR4), TR10B (DR5) 3 15 -2.30258509299405 NA -1.48122694721625 -1.00090826477053 -0.480318682445717 1.59257135446723 1.46043457163572 0.325067219216461 0.301599473768257 0.32888750497583 0.614293745263276 NA NA NA 0.665093075608202 83.9656132525953 a1569 NRAS_mut 1199 Tamoxifen ER 3 16 1.6094379124341 NA 3.37034240289187 3.56029233569661 -0.189949932804742 0.38394158568825 0.611986619351256 0.322084138646461 0.494736542967179 0.310382493339643 0.615283868192922 NA NA NA 0.517556243580101 83.9656132525953 a1570 TP53_mut 1005 Cisplatin DNA crosslinker 10 4 1.79175946922805 2.30258509299405 2.41858255322182 2.74103764687254 -0.322455093650726 1.17613909291537 0.561565567610076 0.30519372473129 0.274164081096426 0.574207380668009 0.615316337237663 NA NA NA 0.503023398339911 83.9656132525953 a1571 ARID1A_mut 166 FTI-277 Farnesyl transferase (FNTA) 5 14 0.0237165266173161 NA 1.35153804640522 1.56720433557833 -0.215666289173111 0.900276154427464 0.778389776208404 0.26667500876174 0.239555705338286 0.277067217177026 0.615331205572193 NA NA NA 0.650250246334179 83.9656132525953 a1572 loss_cnaBLCA5_(FAT1,IRF2) 1058 GDC0941 PI3K (class 1) 3 12 1.38629436111989 0.693147180559945 1.45754262526895 1.01731883778282 0.440223787486124 0.342213801075095 1.43581772766424 0.331602842281307 1.28639986494736 0.306601443208444 0.616069555039048 NA NA NA 0.35530917450633 83.9656132525953 a1573 ARID1A_mut 1243 piperlongumine Increases ROS levels 5 14 2.30258509299405 NA 1.12032928780246 1.3586544116516 -0.238325123849136 0.582933881656181 0.971805193667672 0.266098581300306 0.408837316458648 0.24523960707565 0.616089471075878 NA NA NA 0.529234494731345 83.9656132525953 a1574 loss_cnaBLCA5_(FAT1,IRF2) 1495 AZD-2281 PARP1, PARP2 4 13 2.30258509299405 NA 3.14473592712322 3.35791714627362 -0.213181219150397 0.983872200360156 0.649295854151683 0.2925871606107 0.216675721778052 0.328326783217986 0.616297343940202 NA NA NA 0.705702991576977 83.9656132525953 a1575 gain_cnaBLCA23_(MYC) 1170 CCT018159 HSP90 4 15 2.30258509299405 NA 2.8438632308381 2.57885835270806 0.265004878130039 0.776827492948686 0.951693653570307 0.287036436689643 0.341137357438434 0.278456073691219 0.616555994732755 NA NA NA 0.586301698323591 83.9656132525953 a1576 CDKN1A_mut 171 AKT inhibitor VIII AKT1, AKT2, AKT3 3 16 0.940007258491471 NA 1.73909742862418 2.08374104267369 -0.344643614049519 0.355349465344408 1.13974524867637 0.319848957713422 0.969872330370576 0.302386532823688 0.617720151036306 NA NA NA 0.346563704424512 84.0707754861216 a1577 EP300_mut 298 OSI-930 KIT, VEGFR, PDGFR 4 15 2.32630161961136 NA 4.15137125217086 4.37350659720802 -0.22213534503716 0.365184363039434 0.83980502872826 0.285742338216929 0.608282740225581 0.264508233980863 0.618134046243782 NA NA NA 0.448188078720271 84.0721712246555 a1578 RB1_mut 1502 Bicalutamide ANDR (androgen receptor) 6 11 2.30258509299405 NA 4.39709273532271 4.23686250865008 0.160230226672625 0.319515143965564 0.726102572266803 0.258062428362016 0.50147928728503 0.220671614166585 0.618514328228855 NA NA NA 0.539188382463553 84.0721712246555 a1579 gain_cnaBLCA15_(ASXL1) 1264 SGC0946 Q8TEK3 (DOT1L) 6 12 -0.693147180559945 NA 1.66034284055064 1.54720585959765 0.113136980952993 0.493427860741707 0.424834598938788 0.252875949800135 0.229287784404651 0.266308302656145 0.619927155622085 NA NA NA 0.643066498587705 84.1795382716588 a1580 RB1_mut 1527 GDC0941 (rescreen) PI3K 6 13 1.38629436111989 NA 1.04540755633725 0.752027749081182 0.293379807256069 0.482096815738729 1.36621125796065 0.249208336027922 0.608549564482221 0.214739708479637 0.620089144641683 NA NA NA 0.501582026445499 84.1795382716588 a1581 EP300_mut 176 IPA-3 PAK1, PAK2, PAK3 4 15 3.46573590279973 NA 3.34225037978738 3.80933648544652 -0.467086105659141 1.14802501751562 1.73611907957368 0.283484220946675 0.406860563605082 0.269040362008946 0.620892245034989 NA NA NA 0.541175046243874 84.235248857508 a1582 gain_cnaBLCA9 1038 NU-7441 PRKDC (DNAPK) 3 12 0.693147180559945 NA 2.49098455613787 2.12684343025344 0.36414112588443 0.344839663621689 1.20470808936534 0.326176137280804 1.05597228016066 0.302265029262206 0.621799189809278 NA NA NA 0.381121667407604 84.2605844669036 a1583 TP53_mut 1243 piperlongumine Increases ROS levels 15 4 2.30258509299405 NA 1.34912345682657 1.09648908743404 0.252634369392536 0.917672847075001 0.786235278086575 0.281995670338441 0.275298947983244 0.321321589648535 0.622713635770072 NA NA NA 0.603957198676292 84.2605844669036 a1584 loss_cnaBLCA5_(FAT1,IRF2) 308 XL-880 MET 5 14 1.63315443905142 NA 0.374671362001175 0.756891558273109 -0.382220196271934 1.56845714561639 1.43119207061428 0.260963942941082 0.243691832665103 0.267064221581302 0.622863511865226 NA NA NA 0.647906187411625 84.2605844669036 a1585 gain_cnaBLCA15_(ASXL1) 1010 Gefitinib EGFR 4 10 -0.693147180559945 NA 0.799694795751345 0.495740777643541 0.303954018107804 1.24184898206769 0.931477427621837 0.298585222364292 0.244759244076295 0.326313884904148 0.622908574854288 NA NA NA 0.679046567371501 84.2605844669036 a1586 TP53_mut 1175 AG-014699 PARP1, PARP2 15 4 1.6094379124341 NA 3.08271836117874 3.33038021043161 -0.247661849252875 0.744736185190095 1.33837276827957 0.281714678574976 0.332549772896638 0.185046987747094 0.623057740470016 NA NA NA 0.742389065025077 84.2605844669036 a1587 RB1_mut 157 JNK-9L JNK 6 13 1.63315443905142 NA -0.5889443045439 -0.342335949330779 -0.246608355213121 0.932244676160219 1.02578968325655 0.246809264432432 0.264531792478414 0.240408301271095 0.623436028098153 NA NA NA 0.614285086680394 84.2605844669036 a1588 TP53_mut 305 TPCA-1 IKK 15 4 2.99573227355399 NA 3.46826449280634 3.90878331737698 -0.440518824570649 1.20538735171121 2.68117722092618 0.280570993159603 0.365458310098636 0.164300524833818 0.624459232093129 NA NA NA 0.7679507125976 84.3111096164323 a1589 EP300_mut 204 Tipifarnib Farnesyl-transferase (FNTA) 4 15 2.77258872223978 NA 1.00411980392329 1.36610512185977 -0.361985317936477 1.22623452368734 1.30744725013856 0.279852485839855 0.295200722980766 0.276864185456137 0.625340461896111 NA NA NA 0.627097624636878 84.3111096164323 a1590 RB1_mut 235 QL-XII-47 BTK, BMX 6 13 2.32630161961136 NA 2.14213248833097 1.71447139430357 0.427661094027406 2.03914925081813 1.60436066993368 0.24528443136568 0.209725253733057 0.266561691546006 0.625567705606484 NA NA NA 0.662550423557642 84.3111096164323 a1591 TP53_mut 219 AT-7519 CDK9 15 4 2.32630161961136 NA 1.87325470382902 1.37008667425 0.503168029579022 1.83748972944417 1.6129061021021 0.279554144231183 0.273834471842858 0.311963622013236 0.62570654151535 NA NA NA 0.612546027923964 84.3111096164323 a1592 ARID1A_mut 1053 MK-2206 AKT1, AKT2 5 10 1.38629436111989 0.693147180559945 2.15157153034326 1.84526618322292 0.306305347120336 1.1065761834894 1.12532990427926 0.273586339521584 0.276804572238717 0.27219159995265 0.62577523333723 NA NA NA 0.628473748525813 84.3111096164323 a1593 MLL2_mut 163 JQ1 BRD4 3 16 0.940007258491471 NA 0.112978104061421 -0.319280095377441 0.432258199438862 1.49548656427539 1.37676445744283 0.310695998352904 0.289041847492829 0.313966704400351 0.627744288533802 NA NA NA 0.677075085673131 84.3898087210534 a1594 gain_cnaBLCA9 155 AP-24534 ABL 4 15 -0.669430653942629 NA -0.0126908548040089 0.271173983251564 -0.283864838055573 0.413378297889253 1.10933854758645 0.277869563305324 0.686695067218121 0.255886571933489 0.627775490257465 NA NA NA 0.434760035879378 84.3898087210534 a1595 RB1_mut 326 GSK690693 AKT 6 13 2.32630161961136 NA 4.4226403722382 4.18816056346111 0.234479808777084 0.957518826260061 0.964512648900517 0.243625278111326 0.24488271389183 0.243107033427064 0.627891042474841 NA NA NA 0.631409995396923 84.3898087210534 a1596 gain_cnaBLCA23_(MYC) 1050 ZM-447439 AURKB 3 12 1.38629436111989 0.693147180559945 1.86866772036289 2.29056276000308 -0.421895039640188 1.44532685965584 1.29225866710583 0.320353755839566 0.291902857005403 0.326478785075649 0.627975232119454 NA NA NA 0.67723468887191 84.3898087210534 a1597 RB1_mut 1007 Docetaxel Microtubules 5 9 -4.38202663467388 NA -6.07455920573022 -5.61852666621447 -0.456032539515746 1.78310185489243 1.57752031030477 0.276568087496512 0.255752377949972 0.289081881568702 0.628961542854141 NA NA NA 0.646620127539299 84.3898087210534 a1598 loss_cnaBLCA18_(CHD9,CNOT1,CYLD,MMP2,NUP93) 1039 SL 0101-1 RSK, AURKB, PIM3 3 12 2.30258509299405 NA 4.02503744651299 4.27850035659813 -0.253462910085132 0.98070637765993 0.756156621503989 0.318884418597511 0.258449333927981 0.335198955979511 0.629538462407615 NA NA NA 0.707913669158512 84.3898087210534 a1599 EP300_mut 179 5-Fluorouracil DNA antimetabolite 4 15 3.46573590279973 NA 4.53036876678963 4.19555125950279 0.334817507286836 1.08440482110131 1.23699581741759 0.276373976934519 0.308756933547011 0.270669878242448 0.629614999658427 NA NA NA 0.616201349037155 84.3898087210534 a1600 ARID1A_mut 1114 Cetuximab EGFR 4 14 4.18661983833127 NA 5.93655297139829 5.77510581662518 0.161447154773108 0.652389205132155 0.561943378033581 0.278368032027396 0.247470610339734 0.287301463250734 0.630096296976278 NA NA NA 0.674461617397171 84.3898087210534 a1601 RB1_mut 154 CHIR-99021 GSK3B 6 13 0.940007258491471 NA 2.8553890530941 2.66667256592139 0.188716487172714 0.682129538059747 0.81830467917371 0.241720260242811 0.276657843771875 0.230618853803051 0.630563633472145 NA NA NA 0.609181513670251 84.3898087210534 a1602 NRAS_mut 1259 BMN-673 PARP1 3 15 2.30258509299405 NA 1.47461589087876 1.98583624921443 -0.511220358335677 1.32185501108381 1.69045723453039 0.310038276291151 0.386744653573252 0.30241543405722 0.630637012219925 NA NA NA 0.596574147100431 84.3898087210534 a1603 ARID1A_mut 1026 17-AAG HSP90 5 10 0 NA -1.26315222367913 -1.72693963730239 0.463787413623256 2.00605142905812 1.58333473618721 0.268944375273298 0.231194179224514 0.292918106969655 0.631595078065977 NA NA NA 0.666153826424982 84.3898087210534 a1604 NRAS_mut 312 AV-951 VEGFR 3 16 -2.05572501506252 NA 0.508721566872174 0.390592721482006 0.118128845390168 0.563043907431664 0.354068258196689 0.307152772357341 0.209803967028105 0.33363297233085 0.631645104797624 NA NA NA 0.755359833736784 84.3898087210534 a1605 ARID1A_mut 1268 XAV 939 TNKS1 (tankyrase-1) 4 14 1.6094379124341 NA 3.37037883674607 3.15869131676408 0.211687519981992 0.557713537478508 0.80596716728627 0.27650741009598 0.379563173128373 0.262650302114358 0.632368431537299 NA NA NA 0.566755996333099 84.3898087210534 a1606 EP300_mut 275 I-BET BRD2, BRD3, BRD4 4 15 2.99573227355399 NA 4.88544996204582 4.57488445693865 0.310565505107168 0.668567919657344 1.2094413722052 0.274129645187881 0.464523492641316 0.256784257794081 0.632380138420969 NA NA NA 0.514194477602985 84.3898087210534 a1607 EP300_mut 1052 RO-3306 CDK1 4 11 1.6094379124341 NA 2.5168432637065 2.89430392303645 -0.377460659329945 1.00133742961578 1.40153276090659 0.285956492061265 0.376956506534246 0.269319897371348 0.63246664623454 NA NA NA 0.581108242473796 84.3898087210534 a1608 gain_cnaBLCA9 291 KIN001-266 MAP3K8 (COT) 4 15 2.99573227355399 NA 3.9061090600025 3.58861967261446 0.317489387388036 1.47004405054308 1.0809099581063 0.273907269278319 0.215972703179028 0.293724176567179 0.632654423954595 NA NA NA 0.707456011394765 84.3898087210534 a1609 NRAS_mut 222 BX-912 PDPK1 (PDK1) 3 16 2.32630161961136 NA 3.695700503557 3.23042445770086 0.465276045856137 1.89162759915643 1.46485594863847 0.305842869336252 0.245965985093275 0.317625802242598 0.633090050551124 NA NA NA 0.718618601273655 84.395432255388 a1610 gain_cnaBLCA9 1149 TW 37 BCL2, BCL2L1 4 15 1.6094379124341 NA -0.243188577235114 -0.656761960031405 0.41357338279629 0.859622332196945 1.62194271297077 0.272888531823879 0.481110561354679 0.254986430463247 0.633911671096398 NA NA NA 0.50710235107209 84.4463700024942 a1611 gain_cnaBLCA9 211 TL-2-105 CRAF 4 15 2.32630161961136 1.63315443905142 4.56251124954816 4.33086736859014 0.231643880958012 0.893739111535334 0.844133647780088 0.271532819361738 0.259185122334052 0.274416120678511 0.635586574786827 NA NA NA 0.662760363238704 84.4463700024942 a1612 NRAS_mut 1005 Cisplatin DNA crosslinker 3 11 1.79175946922805 2.30258509299405 2.24760264562908 2.58246983480192 -0.334867189172833 1.24061587732386 1.01736414103195 0.31655458150929 0.269920122169625 0.329151751734797 0.635716776930744 NA NA NA 0.69845696114996 84.4463700024942 a1613 MLL2_mut 151 QS11 ARFGAP 3 16 2.32630161961136 NA 2.6217375179317 3.1314522500281 -0.509714732096409 2.03863672000391 1.62662801004604 0.303338223729912 0.250027249629562 0.313356667257919 0.635857159454253 NA NA NA 0.71477056193844 84.4463700024942 a1614 gain_cnaBLCA23_(MYC) 231 FMK RSK 4 10 2.99573227355399 2.32630161961136 5.3512306275563 5.22590679125688 0.125323836299415 0.629450196985953 0.350618477552322 0.286570069881441 0.199100479910108 0.357436485305351 0.636828471975955 NA NA NA 0.727393195456989 84.4463700024942 a1615 TP53_mut 222 BX-912 PDPK1 (PDK1) 15 4 2.32630161961136 NA 3.21741781160542 3.62815641495087 -0.410738603345441 1.52167520351934 1.52104823682616 0.269944903058693 0.269925278663596 0.270036540197104 0.637550939872764 NA NA NA 0.652657725220889 84.4463700024942 a1616 TP53_mut 1028 VX-702 p38 10 4 0.693147180559945 NA 2.9616237199163 2.7483655682499 0.213258151666403 0.425261123465399 1.29900026760257 0.285620107540823 0.501475775468468 0.164170983628811 0.637935326850039 NA NA NA 0.767336487665824 84.4463700024942 a1617 loss_cnaBLCA5_(FAT1,IRF2) 203 BMS-345541 IKBKB 5 14 2.77258872223978 NA 3.65698499885446 3.45822746990527 0.198757528949189 0.85760277653622 0.779486625538067 0.248896586240054 0.231759428009261 0.254985169004009 0.63892061449148 NA NA NA 0.663576293687896 84.4463700024942 a1618 TP53_mut 1023 GW 441756 NTRK1 10 4 0.693147180559945 NA 2.3657368580929 2.63263523564295 -0.266898377550052 0.861518662030734 1.13874308568666 0.28437816451724 0.309799879344378 0.234379800768769 0.639383760496713 NA NA NA 0.692037907204721 84.4463700024942 a1619 CDKN1A_mut 291 KIN001-266 MAP3K8 (COT) 3 16 2.99573227355399 NA 3.36247053789821 3.71039498222077 -0.347924444322556 0.587848312192596 1.21549951639439 0.300082368175441 0.591860922462879 0.286239887083316 0.639462494399955 NA NA NA 0.474069052156416 84.4463700024942 a1620 RB1_mut 202 GSK-1904529A IGF1R 6 13 0.0237165266173161 NA 1.98967012354496 2.11931498033846 -0.129644856793495 0.456302852928262 0.585897663256136 0.23530933144817 0.284120197718504 0.221275599689187 0.639596274141496 NA NA NA 0.609145115484032 84.4463700024942 a1621 EP300_mut 1377 Afatinib (rescreen) ERBB2, EGFR 3 15 2.30258509299405 NA 3.69137065062909 3.27955200966216 0.411818640966929 0.936393013822052 1.41723836982842 0.301385561983764 0.439792517552026 0.290578246916068 0.640137827256656 NA NA NA 0.56139484196499 84.4463700024942 a1622 gain_cnaBLCA23_(MYC) 1241 CHIR-99021 GSK3B 4 15 2.30258509299405 NA 3.42411443300647 3.66491727219347 -0.240802839186992 1.1154294955874 0.847616496538306 0.267355881779621 0.215883514054092 0.284094092281638 0.640759698440995 NA NA NA 0.708409702796969 84.4463700024942 a1623 RB1_mut 346 THZ-2-102-1 CDK7 6 13 0.916290731874155 2.99573227355399 0.0712535944520542 -0.506926649284944 0.578180243736998 2.71744457458511 2.35424450496452 0.234401276037 0.212766158745031 0.245590567384891 0.640880441625324 NA NA NA 0.664387996727429 84.4463700024942 a1624 EP300_mut 330 XMD13-2 RIPK 4 15 2.32630161961136 NA 3.9866133199809 3.73045460869251 0.256158711288391 0.1480288912935 1.05419681479298 0.267197459517239 1.73046429686823 0.242989456706615 0.640956281201538 NA NA NA 0.377505341597583 84.4463700024942 a1625 EP300_mut 1049 PD-173074 FGFR1, FGFR3 4 11 0.693147180559945 NA 2.40019512462337 2.65618582894654 -0.25599070432317 1.05941424083762 0.871978385343543 0.278664660130098 0.241634192231334 0.293574598437225 0.641094975279196 NA NA NA 0.684732577776024 84.4463700024942 a1626 MLL2_mut 290 KIN001-260 IKK 3 16 2.99573227355399 NA 5.30970712300659 4.95492898493781 0.35477813806878 0.255547118781902 1.26186617292416 0.298495773857102 1.38830811225685 0.281153537261913 0.641222770138935 NA NA NA 0.323139202994976 84.4463700024942 a1627 RB1_mut 312 AV-951 VEGFR 6 13 -2.05572501506252 NA 0.347728607578951 0.437636661450378 -0.0899080538714269 0.435358754687219 0.361580349294262 0.23367836996113 0.206514863669208 0.2486530422544 0.641903610688753 NA NA NA 0.670727384697474 84.4463700024942 a1628 CDKN1A_mut 167 OSU-03012 PDPK1 (PDK1) 3 16 2.77258872223978 NA 1.39705949364102 1.96453191564214 -0.56747242200112 1.11538294847618 1.98675677539135 0.297879097364731 0.50876913868586 0.28562752573945 0.641907547810337 NA NA NA 0.51729181732126 84.4463700024942 a1629 NRAS_mut 255 CP724714 ERBB2 3 16 2.32630161961136 NA 4.53022079167426 4.24548121419504 0.284739577479218 0.427513514044238 1.00604750654915 0.297743221527521 0.66603643656924 0.283027964013257 0.642058473444174 NA NA NA 0.444728269759593 84.4463700024942 a1630 loss_cnaBLCA5_(FAT1,IRF2) 1054 PD-0332991 CDK4, CDK6 3 12 1.38629436111989 0.693147180559945 2.37960600101533 1.84046581956808 0.539140181447247 1.55341861227479 1.79086418518789 0.306953206638965 0.347066899538266 0.301050289523035 0.642300409337998 NA NA NA 0.633854083274651 84.4463700024942 a1631 RB1_mut 221 TAK-715 p38a 6 13 2.99573227355399 2.32630161961136 4.47351977773298 4.65787149841388 -0.184351720680895 0.652178898057776 0.84197163183595 0.233093324353484 0.282670477732267 0.218952413252819 0.642732201349622 NA NA NA 0.611738285910128 84.4463700024942 a1632 gain_cnaBLCA23_(MYC) 1024 CEP-701 FLT3, JAK2, NTRK1, RET 4 10 0.693147180559945 NA -0.449971360159738 -0.065131263044192 -0.384840097115546 1.49385847151303 1.32365341996037 0.281276554635827 0.257614830624328 0.290740832390301 0.643007834290695 NA NA NA 0.671854708597298 84.4463700024942 a1633 RB1_mut 171 AKT inhibitor VIII AKT1, AKT2, AKT3 6 13 0.940007258491471 NA 2.2010200948729 1.95007910764725 0.250940987225645 0.803776166998222 1.17434783562006 0.232642772253738 0.312202572717238 0.213685400197589 0.643370641605374 NA NA NA 0.595811755708568 84.4463700024942 a1634 ARID1A_mut 1019 Bosutinib SRC, ABL, TEC 3 11 0.693147180559945 NA 1.6805459466529 1.36931304154072 0.311232905112173 1.25845667832233 0.952436054162567 0.308181971302385 0.24731316577944 0.326775644151592 0.644595720724964 NA NA NA 0.720134035781715 84.4463700024942 a1635 RB1_mut 1149 TW 37 BCL2, BCL2L1 6 13 1.6094379124341 NA -0.33066734505125 -0.680013818392618 0.349346473341368 0.742913712568297 1.73987880772968 0.230394250711091 0.470238289361568 0.20078782027193 0.64656112106829 NA NA NA 0.548034464631446 84.4463700024942 a1636 RB1_mut 333 T0901317 LXR 6 13 2.32630161961136 NA 4.57209767198943 4.42221866846473 0.149879003524698 0.53978622326828 0.691786838629983 0.230307900217676 0.277663632497354 0.21665489303254 0.646683787714155 NA NA NA 0.616951446786737 84.4463700024942 a1637 MLL2_mut 176 IPA-3 PAK1, PAK2, PAK3 3 16 3.46573590279973 NA 3.30388687738948 3.78733676054243 -0.483449883152954 1.40289401287667 1.67955727328051 0.293103133537426 0.344608985935884 0.287843642395522 0.647222143224249 NA NA NA 0.630871182320424 84.4463700024942 a1638 RB1_mut 277 ABT-869 VEGFR and PDGFR family 6 13 0.0237165266173161 NA 2.26018686387102 2.36657741780295 -0.106390553931933 0.557308464851882 0.41885716755383 0.229345526526721 0.190900660301667 0.254001989635906 0.648051611776442 NA NA NA 0.688396745223589 84.4463700024942 a1639 loss_cnaBLCA18_(CHD9,CNOT1,CYLD,MMP2,NUP93) 1059 AZD8055 MTORC1/2 3 12 0.693147180559945 NA 0.0580971055664757 0.281058964407257 -0.222961858840781 0.604267808397204 0.762996768954775 0.3009768865661 0.368978548488589 0.292218614695073 0.64873789341278 NA NA NA 0.619010621799954 84.4463700024942 a1640 gain_cnaBLCA9 177 GSK-650394 SGK3 4 15 2.77258872223978 NA 2.49921168197346 3.05081175997845 -0.551600078004995 2.29903139949028 2.07529579557871 0.26061924875803 0.239927161554771 0.265793473479851 0.649143140964161 NA NA NA 0.684106467145166 84.4463700024942 a1641 NRAS_mut 226 GSK1070916 AURKB 3 16 0.940007258491471 2.32630161961136 2.58736783486692 1.97295851659159 0.614409318275324 1.31131162039396 2.20120981164413 0.290359387591001 0.468545621589729 0.279123468842077 0.650284246544651 NA NA NA 0.543573277026329 84.4463700024942 a1642 ARID1A_mut 1072 BMS-708163 g-secretase 4 14 1.6094379124341 NA 3.57043397672865 3.40123502719835 0.169198949530303 0.652609173043255 0.64460951937035 0.261870450427557 0.259265355927029 0.262482858918335 0.650374040659726 NA NA NA 0.666495350251545 84.4463700024942 a1643 TP53_mut 255 CP724714 ERBB2 15 4 2.32630161961136 NA 4.2381730417624 4.48644154392685 -0.248268502164447 1.02031338812208 0.572462187781238 0.25952160564808 0.24332573212765 0.43368541619612 0.650513752306568 NA NA NA 0.539465260954396 84.4463700024942 a1644 RB1_mut 1377 Afatinib (rescreen) ERBB2, EGFR 6 12 2.30258509299405 NA 3.13784561590403 3.45335986678296 -0.315514250878932 0.689580496126825 1.58176401293736 0.23080650372606 0.457545207051366 0.199469862949415 0.650572720957263 NA NA NA 0.564674407519915 84.4463700024942 a1645 gain_cnaBLCA9 190 Bleomycin DNA damage 4 15 4.15888308335967 NA 0.775452675718077 1.41285152657148 -0.637398850853398 2.04190699904572 2.53880410868192 0.259271206056852 0.312158610138113 0.251062635621903 0.650826603563971 NA NA NA 0.618893252384277 84.4463700024942 a1646 loss_cnaBLCA18_(CHD9,CNOT1,CYLD,MMP2,NUP93) 1032 Afatinib ERBB2, EGFR 3 11 -0.693147180559945 NA 0.8968517010277 0.430246648538902 0.466605052488799 1.33731034464277 1.58211318614739 0.302203299433302 0.348913065959599 0.294925202933825 0.650971279923906 NA NA NA 0.636258376066747 84.4463700024942 a1647 loss_cnaBLCA5_(FAT1,IRF2) 226 GSK1070916 AURKB 5 14 0.940007258491471 2.32630161961136 1.69591099573924 2.20356319938358 -0.507652203644333 2.36183997845572 2.034510223245 0.239901141326674 0.214939288129189 0.249520596084613 0.651011994503517 NA NA NA 0.683442872492344 84.4463700024942 a1648 loss_cnaBLCA18_(CHD9,CNOT1,CYLD,MMP2,NUP93) 1049 PD-173074 FGFR1, FGFR3 3 12 0.693147180559945 NA 2.80740445068309 2.53305093873802 0.274353511945067 0.106983224627768 0.998144877410464 0.298496461431054 2.56445356643193 0.2748634172795 0.651418409404991 NA NA NA 0.370360424071863 84.4463700024942 a1649 gain_cnaBLCA15_(ASXL1) 147 NSC-87877 PTPN6 (SHP-1), PTPN11 (SHP-2) 6 13 2.77258872223978 NA 5.1734151201296 5.01411774863401 0.159297371495592 0.543247821405802 0.758253189302689 0.226955938113634 0.29323149623199 0.210084670586201 0.651453536910345 NA NA NA 0.610677301531546 84.4463700024942 a1650 EP300_mut 1036 PLX4720 BRAF 4 11 2.30258509299405 NA 3.89059326458122 3.70682907104438 0.183764193536838 0.883945596270588 0.611718268303156 0.26857403970979 0.207890841146953 0.300406581033751 0.65312491429135 NA NA NA 0.720269800132767 84.4463700024942 a1651 gain_cnaBLCA23_(MYC) 1375 Temozolomide DNA akylating agent 4 14 3.40119738166216 NA 5.16746263384933 5.35087794297126 -0.183415309121934 0.777453255763734 0.690702037220603 0.259142322635993 0.235918118243335 0.265549106905781 0.653755369360817 NA NA NA 0.689753111552641 84.4463700024942 a1652 gain_cnaBLCA23_(MYC) 1060 PD-0325901 MAP2K1 (MEK1), MAP2K2 (MEK2) 3 12 -1.38629436111989 0.693147180559945 -1.43158973912571 -0.996320539848778 -0.435269199276936 0.738739623444944 1.56608209778476 0.296214782385246 0.589205161687628 0.277935109463692 0.653888607993733 NA NA NA 0.505326587055306 84.4463700024942 a1653 TP53_mut 265 Tubastatin A HDAC6 15 4 2.99573227355399 NA 4.78896223529083 5.03078530601921 -0.24182307072838 0.879959753233812 1.18880531987059 0.256753286990795 0.274811512503488 0.203416881373566 0.653976232394076 NA NA NA 0.723609139969698 84.4463700024942 a1654 EP300_mut 151 QS11 ARFGAP 4 15 2.32630161961136 NA 2.71036976059006 3.14179796745897 -0.431428206868902 1.67395215438997 1.6831749785407 0.256565624220216 0.257730309517793 0.256318096674029 0.654211247292259 NA NA NA 0.667446942002561 84.4463700024942 a1655 gain_cnaBLCA23_(MYC) 1025 SB 216763 GSK3A, GSK3B 4 8 2.30258509299405 NA 3.90088556255918 3.62216286429332 0.278722698265862 1.3012637124103 0.815325803695777 0.282517607576881 0.21419386063536 0.341854381404887 0.654419893416666 NA NA NA 0.7142672106437 84.4463700024942 a1656 RB1_mut 1025 SB 216763 GSK3A, GSK3B 4 8 2.30258509299405 NA 3.52938767746083 3.8079118068425 -0.278524129381664 1.22770994885214 0.862855295521226 0.282312055832842 0.226864765282771 0.322793556263007 0.654652560890944 NA NA NA 0.702919864657126 84.4463700024942 a1657 gain_cnaBLCA15_(ASXL1) 309 Y-39983 ROCK 6 13 2.99573227355399 NA 4.11874104378417 4.46727480818812 -0.348533764403943 2.29343093642803 1.10332300090032 0.22468318475872 0.151970464367581 0.315894587640734 0.654696489548261 NA NA NA 0.735381321124504 84.4463700024942 a1658 TP53_mut 1268 XAV 939 TNKS1 (tankyrase-1) 14 4 1.6094379124341 NA 3.16176014689727 3.35963793127992 -0.197877784382652 0.639975428223335 1.16489175701801 0.258226901160573 0.309195909180435 0.169867958280687 0.654891724846075 NA NA NA 0.762819685405592 84.4463700024942 a1659 gain_cnaBLCA23_(MYC) 271 VNLG/124 HDAC, RAR 4 15 1.63315443905142 NA 4.0427594142615 3.91847636340379 0.124283050857708 0.666482304787573 0.438339096614132 0.255496195820756 0.186476144925288 0.283531749318527 0.655551232750347 NA NA NA 0.743069291529395 84.4463700024942 a1660 loss_cnaBLCA18_(CHD9,CNOT1,CYLD,MMP2,NUP93) 1038 NU-7441 PRKDC (DNAPK) 3 12 0.693147180559945 NA 1.93615690212092 2.26555034375768 -0.32939344163676 1.20987005000657 1.10093481048086 0.294526001282289 0.272255224133346 0.299194319682644 0.655719659792849 NA NA NA 0.69772656487137 84.4463700024942 a1661 loss_cnaBLCA18_(CHD9,CNOT1,CYLD,MMP2,NUP93) 1067 CCT007093 PPM1D 3 15 1.88706964903238 NA 3.92176691942374 3.77158466325953 0.15018225616421 0.257895481502927 0.550456853867031 0.287201482272599 0.582337679159788 0.272832021454834 0.655852378895988 NA NA NA 0.490964228090656 84.4463700024942 a1662 CDKN1A_mut 271 VNLG/124 HDAC, RAR 3 16 1.63315443905142 NA 4.06147131995601 3.92273557176467 0.138735748191334 0.285724247950995 0.507244041671433 0.285202086392253 0.485558188310041 0.273508876977997 0.656057374040223 NA NA NA 0.535398005664755 84.4463700024942 a1663 MLL2_mut 345 KIN001-270 CDK9 3 16 2.99573227355399 NA 4.70180211384065 4.96730052176161 -0.265498407920966 0.725928848612849 0.955828193135919 0.284952039307054 0.36573613023962 0.277767918782463 0.656337852948732 NA NA NA 0.615645391045616 84.4463700024942 a1664 gain_cnaBLCA9 206 Ruxolitinib JAK1, JAK2, TYK2 4 15 1.65632149833295 0.0237165266173161 4.225697487997 4.103102443773 0.122595044224002 0.622825783112976 0.444986798261454 0.254785183012682 0.196836816246196 0.275502654692175 0.656442796216814 NA NA NA 0.731254323453266 84.4463700024942 a1665 gain_cnaBLCA9 1133 JNJ-26854165 MDM2 4 15 2.30258509299405 NA 2.57043568615604 2.24880277586602 0.321632910290025 1.2905704601536 1.2614147770503 0.253932346318537 0.249217629118634 0.254977915386511 0.657512901528027 NA NA NA 0.676250026320322 84.4463700024942 a1666 gain_cnaBLCA9 277 ABT-869 VEGFR and PDGFR family 4 15 0.0237165266173161 NA 2.42588498032112 2.30820584622533 0.117679134095792 0.683240034397866 0.401830122180477 0.253585461705319 0.172236883337057 0.292857920798028 0.657948377691297 NA NA NA 0.76010137933863 84.4463700024942 a1667 RB1_mut 257 NPK76-II-72-1 PLK3 6 13 2.32630161961136 NA 3.66776942364729 3.36026572222666 0.30750370142063 1.48198832240421 1.34208065164465 0.222072731460084 0.207494011101093 0.229124606664882 0.658430081780946 NA NA NA 0.675321715205663 84.4463700024942 a1668 gain_cnaBLCA9 275 I-BET BRD2, BRD3, BRD4 4 15 2.99573227355399 NA 4.86693172598136 4.5798226532225 0.287109072758852 1.99359279692344 0.84263456088046 0.253168436626571 0.144015905957288 0.340727862454224 0.65847207519447 NA NA NA 0.795178213640397 84.4463700024942 a1669 CDKN1A_mut 1527 GDC0941 (rescreen) PI3K 3 16 1.38629436111989 NA 0.563658306227533 0.897364447337268 -0.333706141109735 0.776398426572485 1.22275408033861 0.283030870176541 0.429813005395857 0.272913537133586 0.65849459623894 NA NA NA 0.570486170390065 84.4463700024942 a1670 gain_cnaBLCA23_(MYC) 1230 IOX2 EGLN1 4 15 -2.30258509299405 NA -0.0104268756886366 -0.188518119561003 0.178091243872367 0.597250281138856 0.724915865482771 0.252945092004164 0.298185282613474 0.245671604598919 0.658752625136669 NA NA NA 0.632487675981196 84.4463700024942 a1671 gain_cnaBLCA15_(ASXL1) 164 JQ12 HDAC 6 13 1.63315443905142 NA 1.00444856182766 1.33642878834084 -0.331980226513185 1.52842344367492 1.4848236770178 0.221648354357221 0.217204353863467 0.2235822553557 0.659037927623309 NA NA NA 0.666900113011189 84.4463700024942 a1672 EP300_mut 332 XMD15-27 CAMK2B, CLK2, DYRK1A, MAST1, STK39 4 15 2.32630161961136 NA 4.6591878993292 4.78719970481359 -0.12801180548439 0.295759611878041 0.541288372734923 0.252648054112589 0.432823821587841 0.236494652263812 0.659125824570792 NA NA NA 0.54459312511728 84.4463700024942 a1673 loss_cnaBLCA18_(CHD9,CNOT1,CYLD,MMP2,NUP93) 256 JW-7-24-1 LCK 3 16 2.32630161961136 NA 1.86937088379606 2.2170617578667 -0.347690874070642 0.249059345793386 1.30806013372359 0.282291170753172 1.39601617021462 0.265806490930112 0.659325825818315 NA NA NA 0.344311660252906 84.4463700024942 a1674 gain_cnaBLCA9 326 GSK690693 AKT 4 15 2.32630161961136 NA 4.45372960035217 4.21113407713433 0.242595523217837 1.29519147268962 0.876475276933699 0.251739132703258 0.187304756349313 0.276785357901416 0.660268371166659 NA NA NA 0.742514310040744 84.4463700024942 a1675 gain_cnaBLCA9 135 Gemcitabine DNA replication 4 15 0.0237165266173161 NA -1.76610012154668 -2.50186731173365 0.73576719018697 2.05724470631261 3.07901920355803 0.251564946066465 0.357646899238231 0.23896154637059 0.660487428735419 NA NA NA 0.588827750661761 84.4463700024942 a1676 gain_cnaBLCA9 224 AS605240 PI3Kgamma 4 15 2.99573227355399 2.32630161961136 3.0544260337215 3.4155595985367 -0.361133564815199 1.053386995538 1.5075392033304 0.251161124261201 0.34283085546424 0.239551690607711 0.660995398091908 NA NA NA 0.599139124054278 84.4463700024942 a1677 MLL2_mut 184 BMS-754807 IGF1R 3 16 0.940007258491471 NA 1.31018619425647 0.824769775139595 0.485416419116875 1.6560312970679 1.73841915373709 0.28076113525006 0.293120317216427 0.279228641765349 0.661046642912161 NA NA NA 0.676451208343116 84.4463700024942 a1678 CDKN1A_mut 344 THZ-2-49 CDK9 3 16 2.99573227355399 NA 4.71522726387391 4.16067606966164 0.554551194212274 1.31015357871959 2.05817186157958 0.279391211146473 0.423271899737308 0.269438721111789 0.66258904371879 NA NA NA 0.575921574187134 84.4463700024942 a1679 TP53_mut 202 GSK-1904529A IGF1R 15 4 0.0237165266173161 NA 2.04939705196471 2.18703992654977 -0.137642874585056 0.520711709056198 0.676652807025084 0.249604244251697 0.264336046590035 0.203417281589661 0.662955396871804 NA NA NA 0.724577828811335 84.4463700024942 a1680 gain_cnaBLCA23_(MYC) 303 PIK-93 PI4K, PI3K 4 15 2.99573227355399 NA 3.01402488653214 3.42599551322522 -0.411970626693085 2.23812933126954 1.49690724876448 0.249368456678853 0.184069178191504 0.275214531182957 0.663252456245575 NA NA NA 0.746524300213412 84.4463700024942 a1681 gain_cnaBLCA23_(MYC) 345 KIN001-270 CDK9 4 15 2.99573227355399 NA 4.74227967892417 4.9742063982674 -0.231926719343229 1.29242561028098 0.834744694164217 0.248851227882534 0.179450730083264 0.277841501676683 0.663904294404544 NA NA NA 0.751974096955511 84.4463700024942 a1682 gain_cnaBLCA9 226 GSK1070916 AURKB 4 15 0.940007258491471 2.32630161961136 1.65428641380325 2.18081960765688 -0.526533193853632 3.78153510667819 1.54219504655593 0.248702916002976 0.139237949404139 0.341418029470072 0.664091255808965 NA NA NA 0.801549660871487 84.4463700024942 a1683 ARID1A_mut 192 LFM-A13 BTK 5 14 2.77258872223978 NA 4.50261556278405 4.34860408941516 0.154011473368883 0.90131102833342 0.578893124092145 0.230250306755005 0.170874946081221 0.266044744632981 0.664096500682565 NA NA NA 0.735248004318125 84.4463700024942 a1684 loss_cnaBLCA18_(CHD9,CNOT1,CYLD,MMP2,NUP93) 286 KIN001-236 TIE2 3 16 2.32630161961136 NA 4.13383176578683 4.36620709410271 -0.23237532831588 1.1208591411703 0.794019812697587 0.276932245283122 0.207318939356871 0.292656838783925 0.66536151299927 NA NA NA 0.759263537799064 84.4463700024942 a1685 gain_cnaBLCA15_(ASXL1) 154 CHIR-99021 GSK3B 6 13 0.940007258491471 NA 2.61022226817254 2.77982646665442 -0.169604198481879 0.79972899482988 0.774179994861552 0.216945896702588 0.212077090587365 0.21907592498849 0.665789735905902 NA NA NA 0.673939442928033 84.4463700024942 a1686 EP300_mut 1047 Nutlin-3a MDM2 4 11 2.07944154167984 1.38629436111989 3.50469409129471 3.81271315176662 -0.308019060471908 1.26020649632663 1.17301596496771 0.258036759706018 0.244419514872959 0.262587270481341 0.665795931886738 NA NA NA 0.687505032809456 84.4463700024942 a1687 gain_cnaBLCA15_(ASXL1) 185 OSI-906 IGF1R 6 13 0.940007258491471 NA 2.45995674074319 2.18805357545846 0.271903165284734 0.982781715454237 1.35234594123201 0.216656114774213 0.276666894600356 0.201060362585203 0.666206781590281 NA NA NA 0.628624157611868 84.4463700024942 a1688 gain_cnaBLCA23_(MYC) 199 Pazopanib VEGFR, PDGFRA, PDGFRB, KIT 4 15 2.07944154167984 NA 2.59260874813934 2.93700413723118 -0.344395389091834 0.955234286520592 1.47257806906274 0.246826943534464 0.360534995394986 0.233872414866965 0.666458064143521 NA NA NA 0.589401478439909 84.4463700024942 a1689 RB1_mut 344 THZ-2-49 CDK9 6 13 2.99573227355399 NA 4.54140280951938 4.11292938839167 0.428473421127712 1.33722985078087 2.19955269872169 0.215833914173098 0.32041867811843 0.194800252513489 0.667390680995324 NA NA NA 0.608187748256855 84.4463700024942 a1690 CDKN1A_mut 225 Genentech Cpd 10 AURKA, AURKB 3 16 2.32630161961136 NA 2.65651673062394 3.08976182374359 -0.433245093119648 0.62839772727272 1.6611420147639 0.275043528877272 0.689444080264191 0.260811591826017 0.667494424852422 NA NA NA 0.452965826659205 84.4463700024942 a1691 gain_cnaBLCA9 1502 Bicalutamide ANDR (androgen receptor) 4 13 2.30258509299405 NA 4.41258298906476 4.25674708083293 0.155835908231822 0.435920625676605 0.660682107655766 0.250435837603665 0.357486888788399 0.235871240383305 0.667628282223541 NA NA NA 0.599557152959182 84.4463700024942 a1692 loss_cnaBLCA18_(CHD9,CNOT1,CYLD,MMP2,NUP93) 1030 KU-55933 ATM 3 12 2.30258509299405 NA 3.27668122065937 3.5511376920574 -0.274456471398025 0.68828830675292 1.01233481348296 0.283074200161463 0.398752192511893 0.271112351114106 0.668196865245549 NA NA NA 0.604409635907647 84.4463700024942 a1693 RB1_mut 196 Phenformin AAPK1 (AMPK) agonist 6 13 8.29404964010203 NA 8.80829862208707 9.08203716859373 -0.273738546506658 0.933818422723778 1.39156997238277 0.214844414111408 0.29313894419454 0.196712024504193 0.668816675094457 NA NA NA 0.621549449159197 84.4463700024942 a1694 loss_cnaBLCA5_(FAT1,IRF2) 176 IPA-3 PAK1, PAK2, PAK3 5 14 3.46573590279973 NA 3.43545516072978 3.80941235694275 -0.373957196212965 0.454416854369182 1.87081182389998 0.226536350783436 0.822938657792722 0.199890331799057 0.669162051843088 NA NA NA 0.498193402477494 84.4463700024942 a1695 NRAS_mut 1052 RO-3306 CDK1 3 12 1.6094379124341 NA 3.09210990824673 2.71903220695723 0.373077701289501 1.3855014851129 1.31064260757902 0.282114163886432 0.269272682345122 0.284652504910273 0.669247607860245 NA NA NA 0.701979478760926 84.4463700024942 a1696 gain_cnaBLCA23_(MYC) 252 WZ3105 CLK2, CNSK1E, FLT3, ULK1 4 15 0.246860077931526 2.32630161961136 0.986021574824909 0.586940023776608 0.399081551048301 2.1915728221552 1.4862546484469 0.244383896487443 0.182098238768924 0.268514922032594 0.66954575118735 NA NA NA 0.749363416169454 84.4463700024942 a1697 NRAS_mut 304 SB52334 ALK5 3 16 2.99573227355399 NA 4.97893658182907 4.69809111199885 0.280845469830224 1.00683913744298 1.03120258930718 0.273098681619615 0.278937776041835 0.27234752195387 0.669693789576258 NA NA NA 0.69009520822582 84.4463700024942 a1698 EP300_mut 276 CAY10603 HDAC6 4 15 2.99573227355399 NA 1.48460170745312 1.18781865810915 0.296783049343966 0.453520400332576 1.32290908213582 0.244156674563739 0.654398455122039 0.22434122900178 0.669833240431912 NA NA NA 0.480104480464261 84.4463700024942 a1699 NRAS_mut 147 NSC-87877 PTPN6 (SHP-1), PTPN11 (SHP-2) 3 16 2.77258872223978 NA 4.90312621951076 5.09466517465547 -0.191538955144706 0.421233421104301 0.731736789089941 0.272704519332707 0.454709777402205 0.261759362110141 0.67013991239706 NA NA NA 0.558386973677453 84.4463700024942 a1700 NRAS_mut 1001 AICAR AAPK1 (AMPK) agonist 3 11 7.60090245954208 NA 7.82323993053534 8.00994523736182 -0.186705306826477 0.687451577683439 0.650231700727359 0.284359660550493 0.271590484170002 0.287136580110791 0.670169976022361 NA NA NA 0.701092760533498 84.4463700024942 a1701 MLL2_mut 177 GSK-650394 SGK3 3 16 2.77258872223978 NA 2.44854223697694 3.02583727603999 -0.577295039063042 1.32326743566026 2.20256494288916 0.272546909004589 0.436264827128457 0.262101256504059 0.670318335263764 NA NA NA 0.569784520702251 84.4463700024942 a1702 RB1_mut 226 GSK1070916 AURKB 6 13 0.940007258491471 2.32630161961136 1.76023164312948 2.21292691625303 -0.452695273123553 2.89578753285627 1.69074431207164 0.213778335650587 0.156328897747907 0.267749103097011 0.670354487210015 NA NA NA 0.7329376192714 84.4463700024942 a1703 gain_cnaBLCA15_(ASXL1) 332 XMD15-27 CAMK2B, CLK2, DYRK1A, MAST1, STK39 6 13 2.32630161961136 NA 4.83436181438499 4.72604432947774 0.108317484907256 0.585992365187023 0.470015264021258 0.2136910409191 0.184844532697428 0.230455249432829 0.670480476218636 NA NA NA 0.701196848408234 84.4463700024942 a1704 RB1_mut 1067 CCT007093 PPM1D 5 13 1.88706964903238 NA 3.7107929966121 3.82962351723874 -0.118830520626632 0.298044373467432 0.579161190948494 0.227105905998386 0.398700768090885 0.205176939483846 0.671814575851318 NA NA NA 0.578092599980187 84.4532371845854 a1705 gain_cnaBLCA23_(MYC) 1043 JNK Inhibitor VIII JNK 3 11 2.30258509299405 NA 3.71347531812103 3.95145350691317 -0.23797818879214 0.628054642891864 0.879500675370294 0.28235989346498 0.378913190891122 0.270583292834818 0.672337180596878 NA NA NA 0.62159071252295 84.4532371845854 a1706 gain_cnaBLCA23_(MYC) 222 BX-912 PDPK1 (PDK1) 4 15 2.32630161961136 NA 3.01273050623876 3.38153138726199 -0.368800881023224 1.67854850066716 1.48824830403629 0.242065396825954 0.219714164277434 0.247808702367069 0.672481671230051 NA NA NA 0.708348620746464 84.4532371845854 a1707 TP53_mut 221 TAK-715 p38a 15 4 2.99573227355399 2.32630161961136 4.55946892857085 4.75035355430388 -0.190884625733032 0.767781243905795 0.895415064803944 0.241076436470783 0.248618505919706 0.213180047149226 0.673735655508581 NA NA NA 0.715373402845931 84.4532371845854 a1708 gain_cnaBLCA9 1067 CCT007093 PPM1D 3 15 1.88706964903238 NA 3.6784331271735 3.82025142170957 -0.141818294536071 0.263137907105693 0.550498554397974 0.271017589321411 0.538950454140034 0.257617923613195 0.673988296785291 NA NA NA 0.519565603043802 84.4532371845854 a1709 loss_cnaBLCA18_(CHD9,CNOT1,CYLD,MMP2,NUP93) 1170 CCT018159 HSP90 3 16 2.30258509299405 NA 2.84448572557687 2.59530443982767 0.249181285749194 0.898397837060686 0.928839631481157 0.269294857646643 0.277361849583752 0.268271591030027 0.674004334532254 NA NA NA 0.69197323466016 84.4532371845854 a1710 gain_cnaBLCA9 133 Doxorubicin DNA intercalating 4 15 0.0237165266173161 NA -2.41100192376937 -1.9862979929886 -0.424703930780773 1.59346103390019 1.79824574403868 0.240784282340573 0.266529222707919 0.236176802969616 0.67410629124068 NA NA NA 0.663553478125661 84.4532371845854 a1711 RB1_mut 1133 JNJ-26854165 MDM2 6 13 2.30258509299405 NA 2.49940209942149 2.23210552200657 0.26729657741492 0.985494000046967 1.36779725551329 0.210904304182274 0.271231055087277 0.195421197357654 0.674507754976135 NA NA NA 0.636615402873274 84.4532371845854 a1712 ARID1A_mut 194 AUY922 HSP90 5 14 -1.36257783450257 NA -2.4262520634724 -2.92819796456594 0.50194590109354 1.91834490901017 2.35182991231338 0.222362169319042 0.261655710991271 0.213427807200479 0.674874961572462 NA NA NA 0.648594460395505 84.4532371845854 a1713 EP300_mut 262 VX-11e ERK 4 15 1.63315443905142 NA 2.56708188687495 2.92229849725598 -0.355216610381032 2.019839868241 1.33787144981484 0.239814684207038 0.17586374839228 0.265508775473303 0.675336971039239 NA NA NA 0.757132820749394 84.4532371845854 a1714 gain_cnaBLCA15_(ASXL1) 1052 RO-3306 CDK1 4 11 1.6094379124341 NA 2.55114367986522 2.88183104443328 -0.330687364568053 1.55247970567319 1.24569459021457 0.249986426269512 0.213005917796947 0.265464237515146 0.67554914416747 NA NA NA 0.718820840808874 84.4532371845854 a1715 NRAS_mut 1010 Gefitinib EGFR 3 11 -0.693147180559945 NA 0.358577373439896 0.643677712647373 -0.285100339207477 1.21453635291766 0.977629451234325 0.279253134818759 0.234740062347732 0.291624131052433 0.675710164402251 NA NA NA 0.734796298004834 84.4532371845854 a1716 gain_cnaBLCA15_(ASXL1) 344 THZ-2-49 CDK9 6 13 2.99573227355399 NA 3.96319943705873 4.37979248337351 -0.416593046314776 2.10802554422721 1.93260748781858 0.209784922566017 0.197622390039631 0.21556009119317 0.67612831502636 NA NA NA 0.69069557687974 84.4532371845854 a1717 gain_cnaBLCA23_(MYC) 308 XL-880 MET 4 15 1.63315443905142 NA 0.933330100569612 0.58243454823673 0.350895552332883 2.59665843205959 1.08198812777811 0.2390875180007 0.135133503891215 0.324306287032425 0.676260561417315 NA NA NA 0.807343034738885 84.4532371845854 a1718 MLL2_mut 1011 ABT-263 BCL2, BCL2L1, BCL2L2 3 12 0.693147180559945 NA 2.06811819648107 2.29669788581059 -0.228579689329523 0.848087705845785 0.828243233727629 0.274957594370933 0.269523644493306 0.27598135429464 0.677103066999642 NA NA NA 0.702776000253087 84.4532371845854 a1719 TP53_mut 274 PXD101, Belinostat HDAC 15 4 2.99573227355399 NA 0.37945733159834 0.723617093862031 -0.344159762263691 1.15730576481473 2.36505402852194 0.238055479689886 0.297380150282745 0.145518773826396 0.677572288812279 NA NA NA 0.79417053038863 84.4532371845854 a1720 RB1_mut 330 XMD13-2 RIPK 6 13 2.32630161961136 NA 3.92144255707067 3.72112438983748 0.200318167233192 1.05928855032725 0.915441082589299 0.208667090504482 0.18910632723379 0.21882147419755 0.67774826595555 NA NA NA 0.699278846452005 84.4532371845854 a1721 NRAS_mut 1024 CEP-701 FLT3, JAK2, NTRK1, RET 3 11 0.693147180559945 NA 0.123032442459169 -0.256390490768944 0.379422933228113 1.92446530995117 1.23044874631066 0.276801306657089 0.197157585156856 0.308361428597302 0.678377300133838 NA NA NA 0.771488871593754 84.4532371845854 a1722 ARID1A_mut 1058 GDC0941 PI3K (class 1) 5 10 1.38629436111989 0.693147180559945 1.31148407632027 1.00230335475994 0.309180721560333 1.14181355626246 1.40803393914826 0.232152502301686 0.270780391303451 0.219583287706375 0.678603947700474 NA NA NA 0.658019219777623 84.4532371845854 a1723 gain_cnaBLCA9 274 PXD101, Belinostat HDAC 4 15 2.99573227355399 NA 0.722099873122812 0.379861923795466 0.342237949327346 1.87610320252872 1.33567293171081 0.236712285179756 0.182419575248344 0.256228857531004 0.679281094888954 NA NA NA 0.749897074342949 84.4532371845854 a1724 TP53_mut 288 KIN001-055 JAK3, MNK1 15 4 2.32630161961136 NA 4.08820357331331 4.28682945083562 -0.198625877522301 0.796850190344977 1.01535316688258 0.236585549162803 0.249263763664674 0.195622453350037 0.679442420885856 NA NA NA 0.735065854786732 84.4532371845854 a1725 MLL2_mut 330 XMD13-2 RIPK 3 16 2.32630161961136 NA 3.99807362966975 3.74431572008137 0.253757909588373 0.179111129741813 1.01995896122082 0.264316766913707 1.41676237514755 0.24879227423488 0.679663231078525 NA NA NA 0.36938729700921 84.4532371845854 a1726 TP53_mut 199 Pazopanib VEGFR, PDGFRA, PDGFRB, KIT 15 4 2.07944154167984 NA 2.79515777814308 3.12453259471972 -0.329374816576648 1.46812884427285 0.99206030640855 0.235947859492662 0.224350075173261 0.332010881242742 0.680254397567255 NA NA NA 0.614049217421374 84.4532371845854 a1727 RB1_mut 155 AP-24534 ABL 6 13 -0.669430653942629 NA 0.0668502519550685 0.278134216755924 -0.211283964800855 0.312086338719541 1.2015858167693 0.206407859499347 0.677004849580191 0.175837598823307 0.681027278168773 NA NA NA 0.562547318197735 84.4532371845854 a1728 RB1_mut 228 KIN001-102 AKT1 6 13 2.32630161961136 NA 3.53257122440377 3.26252614834988 0.270045076053887 1.11975571198326 1.37951354262194 0.206381037780749 0.241164276425611 0.195753841996093 0.681066246456629 NA NA NA 0.658626882044961 84.4532371845854 a1729 loss_cnaBLCA5_(FAT1,IRF2) 164 JQ12 HDAC 5 14 1.63315443905142 NA 1.47217670421029 1.14567014988182 0.326506554328467 1.58777949058062 1.47053931034317 0.217823449027692 0.205637216166 0.22203184371336 0.681110046290449 NA NA NA 0.700102685448674 84.4532371845854 a1730 gain_cnaBLCA15_(ASXL1) 258 STF-62247 stimulates autophagy 6 13 2.32630161961136 NA 4.43056870866293 4.58987826104797 -0.159309552385041 1.01238560989221 0.646693390057922 0.206243086825733 0.157360546049249 0.246344797757671 0.681266684982423 NA NA NA 0.734115544789018 84.4532371845854 a1731 NRAS_mut 332 XMD15-27 CAMK2B, CLK2, DYRK1A, MAST1, STK39 3 16 2.32630161961136 NA 4.87235258222473 4.7392305889279 0.13312199329683 0.612752905156627 0.491282057982235 0.262523877073266 0.21725232500171 0.27096856303603 0.681706169439705 NA NA NA 0.749987460271808 84.4532371845854 a1732 gain_cnaBLCA23_(MYC) 268 YM155 BIRC5 (Survivin) 4 15 1.63315443905142 NA -3.44499184343974 -3.95270600483803 0.507714161398292 3.63782531761234 1.68892911994149 0.234578849608651 0.13956529439174 0.300613066234467 0.681998936582701 NA NA NA 0.801925692766998 84.4532371845854 a1733 EP300_mut 1046 681640 WEE1, CHEK1 4 11 0.693147180559945 NA 1.80535575736057 1.57695782504213 0.228397932318435 0.617578676006763 1.01147575517248 0.244167206217895 0.36982807404434 0.225806630708107 0.682637577940462 NA NA NA 0.611282121967128 84.4532371845854 a1734 gain_cnaBLCA15_(ASXL1) 1017 Olaparib PARP1, PARP2 4 10 1.6094379124341 NA 3.75575118028458 3.54045202238866 0.215299157895927 0.551005888277687 0.951556690124103 0.24778198393211 0.390738397676477 0.226259938194378 0.682740862894493 NA NA NA 0.609450913148021 84.4532371845854 a1735 loss_cnaBLCA5_(FAT1,IRF2) 196 Phenformin AAPK1 (AMPK) agonist 5 14 8.29404964010203 NA 8.79277830152592 9.0680273869008 -0.275249085374881 1.28335658128992 1.27213228282255 0.215918522023339 0.214475921491924 0.216368288967693 0.68373407471584 NA NA NA 0.692173752110921 84.4890439838971 a1736 RB1_mut 1028 VX-702 p38 5 9 0.693147180559945 NA 3.01258524545151 2.838530360545 0.174054884906506 0.590784825975899 0.815956834562433 0.232549251251492 0.294616376815349 0.213313839082977 0.684095188706759 NA NA NA 0.655261991366288 84.4890439838971 a1737 loss_cnaBLCA18_(CHD9,CNOT1,CYLD,MMP2,NUP93) 288 KIN001-055 JAK3, MNK1 3 16 2.32630161961136 NA 3.94628033392621 4.16447065007897 -0.218190316152765 0.852858613678114 0.837933543898827 0.259842186192701 0.255834100346103 0.260390955513662 0.684766617826563 NA NA NA 0.712829463579496 84.4890439838971 a1738 MLL2_mut 206 Ruxolitinib JAK1, JAK2, TYK2 3 16 1.65632149833295 0.0237165266173161 4.02377187650059 4.14862568619257 -0.124853809691985 0.239089528935504 0.505283688276265 0.259213557890912 0.522205260296722 0.247096458066783 0.68548485214882 NA NA NA 0.528739143075479 84.4890439838971 a1739 gain_cnaBLCA9 1011 ABT-263 BCL2, BCL2L1, BCL2L2 3 12 0.693147180559945 NA 2.42827348003056 2.20665906492322 0.22161441510734 1.23827611158605 0.733932817948077 0.266467514095961 0.178970112589416 0.301954633568407 0.686473425216583 NA NA NA 0.790442931936578 84.4890439838971 a1740 MLL2_mut 304 SB52334 ALK5 3 16 2.99573227355399 NA 4.51888115814141 4.78435150394028 -0.265470345798871 0.645479005365201 1.06976837789459 0.257995446403533 0.411276499455893 0.24815684524284 0.686877477746326 NA NA NA 0.590902419069498 84.4890439838971 a1741 loss_cnaBLCA18_(CHD9,CNOT1,CYLD,MMP2,NUP93) 192 LFM-A13 BTK 3 16 2.77258872223978 NA 4.53454520921932 4.36186871487966 0.172676494339661 0.557708925907164 0.682932509628326 0.257950470883546 0.309617591396421 0.252845620768056 0.686928918961899 NA NA NA 0.665690835508288 84.4890439838971 a1742 gain_cnaBLCA15_(ASXL1) 173 FH535 unknown 6 13 3.46573590279973 NA 1.9148604838842 1.66031987964025 0.25454060424395 1.22411594925331 1.27325460340892 0.202176623885576 0.207938312052232 0.199913358697044 0.687186098055297 NA NA NA 0.68606448006483 84.4890439838971 a1743 loss_cnaBLCA5_(FAT1,IRF2) 177 GSK-650394 SGK3 5 14 2.77258872223978 NA 2.60182520545694 3.05356407859185 -0.451738873134911 2.10440848675823 2.12399175463643 0.213144677358665 0.214663111262586 0.212683910918589 0.687562484821645 NA NA NA 0.693099118114491 84.4890439838971 a1744 loss_cnaBLCA18_(CHD9,CNOT1,CYLD,MMP2,NUP93) 1013 Nilotinib ABL 3 11 0.693147180559945 NA 2.78332942608719 2.94819222151104 -0.164862795423851 0.291288402119303 0.660325989438939 0.26832682146502 0.565977890724012 0.249668797019379 0.687630874362175 NA NA NA 0.544073844195136 84.4890439838971 a1745 TP53_mut 1259 BMN-673 PARP1 14 4 2.30258509299405 NA 1.98564771780548 1.60308084039399 0.382566877411494 1.74127281338504 1.19488757101089 0.231487885833193 0.21970530664163 0.320169768849329 0.688461029254178 NA NA NA 0.628661042164939 84.4890439838971 a1746 RB1_mut 1013 Nilotinib ABL 5 9 0.693147180559945 NA 2.82243414965552 2.96310355184504 -0.140669402189521 0.363228461125548 0.707347594947746 0.228938531742044 0.387275275053128 0.198868849196996 0.688709039296274 NA NA NA 0.632083810121003 84.4890439838971 a1747 RB1_mut 1114 Cetuximab EGFR 6 12 4.18661983833127 NA 5.73199352479633 5.85047768079732 -0.118484156000987 0.519029128807245 0.607525624275423 0.203819345545046 0.228280359280161 0.195027421505552 0.688941256063351 NA NA NA 0.674468469051833 84.4890439838971 a1748 NRAS_mut 266 Zibotentan, ZD4054 Endothelin A Receptor 3 16 2.99573227355399 NA 5.54366524757583 5.44489791614678 0.0987673314290509 0.554507866943271 0.357392662273688 0.255976578460071 0.178117096829494 0.276355230128972 0.689188132789074 NA NA NA 0.79087174561695 84.4890439838971 a1749 RB1_mut 1026 17-AAG HSP90 5 10 0 NA -1.31418703153755 -1.70142223337318 0.387235201835629 1.7862504313173 1.70339222958348 0.223924692928448 0.216786624678409 0.227331788363458 0.689320351182437 NA NA NA 0.698600207034657 84.4890439838971 a1750 gain_cnaBLCA9 200 LAQ824 HDAC 4 15 0.0237165266173161 NA -2.94263758452682 -2.70818448152626 -0.23445310300056 0.497317195677723 1.1062947851014 0.228633742374919 0.471435745713673 0.211926428794537 0.689596239161816 NA NA NA 0.547674978757218 84.4890439838971 a1751 gain_cnaBLCA23_(MYC) 277 ABT-869 VEGFR and PDGFR family 4 15 0.0237165266173161 NA 2.41667524849083 2.31066177471341 0.106013473777415 0.426948454826956 0.47225755227875 0.228190584922844 0.248305088304822 0.224482325938199 0.690163935307718 NA NA NA 0.683733348941998 84.4890439838971 a1752 NRAS_mut 235 QL-XII-47 BTK, BMX 3 16 2.32630161961136 NA 1.47474780001787 1.91979247849242 -0.445044678474547 1.92200182771736 1.72318693310042 0.254638467992972 0.231552682238132 0.258268368872671 0.690721386053502 NA NA NA 0.736464083506074 84.4890439838971 a1753 EP300_mut 271 VNLG/124 HDAC, RAR 4 15 1.63315443905142 NA 3.85722152615591 3.96795313356528 -0.110731607409368 0.321706864637305 0.515623310940972 0.227353635615984 0.344200325144471 0.21475291178611 0.691236607414458 NA NA NA 0.610763297159944 84.4890439838971 a1754 NRAS_mut 341 EX-527 SIRT1 3 16 2.99573227355399 NA 5.22939720316901 5.35500160310112 -0.125604399932107 0.909845070597169 0.409858562858147 0.253443081564137 0.13805031646725 0.306457913325527 0.692092272435637 NA NA NA 0.83488889615436 84.4890439838971 a1755 RB1_mut 1261 rTRAIL TR10A (DR4), TR10B (DR5) 6 12 -2.30258509299405 NA -0.881737229153705 -1.18057345319038 0.298836224036672 1.42997785796862 1.50538742629506 0.201612026285642 0.208979616272653 0.198511173148393 0.692120490876474 NA NA NA 0.689533274166391 84.4890439838971 a1756 gain_cnaBLCA15_(ASXL1) 1114 Cetuximab EGFR 6 12 4.18661983833127 NA 5.8890616644087 5.77194361099113 0.117118053417578 0.480370322865512 0.621905181322531 0.201445361050006 0.243807845411732 0.188321398397932 0.692360783877811 NA NA NA 0.666920263834325 84.4890439838971 a1757 loss_cnaBLCA5_(FAT1,IRF2) 1066 AZD6482 PI3Kbeta 5 13 1.6094379124341 NA 2.17773441046873 1.94502747502174 0.232706935446992 0.533122255993681 1.23127033348862 0.211720256961378 0.436498256883408 0.188997435508456 0.692764795493402 NA NA NA 0.584322816670302 84.4890439838971 a1758 MLL2_mut 257 NPK76-II-72-1 PLK3 3 16 2.32630161961136 NA 3.75194866684828 3.40213905814284 0.349809608705443 1.3114885723678 1.39605775059312 0.252319395513876 0.266727149649414 0.250569583211601 0.693381935702286 NA NA NA 0.703732905312713 84.4890439838971 a1759 MLL2_mut 1199 Tamoxifen ER 3 16 1.6094379124341 NA 3.65595326511442 3.50674029902988 0.149212966084543 0.110739138209523 0.628390274883446 0.252265951273529 1.34742755359199 0.237452697867132 0.693443298249524 NA NA NA 0.391334192986488 84.4890439838971 a1760 EP300_mut 1008 Methotrexate Dihydrofolate reductase (DHFR) 3 11 -1.6094379124341 NA -0.0448894602618199 -0.326793552960146 0.281904092698326 0.802651189354662 1.1183380721393 0.262921714819264 0.35121619009246 0.252074126528718 0.693560727369545 NA NA NA 0.646186293804498 84.4890439838971 a1761 gain_cnaBLCA23_(MYC) 150 Bicalutamide ANDR (androgen receptor) 4 15 0.0237165266173161 NA 2.27754108624039 2.39067314383484 -0.113132057594445 0.697596881966262 0.448842656873217 0.22546024517855 0.162173972560727 0.25205282043057 0.693665754342969 NA NA NA 0.77481730186738 84.4890439838971 a1762 loss_cnaBLCA18_(CHD9,CNOT1,CYLD,MMP2,NUP93) 1268 XAV 939 TNKS1 (tankyrase-1) 3 15 1.6094379124341 NA 3.04454651701514 3.2379702820424 -0.193423765027261 0.882563212898442 0.749559846810272 0.25203538234494 0.219161372466494 0.258049795290355 0.695527034327738 NA NA NA 0.749380514183298 84.6272091159778 a1763 ARID1A_mut 205 BMS-708163 g-secretase 5 14 2.32630161961136 0.940007258491471 4.78417578326415 4.70750346777456 0.0766723154895947 0.403951591107876 0.359952227072159 0.206789302785073 0.189805702409325 0.213006920705131 0.696366911750071 NA NA NA 0.719992538197329 84.6272091159778 a1764 NRAS_mut 1046 681640 WEE1, CHEK1 3 12 0.693147180559945 NA 1.44501165548418 1.68607701153777 -0.241065356053581 1.08986313847398 0.905186474992964 0.257555881353466 0.221188649788742 0.266315684903992 0.696367362724573 NA NA NA 0.74897564870407 84.6272091159778 a1765 ARID1A_mut 1014 RDEA119 MAP2K1 (MEK1), MAP2K2 (MEK2) 5 10 1.6094379124341 NA 0.897034156443491 1.18064005969537 -0.283605903251883 1.83087492413785 0.971019732609189 0.218535076309794 0.154901844748041 0.292070175020868 0.696378302032576 NA NA NA 0.758438103475937 84.6272091159778 a1766 loss_cnaBLCA18_(CHD9,CNOT1,CYLD,MMP2,NUP93) 1241 CHIR-99021 GSK3B 3 16 2.30258509299405 NA 3.42472137248729 3.64975329359163 -0.225031921104334 0.0483297611608146 0.960604399285092 0.249347553818753 4.65617697458823 0.234260764651722 0.696797404038825 NA NA NA 0.366341396906175 84.6301912716959 a1767 CDKN1A_mut 153 Midostaurin KIT 3 16 -0.669430653942629 NA -0.568894138012182 -0.266816563230477 -0.302077574781705 1.39767342210907 1.19062918550899 0.248252222023542 0.216128868162832 0.253712556737444 0.698057940274941 NA NA NA 0.752155088707498 84.7353094099531 a1768 MLL2_mut 230 GSK429286A ROCK2 3 16 2.99573227355399 2.32630161961136 5.15586480151057 4.73108238146727 0.4247824200433 0.39803929161958 1.82112146999794 0.247529916211963 1.06718715711433 0.233253205259163 0.698889686028671 NA NA NA 0.417238758539518 84.735361969342 a1769 gain_cnaBLCA9 1236 UNC0638 G9a(EHMT2), GLP(EHMT1) 4 15 2.99573227355399 NA 3.85777453507936 3.57146718419952 0.286307350879842 1.55353200180213 1.23097129903366 0.221300228902908 0.184294466124753 0.232586536424204 0.699014934271635 NA NA NA 0.749909325696732 84.735361969342 a1770 gain_cnaBLCA23_(MYC) 249 XL-184 VEGFR, MET, RET, KIT, FLT1, FLT3, FLT4, Tie2,AXL 4 15 1.63315443905142 NA 2.89645059420744 3.1136992960399 -0.21724870183246 1.33681858040706 0.888407529711495 0.22111290461207 0.162511731222578 0.244537213572481 0.699256192644934 NA NA NA 0.774883048488833 84.735361969342 a1771 RB1_mut 184 BMS-754807 IGF1R 6 13 0.940007258491471 NA 0.672143831505814 1.00723169199754 -0.335087860491727 1.27202173422691 1.88989679671244 0.193556612413623 0.263429351461029 0.177304845997214 0.699802922781036 NA NA NA 0.656578588666534 84.735361969342 a1772 gain_cnaBLCA23_(MYC) 1016 Temsirolimus MTOR 4 10 -1.6094379124341 NA -2.41781198921235 -2.75964770001814 0.341835710805781 1.21043966505183 1.54134825374055 0.233232725822777 0.282406236903301 0.221777077293346 0.700323634816193 NA NA NA 0.673003688032882 84.735361969342 a1773 CDKN1A_mut 193 GW-2580 CSF1R (cFMS) 3 16 2.99573227355399 NA 5.3984631544844 5.28075731168338 0.11770584280102 0.307603145918483 0.496494942070875 0.246163531836618 0.382654873211904 0.237073598997948 0.700464175373099 NA NA NA 0.613938268329248 84.735361969342 a1774 gain_cnaBLCA23_(MYC) 1239 YK 4-279 RNA helicase A 4 13 2.30258509299405 NA 1.06263657528977 1.28814937441884 -0.225512799129069 1.36595829670926 0.898392347450757 0.22341632648187 0.16509493713853 0.251018165692278 0.701480188108928 NA NA NA 0.772537663139988 84.735361969342 a1775 NRAS_mut 133 Doxorubicin DNA intercalating 3 16 0.0237165266173161 NA -1.71126176312595 -2.14404326878304 0.432781505657086 2.34049478949821 1.67390905454243 0.24514047701386 0.184910262393651 0.258545411701228 0.701643964794206 NA NA NA 0.784210612296915 84.735361969342 a1776 loss_cnaBLCA18_(CHD9,CNOT1,CYLD,MMP2,NUP93) 205 BMS-708163 g-secretase 3 16 2.32630161961136 0.940007258491471 4.65136041339605 4.74199038906103 -0.0906299756649789 0.313507020704684 0.377835471349414 0.244386407300797 0.289084357540912 0.239866244800416 0.702514062413722 NA NA NA 0.685382048949574 84.735361969342 a1777 RB1_mut 1020 Lenalidomide TNFA 5 9 1.6094379124341 NA 3.6338553356782 3.8349671806763 -0.201111844998095 0.751118581873656 0.996271562258782 0.218166661514332 0.267749793243597 0.201864484159447 0.702550832105154 NA NA NA 0.678808248610117 84.735361969342 a1778 EP300_mut 1007 Docetaxel Microtubules 3 11 -4.38202663467388 NA -5.45059579756878 -5.87161351198864 0.421017714419858 1.24994035355986 1.72488589040469 0.254357648634278 0.33683024411588 0.244084386545176 0.702999628738923 NA NA NA 0.658627676967978 84.735361969342 a1779 RB1_mut 1022 AZD7762 CHEK1, CHEK2 5 9 0.693147180559945 NA 0.0386187252480458 0.243913844211697 -0.205295118963651 1.35909899506744 0.640785415201948 0.217679173389872 0.151052366096013 0.320380448888574 0.703179941410198 NA NA NA 0.762839222612405 84.735361969342 a1780 MLL2_mut 252 WZ3105 CLK2, CNSK1E, FLT3, ULK1 3 16 0.246860077931526 2.32630161961136 0.335319577091604 0.733889245292122 -0.398569668200518 1.09876979075746 1.69354352624707 0.243797343946482 0.362741742222232 0.23534657481391 0.703194060221106 NA NA NA 0.628413859027768 84.735361969342 a1781 RB1_mut 208 SB-715992 KIF11 6 13 -2.05572501506252 NA -0.959777545379665 -1.26196547308463 0.302187927704969 1.28909568672966 1.69466620477612 0.190512738964666 0.234418539147855 0.178317079111689 0.704280052602219 NA NA NA 0.675589293488726 84.7733952352881 a1782 RB1_mut 1262 UNC1215 LMBL3 6 12 0 NA 2.42545751027863 2.34769403242311 0.0777634778555201 0.268361188644658 0.450672123480903 0.193121200542489 0.289771700029576 0.172550006543316 0.704405023759911 NA NA NA 0.653965300189209 84.7733952352881 a1783 EP300_mut 254 AC220 FLT3 4 15 0.0237165266173161 NA 2.47139373048251 2.35732866409068 0.114065066391835 0.236614712421595 0.569064445379698 0.216896435583697 0.482070895864653 0.200443143685997 0.704695377688776 NA NA NA 0.555932815281369 84.7733952352881 a1784 TP53_mut 231 FMK RSK 11 3 2.99573227355399 2.32630161961136 5.28541080010137 5.17482387389297 0.110586926208395 0.437905335318942 0.443542298064547 0.251992621989162 0.252536147174024 0.249326674571861 0.705615468322332 NA NA NA 0.725483989026724 84.8364994714788 a1785 CDKN1A_mut 224 AS605240 PI3Kgamma 3 16 2.99573227355399 2.32630161961136 3.04714726140784 3.39435352054456 -0.347206259136717 0.307585563466885 1.52892966299281 0.241107228110046 1.12881194820477 0.227091060851732 0.706302736784664 NA NA NA 0.421851672119327 84.8715563589213 a1786 NRAS_mut 193 GW-2580 CSF1R (cFMS) 3 16 2.99573227355399 NA 5.20239551940267 5.3175199932612 -0.11512447385853 0.4036076468817 0.487344361942424 0.240717985902627 0.285238584422247 0.236228184521669 0.70675298638023 NA NA NA 0.689313122440774 84.8750731548824 a1787 gain_cnaBLCA15_(ASXL1) 1375 Temozolomide DNA akylating agent 6 12 3.40119738166216 NA 5.40053567319172 5.26491064148706 0.135625031704656 0.607579621679294 0.750788767323206 0.191250288194991 0.223221824540133 0.180643394796916 0.707123412036233 NA NA NA 0.68761636776353 84.8750731548824 a1788 CDKN1A_mut 1264 SGC0946 Q8TEK3 (DOT1L) 3 15 -0.693147180559945 NA 1.49479423159144 1.60294297758009 -0.108148745988646 0.413356760432548 0.453786920944947 0.240902118207648 0.26163536281704 0.238324951639068 0.708287687379034 NA NA NA 0.710991588589764 84.886301668048 a1789 gain_cnaBLCA23_(MYC) 206 Ruxolitinib JAK1, JAK2, TYK2 4 15 1.65632149833295 0.0237165266173161 4.04755410020298 4.15060734718473 -0.103053246981753 0.637333362438016 0.441690332726466 0.213794259547604 0.161694417796583 0.23331560449971 0.708707699520479 NA NA NA 0.776687388102594 84.886301668048 a1790 NRAS_mut 199 Pazopanib VEGFR, PDGFRA, PDGFRB, KIT 3 16 2.07944154167984 NA 3.14521504911545 2.81186574397992 0.333349305135527 0.691809326582494 1.46589784127234 0.238572333173179 0.481851418196769 0.227402821499616 0.709236939741655 NA NA NA 0.560463852457079 84.886301668048 a1791 MLL2_mut 309 Y-39983 ROCK 3 16 2.99573227355399 NA 4.66934395881063 4.29868668079492 0.370657278015715 0.604290623422943 1.6396800560884 0.238503607764508 0.613375855339546 0.226054635865945 0.709316556859799 NA NA NA 0.508375939788612 84.886301668048 a1792 EP300_mut 238 CAL-101 PI3Kdelta 4 15 2.99573227355399 2.32630161961136 4.97454962150761 4.78666780266287 0.18788181884474 0.68567015870148 0.921487074418107 0.212427154531161 0.274011952336602 0.203889803840583 0.71047870895816 NA NA NA 0.667689731919031 84.886301668048 a1793 loss_cnaBLCA5_(FAT1,IRF2) 1014 RDEA119 MAP2K1 (MEK1), MAP2K2 (MEK2) 3 12 1.6094379124341 NA 1.34045449994675 1.02251732327758 0.317937176669166 0.281240759710978 1.40653148787234 0.24484677079238 1.13048043603601 0.226043412046259 0.710577564764706 NA NA NA 0.480105798236871 84.886301668048 a1794 loss_cnaBLCA18_(CHD9,CNOT1,CYLD,MMP2,NUP93) 1043 JNK Inhibitor VIII JNK 3 11 2.30258509299405 NA 3.7367089698094 3.9451170564527 -0.208408086643307 0.697518999120033 0.870756434954292 0.246825066925073 0.298784817196704 0.239341425773382 0.711344696690593 NA NA NA 0.687426458900498 84.886301668048 a1795 ARID1A_mut 1373 Dabrafenib BRAF 4 13 2.30258509299405 NA 3.33678521824754 3.6233113300473 -0.286526111799752 2.14236223512489 1.03292339672377 0.215275757194552 0.13374307439799 0.277393379517356 0.711812902602096 NA NA NA 0.81080074219178 84.886301668048 a1796 MLL2_mut 298 OSI-930 KIT, VEGFR, PDGFR 3 16 2.32630161961136 NA 4.17157540904346 4.35583485872959 -0.18425944968613 0.444511170594375 0.814402213883937 0.236216990555842 0.41452152808612 0.226251165020027 0.711967529248359 NA NA NA 0.597880184307338 84.886301668048 a1797 RB1_mut 1219 PFI-1 BRD2, BRD3, BRD4 6 13 2.30258509299405 NA 2.42096284396545 2.25090689438224 0.170055949583208 0.388878537508904 1.06654333764292 0.184731063491989 0.437298367435138 0.15944588802086 0.712814844106005 NA NA NA 0.619133738564263 84.886301668048 a1798 loss_cnaBLCA5_(FAT1,IRF2) 182 Obatoclax Mesylate BCL2, BCL2L1, MCL1 5 14 2.77258872223978 NA -1.06310124511416 -0.795418802098146 -0.267682443016011 1.00757387088434 1.47015025402906 0.194624743734291 0.265670290537675 0.182078289128888 0.713343176528884 NA NA NA 0.663415256685716 84.886301668048 a1799 gain_cnaBLCA9 1498 AZD6244 MAP2K1 (MEK1), MAP2K2 (MEK2) 4 15 1.38629436111989 NA 1.57717376306231 1.31535350660721 0.2618202564551 1.04196301571183 1.28616150964088 0.210036129115563 0.251275959421875 0.203567168269719 0.71358024717586 NA NA NA 0.687170077871519 84.886301668048 a1800 loss_cnaBLCA18_(CHD9,CNOT1,CYLD,MMP2,NUP93) 171 AKT inhibitor VIII AKT1, AKT2, AKT3 3 16 0.940007258491471 NA 2.24314087049821 1.98923289732231 0.253907973175893 0.915172834887428 1.10151279133122 0.234826337058741 0.277442646346824 0.230508420032995 0.713581633813005 NA NA NA 0.69703829471091 84.886301668048 a1801 MLL2_mut 1066 AZD6482 PI3Kbeta 3 15 1.6094379124341 NA 2.22600952939623 1.96640004262918 0.259609486767052 0.806197892720575 1.13566673082792 0.236031454326993 0.322017074357488 0.22859654132669 0.713898946206612 NA NA NA 0.662697197333285 84.886301668048 a1802 loss_cnaBLCA5_(FAT1,IRF2) 261 TL-1-85 MAP3K7 (TAK1) 5 14 2.32630161961136 NA 3.36881909682436 3.60286938977925 -0.234050292954889 1.02495207844294 1.25641350869417 0.194078739980992 0.22835242532553 0.186284444838661 0.714108876916619 NA NA NA 0.690395465543143 84.886301668048 a1803 EP300_mut 1006 Cytarabine DNA synthesis 3 10 0.693147180559945 NA 0.391128070588132 0.131447447717606 0.259680622870526 0.752601841612719 1.10926639066144 0.246507554597522 0.345043831296064 0.234101226771761 0.715171939121089 NA NA NA 0.661523192061463 84.886301668048 a1804 loss_cnaBLCA18_(CHD9,CNOT1,CYLD,MMP2,NUP93) 1026 17-AAG HSP90 3 12 0 NA -1.90561531472417 -1.48902596227059 -0.416589352453585 0.90407786537877 1.84206602346848 0.240641433427257 0.460789239961153 0.226153323033003 0.715304827855972 NA NA NA 0.593665527802055 84.886301668048 a1805 gain_cnaBLCA15_(ASXL1) 290 KIN001-260 IKK 6 13 2.99573227355399 NA 5.16015316716912 4.94208200961616 0.21807115755296 0.899089221431652 1.29409396570092 0.183008992822783 0.242546737692748 0.168512614487656 0.715364589728284 NA NA NA 0.677516938520638 84.886301668048 a1806 RB1_mut 1192 GSK269962A ROCK1, ROCK2 6 13 1.6094379124341 NA 1.70085753682021 1.87931906268972 -0.178461525869515 0.547340323792171 1.10595505215748 0.182953021802006 0.326052216714217 0.161364176167354 0.715447520300514 NA NA NA 0.644225692565677 84.886301668048 a1807 gain_cnaBLCA15_(ASXL1) 1008 Methotrexate Dihydrofolate reductase (DHFR) 4 10 -1.6094379124341 NA -0.435603377272757 -0.198698395425604 -0.236904981847153 1.55773136228536 0.852622428843293 0.220737028870133 0.152083335793913 0.277854503743878 0.715571306696662 NA NA NA 0.788981466217094 84.886301668048 a1808 RB1_mut 163 JQ1 BRD4 6 13 0.940007258491471 NA -0.425621751564734 -0.170447438805107 -0.255174312759627 0.914267160180516 1.55269841959068 0.182844769096532 0.279102568563486 0.164342482442209 0.715607925456173 NA NA NA 0.660465008039175 84.886301668048 a1809 gain_cnaBLCA15_(ASXL1) 1026 17-AAG HSP90 4 11 0 NA -1.29663424080691 -1.67260186619926 0.375967625392351 1.94304508387288 1.66239589426469 0.217171188719307 0.193494030845116 0.226160102229227 0.715923604810727 NA NA NA 0.745729397833566 84.886301668048 a1810 EP300_mut 211 TL-2-105 CRAF 4 15 2.32630161961136 1.63315443905142 4.51960139418306 4.3423099966875 0.177291397495557 0.290432495539391 0.933094227521681 0.207233865638411 0.610439259444062 0.190003744816262 0.717221802917921 NA NA NA 0.537374674087628 84.9155152284892 a1811 gain_cnaBLCA15_(ASXL1) 1001 AICAR AAPK1 (AMPK) agonist 4 10 7.60090245954208 NA 8.07303198320045 7.92869894697842 0.144333036222028 0.872477021053527 0.568838075046783 0.219345393009252 0.165429040237351 0.253733078978859 0.717277535949192 NA NA NA 0.774717002395658 84.9155152284892 a1812 ARID1A_mut 1029 AMG-706 VEGFR, RET, c-KIT, PDGFR 5 10 0.693147180559945 NA 2.72217513440907 2.56318677894862 0.158988355460451 0.787872005978624 0.783522543081671 0.202568184638633 0.201794649707055 0.20291484509831 0.717458794967776 NA NA NA 0.721561121133968 84.9155152284892 a1813 gain_cnaBLCA9 230 GSK429286A ROCK2 4 15 2.99573227355399 2.32630161961136 5.07767577779721 4.72361395978795 0.354061818009262 1.06753255518279 1.82649586713608 0.206196017527338 0.33166371956557 0.193847587820949 0.718572277974821 NA NA NA 0.631849935271082 84.9155152284892 a1814 CDKN1A_mut 268 YM155 BIRC5 (Survivin) 3 16 1.63315443905142 NA -4.26558334906717 -3.7671129624455 -0.498470386621671 0.341454198127137 2.3034637793136 0.230039033424467 1.45984553523068 0.216400358059986 0.719148819482867 NA NA NA 0.424168457513215 84.9155152284892 a1815 loss_cnaBLCA18_(CHD9,CNOT1,CYLD,MMP2,NUP93) 1053 MK-2206 AKT1, AKT2 3 12 1.38629436111989 0.693147180559945 2.16076573841674 1.89401852239128 0.266747216025466 0.511673614677628 1.20278856292871 0.2372225784349 0.52132298475763 0.221773987753886 0.719157033560535 NA NA NA 0.573806345882215 84.9155152284892 a1816 MLL2_mut 291 KIN001-266 MAP3K8 (COT) 3 16 2.99573227355399 NA 3.88045750367929 3.61327242613681 0.267185077542471 1.47448752452047 1.11444922990506 0.22981523494578 0.181205383632774 0.239746298326422 0.71940947707584 NA NA NA 0.788955039677839 84.9155152284892 a1817 loss_cnaBLCA18_(CHD9,CNOT1,CYLD,MMP2,NUP93) 1022 AZD7762 CHEK1, CHEK2 3 11 0.693147180559945 NA -0.00689339297578314 0.218999854824805 -0.225893247800588 1.36420552201495 0.834657075139316 0.239349593059599 0.165585935663814 0.270641985228344 0.719665296784149 NA NA NA 0.80626651109932 84.9155152284892 a1818 NRAS_mut 1029 AMG-706 VEGFR, RET, c-KIT, PDGFR 3 12 0.693147180559945 NA 2.46865816236505 2.65306408120303 -0.184405918837985 1.04592540867846 0.727565167597273 0.234914099240513 0.176308862283959 0.253456222274866 0.721762650417893 NA NA NA 0.795179343981429 84.9155152284892 a1819 gain_cnaBLCA23_(MYC) 1021 Axitinib PDGFR, KIT, VEGFR 4 10 0.693147180559945 NA 1.82622475627629 2.09272942859321 -0.266504672316919 0.661500836291387 1.37781624613585 0.215232767507772 0.402878813896957 0.193425410002491 0.722329149250584 NA NA NA 0.635516496072513 84.9155152284892 a1820 loss_cnaBLCA18_(CHD9,CNOT1,CYLD,MMP2,NUP93) 159 HG-6-64-1 BRAFV600E, TAK, MAP4K5 3 16 1.63315443905142 NA 0.105249403655381 0.368989828901202 -0.263740425245821 0.434763441439618 1.22675290506076 0.226982325591537 0.606629721147909 0.214990666953226 0.7227120265451 NA NA NA 0.521437252827323 84.9155152284892 a1821 gain_cnaBLCA15_(ASXL1) 1248 FK866 NAMPT 6 13 0 NA -1.64622295860816 -2.17164741573179 0.525424457123629 3.13902806173287 2.86930866163869 0.178037691027172 0.167384440913081 0.18311883421547 0.722744592119274 NA NA NA 0.735580927963277 84.9155152284892 a1822 ARID1A_mut 1091 BMS-536924 IGF1R 5 14 1.38629436111989 NA 2.53545270736556 2.3425573043229 0.192895403042662 1.00145412151535 1.03395055997966 0.187934513520535 0.192615316966076 0.186561534476519 0.72274684239665 NA NA NA 0.724353578513633 84.9155152284892 a1823 loss_cnaBLCA18_(CHD9,CNOT1,CYLD,MMP2,NUP93) 1199 Tamoxifen ER 3 16 1.6094379124341 NA 3.64342485057881 3.50908937675531 0.134335473823509 0.430603217340131 0.61032561542208 0.226910210982179 0.311970436852074 0.220104597331389 0.722796170218925 NA NA NA 0.670758174071703 84.9155152284892 a1824 loss_cnaBLCA5_(FAT1,IRF2) 301 PHA-793887 CDK-pan 5 14 2.32630161961136 NA 3.04520877291502 3.30318493511588 -0.25797616220086 1.71649426169579 1.25128051742208 0.187622169620561 0.150292469924133 0.206169726619215 0.723186999117608 NA NA NA 0.769143306225778 84.9155152284892 a1825 MLL2_mut 193 GW-2580 CSF1R (cFMS) 3 16 2.99573227355399 NA 5.20819807525794 5.31643201403834 -0.108233938780394 0.404759543881516 0.487482905291232 0.226197249267899 0.267403055509118 0.22202612154314 0.72362825392965 NA NA NA 0.707249960443302 84.9155152284892 a1826 gain_cnaBLCA15_(ASXL1) 1049 PD-173074 FGFR1, FGFR3 4 11 0.693147180559945 NA 2.44559216021527 2.63967781600404 -0.194085655788774 1.29441112292298 0.776258121429209 0.210493857971399 0.149941276269705 0.250027214441806 0.72425414985092 NA NA NA 0.792564094736161 84.9155152284892 a1827 gain_cnaBLCA23_(MYC) 1022 AZD7762 CHEK1, CHEK2 4 10 0.693147180559945 NA 0.31463946264282 0.112976037357422 0.201663425285397 0.892340653087206 0.960550031151415 0.213635592106291 0.225993766604388 0.209945779756691 0.72429469667945 NA NA NA 0.721540022757637 84.9155152284892 a1828 loss_cnaBLCA5_(FAT1,IRF2) 163 JQ1 BRD4 5 14 0.940007258491471 NA -0.0590913294105196 -0.319577897628729 0.260486568218209 1.27152993381639 1.43205235852718 0.186602445943509 0.204860743967214 0.181897377332007 0.724624693792585 NA NA NA 0.713888019548673 84.9155152284892 a1829 gain_cnaBLCA15_(ASXL1) 199 Pazopanib VEGFR, PDGFRA, PDGFRB, KIT 6 13 2.07944154167984 NA 2.69592227232107 2.94230487823835 -0.246382605917281 1.39602893893013 1.39872217511874 0.176248097352694 0.176488179468615 0.176148351902954 0.725408227054532 NA NA NA 0.728367976827283 84.9155152284892 a1830 loss_cnaBLCA5_(FAT1,IRF2) 1133 JNJ-26854165 MDM2 5 14 2.30258509299405 NA 2.14252418707903 2.37865453194423 -0.236130344865205 0.498527341797131 1.42505584712156 0.186014184033268 0.473655755798636 0.165699011264829 0.725454558584546 NA NA NA 0.599555547643399 84.9155152284892 a1831 MLL2_mut 190 Bleomycin DNA damage 3 16 4.15888308335967 NA 1.74414760048437 1.19138379999946 0.552763800484914 3.0883590774399 2.36897541677672 0.224287547674017 0.178983008978065 0.233334544786884 0.72585878219901 NA NA NA 0.791611469700729 84.9155152284892 a1832 loss_cnaBLCA18_(CHD9,CNOT1,CYLD,MMP2,NUP93) 1175 AG-014699 PARP1, PARP2 3 16 1.6094379124341 NA 2.96837924526216 3.16607240772632 -0.197693162464154 1.05742709498911 0.856240915802933 0.224067169639392 0.186956777825131 0.230884975029217 0.726116347068916 NA NA NA 0.783407050348104 84.9155152284892 a1833 loss_cnaBLCA18_(CHD9,CNOT1,CYLD,MMP2,NUP93) 1069 EHT 1864 Rac GTPases 3 15 2.30258509299405 NA 3.30323138883751 3.52529848426397 -0.222067095426462 0.564987049103622 1.03166529033251 0.225336456689545 0.393048116375024 0.215251106640303 0.726279420743 NA NA NA 0.619603544557604 84.9155152284892 a1834 gain_cnaBLCA15_(ASXL1) 1043 JNK Inhibitor VIII JNK 4 10 2.30258509299405 NA 4.02831965857681 3.84931358961007 0.179006068966746 0.148643268659317 0.971812555748857 0.211869182369199 1.20426623136913 0.184198143878485 0.72647090280433 NA NA NA 0.583786509322171 84.9155152284892 a1835 loss_cnaBLCA5_(FAT1,IRF2) 293 MP470 PDGFR 5 14 2.99573227355399 NA 4.17233216152111 3.90136971030261 0.270962451218504 1.07646240206744 1.56232968488439 0.185260628097363 0.251715666704288 0.173434873471379 0.726518118352831 NA NA NA 0.679306923061118 84.9155152284892 a1836 loss_cnaBLCA18_(CHD9,CNOT1,CYLD,MMP2,NUP93) 1526 RDEA119 (rescreen) MAP2K1 (MEK1), MAP2K2 (MEK2) 3 16 1.6094379124341 NA 1.62321220463173 1.40547506846501 0.217737136166721 1.28138404431797 0.926246543636259 0.223373671908949 0.169923402068436 0.235074708416108 0.726927086596031 NA NA NA 0.801147358504642 84.9155152284892 a1837 gain_cnaBLCA9 1268 XAV 939 TNKS1 (tankyrase-1) 4 14 1.6094379124341 NA 3.0856066440084 3.24005480040342 -0.154448156395017 0.255946568827127 0.843362679504832 0.201043347072905 0.603439058014235 0.183133733740387 0.727514554414687 NA NA NA 0.559763338456113 84.9155152284892 a1838 loss_cnaBLCA18_(CHD9,CNOT1,CYLD,MMP2,NUP93) 1021 Axitinib PDGFR, KIT, VEGFR 3 11 0.693147180559945 NA 1.79062600251548 2.07821048213553 -0.287584479620054 1.37083348958016 1.21027932120776 0.232206746472622 0.209788046328027 0.237618270907139 0.727650879235664 NA NA NA 0.76370583070723 84.9155152284892 a1839 loss_cnaBLCA5_(FAT1,IRF2) 281 CH5424802 ALK 5 14 1.63315443905142 NA 4.04577982701128 4.11342217867764 -0.0676423516663611 0.339834721297115 0.376251239367787 0.183807245762525 0.199044851591906 0.179779744460165 0.728571027112402 NA NA NA 0.7203692193236 84.9550942746295 a1840 EP300_mut 178 BAY 61-3606 SYK 4 15 2.07944154167984 NA 2.45261624123493 2.15375429763509 0.298861943599838 1.75579234410739 1.44865585186869 0.198261805794706 0.170214857470388 0.206302927789455 0.728927874553649 NA NA NA 0.769220051037906 84.9550942746295 a1841 loss_cnaBLCA5_(FAT1,IRF2) 258 STF-62247 stimulates autophagy 5 14 2.32630161961136 NA 4.4351376911887 4.57686722783269 -0.141729536643988 0.79694130326948 0.766254296230008 0.183211497567541 0.177841876261824 0.184964100483744 0.729413138815209 NA NA NA 0.740592672410159 84.9550942746295 a1842 MLL2_mut 166 FTI-277 Farnesyl transferase (FNTA) 3 16 0.0237165266173161 NA 1.66103293973744 1.48221575693189 0.178817182805547 0.73742380918256 0.821444200618516 0.220215274476887 0.242489028125858 0.217686341532273 0.730623643840245 NA NA NA 0.73026086935683 84.9550942746295 a1843 EP300_mut 133 Doxorubicin DNA intercalating 4 15 0.0237165266173161 NA -2.35034734279778 -2.00247254791435 -0.347874794883431 1.97704345951336 1.71860246413218 0.196877730478387 0.175957080361328 0.202417255964481 0.730739951610479 NA NA NA 0.763198328740538 84.9550942746295 a1844 MLL2_mut 332 XMD15-27 CAMK2B, CLK2, DYRK1A, MAST1, STK39 3 16 2.32630161961136 NA 4.66621864282396 4.77788070256554 -0.11166205974158 0.361820444285337 0.52426112749965 0.219870210661042 0.308611803189101 0.212989393804816 0.731027918773561 NA NA NA 0.675304017747898 84.9550942746295 a1845 loss_cnaBLCA5_(FAT1,IRF2) 184 BMS-754807 IGF1R 5 14 0.940007258491471 NA 0.669135244145613 0.984371340305347 -0.315236096159734 1.37921067701093 1.82791743181271 0.181920412187617 0.228562685465084 0.172456419898092 0.731239355434739 NA NA NA 0.697594705135712 84.9550942746295 a1846 RB1_mut 345 KIN001-270 CDK9 6 13 2.99573227355399 NA 4.81557018685828 4.97606104373524 -0.160490856876954 1.21489193714872 0.787960672274332 0.171829757650381 0.13210298954952 0.203678765354774 0.731999959361992 NA NA NA 0.775711675957684 84.9550942746295 a1847 loss_cnaBLCA5_(FAT1,IRF2) 1029 AMG-706 VEGFR, RET, c-KIT, PDGFR 3 12 0.693147180559945 NA 2.4743501710379 2.65164107903482 -0.177290907996923 0.925448327849969 0.757030613919999 0.225763294681802 0.191572995122062 0.234192521064489 0.732126610274382 NA NA NA 0.780806653864175 84.9550942746295 a1848 RB1_mut 253 XMD14-99 EPHB3, CAMK1 6 13 2.32630161961136 NA 4.77983694566854 4.69719822048179 0.0826387251867491 0.478990205626953 0.482798583266638 0.171562969295062 0.172526962380332 0.171166047397264 0.73239867898335 NA NA NA 0.734638405250365 84.9550942746295 a1849 loss_cnaBLCA5_(FAT1,IRF2) 171 AKT inhibitor VIII AKT1, AKT2, AKT3 5 14 0.940007258491471 NA 1.88511028659085 2.08082839540696 -0.195718108816114 0.530588909623019 1.20162340848967 0.18091061079662 0.36886958107581 0.162878075970668 0.732668859871323 NA NA NA 0.630769911157517 84.9550942746295 a1850 EP300_mut 1021 Axitinib PDGFR, KIT, VEGFR 3 11 0.693147180559945 NA 2.23782851792961 1.95624615974986 0.281582358179745 1.66785802249034 1.13360844169348 0.227310685656193 0.168828733850681 0.248394725924142 0.733144018454573 NA NA NA 0.803824927987009 84.9550942746295 a1851 TP53_mut 1142 HG-5-113-01 LOK, LTK, TRCB, ABL(T315I) 4 3 2.30258509299405 NA 1.63506752879452 1.84778876227948 -0.212721233484955 0.327496984740108 1.15460081839845 0.27517425957664 0.649536464141079 0.184237902914378 0.733351545441536 NA NA NA 0.783097215426095 84.9550942746295 a1852 loss_cnaBLCA18_(CHD9,CNOT1,CYLD,MMP2,NUP93) 156 AZD6482 PI3Kbeta 3 16 1.63315443905142 NA 2.25901615743006 1.95114232675993 0.307873830670129 0.782358084511847 1.47796726768576 0.217731768772398 0.393520354381238 0.208308964211505 0.733535118553152 NA NA NA 0.619296362774033 84.9550942746295 a1853 EP300_mut 1020 Lenalidomide TNFA 3 11 1.6094379124341 NA 3.5996597899322 3.80772744860738 -0.208067658675176 1.0062197566994 0.90554820071959 0.225403546590371 0.206781527881821 0.229769832803859 0.73528793843146 NA NA NA 0.767434297857119 85.0100746108715 a1854 loss_cnaBLCA5_(FAT1,IRF2) 1038 NU-7441 PRKDC (DNAPK) 3 12 0.693147180559945 NA 1.99969010557602 2.24966704289391 -0.249976937317884 0.765001605792464 1.17551443116989 0.222760872878362 0.326766552416493 0.212653227122957 0.735539142887985 NA NA NA 0.67327417817145 85.0100746108715 a1855 NRAS_mut 206 Ruxolitinib JAK1, JAK2, TYK2 3 16 1.65632149833295 0.0237165266173161 4.21630012065986 4.11252664041271 0.103773480247145 0.553275672339412 0.472154595268814 0.215116124734174 0.18756197938066 0.219787080941283 0.73660602618817 NA NA NA 0.783485895755031 85.0100746108715 a1856 TP53_mut 1158 XMD11-85h BRSK2, FLT4, MARK4, PRKCD, RET, SPRK1 4 3 2.30258509299405 NA 3.64191850860344 3.93225843213826 -0.290339923534823 0.695022614616982 1.46275088632133 0.271252163930484 0.417741692757473 0.198488974609339 0.736965630670959 NA NA NA 0.77364685278572 85.0100746108715 a1857 RB1_mut 306 TG101348 JAK2 6 13 2.32630161961136 NA 3.10850219295386 2.94706156130665 0.16144063164721 1.1095295493687 0.888366309890993 0.168390948005289 0.145503679229695 0.181727548478307 0.737145324367197 NA NA NA 0.762122275712082 85.0100746108715 a1858 gain_cnaBLCA9 229 LY317615 PRKCB (PKCbeta) 4 15 2.99573227355399 2.32630161961136 4.05475668869642 3.73120446443547 0.323552224260948 2.20002551177042 1.56120109913598 0.191274769889448 0.14706748741317 0.207245706168163 0.738092186473652 NA NA NA 0.7966182359608 85.0100746108715 a1859 loss_cnaBLCA5_(FAT1,IRF2) 193 GW-2580 CSF1R (cFMS) 5 14 2.99573227355399 NA 5.36157275061195 5.27711733552339 0.0844554150885557 0.470961450045679 0.481052682389439 0.176427556777198 0.179325537324476 0.175563754616348 0.739027353338275 NA NA NA 0.741894813899354 85.0100746108715 a1860 RB1_mut 301 PHA-793887 CDK-pan 6 13 2.32630161961136 NA 3.3925627936967 3.16271201492441 0.229850778772297 1.44025924089919 1.34771778339352 0.167093443307686 0.159589865661126 0.170548153036565 0.739090091897148 NA NA NA 0.7488430279824 85.0100746108715 a1861 ARID1A_mut 1046 681640 WEE1, CHEK1 5 10 0.693147180559945 NA 1.75426651994604 1.57966265051755 0.174603869428487 0.519149400376148 1.07229635887176 0.186238760890908 0.336326824806074 0.162831728359314 0.739269737296607 NA NA NA 0.677882095751688 85.0100746108715 a1862 MLL2_mut 1050 ZM-447439 AURKB 3 12 1.38629436111989 0.693147180559945 1.97391753931125 2.26425030526599 -0.290332765954744 1.08908313985626 1.36181289343637 0.219364505433585 0.266584574978421 0.213195782881835 0.739406480264784 NA NA NA 0.716558182727917 85.0100746108715 a1863 loss_cnaBLCA18_(CHD9,CNOT1,CYLD,MMP2,NUP93) 147 NSC-87877 PTPN6 (SHP-1), PTPN11 (SHP-2) 3 16 2.77258872223978 NA 4.93838286721785 5.08805455321039 -0.149671685992539 0.450320263463971 0.73107087063924 0.212638753177953 0.332367202046891 0.204729379877586 0.739518831231471 NA NA NA 0.66045760449542 85.0100746108715 a1864 gain_cnaBLCA23_(MYC) 326 GSK690693 AKT 4 15 2.32630161961136 NA 4.11754241970207 4.30078399197436 -0.183241572272282 1.03548636479685 0.950586575395968 0.189669239261152 0.176961839867617 0.192766842090056 0.740203833648033 NA NA NA 0.763569173850322 85.0100746108715 a1865 EP300_mut 301 PHA-793887 CDK-pan 4 15 2.32630161961136 NA 3.02937622893202 3.29020853603129 -0.260832307099269 0.949209253852918 1.45078554038277 0.189609901959688 0.274789047873827 0.179786949786149 0.740281917080279 NA NA NA 0.67864221637394 85.0100746108715 a1866 NRAS_mut 135 Gemcitabine DNA replication 3 16 0.0237165266173161 NA -1.82425750685064 -2.44497735260247 0.620719845751828 4.18965446673746 2.72092573261819 0.211694147993648 0.148155379084326 0.228128183842248 0.74063054092673 NA NA NA 0.825008850785475 85.0100746108715 a1867 loss_cnaBLCA18_(CHD9,CNOT1,CYLD,MMP2,NUP93) 1373 Dabrafenib BRAF 3 14 2.30258509299405 NA 3.32061740637544 3.60630971031991 -0.285692303944475 1.60682787785758 1.28476266437399 0.214449758027597 0.177798946533959 0.222369712217377 0.740730987507828 NA NA NA 0.794355535520198 85.0100746108715 a1868 gain_cnaBLCA15_(ASXL1) 1016 Temsirolimus MTOR 4 10 -1.6094379124341 NA -2.87167868188297 -2.57810102294989 -0.293577658933082 1.63460217038181 1.40827398791396 0.199966976282358 0.179601902072911 0.208466293812578 0.741198530857699 NA NA NA 0.765428862237238 85.0100746108715 a1869 EP300_mut 1261 rTRAIL TR10A (DR4), TR10B (DR5) 3 15 -2.30258509299405 NA -0.818219934438154 -1.13350966732615 0.315289732887999 1.44505150857446 1.49007749794337 0.212384405147589 0.21818580930657 0.211592842199931 0.741377950214313 NA NA NA 0.754664705722949 85.0100746108715 a1870 NRAS_mut 1149 TW 37 BCL2, BCL2L1 3 16 1.6094379124341 NA -0.300052370698871 -0.620251662332182 0.320199291633312 1.2589791077562 1.55258253074854 0.21052094341835 0.25433249023805 0.206236567326914 0.742012112588453 NA NA NA 0.721534899954312 85.0100746108715 a1871 ARID1A_mut 1170 CCT018159 HSP90 5 14 2.30258509299405 NA 2.51563685144932 2.6771531397662 -0.161516288316872 0.855633886331329 0.948184348086772 0.174190527315495 0.188767989320058 0.170342706713917 0.74220754704775 NA NA NA 0.734197028812186 85.0100746108715 a1872 loss_cnaBLCA5_(FAT1,IRF2) 255 CP724714 ERBB2 5 14 2.32630161961136 NA 4.4135794987083 4.2464617363287 0.167117762379599 0.783236120765013 1.00749519419123 0.174179750085291 0.213368303566451 0.165874500784843 0.742222879791459 NA NA NA 0.713872926484849 85.0100746108715 a1873 gain_cnaBLCA23_(MYC) 1218 JQ1 BRD2, BRD3, BRD4 4 15 0 NA 2.08165196755113 1.94551373206941 0.136138235481719 0.349337541836543 0.782766600948109 0.18768642366021 0.389703994497731 0.173919320672119 0.742814645976201 NA NA NA 0.619658529610091 85.0100746108715 a1874 MLL2_mut 293 MP470 PDGFR 3 16 2.99573227355399 NA 3.71428891466651 4.02112312549016 -0.306834210823653 1.07722692711473 1.50727709403764 0.209692512026196 0.28483711565351 0.203568548900134 0.742988224257593 NA NA NA 0.696582354777364 85.0100746108715 a1875 RB1_mut 1243 piperlongumine Increases ROS levels 6 13 2.30258509299405 NA 1.39712459890165 1.24923543144037 0.147889167461278 0.192402808862683 1.06344153202401 0.16440496018437 0.768643495048065 0.139066571135139 0.743125512985088 NA NA NA 0.635725189536759 85.0100746108715 a1876 loss_cnaBLCA5_(FAT1,IRF2) 150 Bicalutamide ANDR (androgen receptor) 5 14 0.0237165266173161 NA 2.43091916304457 2.34397612051866 0.0869430425259012 0.284589629239644 0.552544018532532 0.173014483479156 0.305503200373789 0.157350436544057 0.743881359021383 NA NA NA 0.662370094580119 85.0112506015083 a1877 gain_cnaBLCA9 150 Bicalutamide ANDR (androgen receptor) 4 15 0.0237165266173161 NA 2.44094524922895 2.34709870037122 0.0938465488577247 0.404056144966278 0.52120613435089 0.186751480461624 0.232261159808761 0.180056493338478 0.744046826339319 NA NA NA 0.712389042548596 85.0112506015083 a1878 EP300_mut 1019 Bosutinib SRC, ABL, TEC 3 11 0.693147180559945 NA 1.26271148058247 1.48326789592357 -0.220556415341097 0.297365175568001 1.10343019660967 0.217387238244893 0.741702235037474 0.199882526342641 0.744324810313696 NA NA NA 0.566853493194582 85.0112506015083 a1879 EP300_mut 1061 SB590885 BRAF 4 11 1.6094379124341 NA 3.65392572974247 3.81616529669887 -0.162239566956391 0.411155828451996 0.929539229722078 0.193408415433423 0.394593863760181 0.174537622263559 0.745734468001401 NA NA NA 0.648998917838471 85.0852185751697 a1880 TP53_mut 1015 CI-1040 MAP2K1 (MEK1), MAP2K2 (MEK2) 10 4 2.30258509299405 NA 2.22409688855441 2.44205685689885 -0.21795996834444 0.907820145296728 1.57451092052071 0.195901822642891 0.24009157482752 0.138430267776331 0.746253685270481 NA NA NA 0.808167828611 85.0852185751697 a1881 EP300_mut 224 AS605240 PI3Kgamma 4 15 2.99573227355399 2.32630161961136 3.1290914382942 3.39564882398398 -0.266557385689774 2.17930001425515 1.22724244664513 0.184892850716543 0.122313304247318 0.217200265863076 0.746498471980269 NA NA NA 0.827295996650046 85.0852185751697 a1882 ARID1A_mut 1502 Bicalutamide ANDR (androgen receptor) 3 14 2.30258509299405 NA 4.18579238380691 4.31647620397618 -0.13068382016927 0.718774919384729 0.608080551007874 0.209437442979707 0.18181466359613 0.21491202103515 0.746559180340051 NA NA NA 0.790774718203552 85.0852185751697 a1883 CDKN1A_mut 1133 JNJ-26854165 MDM2 3 16 2.30258509299405 NA 2.09646583495535 2.35777417985927 -0.261308344903918 0.213260652209306 1.34996969096767 0.205724845191699 1.22530031769506 0.193566082744132 0.747669408691339 NA NA NA 0.476897894880873 85.1218934833748 a1884 gain_cnaBLCA15_(ASXL1) 165 DMOG Prolyl-4-Hydroxylase 6 13 8.29404964010203 NA 5.85030637581679 5.68987243145868 0.160433944358106 1.164961532905 0.914034975058208 0.161332333218266 0.137716087464314 0.175522763062638 0.747746970062148 NA NA NA 0.77354963814429 85.1218934833748 a1885 NRAS_mut 283 GSK2126458 PI3K, MTOR 3 16 -2.05572501506252 0.0237165266173161 -1.93775813454271 -2.27061099114334 0.332852856600634 1.63217985911168 1.61908776080288 0.205384411217077 0.203931481412711 0.205580490853429 0.748071540025305 NA NA NA 0.768292747796519 85.1218934833748 a1886 RB1_mut 164 JQ12 HDAC 6 13 1.63315443905142 NA 1.06695263537974 1.30758075439373 -0.240628119013981 1.24324263776183 1.59747947772407 0.160206222190969 0.193548798685972 0.150629865591015 0.74944321331487 NA NA NA 0.726931000502997 85.1687586084219 a1887 loss_cnaBLCA5_(FAT1,IRF2) 159 HG-6-64-1 BRAFV600E, TAK, MAP4K5 5 14 1.63315443905142 NA 0.18260089446285 0.379041500076509 -0.196440605613659 1.16511063135265 1.16207725395252 0.168938774952068 0.168602534667115 0.169042638899879 0.749692305799281 NA NA NA 0.755423807660972 85.1687586084219 a1888 NRAS_mut 211 TL-2-105 CRAF 3 16 2.32630161961136 1.63315443905142 4.52606038153267 4.35217964890292 0.173880732629752 0.825352009782253 0.860342053430932 0.203060580741724 0.210674634057807 0.202106513259858 0.750818512750897 NA NA NA 0.762158670981354 85.1687586084219 a1889 gain_cnaBLCA15_(ASXL1) 1031 Elesclomol HSP70 4 10 -1.6094379124341 NA -3.86677225475224 -3.56723217768951 -0.299540077062736 1.44579812600665 1.59876932898638 0.191775402484227 0.207179738080085 0.187356657168701 0.751397669326518 NA NA NA 0.745467171532976 85.1687586084219 a1890 RB1_mut 225 Genentech Cpd 10 AURKA, AURKB 6 13 2.32630161961136 NA 2.85014184229736 3.10037602446039 -0.250234182163027 2.07386824955024 1.31950573592841 0.158452637985069 0.120660597517367 0.189642360278912 0.752087239661772 NA NA NA 0.794052743396846 85.1687586084219 a1891 TP53_mut 272 AR-42 HDAC 15 4 1.63315443905142 NA 0.112183200740736 -0.148503876781567 0.260687077522303 1.24804306371679 2.13240038332555 0.180529579687507 0.208876668683173 0.122250530229109 0.752264853729496 NA NA NA 0.827758959285179 85.1687586084219 a1892 loss_cnaBLCA18_(CHD9,CNOT1,CYLD,MMP2,NUP93) 1058 GDC0941 PI3K (class 1) 3 12 1.38629436111989 0.693147180559945 0.883451694349283 1.16084157051274 -0.277389876163455 0.886198766415763 1.4019877608444 0.207679451470283 0.313010903056614 0.19785470594721 0.75276770965087 NA NA NA 0.688590367922863 85.1687586084219 a1893 TP53_mut 1143 HG-5-88-01 EGFR, ADCK4 4 3 2.30258509299405 NA 3.76601787508115 3.57038254255144 0.195635332529712 0.367072133759994 1.13113644235032 0.254129080992771 0.532961547709382 0.172954672137708 0.75283327237314 NA NA NA 0.796824986091292 85.1687586084219 a1894 RB1_mut 1005 Cisplatin DNA crosslinker 5 9 1.79175946922805 2.30258509299405 2.38804341103253 2.57886211828285 -0.190818707250323 1.3129170045844 0.91384024946197 0.179402411614212 0.145339504769934 0.208809698809687 0.753258696415267 NA NA NA 0.782357622469679 85.1687586084219 a1895 loss_cnaBLCA18_(CHD9,CNOT1,CYLD,MMP2,NUP93) 310 YM201636 FYV1 3 16 1.63315443905142 NA 2.58950508963351 2.83473720019674 -0.24523211056323 0.680093540447828 1.27543886193552 0.200916969642473 0.360585854707207 0.192272728926483 0.753355508660449 NA NA NA 0.647514111933094 85.1687586084219 a1896 EP300_mut 1062 AZD6244 MAP2K1 (MEK1), MAP2K2 (MEK2) 4 10 1.38629436111989 0.693147180559945 1.8232623824441 2.13549963303983 -0.31223725059573 1.69153793836224 1.63448277736646 0.189357302445451 0.184587790503853 0.191031227076505 0.75441789253615 NA NA NA 0.764550678622007 85.1687586084219 a1897 CDKN1A_mut 185 OSI-906 IGF1R 3 16 0.940007258491471 NA 2.48545795307491 2.23425394163715 0.251204011437753 1.03849412269287 1.28484816917629 0.199626338046814 0.241892569200456 0.195512604106988 0.754884394297768 NA NA NA 0.734486973217994 85.1687586084219 a1898 RB1_mut 1091 BMS-536924 IGF1R 6 13 1.38629436111989 NA 2.50307889874155 2.34266095422301 0.160417944518532 0.849325169642129 1.0929323723587 0.156155305545204 0.188876946371582 0.146777557857791 0.755555922113532 NA NA NA 0.733392002534983 85.1687586084219 a1899 NRAS_mut 281 CH5424802 ALK 3 16 1.63315443905142 NA 4.15728622615227 4.08405943488041 0.0732267912718658 0.509509017508725 0.345099710530706 0.198839157867175 0.143720304755179 0.212190242522241 0.755817404865856 NA NA NA 0.830413041732524 85.1687586084219 a1900 CDKN1A_mut 332 XMD15-27 CAMK2B, CLK2, DYRK1A, MAST1, STK39 3 16 2.32630161961136 NA 4.8453106180924 4.74430095720271 0.101009660889691 0.179755020157502 0.537008600665159 0.198765226931654 0.561929568371364 0.188096914583075 0.755905051976147 NA NA NA 0.564384626679396 85.1687586084219 a1901 ARID1A_mut 1057 NVP-BEZ235 PI3K (Class 1) and MTORC1/2 5 10 -1.38629436111989 0.693147180559945 -2.37140634911463 -2.59555912804961 0.224152778934971 1.28372576726608 1.2922777038359 0.173808681017998 0.174611108268352 0.173455580228316 0.756032396257622 NA NA NA 0.758416584023961 85.1687586084219 a1902 gain_cnaBLCA23_(MYC) 1010 Gefitinib EGFR 4 10 -0.693147180559945 NA 0.720063191329463 0.527593419412294 0.192469771917169 0.548887508886312 1.13967393317201 0.187879414293268 0.350654312224536 0.168881437326091 0.75626587893747 NA NA NA 0.67898257417166 85.1687586084219 a1903 TP53_mut 271 VNLG/124 HDAC, RAR 15 4 1.63315443905142 NA 3.92642124230298 4.01296611838952 -0.086544876086541 0.492562014832515 0.465852113626824 0.177362502099826 0.175703512411465 0.185777575232531 0.756459864590451 NA NA NA 0.757647315159289 85.1687586084219 a1904 MLL2_mut 197 Bryostatin 1 PRKC 3 16 -4.8283137373023 NA -3.23962394731361 -3.07250550681123 -0.167118440502384 0.848079855024283 0.844814296867146 0.197726705546438 0.197055076255288 0.19781677597327 0.757136608451373 NA NA NA 0.775854585248993 85.1687586084219 a1905 RB1_mut 309 Y-39983 ROCK 6 13 2.99573227355399 NA 4.52228354456599 4.2810244232119 0.241259121354092 1.35463141906633 1.63277868706914 0.15503688591848 0.178099457873477 0.147759842325696 0.75724654676696 NA NA NA 0.741670643881556 85.1687586084219 a1906 MLL2_mut 202 GSK-1904529A IGF1R 3 16 0.0237165266173161 NA 1.98635280916122 2.09562856613663 -0.109275756975413 0.503701256291291 0.55927200272397 0.197596709787663 0.21694557162712 0.195389285433882 0.757290814602254 NA NA NA 0.757119086668893 85.1687586084219 a1907 RB1_mut 1236 UNC0638 G9a(EHMT2), GLP(EHMT1) 6 13 2.99573227355399 NA 3.49448258956 3.69509310507309 -0.200610515513091 1.36523651696166 1.26585742002582 0.154806644375693 0.146941949633424 0.158477971009562 0.757594741891058 NA NA NA 0.767520196957012 85.1687586084219 a1908 EP300_mut 158 PF-562271 FAK 4 15 0.940007258491471 NA 1.55720573217263 1.73337120835215 -0.176165476179525 0.707415296590718 1.05200314623974 0.176190051838616 0.249026953514475 0.167457176158844 0.758014850293848 NA NA NA 0.70450078207512 85.1687586084219 a1909 gain_cnaBLCA23_(MYC) 166 FTI-277 Farnesyl transferase (FNTA) 4 15 0.0237165266173161 NA 1.62312122178179 1.48040440286637 0.142716818915419 1.063156813583 0.748078456460744 0.175628385986805 0.134238728560128 0.190777875880333 0.758760149749662 NA NA NA 0.813740191272016 85.1687586084219 a1910 ARID1A_mut 1175 AG-014699 PARP1, PARP2 5 14 1.6094379124341 NA 3.24062560891981 3.09708344391489 0.143542165004924 0.98686549603928 0.848561763419724 0.162551834620165 0.145452612925491 0.169159360217276 0.758829611327516 NA NA NA 0.781711501836877 85.1687586084219 a1911 EP300_mut 277 ABT-869 VEGFR and PDGFR family 4 15 0.0237165266173161 NA 2.26854597041324 2.3501629155341 -0.0816169451208575 0.402349928920328 0.477944606295781 0.175332811387014 0.202850651272313 0.170766536635729 0.759152459080141 NA NA NA 0.742282496945115 85.1687586084219 a1912 ARID1A_mut 185 OSI-906 IGF1R 5 14 0.940007258491471 NA 2.12358200035393 2.32760906597496 -0.204027065621029 0.731567853996504 1.38076769942428 0.162117614261326 0.278890146015087 0.147763498310468 0.759452170040649 NA NA NA 0.685454536058616 85.1687586084219 a1913 NRAS_mut 1023 GW 441756 NTRK1 3 11 0.693147180559945 NA 2.5927208290018 2.40088609422685 0.191834734774945 1.13053203393815 0.90170479543583 0.203278559628471 0.169685359650269 0.212746716825681 0.760325875283001 NA NA NA 0.805305844256077 85.1687586084219 a1914 loss_cnaBLCA5_(FAT1,IRF2) 200 LAQ824 HDAC 5 14 0.0237165266173161 NA -2.87967151103094 -2.71392571470332 -0.165745796327617 1.02996263944183 1.02677567414958 0.161305627047958 0.160924085962418 0.161423571380276 0.760616803771268 NA NA NA 0.766131762554348 85.1687586084219 a1915 gain_cnaBLCA15_(ASXL1) 1527 GDC0941 (rescreen) PI3K 6 13 1.38629436111989 NA 0.721043479119195 0.901734246258747 -0.180690767139551 1.11545013695454 1.20963678206065 0.152776422027995 0.161989103011706 0.149376052232588 0.760667368408825 NA NA NA 0.755588554033155 85.1687586084219 a1916 gain_cnaBLCA15_(ASXL1) 1378 Bleomycin (50 uM) DNA damage 6 12 3.91202300542815 NA 0.687333741350315 0.937060606582942 -0.249726865232627 1.89841222575133 1.46557171108212 0.154787077443621 0.131545120625102 0.170395527795933 0.760880099596217 NA NA NA 0.784408320619061 85.1687586084219 a1917 gain_cnaBLCA9 196 Phenformin AAPK1 (AMPK) agonist 4 15 8.29404964010203 NA 8.82029093022451 9.04234074688952 -0.222049816665015 1.17855314280856 1.29787300852715 0.173798686349345 0.188408828248387 0.171087475589774 0.761189751471762 NA NA NA 0.75617152353546 85.1687586084219 a1918 gain_cnaBLCA23_(MYC) 229 LY317615 PRKCB (PKCbeta) 4 15 2.99573227355399 2.32630161961136 4.03104170499789 3.73752846008841 0.293513244909477 1.52268904979479 1.72680567869454 0.173412282780658 0.192759805391018 0.169974681303673 0.761703174380577 NA NA NA 0.75219244964911 85.1817700484394 a1919 NRAS_mut 163 JQ1 BRD4 3 16 0.940007258491471 NA -0.477955907485136 -0.208479968212462 -0.269475939272674 1.91884468203657 1.31224531729627 0.192848523921432 0.140436556327563 0.205354849219731 0.762930471814626 NA NA NA 0.83426166245507 85.2181672265437 a1920 RB1_mut 305 TPCA-1 IKK 6 13 2.99573227355399 NA 3.7240982948113 3.48573160713347 0.238366687677829 1.55507617562256 1.58629025008161 0.151135336124665 0.153282965435697 0.150266754564977 0.7631540739533 NA NA NA 0.763958816191886 85.2181672265437 a1921 NRAS_mut 151 QS11 ARFGAP 3 16 2.32630161961136 NA 3.32461656102651 2.99966242944783 0.324954131578681 1.6816205506995 1.68789330838776 0.192604611638176 0.193238677681187 0.192520540228381 0.763220552600602 NA NA NA 0.780175930961105 85.2181672265437 a1922 gain_cnaBLCA9 197 Bryostatin 1 PRKC 4 15 -4.8283137373023 NA -2.98476797288757 -3.12932587062468 0.14455789773711 0.363539914438173 0.916212269913757 0.171001985471804 0.397639686856709 0.157777736103356 0.764908362976588 NA NA NA 0.635773106191452 85.3350092889077 a1923 CDKN1A_mut 279 BIX02189 MAP2K5 (MEK5) 3 16 2.99573227355399 NA 4.86645383597661 4.65559895653965 0.210854879436964 1.07963363017033 1.10678630237833 0.191056368230923 0.195302252120193 0.190510922464316 0.765062696256669 NA NA NA 0.77839083613546 85.3350092889077 a1924 gain_cnaBLCA15_(ASXL1) 221 TAK-715 p38a 6 13 2.99573227355399 2.32630161961136 4.51882276651528 4.6369624266682 -0.118139660152913 0.455577488554038 0.898060394339151 0.14880097357887 0.259318476265975 0.131549794309599 0.766695877962596 NA NA NA 0.708708680795797 85.4577604874722 a1925 EP300_mut 331 QL-X-138 MNK2, PRKDC (DNAPK), MTOR, BTK, JAK3 4 15 2.32630161961136 NA 2.2519458683011 2.01171289706191 0.240232971239192 1.26370779129341 1.44848815922198 0.169460853747303 0.190101677693474 0.165850835375987 0.76696005175791 NA NA NA 0.755990511124689 85.4577604874722 a1926 RB1_mut 332 XMD15-27 CAMK2B, CLK2, DYRK1A, MAST1, STK39 6 13 2.32630161961136 NA 4.81152320548286 4.73658522589411 0.0749379795887579 0.427498584120808 0.538457986864143 0.147416089955013 0.175294100079595 0.139171451472342 0.768799608726487 NA NA NA 0.749740697945147 85.5460814520543 a1927 gain_cnaBLCA23_(MYC) 1495 AZD-2281 PARP1, PARP2 4 13 2.30258509299405 NA 3.21219000706347 3.33716204475355 -0.12497203769008 0.583662922388795 0.765521981009743 0.17054746914899 0.214116800804476 0.163250750194317 0.76958235542842 NA NA NA 0.739972572602858 85.5460814520543 a1928 loss_cnaBLCA18_(CHD9,CNOT1,CYLD,MMP2,NUP93) 258 STF-62247 stimulates autophagy 3 16 2.32630161961136 NA 4.41760983767161 4.56243750828664 -0.144827670615032 0.295956894232287 0.81727964578625 0.187023329149508 0.489353934432632 0.177206995624739 0.76986810296668 NA NA NA 0.599436232179802 85.5460814520543 a1929 gain_cnaBLCA23_(MYC) 301 PHA-793887 CDK-pan 4 15 2.32630161961136 NA 3.05375086904002 3.28370863200249 -0.229957762962476 2.39164839516183 1.03709075882066 0.167041718354339 0.096150321856535 0.221733499220429 0.770184205730454 NA NA NA 0.862082786853276 85.5460814520543 a1930 EP300_mut 165 DMOG Prolyl-4-Hydroxylase 4 15 8.29404964010203 NA 5.87142419328364 5.7056322060486 0.165791987235044 1.22467251937852 0.938486331844864 0.166626916304101 0.135376588117759 0.176658925771601 0.770737479078799 NA NA NA 0.813657448305069 85.5460814520543 a1931 TP53_mut 1248 FK866 NAMPT 15 4 0 NA -2.10929506622793 -1.61733204068581 -0.491963025542124 2.70300905115869 3.92190884520245 0.16649207552395 0.182005689300684 0.125439688926969 0.7709173604975 NA NA NA 0.825360344492825 85.5460814520543 a1932 NRAS_mut 1006 Cytarabine DNA synthesis 3 10 0.693147180559945 NA 0.350853194853984 0.143529910437851 0.207323284416133 2.11700082376717 0.605539886785649 0.196352912457113 0.0979325478235781 0.342377585590034 0.771047160939524 NA NA NA 0.881677867146085 85.5460814520543 a1933 TP53_mut 308 XL-880 MET 15 4 1.63315443905142 NA 0.604769271086322 0.84957488988364 -0.244805618797318 1.52416134163667 1.19642586246386 0.166348981950592 0.160616604102057 0.204614114821271 0.771108266068372 NA NA NA 0.744246777914682 85.5460814520543 a1934 gain_cnaBLCA9 1375 Temozolomide DNA akylating agent 4 14 3.40119738166216 NA 5.40261519477383 5.28369149699283 0.118923697780997 0.452519460494624 0.757604602244302 0.167391700472693 0.262803499436263 0.156973304318244 0.771598933615379 NA NA NA 0.704964888239622 85.5460814520543 a1935 loss_cnaBLCA5_(FAT1,IRF2) 190 Bleomycin DNA damage 5 14 4.15888308335967 NA 0.999996922652707 1.37818564201292 -0.378188719360215 1.11551372699442 2.75295753886207 0.153270855263584 0.339026504298775 0.137375427706937 0.772172561526847 NA NA NA 0.676040893134162 85.5460814520543 a1936 RB1_mut 304 SB52334 ALK5 6 13 2.99573227355399 NA 4.63998506794393 4.78971977921578 -0.149734711271852 1.12719874255734 0.98878991151128 0.145172207389792 0.132837897718143 0.151432280536717 0.772212153382126 NA NA NA 0.786364038250811 85.5460814520543 a1937 NRAS_mut 275 I-BET BRD2, BRD3, BRD4 3 16 2.99573227355399 NA 4.46421930817132 4.67327554860931 -0.209056240437992 1.1082567866344 1.14184445917522 0.183713928242664 0.188635199855497 0.183086442954758 0.773818507702438 NA NA NA 0.785767647143662 85.5460814520543 a1938 gain_cnaBLCA15_(ASXL1) 177 GSK-650394 SGK3 6 13 2.77258872223978 NA 3.14409831754119 2.83803332479411 0.306064992747083 1.96504799006432 2.18749801410112 0.144065107104356 0.155754462127444 0.139915552276673 0.773897631739346 NA NA NA 0.766646614107681 85.5460814520543 a1939 gain_cnaBLCA15_(ASXL1) 180 Thapsigargin sarco-endoplasmic reticulum Ca2+-ATPases 6 13 -0.669430653942629 NA -4.19454684527476 -4.44050958720474 0.245962741929984 2.00306065749103 1.57056369535164 0.143907930471723 0.122793456608583 0.156607938065774 0.774137016015981 NA NA NA 0.797384666698519 85.5460814520543 a1940 RB1_mut 331 QL-X-138 MNK2, PRKDC (DNAPK), MTOR, BTK, JAK3 6 13 2.32630161961136 NA 2.20168792654747 1.99794995152678 0.203737975020689 1.73157384771634 1.26440451948553 0.143692304104001 0.117660575256081 0.16113353905409 0.774465458923931 NA NA NA 0.803141482920398 85.5460814520543 a1941 TP53_mut 301 PHA-793887 CDK-pan 15 4 2.32630161961136 NA 3.18781556935225 3.41334985397844 -0.225534284626189 1.48544524954066 0.666444293394782 0.163812321083004 0.15182941592491 0.338414308384796 0.774495002458177 NA NA NA 0.665157222231774 85.5460814520543 a1942 MLL2_mut 253 XMD14-99 EPHB3, CAMK1 3 16 2.32630161961136 NA 4.64900671104991 4.7372236504453 -0.0882169393953909 0.314156609387624 0.500351751404212 0.182949547528831 0.280805613376556 0.17630984432015 0.774731855971689 NA NA NA 0.708286866709029 85.5460814520543 a1943 gain_cnaBLCA23_(MYC) 274 PXD101, Belinostat HDAC 4 15 2.99573227355399 NA 0.638546623640504 0.402142790324081 0.236403833316423 1.40488510523553 1.45915541458679 0.163067948092958 0.168272716705036 0.162014156239395 0.775489718830655 NA NA NA 0.778975360477463 85.5460814520543 a1944 CDKN1A_mut 258 STF-62247 stimulates autophagy 3 16 2.32630161961136 NA 4.65842142839752 4.51728533502553 0.14113609337199 0.467988646150834 0.806598265790643 0.182232372785009 0.301580165529275 0.174976936298822 0.775589107661742 NA NA NA 0.694096869497498 85.5460814520543 a1945 RB1_mut 197 Bryostatin 1 PRKC 6 13 -4.8283137373023 NA -3.1815071186768 -3.06076286452767 -0.120744254149123 0.738262603649704 0.886458003791658 0.142796018560826 0.163551903553298 0.136209785046401 0.775831155569753 NA NA NA 0.761688161355293 85.5460814520543 a1946 NRAS_mut 1059 AZD8055 MTORC1/2 3 12 0.693147180559945 NA 0.347808816768948 0.208631036606639 0.13917778016231 1.30977447926002 0.585885906182385 0.186924929052413 0.10626087342986 0.237550995328063 0.776702359883507 NA NA NA 0.87263358965394 85.5460814520543 a1947 TP53_mut 186 Bexarotene Retinioic acid X family agonist 15 4 2.07944154167984 NA 3.57731490288021 3.41237043741015 0.164944465470053 0.866497386361165 1.53679919730354 0.162123716737822 0.190357718403207 0.107329874819992 0.776752086734533 NA NA NA 0.848057375082799 85.5460814520543 a1948 CDKN1A_mut 292 Masitinib KIT 3 16 2.99573227355399 NA 4.4138327941714 4.24612790823127 0.167704885940138 0.682955308092645 0.954847045693502 0.180909833733028 0.245557628666074 0.175635340441708 0.777170743441253 NA NA NA 0.735963975190904 85.5460814520543 a1949 gain_cnaBLCA9 1052 RO-3306 CDK1 3 12 1.6094379124341 NA 2.99115097508612 2.74427194024738 0.246879034838741 1.6722422744705 1.2551651570545 0.185918978331901 0.14763353289637 0.196690478102573 0.777868729197759 NA NA NA 0.828433264721132 85.5460814520543 a1950 gain_cnaBLCA23_(MYC) 1004 Vinblastine Microtubules 4 10 -2.30258509299405 NA -4.55497030258345 -4.3098024710734 -0.24516783151005 1.1392147321189 1.52846631337705 0.170132023352472 0.215207743191704 0.160401200448028 0.77857757117079 NA NA NA 0.7516672892329 85.5460814520543 a1951 MLL2_mut 256 JW-7-24-1 LCK 3 16 2.32630161961136 NA 2.34854147206976 2.12721727256538 0.221324199504374 0.223361766670395 1.31329746416565 0.179064188581654 0.990877726316396 0.1685255667839 0.77937964916248 NA NA NA 0.538728871502201 85.5460814520543 a1952 loss_cnaBLCA18_(CHD9,CNOT1,CYLD,MMP2,NUP93) 186 Bexarotene Retinioic acid X family agonist 3 16 2.07944154167984 NA 3.38916680939385 3.57135655404139 -0.182189744647534 1.12298422341763 1.00254927842887 0.179063602188913 0.162237136415922 0.181726473269273 0.779380351279191 NA NA NA 0.81237274784367 85.5460814520543 a1953 CDKN1A_mut 277 ABT-869 VEGFR and PDGFR family 3 16 0.0237165266173161 NA 2.26309098091268 2.3460846669954 -0.0829936860827272 0.572512210790818 0.449576482945716 0.178202489088175 0.144964045339901 0.184604153533423 0.780411615578273 NA NA NA 0.83031065353583 85.5460814520543 a1954 EP300_mut 171 AKT inhibitor VIII AKT1, AKT2, AKT3 4 15 0.940007258491471 NA 2.16539216796561 1.99303868645261 0.172353481513 0.724029944619872 1.14553303739963 0.159124585794058 0.238047449271575 0.150457015106473 0.780765953842363 NA NA NA 0.722400428911279 85.5460814520543 a1955 RB1_mut 1004 Vinblastine Microtubules 5 9 -2.30258509299405 NA -4.52621318925885 -4.29853777497484 -0.227675414284016 1.46065058441936 1.43136440879085 0.157977091592829 0.155872606845615 0.159061810455624 0.781828780111492 NA NA NA 0.785303253169245 85.5460814520543 a1956 CDKN1A_mut 295 NVP-BHG712 EPHB4 3 16 2.32630161961136 NA 3.85794148720621 3.59543979686075 0.262501690345458 0.859679630466885 1.54934918099987 0.176777028615716 0.305348272824489 0.169427068839351 0.782119664456604 NA NA NA 0.69423915105172 85.5460814520543 a1957 EP300_mut 231 FMK RSK 4 10 2.99573227355399 2.32630161961136 5.20930638521831 5.28267648819208 -0.073370102973767 0.388263860764122 0.456103058882291 0.166703008215215 0.188969694035832 0.160862992573575 0.782913050658329 NA NA NA 0.770999242977019 85.5460814520543 a1958 NRAS_mut 1025 SB 216763 GSK3A, GSK3B 3 9 2.30258509299405 NA 3.57464033736866 3.76188046138637 -0.187240124017705 0.916747845989777 1.01122344344859 0.188550999452489 0.204243865787925 0.185161969128362 0.783077806296628 NA NA NA 0.781024354607672 85.5460814520543 a1959 RB1_mut 298 OSI-930 KIT, VEGFR, PDGFR 6 13 2.32630161961136 NA 4.25316645441244 4.3606988646407 -0.10753241022826 0.426743777984986 0.888430069314121 0.137599913225283 0.251983545573905 0.121036437129235 0.783763379670602 NA NA NA 0.726006621071458 85.5460814520543 a1960 CDKN1A_mut 1526 RDEA119 (rescreen) MAP2K1 (MEK1), MAP2K2 (MEK2) 3 16 1.6094379124341 NA 1.58311302628682 1.41299366440468 0.170119361882139 0.79790648566698 0.997537925526669 0.17427170829452 0.213207142613879 0.170539242197054 0.785124421310946 NA NA NA 0.764847913157049 85.5460814520543 a1961 gain_cnaBLCA15_(ASXL1) 295 NVP-BHG712 EPHB4 6 13 2.32630161961136 NA 3.77542902095412 3.57294516043584 0.202483860518281 1.51333821722815 1.47309609271084 0.136348616438201 0.133799476028004 0.137454617876057 0.785677277045748 NA NA NA 0.790377884819549 85.5460814520543 a1962 NRAS_mut 1039 SL 0101-1 RSK, AURKB, PIM3 3 12 2.30258509299405 NA 4.34220522342492 4.19920841237014 0.142996811054775 1.29622689574583 0.671346796149646 0.178765566746256 0.11031773181384 0.212999915803428 0.786178892862959 NA NA NA 0.868450356547888 85.5460814520543 a1963 loss_cnaBLCA5_(FAT1,IRF2) 1011 ABT-263 BCL2, BCL2L1, BCL2L2 3 12 0.693147180559945 NA 2.37028418326946 2.22115638911349 0.149127794155974 0.777604337904083 0.844611092765756 0.178670502306855 0.191778500822058 0.17656385931144 0.786289516168573 NA NA NA 0.787757776134988 85.5460814520543 a1964 CDKN1A_mut 151 QS11 ARFGAP 3 16 2.32630161961136 NA 3.29726464555306 3.0047909135991 0.292473731953965 1.53879531482503 1.70695311638253 0.173262372396763 0.190066689920498 0.171342568900658 0.786335959066418 NA NA NA 0.785970536682932 85.5460814520543 a1965 gain_cnaBLCA23_(MYC) 1175 AG-014699 PARP1, PARP2 4 15 1.6094379124341 NA 3.02683609813748 3.16366345779051 -0.136827359653022 0.72165921364499 0.914594733169149 0.154849740122024 0.189601070790641 0.14960435993208 0.786498166503609 NA NA NA 0.761969855150579 85.5460814520543 a1966 loss_cnaBLCA5_(FAT1,IRF2) 228 KIN001-102 AKT1 5 14 2.32630161961136 NA 3.48536807065841 3.2986733515485 0.186694719109904 1.41161907987787 1.28021160209945 0.142263610982375 0.132255735113793 0.145831141354865 0.788092733338794 NA NA NA 0.802878294384001 85.5460814520543 a1967 CDKN1A_mut 1149 TW 37 BCL2, BCL2L1 3 16 1.6094379124341 NA -0.789912853309071 -0.52840282184277 -0.261510031466301 0.626902544749791 1.60474254541587 0.171746381296473 0.41714622736246 0.162960739224703 0.788156710518436 NA NA NA 0.640954051553613 85.5460814520543 a1968 NRAS_mut 330 XMD13-2 RIPK 3 16 2.32630161961136 NA 3.92335266719816 3.75832590054479 0.165026766653368 1.66394483059781 0.825645485500065 0.17138090004069 0.0991780277919902 0.199876060066406 0.788595853961017 NA NA NA 0.880880542304935 85.5460814520543 a1969 MLL2_mut 136 Mitomycin C DNA crosslinker 3 16 2.77258872223978 NA -0.981001956914614 -1.26094051388666 0.279938556972041 2.2019648184495 1.54230238042051 0.171342741991529 0.127131257786924 0.181506921422059 0.7886417069328 NA NA NA 0.849793643485405 85.5460814520543 a1970 EP300_mut 266 Zibotentan, ZD4054 Endothelin A Receptor 4 15 2.99573227355399 NA 5.41386024697641 5.47292809421135 -0.0590678472349389 0.22447940769499 0.413465658245773 0.152676458925554 0.263132586821491 0.14286034657763 0.78941722432449 NA NA NA 0.711566007310755 85.5460814520543 a1971 RB1_mut 200 LAQ824 HDAC 6 13 0.0237165266173161 NA -2.85157717743105 -2.71414265357038 -0.137434523860677 0.514424465365824 1.17789669146327 0.133664679176859 0.267161717829541 0.116677909749407 0.789787194997274 NA NA NA 0.72778363901167 85.5460814520543 a1972 RB1_mut 1194 SB-505124 TGFR1 (ALK5) 6 13 2.30258509299405 NA 3.98601465881667 4.12589885837395 -0.139884199557281 1.20087686506102 0.975109109884293 0.133658482472769 0.11648504824029 0.143454920212857 0.78979669145595 NA NA NA 0.808866665707356 85.5460814520543 a1973 loss_cnaBLCA5_(FAT1,IRF2) 245 UNC0638 G9a(EHMT2), GLP(EHMT1) 5 14 3.68887945411394 NA 4.12643731805322 3.95717573840357 0.169261579649643 0.740326039624216 1.31125723376948 0.140865940376213 0.228631130867096 0.12908342870534 0.790121325917566 NA NA NA 0.73116061614129 85.5460814520543 a1974 gain_cnaBLCA15_(ASXL1) 203 BMS-345541 IKBKB 6 13 2.77258872223978 NA 3.5837253016813 3.47675059714295 0.106974704538347 0.851164753648241 0.780858462039429 0.133355539024758 0.125680373957962 0.136996280041524 0.790260994246671 NA NA NA 0.799725689074122 85.5460814520543 a1975 EP300_mut 1013 Nilotinib ABL 3 11 0.693147180559945 NA 2.99843543833791 2.88952694544266 0.108908492895246 0.476093663427534 0.641309594318334 0.17655465462353 0.228754342393852 0.169822023341172 0.790948104686009 NA NA NA 0.761180714956976 85.5460814520543 a1976 gain_cnaBLCA15_(ASXL1) 1218 JQ1 BRD2, BRD3, BRD4 6 13 0 NA 1.90818500064723 2.00463106518171 -0.0964460645344838 0.654171074864144 0.754148615097369 0.132814038956766 0.147432480952346 0.127887345549301 0.791091120256419 NA NA NA 0.781334057111587 85.5460814520543 a1977 EP300_mut 273 CUDC-101 HDAC, EGFR 4 15 1.63315443905142 NA 0.1192190502436 -0.101341502798927 0.220560553042527 0.567146694578681 1.59340621402392 0.150503069060095 0.388895069213752 0.13842079383231 0.79233965471951 NA NA NA 0.665284026243254 85.5460814520543 a1978 gain_cnaBLCA23_(MYC) 1529 MLN4924 NEDD8-activating enzyme 4 12 0 NA -0.0408267903438495 -0.295881045964201 0.255054255620351 2.36513458215976 1.38796467831997 0.1548681293893 0.107839214539515 0.183761344654013 0.792426930411442 NA NA NA 0.848837778431652 85.5460814520543 a1979 gain_cnaBLCA23_(MYC) 1033 Vismodegib SMO 4 10 2.30258509299405 NA 4.41189526798036 4.53932999828065 -0.127434730300288 0.973072467471826 0.736911728923765 0.158798351732925 0.130961192059396 0.17293079387731 0.792936134077493 NA NA NA 0.82372559248097 85.5460814520543 a1980 loss_cnaBLCA5_(FAT1,IRF2) 1036 PLX4720 BRAF 3 12 2.30258509299405 NA 3.85090767528757 3.73206415116253 0.11884352412504 0.922423760240725 0.636003154210553 0.172769138709198 0.128838316235507 0.186859960266323 0.793166094968647 NA NA NA 0.848917385268886 85.5460814520543 a1981 loss_cnaBLCA5_(FAT1,IRF2) 292 Masitinib KIT 5 14 2.99573227355399 NA 4.1778014989908 4.30646695851861 -0.12866545952781 0.664586962762414 0.994299400540783 0.138748704557242 0.19360214198756 0.129403134969036 0.793197253869198 NA NA NA 0.75305376227813 85.5460814520543 a1982 NRAS_mut 1060 PD-0325901 MAP2K1 (MEK1), MAP2K2 (MEK2) 3 12 -1.38629436111989 0.693147180559945 -1.28751129744156 -1.03234015026982 -0.255171147171744 1.41383937972201 1.4884637013862 0.172736418251036 0.180481001471267 0.171432562939966 0.793204273388678 NA NA NA 0.798903966951103 85.5460814520543 a1983 loss_cnaBLCA5_(FAT1,IRF2) 310 YM201636 FYV1 5 14 1.63315443905142 NA 2.67115669690164 2.84060907053858 -0.169452373636935 1.30381420051234 1.19526738825451 0.138704863315832 0.129966657496404 0.141769427746532 0.793260983871198 NA NA NA 0.806604889927512 85.5460814520543 a1984 gain_cnaBLCA15_(ASXL1) 329 QL-XI-92 DDR1 6 13 2.32630161961136 NA 4.32856945059831 4.20437653200121 0.124192918597093 1.0372615198365 0.904357391254973 0.131367094220758 0.11973153946429 0.137327255571773 0.793310568990087 NA NA NA 0.80665434568858 85.5460814520543 a1985 loss_cnaBLCA5_(FAT1,IRF2) 306 TG101348 JAK2 5 14 2.32630161961136 NA 3.09612454662405 2.96301362297067 0.133110923653373 0.994824107791943 0.949033213771947 0.138656625586297 0.133803476022328 0.140259499585185 0.793331106585887 NA NA NA 0.802616648450179 85.5460814520543 a1986 gain_cnaBLCA15_(ASXL1) 156 AZD6482 PI3Kbeta 6 13 1.63315443905142 NA 1.87250157590537 2.0584858650013 -0.18598428909593 1.94375696211445 1.12533253582568 0.131341978937772 0.0956828928312176 0.165270516202991 0.793349109162988 NA NA NA 0.833931839081423 85.5460814520543 a1987 loss_cnaBLCA18_(CHD9,CNOT1,CYLD,MMP2,NUP93) 1218 JQ1 BRD2, BRD3, BRD4 3 16 0 NA 1.8718835157399 1.99335395650162 -0.121470440761724 0.464803341485335 0.754250481865975 0.167266136355459 0.261337279490184 0.161047879560133 0.793544963882395 NA NA NA 0.728557377506904 85.5460814520543 a1988 gain_cnaBLCA23_(MYC) 1133 JNJ-26854165 MDM2 4 15 2.30258509299405 NA 2.46643183146327 2.27653713711742 0.189894694345844 1.23509656318019 1.27921489605462 0.149342225176993 0.153748864669248 0.148446281333591 0.793901881105186 NA NA NA 0.797377224525121 85.5460814520543 a1989 loss_cnaBLCA5_(FAT1,IRF2) 1239 YK 4-279 RNA helicase A 5 12 2.30258509299405 NA 1.13434373331369 1.27706412516963 -0.142720391855943 0.728192182491175 1.0973292009185 0.141008135826113 0.195992754780325 0.130061600234899 0.794685900152422 NA NA NA 0.75906845337341 85.5460814520543 a1990 gain_cnaBLCA23_(MYC) 1003 Camptothecin TOP1 4 10 -2.30258509299405 NA -4.02616440986077 -4.35258171700323 0.326417307142457 2.57891221306864 1.87651001151529 0.157345373580846 0.126571701622233 0.17394914236502 0.794782778290481 NA NA NA 0.828558400573582 85.5460814520543 a1991 RB1_mut 1043 JNK Inhibitor VIII JNK 5 9 2.30258509299405 NA 3.81976284117943 3.94528892494564 -0.125526083766216 1.03320916993363 0.73628132976823 0.148217522876489 0.121491453443332 0.170486577196965 0.794956900737423 NA NA NA 0.817981631073622 85.5460814520543 a1992 RB1_mut 300 CX-5461 RNA Pol I 6 13 2.32630161961136 NA 4.16299873241208 3.99104694581304 0.171951786599038 1.1392981478956 1.39134978745925 0.130048368618495 0.150927820708433 0.123586310321749 0.795334935884534 NA NA NA 0.780900556953822 85.5460814520543 a1993 EP300_mut 197 Bryostatin 1 PRKC 4 15 -4.8283137373023 NA -3.00038154764231 -3.12516225069009 0.124780703047777 0.841689172755563 0.846851821270376 0.147504849527967 0.148250336450526 0.147346560417845 0.796376403529394 NA NA NA 0.803465632086703 85.5460814520543 a1994 NRAS_mut 1243 piperlongumine Increases ROS levels 3 16 2.30258509299405 NA 1.17109170366157 1.31934581819688 -0.148254114535309 0.840196986978221 0.908419411288349 0.164605808557069 0.176451614125048 0.16320007332852 0.796749570473223 NA NA NA 0.800176480101199 85.5460814520543 a1995 NRAS_mut 1069 EHT 1864 Rac GTPases 3 15 2.30258509299405 NA 3.35210106977587 3.5155245480763 -0.163423478300428 0.31670516680914 1.04863852575773 0.165528719856591 0.516011405645663 0.155843481129345 0.796873730205226 NA NA NA 0.625917786962976 85.5460814520543 a1996 RB1_mut 153 Midostaurin KIT 6 13 -0.669430653942629 NA -0.206930266265577 -0.364166602163901 0.157236335898324 0.987880336953465 1.30449367671136 0.128889417897582 0.159165366509092 0.120534379510921 0.797115275183138 NA NA NA 0.776295587948696 85.5460814520543 a1997 gain_cnaBLCA23_(MYC) 269 NSC-207895 MDM4 4 15 2.99573227355399 NA 3.45072106076428 3.64543071345893 -0.194709652694654 1.79434640306205 1.20522989062585 0.146583965062223 0.108512855913653 0.161553952660056 0.797617465285703 NA NA NA 0.848173443761339 85.5460814520543 a1998 gain_cnaBLCA15_(ASXL1) 1021 Axitinib PDGFR, KIT, VEGFR 4 10 0.693147180559945 NA 2.15385977455476 1.96167542128183 0.192184353272928 1.09338054529605 1.2870770178174 0.15480145715169 0.175770781819509 0.149318456170425 0.798019059557545 NA NA NA 0.786630399950733 85.5460814520543 a1999 loss_cnaBLCA5_(FAT1,IRF2) 1049 PD-173074 FGFR1, FGFR3 3 12 0.693147180559945 NA 2.71248757085105 2.55678015869603 0.155707412155022 0.308589151542441 0.996088786398271 0.168472868554369 0.504578373467567 0.15631880840466 0.798183717374575 NA NA NA 0.65377866830173 85.5460814520543 a2000 RB1_mut 1012 Vorinostat HDAC inhibitor Class I, IIa, IIb, IV 5 9 2.30258509299405 NA 1.55850833754214 1.47511771764023 0.0833906199019094 0.671498359338982 0.515327437183579 0.145751956996339 0.124185887786827 0.161820648164329 0.798284049712428 NA NA NA 0.816745692813269 85.5460814520543 a2001 loss_cnaBLCA5_(FAT1,IRF2) 152 CP466722 ATM 5 14 2.77258872223978 NA 2.9629075398439 3.13281078562228 -0.169903245778383 1.05466996480508 1.31307173401318 0.135159309134787 0.161096126227302 0.129393727225475 0.798419939041572 NA NA NA 0.779254662002247 85.5460814520543 a2002 gain_cnaBLCA23_(MYC) 1023 GW 441756 NTRK1 4 10 0.693147180559945 NA 2.33778234622253 2.48367801386107 -0.145895667638541 0.791577100779466 0.9906824901152 0.154411814102249 0.184310116468601 0.147267837167058 0.798515097857351 NA NA NA 0.780906752918712 85.5460814520543 a2003 EP300_mut 1230 IOX2 EGLN1 4 15 -2.30258509299405 NA -0.069740447548929 -0.172701167064925 0.102960719515996 0.191636589613467 0.773843510353806 0.145661179282712 0.53727067322409 0.133051086089644 0.798861649191235 NA NA NA 0.648089817764213 85.5460814520543 a2004 MLL2_mut 344 THZ-2-49 CDK9 3 16 2.99573227355399 NA 3.97686978437724 4.29911809706727 -0.322248312690022 1.86037719535286 2.00942175876373 0.161733417172661 0.173216653856532 0.160368678842355 0.800213825323661 NA NA NA 0.803698818214966 85.6328169915532 a2005 RB1_mut 229 LY317615 PRKCB (PKCbeta) 6 13 2.99573227355399 2.32630161961136 3.9461827393128 3.73153825272623 0.214644486586577 1.71530112829655 1.68506626792895 0.126707555867777 0.125135163176706 0.127380442343308 0.800470092356929 NA NA NA 0.804111526541388 85.6328169915532 a2006 ARID1A_mut 1010 Gefitinib EGFR 3 11 -0.693147180559945 NA 0.447581693944778 0.619403807055132 -0.171822113110354 1.20154571871333 0.987034474229932 0.167483308800636 0.143000894959161 0.174079140695067 0.801429120883675 NA NA NA 0.835613464546342 85.6720904491473 a2007 CDKN1A_mut 1066 AZD6482 PI3Kbeta 3 15 1.6094379124341 NA 2.15801737750469 1.97999847300748 0.178018904497213 0.383779140983748 1.16958319937457 0.161479101684498 0.463857686587379 0.152207132072697 0.801728339159645 NA NA NA 0.643934190874822 85.6720904491473 a2008 gain_cnaBLCA15_(ASXL1) 158 PF-562271 FAK 6 13 0.940007258491471 NA 1.61031233589443 1.73596284912355 -0.125650513229119 0.772416687756456 1.08186987246337 0.125545517081151 0.162671929828549 0.116141983825668 0.802258479815458 NA NA NA 0.777213772397675 85.6720904491473 a2009 gain_cnaBLCA9 1069 EHT 1864 Rac GTPases 3 15 2.30258509299405 NA 3.62066799162761 3.46181116370595 0.158856827921657 0.746225494744612 1.01719422604207 0.160884264330047 0.212880461791277 0.156171578499588 0.802442132077629 NA NA NA 0.769878618868302 85.6720904491473 a2010 loss_cnaBLCA5_(FAT1,IRF2) 341 EX-527 SIRT1 5 14 2.99573227355399 NA 5.28679387090845 5.35244627889876 -0.0656524079903074 0.459409770234588 0.508023612935598 0.132093936433538 0.142905989911323 0.129231016666601 0.802887964932019 NA NA NA 0.796695476872574 85.6720904491473 a2011 gain_cnaBLCA9 1218 JQ1 BRD2, BRD3, BRD4 4 15 0 NA 1.89266848139285 1.99590932837828 -0.103240846985427 0.775551851258723 0.715375331403473 0.142135116442574 0.133119206430707 0.144317035342667 0.803620911832485 NA NA NA 0.820684693640531 85.6720904491473 a2012 NRAS_mut 300 CX-5461 RNA Pol I 3 16 2.32630161961136 NA 4.22143949650624 4.0123302625327 0.209109233973532 1.51860092025464 1.29406000009952 0.158121780246049 0.137698608755267 0.16159160622958 0.804575730011388 NA NA NA 0.839493208223634 85.6720904491473 a2013 gain_cnaBLCA15_(ASXL1) 178 BAY 61-3606 SYK 6 13 2.07944154167984 NA 2.34430309887625 2.1577662181699 0.18653688070635 1.94364507273573 1.28709310181885 0.123524185290273 0.0959727078379563 0.144928817070611 0.805372013450191 NA NA NA 0.836265908512946 85.6720904491473 a2014 gain_cnaBLCA9 186 Bexarotene Retinioic acid X family agonist 4 15 2.07944154167984 NA 3.6551058602685 3.51258545678465 0.142520403483856 1.16293098760876 0.984205641162321 0.139996550866891 0.122552761085943 0.14480754582502 0.806511301814645 NA NA NA 0.832748902340274 85.6720904491473 a2015 RB1_mut 1009 ATRA Retinoic acid and retinoid X receptor agonist 5 9 2.30258509299405 NA 4.0586404265749 3.99747489209112 0.061165534483786 0.527887630406238 0.38728257000093 0.139271684359284 0.115868474578038 0.157935159549368 0.807048415531754 NA NA NA 0.827197034527998 85.6720904491473 a2016 loss_cnaBLCA18_(CHD9,CNOT1,CYLD,MMP2,NUP93) 1495 AZD-2281 PARP1, PARP2 3 14 2.30258509299405 NA 3.21223400943142 3.32822604155398 -0.115992032122562 0.321434702420654 0.777677340380043 0.158149971995396 0.360857216875003 0.149151873276747 0.807055551287166 NA NA NA 0.687907083991957 85.6720904491473 a2017 EP300_mut 152 CP466722 ATM 4 15 2.77258872223978 NA 3.22628180364742 3.05125076555611 0.175031038091301 0.820043259850189 1.33244018101852 0.1392136138003 0.213441225190092 0.131361272787126 0.807570208137901 NA NA NA 0.752178222107665 85.6720904491473 a2018 EP300_mut 295 NVP-BHG712 EPHB4 4 15 2.32630161961136 NA 3.800022989018 3.59338461702125 0.206638371996748 1.21424998361578 1.5376552944037 0.13908410454639 0.170177784463643 0.134385367610549 0.80774540387183 NA NA NA 0.785514739590854 85.6720904491473 a2019 RB1_mut 252 WZ3105 CLK2, CNSK1E, FLT3, ULK1 6 13 0.246860077931526 2.32630161961136 0.80772251490867 0.607834735884365 0.199887779024305 1.82896499141845 1.55315992833855 0.12194944325364 0.109290106679014 0.128697486573794 0.807799985053215 NA NA NA 0.822121004063427 85.6720904491473 a2020 loss_cnaBLCA5_(FAT1,IRF2) 185 OSI-906 IGF1R 5 14 0.940007258491471 NA 2.15445944294497 2.31658140790674 -0.162121964961765 0.728012882701375 1.38291877830078 0.128685278844183 0.222691066070415 0.11723173298794 0.807864611889937 NA NA NA 0.746962065820491 85.6720904491473 a2021 gain_cnaBLCA9 1058 GDC0941 PI3K (class 1) 3 12 1.38629436111989 0.693147180559945 1.27540128833381 1.06285417201661 0.212547116317197 0.417327090772787 1.44347700435517 0.158871290006755 0.509305820342534 0.147246624418618 0.809430878710533 NA NA NA 0.66656845912566 85.6720904491473 a2022 EP300_mut 255 CP724714 ERBB2 4 15 2.32630161961136 NA 4.39483188409426 4.26260228438442 0.132229599709836 0.281113544348577 1.05085153706492 0.137607833476733 0.470377903762165 0.125830904790947 0.809743194182642 NA NA NA 0.670699786041661 85.6720904491473 a2023 MLL2_mut 156 AZD6482 PI3Kbeta 3 16 1.63315443905142 NA 2.18324216739045 1.96534994989236 0.21789221749809 1.8173751028852 1.3540997170267 0.153825570144973 0.11989391576465 0.160912977647268 0.809773058739851 NA NA NA 0.858643094232298 85.6720904491473 a2024 NRAS_mut 1230 IOX2 EGLN1 3 16 -2.30258509299405 NA -0.242545519020447 -0.133865171194266 -0.108680347826181 0.401191978494553 0.738267062103392 0.153719975618567 0.270893621138681 0.147210072621337 0.809900917791815 NA NA NA 0.728463685180414 85.6720904491473 a2025 MLL2_mut 157 JNK-9L JNK 3 16 1.63315443905142 NA -0.290356927858083 -0.444560149061829 0.154203221203746 1.11538917556519 0.989064891146902 0.153474027081034 0.138250598608874 0.155908093173679 0.810198745834514 NA NA NA 0.839350348091269 85.6720904491473 a2026 loss_cnaBLCA5_(FAT1,IRF2) 180 Thapsigargin sarco-endoplasmic reticulum Ca2+-ATPases 5 14 -0.669430653942629 NA -4.52171807548884 -4.30609395199043 -0.215624123498412 0.895352390791201 1.89192100735322 0.126059631675798 0.240825987305255 0.113970997023849 0.811703863205851 NA NA NA 0.74274073077533 85.6720904491473 a2027 loss_cnaBLCA5_(FAT1,IRF2) 1498 AZD6244 MAP2K1 (MEK1), MAP2K2 (MEK2) 5 14 1.38629436111989 NA 1.48644544344746 1.32905503100857 0.157390412438884 0.291331359035768 1.41968939797398 0.125962773363623 0.540245351409495 0.110862568012056 0.811845585666224 NA NA NA 0.700145349108913 85.6720904491473 a2028 CDKN1A_mut 190 Bleomycin DNA damage 3 16 4.15888308335967 NA 0.962410885587967 1.33795943404253 -0.375548548454566 1.10319740665157 2.5979236508228 0.152075549458036 0.34041826620535 0.144557192177539 0.811892781654869 NA NA NA 0.691624617988888 85.6720904491473 a2029 CDKN1A_mut 1069 EHT 1864 Rac GTPases 3 15 2.30258509299405 NA 3.61362428150982 3.46321990572951 0.150404375780308 1.28541457851342 0.937368506908693 0.152292039711797 0.117008456488996 0.160453839308428 0.812772481085092 NA NA NA 0.862071573770307 85.6720904491473 a2030 gain_cnaBLCA23_(MYC) 1015 CI-1040 MAP2K1 (MEK1), MAP2K2 (MEK2) 4 10 2.30258509299405 NA 2.17246512830689 2.3319335799912 -0.159468451684313 1.06230687138771 1.13196379563821 0.143026468968976 0.150115240689347 0.140877696176143 0.81304897836552 NA NA NA 0.811774968900934 85.6720904491473 a2031 RB1_mut 282 EKB-569 EGFR 6 13 0.916290731874155 2.99573227355399 2.04607980460486 1.85791526721248 0.188164537392379 1.40182243855321 1.66994364382103 0.117914736155935 0.134228510128985 0.112677178112332 0.814029946185046 NA NA NA 0.802744781626547 85.6720904491473 a2032 gain_cnaBLCA15_(ASXL1) 157 JNK-9L JNK 6 13 1.63315443905142 NA -0.33917966749443 -0.457611935661303 0.118432268166873 0.838598367528266 1.06646539971628 0.117863673489229 0.141226447311062 0.111051205410303 0.814108874898128 NA NA NA 0.797806578870614 85.6720904491473 a2033 gain_cnaBLCA23_(MYC) 254 AC220 FLT3 4 15 0.0237165266173161 NA 2.43719229349969 2.3664490472861 0.0707432462135902 0.573374683414254 0.516903391431404 0.134159110989797 0.123380484454489 0.136859706061685 0.814415487440581 NA NA NA 0.833000272134224 85.6720904491473 a2034 EP300_mut 346 THZ-2-102-1 CDK7 4 15 0.916290731874155 2.99573227355399 -0.586800555589373 -0.254354843442297 -0.332445712147076 0.918391041955726 2.69821571038818 0.134115688945968 0.361987102399354 0.123209464264534 0.814474361494491 NA NA NA 0.695815003557093 85.6720904491473 a2035 EP300_mut 177 GSK-650394 SGK3 4 15 2.77258872223978 NA 2.71045196836931 2.99448101693956 -0.284029048570251 1.20072671069565 2.27617180682076 0.133579819287335 0.236547622402516 0.124783659879773 0.815201017725274 NA NA NA 0.742574255163427 85.6720904491473 a2036 gain_cnaBLCA23_(MYC) 171 AKT inhibitor VIII AKT1, AKT2, AKT3 4 15 0.940007258491471 NA 1.91533145429391 2.05972154343173 -0.144390089137829 1.18622592067889 1.06068292076715 0.133214129122393 0.121722250897361 0.136129361858111 0.815697004734862 NA NA NA 0.835018220760341 85.6720904491473 a2037 CDKN1A_mut 303 PIK-93 PI4K, PI3K 3 16 2.99573227355399 NA 3.13123436766895 3.37827057134375 -0.247036203674802 0.875698846998249 1.73677851587071 0.148921153111725 0.282101780219993 0.14223817338675 0.815717351644313 NA NA NA 0.724419871060498 85.6720904491473 a2038 gain_cnaBLCA23_(MYC) 219 AT-7519 CDK9 4 15 2.32630161961136 NA 1.95709936941336 1.7167179851188 0.240381384294561 2.12643973548343 1.73463367696491 0.132811098378311 0.113044061528465 0.138577607183989 0.816243730195622 NA NA NA 0.84482207261302 85.6720904491473 a2039 loss_cnaBLCA5_(FAT1,IRF2) 157 JNK-9L JNK 5 14 1.63315443905142 NA -0.329194420904565 -0.452718647431478 0.123524226526913 0.875595663481938 1.04141594197432 0.122926291443864 0.141074506965578 0.118611806818258 0.816291930410392 NA NA NA 0.803271988664174 85.6720904491473 a2040 NRAS_mut 182 Obatoclax Mesylate BCL2, BCL2L1, MCL1 3 16 2.77258872223978 NA -0.69380200178878 -0.898122715598656 0.204320713809876 1.67163482052228 1.33486727192579 0.148191324730108 0.122228079543138 0.153064441766638 0.816602923415063 NA NA NA 0.856540725370221 85.6720904491473 a2041 CDKN1A_mut 1243 piperlongumine Increases ROS levels 3 16 2.30258509299405 NA 1.40822712717865 1.27488292628742 0.133344200891228 0.171996293142708 0.957137778737096 0.147994500028386 0.775273690233485 0.139315575932203 0.816841793748314 NA NA NA 0.6134432408283 85.6720904491473 a2042 gain_cnaBLCA9 1495 AZD-2281 PARP1, PARP2 4 13 2.30258509299405 NA 3.23290336950236 3.33078870246465 -0.0978853329622904 0.302643291728919 0.806120321752059 0.133429791669577 0.323434669254019 0.12142769549531 0.818635044411242 NA NA NA 0.722387512760104 85.6720904491473 a2043 loss_cnaBLCA5_(FAT1,IRF2) 194 AUY922 HSP90 5 14 -1.36257783450257 NA -2.9983589719829 -2.72387406866933 -0.274484903313567 2.22680061143075 2.27766135327337 0.121142769379627 0.123264248224365 0.120511727048047 0.818906576064234 NA NA NA 0.820592025367236 85.6720904491473 a2044 gain_cnaBLCA9 1527 GDC0941 (rescreen) PI3K 4 15 1.38629436111989 NA 0.722487531728012 0.877257063277789 -0.154769531549776 0.538360630989195 1.28086724697781 0.130699310920486 0.287483004218565 0.120831828524738 0.819110032711403 NA NA NA 0.722612419738338 85.6720904491473 a2045 CDKN1A_mut 308 XL-880 MET 3 16 1.63315443905142 NA 0.475216851981466 0.690261754367812 -0.215044902386346 2.12706059308022 1.36237303691102 0.145982629183667 0.101099565797953 0.157845829710435 0.819284499769259 NA NA NA 0.879604463143063 85.6720904491473 a2046 RB1_mut 293 MP470 PDGFR 6 13 2.99573227355399 NA 3.85808502811139 4.02556358332105 -0.16747855520966 1.87853429424287 1.25423750564792 0.114263520979816 0.0891538449539784 0.133530176266849 0.819678850458928 NA NA NA 0.847900331593296 85.6720904491473 a2047 RB1_mut 1032 Afatinib ERBB2, EGFR 5 9 -0.693147180559945 NA 0.400648080449199 0.602225314973892 -0.201577234524693 0.961547057587725 1.77805788612357 0.129689981110983 0.209638449760742 0.113369331841137 0.8200573119091 NA NA NA 0.787783199420344 85.6720904491473 a2048 RB1_mut 1058 GDC0941 PI3K (class 1) 5 10 1.38629436111989 0.693147180559945 0.992018267190747 1.1620362593247 -0.170017992133951 0.915322822358461 1.48806414685742 0.127049359975506 0.18574647980029 0.114254477868447 0.820181047232117 NA NA NA 0.789745055858644 85.6720904491473 a2049 TP53_mut 152 CP466722 ATM 15 4 2.77258872223978 NA 3.05399625164948 3.21598623079729 -0.161989979147805 1.17885712289677 1.57384774982124 0.128807949121465 0.137412733062809 0.102926079835997 0.821679394858989 NA NA NA 0.857224123968154 85.6720904491473 a2050 gain_cnaBLCA23_(MYC) 1005 Cisplatin DNA crosslinker 4 10 1.79175946922805 2.30258509299405 2.40695956202613 2.55221378716038 -0.145254225134256 1.19379828332322 1.01964747919627 0.136279389882851 0.121674010729775 0.142455336866768 0.821696746568462 NA NA NA 0.839142347504736 85.6720904491473 a2051 gain_cnaBLCA23_(MYC) 304 SB52334 ALK5 4 15 2.99573227355399 NA 4.63815356070451 4.77024355297672 -0.132089992272212 1.05850546163724 1.02681870829273 0.127934531047164 0.124789145695953 0.128640032758883 0.822866615188348 NA NA NA 0.832925081031558 85.6720904491473 a2052 EP300_mut 1050 ZM-447439 AURKB 4 11 1.38629436111989 0.693147180559945 2.33524532528158 2.15925227090903 0.175993054372549 1.14584719720228 1.37639501637938 0.132649524300735 0.153592079993088 0.127865222031608 0.823810886863694 NA NA NA 0.811277149824488 85.6720904491473 a2053 ARID1A_mut 274 PXD101, Belinostat HDAC 5 14 2.99573227355399 NA 0.57723738691996 0.407152958201674 0.170084428718286 1.23401379966636 1.5116912244852 0.117207177106782 0.137830248546873 0.112512678491077 0.824683891436832 NA NA NA 0.809398563220754 85.6720904491473 a2054 CDKN1A_mut 1494 SN-38 TOP1 3 15 -2.99573227355399 NA -5.10406585283013 -4.85590815753947 -0.24815769529066 1.6684873259999 1.7544089987115 0.142300390106948 0.148732142835992 0.141448029206939 0.824830284518143 NA NA NA 0.830847202391544 85.6720904491473 a2055 CDKN1A_mut 229 LY317615 PRKCB (PKCbeta) 3 16 2.99573227355399 2.32630161961136 4.00108067039255 3.76149073188376 0.239589938508794 1.1145627071716 1.75773129246823 0.141369283787154 0.214963175214068 0.13630635099655 0.824892962304258 NA NA NA 0.773200289737058 85.6720904491473 a2056 CDKN1A_mut 283 GSK2126458 PI3K, MTOR 3 16 -2.05572501506252 0.0237165266173161 -2.41109061940547 -2.18186115023158 -0.229229469173896 1.31615656788658 1.65996603512852 0.141211867446378 0.174165805776422 0.138092867156856 0.825084507946758 NA NA NA 0.80674822249812 85.6720904491473 a2057 EP300_mut 328 SNX-2112 HSP90 4 14 0.940007258491471 NA -0.251731442559751 -0.51884493363999 0.267113491080239 1.13873518683917 2.26894354330594 0.126967217781794 0.234570332213653 0.117725931025611 0.825631457500685 NA NA NA 0.754394879668424 85.6720904491473 a2058 NRAS_mut 273 CUDC-101 HDAC, EGFR 3 16 1.63315443905142 NA 0.118090496056131 -0.087344864323619 0.20543536037975 0.801509045321737 1.53345670148983 0.140092002468772 0.256310719858795 0.133968804062194 0.826447496947247 NA NA NA 0.745471144281512 85.6720904491473 a2059 loss_cnaBLCA18_(CHD9,CNOT1,CYLD,MMP2,NUP93) 1001 AICAR AAPK1 (AMPK) agonist 3 11 7.60090245954208 NA 7.89421757184907 7.99058769882171 -0.0963701269726354 0.609940326846568 0.67003086979737 0.14592787718286 0.157999270962908 0.143829383565237 0.826493014970172 NA NA NA 0.825749951514231 85.6720904491473 a2060 CDKN1A_mut 326 GSK690693 AKT 3 16 2.32630161961136 NA 4.14825048136253 4.283573632146 -0.135323150783473 1.10470439080574 0.948202914687286 0.139806881301455 0.122497160244627 0.142715392124799 0.826794609537002 NA NA NA 0.856950399325812 85.6720904491473 a2061 loss_cnaBLCA5_(FAT1,IRF2) 1259 BMN-673 PARP1 4 14 2.30258509299405 NA 1.73807082125714 1.94707915184458 -0.20900833058744 2.01055430821217 1.56628205254268 0.126009420244951 0.103955575700562 0.133442332591464 0.826923937077484 NA NA NA 0.856920904414972 85.6720904491473 a2062 gain_cnaBLCA9 1243 piperlongumine Increases ROS levels 4 15 2.30258509299405 NA 1.38480003068349 1.27224053862672 0.112559492056767 0.234139827795933 0.987106239770208 0.12490399294845 0.480736204157753 0.11402976449928 0.826989378851379 NA NA NA 0.69318206371355 85.6720904491473 a2063 NRAS_mut 1031 Elesclomol HSP70 3 11 -1.6094379124341 NA -3.83142925773952 -3.60410209297141 -0.227327164768113 1.13893958694677 1.63755133190983 0.145209032224223 0.199595454731295 0.13882139774085 0.827332485047606 NA NA NA 0.794189306366654 85.6720904491473 a2064 NRAS_mut 1008 Methotrexate Dihydrofolate reductase (DHFR) 3 11 -1.6094379124341 NA -0.143488110882581 -0.299903011881757 0.156414900999176 0.736976044455975 1.13307916330959 0.145201768162051 0.212238786017311 0.138044106770357 0.827340969188241 NA NA NA 0.785893657789486 85.6720904491473 a2065 loss_cnaBLCA5_(FAT1,IRF2) 208 SB-715992 KIF11 5 14 -2.05572501506252 NA -1.30170223975385 -1.11826465882921 -0.183437580924632 2.12017067730648 1.38791424762642 0.115309501215779 0.0865201952314876 0.132167805927738 0.827473342347811 NA NA NA 0.863732679836373 85.6720904491473 a2066 CDKN1A_mut 1259 BMN-673 PARP1 3 15 2.30258509299405 NA 1.70723764984073 1.93931189742204 -0.232074247581303 2.23470576156345 1.55913301045249 0.139913669507412 0.103850024272967 0.148848267611209 0.827717392588751 NA NA NA 0.877058194468384 85.6720904491473 a2067 loss_cnaBLCA5_(FAT1,IRF2) 155 AP-24534 ABL 5 14 -0.669430653942629 NA 0.124264157551668 0.242537538699934 -0.118273381148266 1.25253447594543 0.9474275470304 0.115118944206053 0.0944272460516438 0.124836333415658 0.827753579674021 NA NA NA 0.854066741397488 85.6720904491473 a2068 CDKN1A_mut 300 CX-5461 RNA Pol I 3 16 2.32630161961136 NA 4.19903056321862 4.01653193752413 0.182498625694485 0.74268095457801 1.38213224911079 0.137938623150314 0.245729508168391 0.13204136276532 0.829069976816329 NA NA NA 0.753398102670486 85.6720904491473 a2069 NRAS_mut 258 STF-62247 stimulates autophagy 3 16 2.32630161961136 NA 4.62953969138147 4.52270066071604 0.106839030665424 0.7316431171186 0.780936221757882 0.137803520997112 0.146026154235119 0.136808906654285 0.82923457976539 NA NA NA 0.833511498551412 85.6720904491473 a2070 MLL2_mut 170 Shikonin unknown 3 16 2.77258872223978 NA -0.0213013379016732 -0.228991172392044 0.207689834490371 1.37468786513981 1.52418409908633 0.137783277277567 0.151081448928952 0.136262958401724 0.829259244591387 NA NA NA 0.828664062315587 85.6720904491473 a2071 gain_cnaBLCA23_(MYC) 226 GSK1070916 AURKB 4 15 0.940007258491471 2.32630161961136 2.2766483864875 2.01485641494108 0.261791971546421 1.28081885461524 2.26675838107247 0.12312360665137 0.204394220621512 0.115491784979112 0.829413863239691 NA NA NA 0.769856054632739 85.6720904491473 a2072 gain_cnaBLCA9 1037 BX-795 TBK1, PDPK1, IKK, AURKB, AURKC 3 12 1.6094379124341 NA 1.8055899879862 1.98267659299906 -0.177086605012861 0.632071643698925 1.33575362274084 0.14127636305375 0.280168564399659 0.132574302624384 0.830154319974542 NA NA NA 0.748086091842209 85.6720904491473 a2073 EP300_mut 1262 UNC1215 LMBL3 3 15 0 NA 2.32723009767291 2.38289221051536 -0.0556621128424521 0.249227212635427 0.421431419557712 0.137797702656753 0.223338825057902 0.132078697171817 0.830279119405822 NA NA NA 0.770815366389139 85.6720904491473 a2074 NRAS_mut 252 WZ3105 CLK2, CNSK1E, FLT3, ULK1 3 16 0.246860077931526 2.32630161961136 0.482138827566885 0.706360635828007 -0.224221808261121 1.82370742282661 1.61365901066998 0.136739982465479 0.122948344375105 0.138952409882448 0.830530636557706 NA NA NA 0.856769303997016 85.6720904491473 a2075 gain_cnaBLCA15_(ASXL1) 151 QS11 ARFGAP 6 13 2.32630161961136 NA 3.17496103279781 2.99374479672753 0.181216236070273 1.63484720770609 1.71169454098905 0.107263115105695 0.11084597705283 0.105869494662034 0.830537709891857 NA NA NA 0.829241894463671 85.6720904491473 a2076 ARID1A_mut 1001 AICAR AAPK1 (AMPK) agonist 3 11 7.60090245954208 NA 7.89602333262399 7.99009521861036 -0.094071885986371 0.599332028396666 0.672019492802714 0.142433741429812 0.156961219372894 0.13998386504242 0.830575562883 NA NA NA 0.827505501558622 85.6720904491473 a2077 loss_cnaBLCA18_(CHD9,CNOT1,CYLD,MMP2,NUP93) 1236 UNC0638 G9a(EHMT2), GLP(EHMT1) 3 16 2.99573227355399 NA 3.48312982204711 3.65960727732306 -0.176477455275946 0.573128521831756 1.36571533137235 0.135977771702189 0.307919512907702 0.12921979509347 0.831459796748869 NA NA NA 0.720902479201277 85.6720904491473 a2078 MLL2_mut 1129 PF-4708671 RPS6KB1 (p70S6KA) 3 16 2.30258509299405 NA 3.58106460930216 3.70284162487361 -0.121777015571448 0.864605595975179 0.900319795684161 0.135882730127523 0.14084689728858 0.13525973343606 0.831575673623163 NA NA NA 0.838840134914517 85.6720904491473 a2079 gain_cnaBLCA9 1029 AMG-706 VEGFR, RET, c-KIT, PDGFR 3 12 0.693147180559945 NA 2.70439465501912 2.59412995803952 0.110264696979603 0.680530512675848 0.805490902978256 0.14000838360824 0.162027557803459 0.136891300164789 0.831653082700875 NA NA NA 0.822393745516643 85.6720904491473 a2080 gain_cnaBLCA15_(ASXL1) 1175 AG-014699 PARP1, PARP2 6 13 1.6094379124341 NA 3.07039384399313 3.16461024580375 -0.0942164018106233 0.989816417874361 0.836517714823948 0.106535248690986 0.0951857335453718 0.112629296595891 0.831668827761267 NA NA NA 0.844540978574275 85.6720904491473 a2081 RB1_mut 1037 BX-795 TBK1, PDPK1, IKK, AURKB, AURKC 5 10 1.6094379124341 NA 2.04606989856198 1.89785395871375 0.148215939848225 0.680070621205729 1.43672841018711 0.118237994719945 0.217941983121468 0.103162113867382 0.832437702368825 NA NA NA 0.790576152535827 85.6720904491473 a2082 NRAS_mut 1057 NVP-BEZ235 PI3K (Class 1) and MTORC1/2 3 12 -1.38629436111989 0.693147180559945 -2.66471666223098 -2.48487275328136 -0.179843908949628 1.00483194429165 1.33798098401092 0.139162591602823 0.178979091947966 0.134414398335096 0.832653197623458 NA NA NA 0.809039536588462 85.6720904491473 a2083 NRAS_mut 1053 MK-2206 AKT1, AKT2 3 12 1.38629436111989 0.693147180559945 2.07282846690733 1.91600284026863 0.156825626638697 0.483168268356696 1.20913807555263 0.13899588784926 0.324577661467871 0.129700345898892 0.832850353912026 NA NA NA 0.733587531795781 85.6720904491473 a2084 loss_cnaBLCA5_(FAT1,IRF2) 1026 17-AAG HSP90 3 12 0 NA -1.38008524967357 -1.62040847853324 0.240323228859663 2.73229864048017 1.48651455905106 0.138329430647339 0.0879564280782385 0.161668937176826 0.833638673302012 NA NA NA 0.895004166068807 85.6720904491473 a2085 EP300_mut 288 KIN001-055 JAK3, MNK1 4 15 2.32630161961136 NA 4.20985403270539 4.10873035148138 0.101123681224013 0.588140995819157 0.887893704224498 0.119988357432614 0.171937820935554 0.113891652506238 0.833687659758608 NA NA NA 0.793862281525666 85.6720904491473 a2086 MLL2_mut 1498 AZD6244 MAP2K1 (MEK1), MAP2K2 (MEK2) 3 16 1.38629436111989 NA 1.23055946140324 1.39670745419673 -0.166147992793487 2.08689151178804 1.09094828104031 0.132917757125496 0.0796150599372232 0.152296855571423 0.835192628451636 NA NA NA 0.904278289208901 85.6720904491473 a2087 NRAS_mut 1054 PD-0332991 CDK4, CDK6 3 12 1.38629436111989 0.693147180559945 1.7546651281271 1.99670103779014 -0.242035909663047 2.16467367100964 1.68659830326977 0.136853246022115 0.111811730749309 0.143505367694144 0.835385444672109 NA NA NA 0.869731101454458 85.6720904491473 a2088 RB1_mut 261 TL-1-85 MAP3K7 (TAK1) 6 13 2.32630161961136 NA 3.62706144305991 3.50168448328245 0.125376959777462 1.47285280496241 1.08067845380974 0.103677389057106 0.0851252476520634 0.116016895992946 0.836113649072576 NA NA NA 0.856849205412157 85.6720904491473 a2089 EP300_mut 134 Etoposide TOP2 4 15 2.77258872223978 NA 1.01812277274288 1.19764878812276 -0.179526015379878 1.93972745490226 1.42531111289614 0.117435437308077 0.0925521855795582 0.125955669436333 0.8371716265889 NA NA NA 0.871191906257687 85.6720904491473 a2090 ARID1A_mut 196 Phenformin AAPK1 (AMPK) agonist 5 14 8.29404964010203 NA 8.89324017395517 9.0321481467475 -0.138907972792328 1.54177762636001 1.18730157905326 0.108558071055598 0.0900959842829453 0.116994683779576 0.837416474978868 NA NA NA 0.861025351329833 85.6720904491473 a2091 gain_cnaBLCA9 1072 BMS-708163 g-secretase 3 15 1.6094379124341 NA 3.51015518258218 3.42457071599633 0.0855844665858467 0.621067473427849 0.653494957293083 0.131763672650144 0.137802203862781 0.130964234124095 0.837595078417706 NA NA NA 0.843026615811899 85.6720904491473 a2092 loss_cnaBLCA18_(CHD9,CNOT1,CYLD,MMP2,NUP93) 1066 AZD6482 PI3Kbeta 3 15 1.6094379124341 NA 2.13052761137329 1.98549642623376 0.145031185139533 0.704321084195404 1.14891334488266 0.131466255510873 0.205916290728698 0.126233354138946 0.837956086168157 NA NA NA 0.786001751507978 85.6720904491473 a2093 RB1_mut 170 Shikonin unknown 6 13 2.77258872223978 NA -0.301879570978258 -0.147421949700629 -0.154457621277629 1.53870721602793 1.49442085726217 0.102453924264302 0.100381423878905 0.10335617341463 0.838018255771919 NA NA NA 0.841698660254705 85.6720904491473 a2094 gain_cnaBLCA9 176 IPA-3 PAK1, PAK2, PAK3 4 15 3.46573590279973 NA 3.86360664866901 3.67030814707809 0.193298501590921 1.67102757842365 1.65497908429375 0.116597830107478 0.115676428137271 0.116798153780542 0.838315470920048 NA NA NA 0.845420839987349 85.6720904491473 a2095 gain_cnaBLCA9 140 Vinorelbine Microtubules 4 15 -2.74887219562247 NA -3.86715724670117 -4.02168170360267 0.1545244569015 1.16284921677506 1.36232373922719 0.116245053098675 0.132884345341044 0.11342711901149 0.838797338218004 NA NA NA 0.828417033947629 85.6720904491473 a2096 loss_cnaBLCA5_(FAT1,IRF2) 332 XMD15-27 CAMK2B, CLK2, DYRK1A, MAST1, STK39 5 14 2.32630161961136 NA 4.71991737421983 4.7746543070301 -0.0547369328102736 0.529782677772184 0.502482762585512 0.107530148943836 0.103319597085451 0.108932956284164 0.838932874100925 NA NA NA 0.846614174633949 85.6720904491473 a2097 loss_cnaBLCA5_(FAT1,IRF2) 175 PAC-1 CASP3 agonist 5 14 0.940007258491471 NA 2.69133779658417 2.58935257633517 0.101985220249004 0.955218209617319 0.947935614983881 0.107391955103018 0.10676641129974 0.107586653182915 0.839136788663625 NA NA NA 0.843116208491142 85.6720904491473 a2098 CDKN1A_mut 1114 Cetuximab EGFR 3 15 4.18661983833127 NA 5.74766555840185 5.82364644287601 -0.0759808844741618 0.46513638007239 0.598565842431569 0.130202802645956 0.163351842017468 0.126938223146017 0.839490093145894 NA NA NA 0.820014755248114 85.6720904491473 a2099 gain_cnaBLCA23_(MYC) 163 JQ1 BRD4 4 15 0.940007258491471 NA -0.378852683672236 -0.21694243194439 -0.161910251727845 2.23891228926139 1.14193544662105 0.115694603992145 0.0723164781864944 0.141785818285028 0.839549342566167 NA NA NA 0.89659259441979 85.6720904491473 a2100 RB1_mut 1259 BMN-673 PARP1 6 12 2.30258509299405 NA 1.78764549049214 1.95712653899166 -0.169481048499517 1.93560358309992 1.5167940108458 0.102154365648138 0.0875597927071866 0.111736364521251 0.840688446199439 NA NA NA 0.855753285569629 85.6720904491473 a2101 NRAS_mut 302 PI-103 PI3Ka, PRKDC (DNAPK) 3 16 2.32630161961136 NA 2.46463206181638 2.16317203576933 0.301460026047049 1.87297178949522 2.40734188573782 0.128237862072958 0.160952785160899 0.125225265191053 0.840909318487197 NA NA NA 0.821567481654203 85.6720904491473 a2102 ARID1A_mut 1375 Temozolomide DNA akylating agent 4 14 3.40119738166216 NA 5.37408523427875 5.29184291427714 0.082242320001602 0.26863368435938 0.778673822542357 0.11559644197847 0.306150437528816 0.105618447186374 0.841007905805883 NA NA NA 0.7444892979587 85.6720904491473 a2103 RB1_mut 1129 PF-4708671 RPS6KB1 (p70S6KA) 6 13 2.30258509299405 NA 3.62202700433418 3.71203829229839 -0.0900112879642094 1.07866498156106 0.808307612787286 0.100422047921193 0.0834469362618442 0.111357713994334 0.841183624468448 NA NA NA 0.860157125231145 85.6720904491473 a2104 ARID1A_mut 224 AS605240 PI3Kgamma 5 14 2.99573227355399 2.32630161961136 3.45232789323323 3.29924704619788 0.153080847035346 1.94788372046207 1.2494558987773 0.105975031346393 0.0785882881135392 0.122518007386374 0.841228234398495 NA NA NA 0.875820742596795 85.6720904491473 a2105 TP53_mut 1262 UNC1215 LMBL3 14 4 0 NA 2.38392521338029 2.33753011585628 0.0463950975240084 0.265260136342888 0.752112882028486 0.114833115544987 0.174904145657363 0.0616863487285027 0.842042596681083 NA NA NA 0.910686151425358 85.6720904491473 a2106 MLL2_mut 158 PF-562271 FAK 3 16 0.940007258491471 NA 1.58912005355033 1.71637693083261 -0.127256877282279 0.862869317638426 1.01860237542085 0.127061394565028 0.147481054988218 0.12493282987849 0.842347876984282 NA NA NA 0.834029669267615 85.6720904491473 a2107 RB1_mut 1060 PD-0325901 MAP2K1 (MEK1), MAP2K2 (MEK2) 5 10 -1.38629436111989 0.693147180559945 -1.19283415697981 -1.02864449106634 -0.164189665913471 2.0140887003937 1.16470526734386 0.11101724175052 0.081520573488832 0.140970999717302 0.842516066215083 NA NA NA 0.872172205509012 85.6720904491473 a2108 gain_cnaBLCA15_(ASXL1) 182 Obatoclax Mesylate BCL2, BCL2L1, MCL1 6 13 2.77258872223978 NA -0.7719912710873 -0.909186294493925 0.137195023406625 1.8233453385873 1.14462654429653 0.0994625006247228 0.0752435759168483 0.119860074965274 0.842679437334986 NA NA NA 0.870246966751943 85.6720904491473 a2109 RB1_mut 222 BX-912 PDPK1 (PDK1) 6 13 2.32630161961136 NA 3.40733734386462 3.25614375159208 0.151193592272541 1.8388464308088 1.38111761311243 0.0988177132712602 0.0822219788120319 0.109471916683343 0.843684927444549 NA NA NA 0.862241949176841 85.6720904491473 a2110 MLL2_mut 275 I-BET BRD2, BRD3, BRD4 3 16 2.99573227355399 NA 4.76109885826318 4.61761063296709 0.143488225296084 0.760062768934682 1.1808642125592 0.125927310730622 0.188784704580648 0.121511198129303 0.843735153030143 NA NA NA 0.799247572266087 85.6720904491473 a2111 gain_cnaBLCA9 245 UNC0638 G9a(EHMT2), GLP(EHMT1) 4 15 3.68887945411394 NA 4.10855371219975 3.97322880527447 0.13532490692527 1.94650817411424 0.971946170913716 0.112513223228223 0.0695218796020983 0.139230865839054 0.843898741075229 NA NA NA 0.900461575982894 85.6720904491473 a2112 loss_cnaBLCA5_(FAT1,IRF2) 290 KIN001-260 IKK 5 14 2.99573227355399 NA 5.1026418351902 4.97819828229098 0.124443552899218 1.02622542236007 1.24231714251769 0.104137499342498 0.121263369809168 0.100170518976354 0.843942335932173 NA NA NA 0.831261103009753 85.6720904491473 a2113 MLL2_mut 308 XL-880 MET 3 16 1.63315443905142 NA 0.812210207685567 0.627075500173293 0.185134707512274 0.749424881331682 1.54481155731274 0.12562669943861 0.247035709814306 0.119842906816624 0.844102966762225 NA NA NA 0.760468953455384 85.6720904491473 a2114 gain_cnaBLCA23_(MYC) 152 CP466722 ATM 4 15 2.77258872223978 NA 2.97669431331036 3.117807429646 -0.14111311633564 2.01405568317936 1.02600367651134 0.112165829418966 0.0700641583617391 0.137536657583391 0.844373994875412 NA NA NA 0.899781931625548 85.6720904491473 a2115 gain_cnaBLCA23_(MYC) 1242 (5Z)-7-Oxozeaenol MAP3K7 (TAK1) 4 15 2.30258509299405 NA 0.45440745419954 0.568763858421203 -0.114356404221663 0.704814715021357 1.08634521259666 0.111096391565161 0.162250307470095 0.105267094562253 0.845837431601208 NA NA NA 0.806513943016792 85.6981233233367 a2116 gain_cnaBLCA23_(MYC) 192 LFM-A13 BTK 4 15 2.77258872223978 NA 4.33027163584174 4.40482990149104 -0.0745582656492934 0.671336961869703 0.672082254410867 0.110957925055762 0.111059378350993 0.110936221213949 0.846026954032732 NA NA NA 0.851754889338651 85.6981233233367 a2117 CDKN1A_mut 156 AZD6482 PI3Kbeta 3 16 1.63315443905142 NA 2.14775782785937 1.97200326355444 0.17575456430493 0.699034539471124 1.48714719059426 0.124001465164018 0.251424721356261 0.118182359766755 0.846092166244393 NA NA NA 0.759209144563056 85.6981233233367 a2118 NRAS_mut 256 JW-7-24-1 LCK 3 16 2.32630161961136 NA 2.29127323402764 2.13795506719828 0.153318166829359 0.323841237946735 1.31213956138405 0.123889914633018 0.473436205350031 0.116845929611053 0.846228737504464 NA NA NA 0.690550998742455 85.6981233233367 a2119 loss_cnaBLCA18_(CHD9,CNOT1,CYLD,MMP2,NUP93) 344 THZ-2-49 CDK9 3 16 2.99573227355399 NA 4.0418879421197 4.28692719249056 -0.245039250370859 0.72540645765025 2.10629004976451 0.122882214812557 0.337795794049856 0.116336897854242 0.847462691659316 NA NA NA 0.72329864567671 85.7471842617235 a2120 ARID1A_mut 1199 Tamoxifen ER 5 14 1.6094379124341 NA 3.4859538290975 3.54613824530956 -0.0601844162120568 0.660304387591842 0.571538827443355 0.101385393483944 0.0911464732675061 0.105302410478878 0.848011067716127 NA NA NA 0.862042491723585 85.7471842617235 a2121 gain_cnaBLCA23_(MYC) 193 GW-2580 CSF1R (cFMS) 4 15 2.99573227355399 NA 5.25788509850412 5.31039773709138 -0.052512638587265 0.59289385164329 0.451866886752549 0.109452467593172 0.088570050847582 0.116212628379698 0.84808813425343 NA NA NA 0.877106137298389 85.7471842617235 a2122 gain_cnaBLCA15_(ASXL1) 1053 MK-2206 AKT1, AKT2 4 11 1.38629436111989 0.693147180559945 1.85307374683901 1.98165677241723 -0.128583025578213 0.926541852126818 1.18254620225039 0.113927998118947 0.138777352888117 0.108734039594832 0.848312271865331 NA NA NA 0.832289184362897 85.7471842617235 a2123 loss_cnaBLCA5_(FAT1,IRF2) 1261 rTRAIL TR10A (DR4), TR10B (DR5) 4 14 -2.30258509299405 NA -0.955161563496206 -1.11690418280157 0.161742619305361 1.91806550270624 1.36976094146551 0.108695224301559 0.0843259101825015 0.118080910623946 0.850373233010913 NA NA NA 0.882585576608267 85.8162322456346 a2124 gain_cnaBLCA9 1192 GSK269962A ROCK1, ROCK2 4 15 1.6094379124341 NA 1.73999500546527 1.84508753426843 -0.10509252880316 0.755632271864944 1.01975049646758 0.107419626084521 0.139078931268758 0.103057099915323 0.85087317219367 NA NA NA 0.826708903107807 85.8162322456346 a2125 ARID1A_mut 1372 Trametinib MAP2K1 (MEK1), MAP2K2 (MEK2) 4 11 0 NA -1.69835137704721 -1.45205860785634 -0.246292769190873 3.13710634842887 1.82983264952747 0.111873777600693 0.0785095377191218 0.134598521484724 0.851011209305714 NA NA NA 0.889825041839813 85.8162322456346 a2126 gain_cnaBLCA23_(MYC) 331 QL-X-138 MNK2, PRKDC (DNAPK), MTOR, BTK, JAK3 4 15 2.32630161961136 NA 1.94300268631589 2.0940977455913 -0.151095059275403 2.31846308709314 1.13857255089134 0.106411370062713 0.065170353634935 0.132705692893366 0.852255260654761 NA NA NA 0.906580093606194 85.8162322456346 a2127 gain_cnaBLCA9 1050 ZM-447439 AURKB 3 12 1.38629436111989 0.693147180559945 2.07613715028396 2.23869540252282 -0.162558252238859 1.470622067204 1.29984287851357 0.12245006085366 0.110537068539928 0.125059924492375 0.852475039858455 NA NA NA 0.872729560743824 85.8162322456346 a2128 loss_cnaBLCA5_(FAT1,IRF2) 298 OSI-930 KIT, VEGFR, PDGFR 5 14 2.32630161961136 NA 4.27053122551824 4.34681627422947 -0.0762850487112265 1.14910985907851 0.627967623822326 0.097493230781067 0.0663862102553022 0.121479270295646 0.85377278780811 NA NA NA 0.893420885583402 85.8162322456346 a2129 gain_cnaBLCA9 204 Tipifarnib Farnesyl-transferase (FNTA) 4 15 2.77258872223978 NA 1.18226238674682 1.31860043310683 -0.136338046360013 0.907486964552502 1.37132111379779 0.104751708870965 0.150236919851784 0.0994209488851473 0.854531352255656 NA NA NA 0.819349837073251 85.8162322456346 a2130 MLL2_mut 271 VNLG/124 HDAC, RAR 3 16 1.63315443905142 NA 3.89655460982609 3.95365745491403 -0.0571028450879472 0.382047655805027 0.501410778088129 0.116802675844309 0.149465241365305 0.113884359059212 0.854915781755305 NA NA NA 0.834600478394418 85.8162322456346 a2131 MLL2_mut 1042 BIRB 0796 p38, JNK2 3 12 2.30258509299405 NA 3.89565526388705 4.01149893404742 -0.115843670160375 0.486881686794047 1.0265909332136 0.120239283797615 0.23792981601581 0.112843067683972 0.855105271277438 NA NA NA 0.784605868223535 85.8162322456346 a2132 RB1_mut 1031 Elesclomol HSP70 5 9 -1.6094379124341 NA -3.75742198670049 -3.5947000958224 -0.162721890878096 1.24933803690929 1.70306454231987 0.103876535725534 0.130246487396357 0.0955465203077041 0.855372184804215 NA NA NA 0.841931711149295 85.8162322456346 a2133 TP53_mut 1054 PD-0332991 CDK4, CDK6 11 4 1.38629436111989 0.693147180559945 1.89743311750443 2.08816088632858 -0.190727768824155 1.71140526538288 1.94997314441195 0.107797409632616 0.11144512213563 0.0978104592725927 0.856372699233346 NA NA NA 0.869779317870858 85.8162322456346 a2134 gain_cnaBLCA23_(MYC) 158 PF-562271 FAK 4 15 0.940007258491471 NA 1.61455415774554 1.71807829486604 -0.1035241371205 0.973737940510542 1.00764648658028 0.103343695713069 0.106316220015235 0.102738548190484 0.856463365220852 NA NA NA 0.858798856685239 85.8162322456346 a2135 gain_cnaBLCA23_(MYC) 1053 MK-2206 AKT1, AKT2 3 12 1.38629436111989 0.693147180559945 1.84012488889877 1.97417873477077 -0.134053845871993 1.13245328146962 1.12815469802842 0.118756039194554 0.118374725090669 0.118825765744953 0.856870946832631 NA NA NA 0.865802980372073 85.8162322456346 a2136 gain_cnaBLCA23_(MYC) 1192 GSK269962A ROCK1, ROCK2 4 15 1.6094379124341 NA 1.90251063204746 1.80175003384652 0.10076059820094 1.43018636957865 0.850962997012062 0.102982861145043 0.0704527747881037 0.118407731657822 0.856958637889698 NA NA NA 0.900070843856499 85.8162322456346 a2137 CDKN1A_mut 273 CUDC-101 HDAC, EGFR 3 16 1.63315443905142 NA -0.19685602496205 -0.0282923916327101 -0.168563633329339 0.87735691881152 1.52867050886555 0.114893429354794 0.192126635939314 0.110268126683777 0.857259335818138 NA NA NA 0.801717324405835 85.8162322456346 a2138 ARID1A_mut 1236 UNC0638 G9a(EHMT2), GLP(EHMT1) 5 14 2.99573227355399 NA 3.72265047065179 3.59927525357509 0.123375217076695 1.58347341976316 1.19703727620623 0.0950244337447588 0.0779142962154347 0.103067147138231 0.857431879614537 NA NA NA 0.879300092911931 85.8162322456346 a2139 EP300_mut 1066 AZD6482 PI3Kbeta 4 14 1.6094379124341 NA 2.09835405039274 1.9843295018611 0.114024548531643 0.706036151172991 1.17633188580755 0.103327510899712 0.161499589422164 0.0969322942847592 0.857673621925791 NA NA NA 0.815160206841635 85.8162322456346 a2140 RB1_mut 230 GSK429286A ROCK2 6 13 2.99573227355399 2.32630161961136 4.69278084354681 4.84678672667132 -0.154005883124516 1.0919315889723 1.92485994149538 0.0894229810008244 0.14103986429174 0.0800088774276599 0.858365828801278 NA NA NA 0.827566481529791 85.8162322456346 a2141 loss_cnaBLCA5_(FAT1,IRF2) 272 AR-42 HDAC 5 14 1.63315443905142 NA 0.157942572238571 0.0213585459137085 0.136584026324863 0.813155941298703 1.59202189895144 0.094392397755473 0.167967814521188 0.0857928062514854 0.858369183503398 NA NA NA 0.810693854658934 85.8162322456346 a2142 MLL2_mut 1046 681640 WEE1, CHEK1 3 12 0.693147180559945 NA 1.7259210716169 1.61584965750459 0.110071414112309 0.730921278792883 0.973769241120637 0.117035197583165 0.150592707184681 0.113036445868465 0.858920465542187 NA NA NA 0.838706018566372 85.8162322456346 a2143 gain_cnaBLCA15_(ASXL1) 192 LFM-A13 BTK 6 13 2.77258872223978 NA 4.34819349511849 4.40802877654012 -0.0598352814216296 0.896135142082832 0.552522201422663 0.0890305526865701 0.0667703771582467 0.10829480022262 0.858980270139888 NA NA NA 0.884454943677891 85.8162322456346 a2144 MLL2_mut 211 TL-2-105 CRAF 3 16 2.32630161961136 1.63315443905142 4.46127870741101 4.36432621280073 0.096952494610278 0.325756560861015 0.905746065566821 0.112984317360596 0.297622538603737 0.107041585159528 0.859604097483681 NA NA NA 0.74911598293993 85.8162322456346 a2145 ARID1A_mut 1371 PLX4720 (rescreen) BRAF 4 14 2.30258509299405 NA 4.00279141643292 3.90737648907909 0.0954149273538256 0.574133412385985 1.00210947291245 0.101843689959742 0.166189469721506 0.0952140758399574 0.859694087941226 NA NA NA 0.813469402822844 85.8162322456346 a2146 RB1_mut 238 CAL-101 PI3Kdelta 6 13 2.99573227355399 2.32630161961136 4.77257772067409 4.85098070784069 -0.0784029871666032 0.645963555544022 0.970320449753857 0.088359708940699 0.121373700565155 0.0808011283143541 0.860030853592795 NA NA NA 0.838088857246603 85.8162322456346 a2147 gain_cnaBLCA9 1371 PLX4720 (rescreen) BRAF 4 14 2.30258509299405 NA 4.00253912459934 3.90744857246011 0.0950905521392249 0.622225826128148 0.995470085536303 0.10149676463124 0.152823216501529 0.0955232643560509 0.860166629615927 NA NA NA 0.822140528962053 85.8162322456346 a2148 gain_cnaBLCA23_(MYC) 204 Tipifarnib Farnesyl-transferase (FNTA) 4 15 2.77258872223978 NA 1.18649090614264 1.31747282793461 -0.130981921791967 1.27600458849958 1.30706482716127 0.100628573745527 0.102650039798042 0.100210730998277 0.860191573314285 NA NA NA 0.863359458849101 85.8162322456346 a2149 MLL2_mut 201 Epothilone B Microtubules 3 16 -3.44201937618241 NA -5.0087187660516 -5.28358757804702 0.274868811995426 3.58093432630715 2.2611408823674 0.112029503869083 0.0767589648254973 0.121562001792493 0.860777302639809 NA NA NA 0.9082756128441 85.8162322456346 a2150 RB1_mut 299 OSI-027 MTORC1/2 6 13 2.99573227355399 NA 2.00628330645228 1.84294829792903 0.163335008523257 2.00519754819207 1.79595505854078 0.0878172525535961 0.081455818989268 0.0909460444160377 0.860880572059593 NA NA NA 0.868475588158467 85.8162322456346 a2151 CDKN1A_mut 276 CAY10603 HDAC6 3 16 2.99573227355399 NA 1.13528167865267 1.27186510409323 -0.136583425440555 0.715411894826637 1.27346434280557 0.111850898423051 0.190915787713667 0.107253435254927 0.860996797269226 NA NA NA 0.804144053965549 85.8162322456346 a2152 gain_cnaBLCA15_(ASXL1) 1494 SN-38 TOP1 6 12 -2.99573227355399 NA -4.79376609238691 -4.94901861393842 0.155252521551512 1.72824942388936 1.75246125277749 0.0889734371350675 0.0898322426181529 0.0885911293647442 0.860998138101536 NA NA NA 0.861565689378791 85.8162322456346 a2153 MLL2_mut 288 KIN001-055 JAK3, MNK1 3 16 2.32630161961136 NA 4.20882567362973 4.11524339888456 0.0935822747451711 0.720318263901723 0.858182341493744 0.110993373885099 0.129917953542185 0.1090470756859 0.862050802616647 NA NA NA 0.853621165166368 85.8691747820045 a2154 gain_cnaBLCA9 194 AUY922 HSP90 4 15 -1.36257783450257 NA -2.61876758941129 -2.84339743090933 0.224629841498044 2.28737220442663 2.26301344578179 0.0990723608228985 0.0982043241862123 0.0992613817283098 0.86232999076276 NA NA NA 0.86843488352695 85.8691747820045 a2155 RB1_mut 165 DMOG Prolyl-4-Hydroxylase 6 13 8.29404964010203 NA 5.79883591328073 5.71362802955224 0.0852078837284873 1.09483790349276 0.952790013142738 0.0854923528317762 0.0778269399119781 0.0894298665531061 0.864524334883367 NA NA NA 0.873415132569344 85.8717484300717 a2156 gain_cnaBLCA9 1046 681640 WEE1, CHEK1 3 12 0.693147180559945 NA 1.55342740066597 1.65897307524232 -0.105545674576353 0.425488614357025 1.00630939478905 0.112211705957999 0.248057576665942 0.104883920514802 0.864670858967965 NA NA NA 0.788088494261198 85.8717484300717 a2157 gain_cnaBLCA9 170 Shikonin unknown 4 15 2.77258872223978 NA -0.0805536763773829 -0.227036537764546 0.146482861387163 1.80874131835823 1.43559765139676 0.0971262275310054 0.0809860757314505 0.102036152848706 0.865005751048283 NA NA NA 0.888003367262467 85.8717484300717 a2158 RB1_mut 205 BMS-708163 g-secretase 6 13 2.32630161961136 0.940007258491471 4.74934948330705 4.71767927425556 0.0316702090514962 0.237960268773122 0.415479196586619 0.0850974857140837 0.133090323081167 0.0762257396078641 0.865143515794067 NA NA NA 0.836241375831089 85.8717484300717 a2159 NRAS_mut 1036 PLX4720 BRAF 3 12 2.30258509299405 NA 3.69503709022168 3.771031797429 -0.0759947072073173 0.999915487016839 0.615822138495403 0.110298046629331 0.0760011302895616 0.123403662286306 0.866954498617477 NA NA NA 0.90967853098046 85.8717484300717 a2160 NRAS_mut 1030 KU-55933 ATM 3 12 2.30258509299405 NA 3.4103039435481 3.51773201133521 -0.107428067787119 1.05748983446817 0.959973340670032 0.110113683551 0.10158780187343 0.111907344960368 0.86717457181445 NA NA NA 0.883256384142083 85.8717484300717 a2161 loss_cnaBLCA18_(CHD9,CNOT1,CYLD,MMP2,NUP93) 1372 Trametinib MAP2K1 (MEK1), MAP2K2 (MEK2) 3 12 0 NA -1.32418599999604 -1.5661243495517 0.241938349555663 3.3202873663175 1.93052093692416 0.109863216769503 0.0728666897961892 0.125322831225615 0.867473571095415 NA NA NA 0.913129918464306 85.8717484300717 a2162 EP300_mut 1194 SB-505124 TGFR1 (ALK5) 4 15 2.30258509299405 NA 4.00290927941958 4.10274239960553 -0.0998331201859566 1.52153774929354 0.915119220867619 0.0952650295050862 0.0656133048505102 0.109093020788379 0.867566313099554 NA NA NA 0.906951139707354 85.8717484300717 a2163 MLL2_mut 346 THZ-2-102-1 CDK7 3 16 0.916290731874155 2.99573227355399 -0.546793755216158 -0.282633975521467 -0.26415977969469 1.12051769038252 2.60917716929654 0.106479688679682 0.235747977887357 0.101242561372676 0.867603057902419 NA NA NA 0.781858561612889 85.8717484300717 a2164 loss_cnaBLCA5_(FAT1,IRF2) 282 EKB-569 EGFR 5 14 0.916290731874155 2.99573227355399 2.02059567390627 1.88045706656144 0.140138607344835 1.47342191924708 1.6332878673041 0.0877449745621183 0.0951109831571164 0.0858015357550826 0.868240172518572 NA NA NA 0.863780148068675 85.8717484300717 a2165 EP300_mut 1241 CHIR-99021 GSK3B 4 15 2.30258509299405 NA 3.54661288610011 3.63225101803516 -0.0856381319350574 1.02546576988232 0.878152075671553 0.0945346960437612 0.0835114486024091 0.0975208444045036 0.868571492480941 NA NA NA 0.885568131510266 85.8717484300717 a2166 loss_cnaBLCA18_(CHD9,CNOT1,CYLD,MMP2,NUP93) 166 FTI-277 Farnesyl transferase (FNTA) 3 16 0.0237165266173161 NA 1.43797915873666 1.52403834086954 -0.0860591821328771 0.628157658337476 0.835944669241285 0.105690579800051 0.137002519973484 0.102948419075375 0.868574476210522 NA NA NA 0.848502623095957 85.8717484300717 a2167 loss_cnaBLCA5_(FAT1,IRF2) 326 GSK690693 AKT 5 14 2.32630161961136 NA 4.19981492524759 4.28448963801326 -0.0846747127656746 1.00883870123183 0.955788064157346 0.0874258265198433 0.0839328553338447 0.0885915151496756 0.868714664358421 NA NA NA 0.875040979730402 85.8717484300717 a2168 loss_cnaBLCA5_(FAT1,IRF2) 156 AZD6482 PI3Kbeta 5 14 1.63315443905142 NA 1.90852303852328 2.03233646484519 -0.123813426321909 0.623184983441043 1.5840435345384 0.0873274763405866 0.198678449596535 0.0781628936467259 0.868860896423136 NA NA NA 0.810011228203027 85.8717484300717 a2169 RB1_mut 1011 ABT-263 BCL2, BCL2L1, BCL2L2 5 10 0.693147180559945 NA 2.19961618929383 2.27666482727011 -0.0770486379762794 0.930813661729212 0.790521145147116 0.0921415324558147 0.0827755770506665 0.0974656256183262 0.868994018104412 NA NA NA 0.878403273359455 85.8717484300717 a2170 loss_cnaBLCA18_(CHD9,CNOT1,CYLD,MMP2,NUP93) 293 MP470 PDGFR 3 16 2.99573227355399 NA 4.10240983457633 3.94835045300707 0.154059381569256 0.666046054651199 1.54250337452112 0.10502886230228 0.23130439778663 0.0998762039124132 0.869389238514297 NA NA NA 0.785343352771441 85.8717484300717 a2171 EP300_mut 256 JW-7-24-1 LCK 4 15 2.32630161961136 NA 2.25394691285854 2.13768754172142 0.116259371137127 0.262779074007431 1.3587006154009 0.0939141535555428 0.442422485794435 0.0855665845877485 0.869425745454225 NA NA NA 0.760143958090502 85.8717484300717 a2172 gain_cnaBLCA23_(MYC) 228 KIN001-102 AKT1 4 15 2.32630161961136 NA 3.25047412157172 3.37375805257894 -0.123283931007224 1.52214803615747 1.26509538650596 0.0938150766010937 0.080993390970331 0.0974503047930001 0.869562152468561 NA NA NA 0.888579951123565 85.8717484300717 a2173 CDKN1A_mut 152 CP466722 ATM 3 16 2.77258872223978 NA 2.97788342277026 3.10876490185129 -0.130881479081026 0.782511498581084 1.30898915705694 0.103995178449389 0.167258218337177 0.099986679320777 0.870662299418259 NA NA NA 0.824835491710562 85.9196771748081 a2174 EP300_mut 225 Genentech Cpd 10 AURKA, AURKB 4 15 2.32630161961136 NA 3.13741286839206 2.99040585988006 0.147007008511996 1.04576067467445 1.67557581722966 0.0928808075411692 0.140574236603189 0.0877352173505656 0.870848641499501 NA NA NA 0.834110860409602 85.9196771748081 a2175 ARID1A_mut 268 YM155 BIRC5 (Survivin) 5 14 1.63315443905142 NA -3.70868400927132 -3.89479552856949 0.186111519298174 3.32603257878996 1.66577541555269 0.0856207807660976 0.0559560121223716 0.11172665748367 0.871399272775212 NA NA NA 0.909504506208541 85.9344752856111 a2176 NRAS_mut 184 BMS-754807 IGF1R 3 16 0.940007258491471 NA 0.751838317155192 0.929460002096084 -0.177621684940892 3.20121755769177 1.43379167549587 0.10221779216286 0.0554856649820969 0.123882491422237 0.872852139528769 NA NA NA 0.932889184540651 86.0381943442259 a2177 MLL2_mut 272 AR-42 HDAC 3 16 1.63315443905142 NA 0.180458197129641 0.0342098695372409 0.1462483275924 0.930574389730511 1.50281040670134 0.101050480283186 0.157159201033624 0.0973165523343787 0.874290912915614 NA NA NA 0.833683381074165 86.0733949805568 a2178 EP300_mut 167 OSU-03012 PDPK1 (PDK1) 4 15 2.77258872223978 NA 1.73835658622575 1.91135085241962 -0.172994266193873 2.65590737691104 1.71659325983867 0.0902840216796825 0.0651356548416514 0.100777668327867 0.87442636356347 NA NA NA 0.908080483899538 86.0733949805568 a2179 EP300_mut 1268 XAV 939 TNKS1 (tankyrase-1) 3 15 1.6094379124341 NA 3.27080904124374 3.19271777719668 0.0780912640470577 0.636055547631138 0.787978792946777 0.10133457282308 0.122774283374924 0.0991032560089879 0.874709983663883 NA NA NA 0.863078026093715 86.0733949805568 a2180 RB1_mut 302 PI-103 PI3Ka, PRKDC (DNAPK) 6 13 2.32630161961136 NA 2.33779610068995 2.15214401181682 0.185652088873127 1.58893449014938 2.6046432726564 0.0789374067168784 0.116840618681311 0.0712773571805808 0.8748144118572 NA NA NA 0.850871482832152 86.0733949805568 a2181 EP300_mut 190 Bleomycin DNA damage 4 15 4.15888308335967 NA 1.45313317310687 1.2321367272678 0.220996445839078 2.58793330321791 2.44631027730629 0.0894037537043054 0.0853949541760928 0.0903386818463699 0.875639792576891 NA NA NA 0.884598148240229 86.1047635782812 a2182 gain_cnaBLCA23_(MYC) 1007 Docetaxel Microtubules 4 10 -4.38202663467388 NA -5.89353953280149 -5.73653778933754 -0.157001743463955 2.01650033279228 1.52845545077907 0.0943553412736988 0.077858525937634 0.102719214605784 0.875936103841925 NA NA NA 0.894450047915926 86.1047635782812 a2183 gain_cnaBLCA23_(MYC) 255 CP724714 ERBB2 4 15 2.32630161961136 NA 4.22450539178467 4.30802268233365 -0.0835172905489712 0.924677535631771 0.969728318656942 0.0868224919989229 0.0903204493790469 0.0861244215953612 0.879199829204813 NA NA NA 0.88009759944369 86.2483027702754 a2184 EP300_mut 173 FH535 unknown 4 15 3.46573590279973 NA 1.65405223163738 1.76380749413859 -0.109755262501216 1.0574557925269 1.30438084748908 0.0868100633098758 0.103791821158731 0.0841435710379329 0.879216977171064 NA NA NA 0.867041277830552 86.2483027702754 a2185 RB1_mut 281 CH5424802 ALK 6 13 1.63315443905142 NA 4.11461572510577 4.08685502199298 0.027760703112798 0.430843326164847 0.340080743000599 0.075211923367858 0.0644334063612172 0.0816297414192284 0.880673175561799 NA NA NA 0.892809652841724 86.2483027702754 a2186 RB1_mut 1029 AMG-706 VEGFR, RET, c-KIT, PDGFR 5 10 0.693147180559945 NA 2.66022510898115 2.59416179166258 0.0660633173185761 0.978748936354 0.686864796130745 0.0838077609749921 0.0674977155680728 0.0961809626737674 0.880738828482952 NA NA NA 0.896841344281931 86.2483027702754 a2187 EP300_mut 344 THZ-2-49 CDK9 4 15 2.99573227355399 NA 4.38265166424513 4.21239281661516 0.170258847629969 1.72219954576769 2.04871965669533 0.0853433987855816 0.0988612777470419 0.0831050002734896 0.881240977908056 NA NA NA 0.872209524745314 86.2483027702754 a2188 MLL2_mut 205 BMS-708163 g-secretase 3 16 2.32630161961136 0.940007258491471 4.69789226105751 4.7332656676245 -0.0353734065669897 0.281171206793185 0.382748217562689 0.0950286357657892 0.125807357625379 0.0924195200496161 0.881720243355623 NA NA NA 0.861263595494314 86.2483027702754 a2189 EP300_mut 180 Thapsigargin sarco-endoplasmic reticulum Ca2+-ATPases 4 15 -0.669430653942629 NA -4.4768200984544 -4.33244168743284 -0.14437841102156 1.44974950818501 1.76348913637453 0.0843181344896245 0.099588522159467 0.0818708820165343 0.882656348537938 NA NA NA 0.871940669535463 86.2483027702754 a2190 EP300_mut 1069 EHT 1864 Rac GTPases 4 14 2.30258509299405 NA 3.42320840355682 3.50688127258892 -0.0836728690321031 1.0388962180084 0.976755760688852 0.0846287820697773 0.08054016135751 0.0856640650607408 0.883204998284823 NA NA NA 0.891599441888894 86.2483027702754 a2191 loss_cnaBLCA5_(FAT1,IRF2) 295 NVP-BHG712 EPHB4 5 14 2.32630161961136 NA 3.72189545525563 3.60652742393661 0.115368031319021 1.44349968391261 1.50065681010259 0.0775632581481549 0.0799224500045027 0.0768783578912583 0.883402311735191 NA NA NA 0.883428781776187 86.2483027702754 a2192 gain_cnaBLCA23_(MYC) 256 JW-7-24-1 LCK 4 15 2.32630161961136 NA 2.08047349298426 2.18394712035456 -0.103473627370295 2.39035807079034 0.798191635792591 0.0835716192545547 0.0432879193434322 0.12963506848521 0.883687165284546 NA NA NA 0.937099487866887 86.2483027702754 a2193 TP53_mut 1042 BIRB 0796 p38, JNK2 11 4 2.30258509299405 NA 3.9660754897946 4.04953065312239 -0.0834551633277889 1.0735073878325 0.429915596848636 0.0865795747862851 0.0777406511344942 0.194119878272692 0.884393526717122 NA NA NA 0.833372410137396 86.2483027702754 a2194 ARID1A_mut 200 LAQ824 HDAC 5 14 0.0237165266173161 NA -2.81581290555449 -2.73673235951634 -0.0790805460381434 0.438638016829018 1.15216645314279 0.0767950059692469 0.180286575727815 0.0686363900132948 0.884548327446352 NA NA NA 0.831140722179791 86.2483027702754 a2195 loss_cnaBLCA5_(FAT1,IRF2) 1050 ZM-447439 AURKB 3 12 1.38629436111989 0.693147180559945 2.10499909581252 2.23147991614068 -0.126480820328157 1.35102520558001 1.32409329538851 0.0952220632298462 0.0936184016447403 0.0955225895098624 0.884987029178543 NA NA NA 0.893339172217874 86.2483027702754 a2196 EP300_mut 1024 CEP-701 FLT3, JAK2, NTRK1, RET 3 11 0.693147180559945 NA -0.0707709703150984 -0.20353501455778 0.132764044242681 0.78574244047195 1.47004023817395 0.0962223245051247 0.168966365318052 0.0903132042205853 0.885009029164471 NA NA NA 0.840634566856588 86.2483027702754 a2197 CDKN1A_mut 184 BMS-754807 IGF1R 3 16 0.940007258491471 NA 0.767312329565977 0.926558624769062 -0.159246295203085 1.57563490349617 1.75845298740783 0.091629159977832 0.101068016994124 0.0905604507731727 0.885919342782339 NA NA NA 0.884705490942393 86.2483027702754 a2198 gain_cnaBLCA15_(ASXL1) 1047 Nutlin-3a MDM2 4 11 2.07944154167984 1.38629436111989 3.65577191620486 3.7577757608902 -0.102003844685349 1.77411661798506 0.965884979327698 0.0848858250798027 0.0574955691476468 0.105606616593571 0.886637865899511 NA NA NA 0.918712311939263 86.2483027702754 a2199 TP53_mut 1021 Axitinib PDGFR, KIT, VEGFR 10 4 0.693147180559945 NA 1.98612896633757 2.09272591191541 -0.106596945577845 1.07497059303195 1.65010655567255 0.0856930647892632 0.0991626620010024 0.06460003762266 0.887235486612572 NA NA NA 0.910583009793031 86.2483027702754 a2200 TP53_mut 245 UNC0638 G9a(EHMT2), GLP(EHMT1) 15 4 3.68887945411394 NA 3.98120067716846 4.07865919259729 -0.097458515428833 1.085285301982 1.64622906712997 0.0809841394793343 0.0897999035376686 0.0592010658630525 0.887261706607356 NA NA NA 0.916533268144202 86.2483027702754 a2201 loss_cnaBLCA18_(CHD9,CNOT1,CYLD,MMP2,NUP93) 1020 Lenalidomide TNFA 3 11 1.6094379124341 NA 3.83133779378318 3.7445425384662 0.086795255316976 0.459196761629288 0.994368993333175 0.0936417423181619 0.189015390720561 0.0872867676877513 0.888069725186007 NA NA NA 0.833856385658326 86.2483027702754 a2202 loss_cnaBLCA5_(FAT1,IRF2) 344 THZ-2-49 CDK9 5 14 2.99573227355399 NA 4.35721118987363 4.20931735405999 0.147893835813644 2.54012736121065 1.79446617521546 0.0741267828468563 0.0582230001818318 0.0824166194137855 0.888530594211407 NA NA NA 0.908791309241397 86.2483027702754 a2203 MLL2_mut 254 AC220 FLT3 3 16 0.0237165266173161 NA 2.42090144092695 2.37392503503184 0.0469764058951161 0.262074331772791 0.553762060139804 0.0889908956810481 0.179248404745883 0.0848313910910695 0.889180594589076 NA NA NA 0.826224737114131 86.2483027702754 a2204 loss_cnaBLCA5_(FAT1,IRF2) 1046 681640 WEE1, CHEK1 3 12 0.693147180559945 NA 1.7068138706883 1.62062645773674 0.0861874129515596 0.42555980581922 1.00670620838158 0.0915953554697164 0.202527146062691 0.0856132725059064 0.889335344253409 NA NA NA 0.826187877959815 86.2483027702754 a2205 loss_cnaBLCA5_(FAT1,IRF2) 263 FR-180204 ERK 5 14 2.99573227355399 NA 5.07527863757232 5.02518168801247 0.0500969495598476 0.61786036972079 0.699610886026287 0.0735358780207808 0.0810813446126773 0.0716068754224119 0.889412926226088 NA NA NA 0.884364708239456 86.2483027702754 a2206 loss_cnaBLCA5_(FAT1,IRF2) 158 PF-562271 FAK 5 14 0.940007258491471 NA 1.75054746126478 1.67690383911778 0.073643622146996 1.21097950825628 0.928497317517995 0.0734854098539291 0.0608132686349394 0.0793148464271883 0.889488291630238 NA NA NA 0.905801925502982 86.2483027702754 a2207 gain_cnaBLCA23_(MYC) 165 DMOG Prolyl-4-Hydroxylase 4 15 8.29404964010203 NA 5.80299239379525 5.72388068591217 0.0791117078830768 0.474588788604165 1.07641580910991 0.0793522355258796 0.166695273429775 0.0734954905098376 0.889517434532465 NA NA NA 0.832243813532278 86.2483027702754 a2208 RB1_mut 258 STF-62247 stimulates autophagy 6 13 2.32630161961136 NA 4.50279478474388 4.5565431490106 -0.053748364266724 0.62839917030339 0.82971248243573 0.06926839983575 0.0855322011974878 0.0647795054365563 0.890034690498081 NA NA NA 0.878493149133657 86.2483027702754 a2209 EP300_mut 202 GSK-1904529A IGF1R 4 15 0.0237165266173161 NA 2.04402208758717 2.08753514235474 -0.0435130547675695 0.427137315652663 0.577930838263295 0.0784996235499803 0.101871349500527 0.0752911107812276 0.890696361744485 NA NA NA 0.872574342574995 86.2483027702754 a2210 loss_cnaBLCA5_(FAT1,IRF2) 279 BIX02189 MAP2K5 (MEK5) 5 14 2.99573227355399 NA 4.74780505841989 4.66785139431891 0.079953664100973 1.08521527996197 1.1123037536679 0.072291509711543 0.0736753947141023 0.0718811420327588 0.891271489252844 NA NA NA 0.892101447753066 86.2483027702754 a2211 loss_cnaBLCA18_(CHD9,CNOT1,CYLD,MMP2,NUP93) 1028 VX-702 p38 3 11 0.693147180559945 NA 2.84694924437463 2.91535015809443 -0.0684009137197967 0.232698762247331 0.818562315843893 0.0908069624597638 0.293946186301991 0.0835622559160681 0.89143408390909 NA NA NA 0.811905722939742 86.2483027702754 a2212 EP300_mut 205 BMS-708163 g-secretase 4 15 2.32630161961136 0.940007258491471 4.75048755523172 4.72159848294918 0.028889072282535 0.252527011552113 0.393225980388204 0.0776001849240577 0.114399929357946 0.0734668453341128 0.891940322912837 NA NA NA 0.863227137090772 86.2483027702754 a2213 gain_cnaBLCA9 1175 AG-014699 PARP1, PARP2 4 15 1.6094379124341 NA 3.18866992332304 3.12050777107436 0.0681621522486786 0.863594604142462 0.889631059840469 0.0770113712816356 0.0789284137739174 0.0766184492939148 0.892754834041909 NA NA NA 0.894758175728751 86.2483027702754 a2214 CDKN1A_mut 245 UNC0638 G9a(EHMT2), GLP(EHMT1) 3 16 3.68887945411394 NA 3.91446655959445 4.0180779530708 -0.103611393476349 0.189857844417333 1.27934385322886 0.0860919120315731 0.545731432874575 0.0809879167472063 0.892766488258769 NA NA NA 0.762986454844941 86.2483027702754 a2215 MLL2_mut 173 FH535 unknown 3 16 3.46573590279973 NA 1.83236239684199 1.7235146342564 0.108847762585587 1.21924240396702 1.27041659907148 0.0860794405180293 0.0892749154978795 0.0856787943932261 0.892781920103668 NA NA NA 0.89718541186161 86.2483027702754 a2216 loss_cnaBLCA5_(FAT1,IRF2) 277 ABT-869 VEGFR and PDGFR family 5 14 0.0237165266173161 NA 2.35741637476447 2.32425326720301 0.0331631075614656 0.51158320523921 0.451817308832889 0.0710786564370497 0.064824464958655 0.0733993738467674 0.893083609191227 NA NA NA 0.901939129009119 86.2483027702754 a2217 ARID1A_mut 1028 VX-702 p38 3 11 0.693147180559945 NA 2.84788367067618 2.91509531455764 -0.0672116438814605 1.63989762589991 0.378231647282144 0.0892256332896887 0.0409852681167078 0.177699683155607 0.893311792767163 NA NA NA 0.950063816330325 86.2483027702754 a2218 loss_cnaBLCA18_(CHD9,CNOT1,CYLD,MMP2,NUP93) 1023 GW 441756 NTRK1 3 11 0.693147180559945 NA 2.37570927336844 2.46007106394504 -0.0843617905766032 0.657275229998938 0.994628970879444 0.0891031507694677 0.128350783243025 0.0848173470173617 0.893457259842489 NA NA NA 0.868517826243509 86.2483027702754 a2219 gain_cnaBLCA23_(MYC) 155 AP-24534 ABL 4 15 -0.669430653942629 NA 0.27322407961327 0.194930000740289 0.0782940788729805 1.09081757153348 1.01442971710271 0.0761376819028615 0.0717755937529627 0.0771803877124131 0.893963643366052 NA NA NA 0.902630038568058 86.2483027702754 a2220 gain_cnaBLCA15_(ASXL1) 1133 JNJ-26854165 MDM2 6 13 2.30258509299405 NA 2.25862518103042 2.34323333049476 -0.0846081494643465 1.45638893130726 1.1890123159929 0.0664378455329519 0.0580944743849447 0.0711583457347903 0.894499008760653 NA NA NA 0.903952710069088 86.2483027702754 a2221 gain_cnaBLCA9 221 TAK-715 p38a 4 15 2.99573227355399 2.32630161961136 4.55219629980126 4.61231086310488 -0.0601145633036193 0.818755528476312 0.790601364860952 0.0755547753862227 0.0734218716244779 0.0760365033194599 0.894770284180549 NA NA NA 0.90098203033479 86.2483027702754 a2222 gain_cnaBLCA9 1030 KU-55933 ATM 3 12 2.30258509299405 NA 3.56418904103552 3.47926073696336 0.0849283040721653 0.604411356164617 1.02927014842613 0.0870149286707451 0.140514077384467 0.0825131324385828 0.894832451268912 NA NA NA 0.859712622942774 86.2483027702754 a2223 loss_cnaBLCA5_(FAT1,IRF2) 252 WZ3105 CLK2, CNSK1E, FLT3, ULK1 5 14 0.246860077931526 2.32630161961136 0.586899962141407 0.70097763180298 -0.114077669661573 1.70228659829536 1.62192184765734 0.0695093182400336 0.0670143733586393 0.0703348745356279 0.89542925411752 NA NA NA 0.900164559194852 86.2483027702754 a2224 loss_cnaBLCA5_(FAT1,IRF2) 1129 PF-4708671 RPS6KB1 (p70S6KA) 5 14 2.30258509299405 NA 3.63777858898734 3.6999833486391 -0.0622047596517654 1.06519490669621 0.838422029247475 0.0693511650158559 0.0583975376344023 0.074192658925717 0.895665696902613 NA NA NA 0.909874490842846 86.2483027702754 a2225 gain_cnaBLCA15_(ASXL1) 172 Embelin XIAP 6 13 3.46573590279973 NA 2.75952560218922 2.70930567188756 0.0502199303016528 0.905346060274077 0.698394120256038 0.0656387719417861 0.0554704245208177 0.071907722079965 0.895759965263916 NA NA NA 0.907220225896853 86.2483027702754 a2226 gain_cnaBLCA23_(MYC) 1031 Elesclomol HSP70 4 10 -1.6094379124341 NA -3.56500824325627 -3.6879377822879 0.122929539031623 1.24315235310834 1.66174147166491 0.0784185351243626 0.098885336720196 0.0739763321357434 0.896744791562841 NA NA NA 0.883914917974965 86.2483027702754 a2227 RB1_mut 179 5-Fluorouracil DNA antimetabolite 6 13 3.46573590279973 NA 4.32015818191594 4.24106114370805 0.0790970382078857 1.27021574767067 1.19760549813748 0.0648649882084304 0.0622705539219886 0.0660459878740519 0.896981287549725 NA NA NA 0.900536462870216 86.2483027702754 a2228 gain_cnaBLCA15_(ASXL1) 1170 CCT018159 HSP90 6 13 2.30258509299405 NA 2.59346405908126 2.65365721996044 -0.0601931608791819 0.786150969926417 0.98349735349565 0.0647368819659297 0.0765669231252312 0.0612031752451972 0.897183513238499 NA NA NA 0.888698947734486 86.2483027702754 a2229 NRAS_mut 1012 Vorinostat HDAC inhibitor Class I, IIa, IIb, IV 3 11 2.30258509299405 NA 1.46630633377664 1.51542564955844 -0.0491193157817926 0.575044525264696 0.573014113898614 0.0856702842517565 0.0854182826263458 0.085720952748615 0.897535950270544 NA NA NA 0.903444142569903 86.2483027702754 a2230 loss_cnaBLCA5_(FAT1,IRF2) 276 CAY10603 HDAC6 5 14 2.99573227355399 NA 1.18926957727951 1.27209562964658 -0.0828260523670741 0.534806296780693 1.36514532873161 0.0677986914460201 0.154871124116623 0.0606719670234888 0.897987214342413 NA NA NA 0.851722866130528 86.2483027702754 a2231 gain_cnaBLCA9 1377 Afatinib (rescreen) ERBB2, EGFR 4 14 2.30258509299405 NA 3.42717761562139 3.32562011673815 0.101557498883233 1.32618666825949 1.38644963253981 0.0738411241185129 0.0765785852880866 0.0732500456559621 0.897997208352469 NA NA NA 0.898803669813489 86.2483027702754 a2232 RB1_mut 1023 GW 441756 NTRK1 5 9 0.693147180559945 NA 2.39767831070007 2.46661310777783 -0.0689347970777532 0.986904051055994 0.926179801719626 0.0728040383972887 0.0698495431283239 0.0744291734172596 0.898312723978161 NA NA NA 0.901349600036771 86.2483027702754 a2233 NRAS_mut 1043 JNK Inhibitor VIII JNK 3 11 2.30258509299405 NA 3.95699303703116 3.88503958357404 0.0719534534571236 0.887982962637701 0.84073670428433 0.0847714243815084 0.0810302184665684 0.0855838136844202 0.898604422669409 NA NA NA 0.907693001184357 86.2483027702754 a2234 gain_cnaBLCA15_(ASXL1) 1038 NU-7441 PRKDC (DNAPK) 4 11 0.693147180559945 NA 2.26126029419146 2.17727578678992 0.0839845074015337 1.11956827961727 1.12869897813529 0.0745469750151594 0.0750150829838128 0.0744082426124667 0.900358918858439 NA NA NA 0.902626182617338 86.2483027702754 a2235 TP53_mut 279 BIX02189 MAP2K5 (MEK5) 15 4 2.99573227355399 NA 4.67223927919483 4.75133890616042 -0.0790996269655855 0.853956167628396 1.87874441353868 0.0715127944354823 0.0926272681948779 0.0421023883800131 0.900366895467558 NA NA NA 0.939338568275709 86.2483027702754 a2236 TP53_mut 1009 ATRA Retinoic acid and retinoid X receptor agonist 10 4 2.30258509299405 NA 4.02875791091491 3.99572426313638 0.0330336477785256 0.50139790368754 0.142445983592275 0.075072089024622 0.0658830991026868 0.231902977854947 0.901125011553721 NA NA NA 0.852561684757967 86.2483027702754 a2237 EP300_mut 282 EKB-569 EGFR 4 15 0.916290731874155 2.99573227355399 2.00675189630971 1.89349131441017 0.113260581899539 1.21357148306823 1.66854611559631 0.0708898140720019 0.0933283152082527 0.0678798031656809 0.901229975480455 NA NA NA 0.883691531534182 86.2483027702754 a2238 gain_cnaBLCA15_(ASXL1) 171 AKT inhibitor VIII AKT1, AKT2, AKT3 6 13 0.940007258491471 NA 2.07510613766455 2.00819324174341 0.0669128959211323 1.19916613405624 1.03398626109455 0.0616605463166636 0.0557995210345007 0.0647135251587388 0.902041903576574 NA NA NA 0.908827638799786 86.2483027702754 a2239 NRAS_mut 1527 GDC0941 (rescreen) PI3K 3 16 1.38629436111989 NA 0.766347954747718 0.859360138239733 -0.0930121834920155 1.33222048758111 1.16454149646887 0.0784581859823987 0.0698174096248107 0.0798702182567536 0.902220252233768 NA NA NA 0.918086697199186 86.2483027702754 a2240 gain_cnaBLCA15_(ASXL1) 1032 Afatinib ERBB2, EGFR 4 10 -0.693147180559945 NA 0.447725611693581 0.56323657902367 -0.115510967330089 0.891897571805092 1.72228049625828 0.074198738378903 0.129511471924191 0.0670686148865074 0.902268720946253 NA NA NA 0.872714403625274 86.2483027702754 a2241 CDKN1A_mut 1375 Temozolomide DNA akylating agent 3 15 3.40119738166216 NA 5.26335376829079 5.31947202880818 -0.0561182605173913 1.26002836768472 0.593816166970399 0.0788134775343481 0.0445372992835929 0.0945044335921369 0.902380519831307 NA NA NA 0.946190942624989 86.2483027702754 a2242 RB1_mut 1049 PD-173074 FGFR1, FGFR3 5 10 0.693147180559945 NA 2.62957018895792 2.56709736721159 0.062472821746332 1.09939361294057 0.837661350469294 0.0674574862815546 0.0568247996086086 0.0745800456369773 0.903864172255655 NA NA NA 0.91434962129778 86.2483027702754 a2243 RB1_mut 1021 Axitinib PDGFR, KIT, VEGFR 5 9 0.693147180559945 NA 2.07155021667553 1.98604913640663 0.0855010802689 1.40500861316076 1.15549674024704 0.0687175507443627 0.0608544883412163 0.0739950856552135 0.903988307689901 NA NA NA 0.910868098517086 86.2483027702754 a2244 NRAS_mut 221 TAK-715 p38a 3 16 2.99573227355399 2.32630161961136 4.65112756209178 4.59000409121893 0.0611234708728512 1.08713930194271 0.748332311994571 0.0768157748494519 0.0562241386762709 0.0816795825773385 0.9042562771907 NA NA NA 0.932954943586666 86.2483027702754 a2245 CDKN1A_mut 1192 GSK269962A ROCK1, ROCK2 3 16 1.6094379124341 NA 1.88602411765579 1.81113879268251 0.0748853249732799 0.079251522378639 1.04177937228805 0.0764948691124392 0.944907084756066 0.0718821345145371 0.904654170577429 NA NA NA 0.780700669067266 86.2483027702754 a2246 MLL2_mut 224 AS605240 PI3Kgamma 3 16 2.99573227355399 2.32630161961136 3.24684914818924 3.35690941677305 -0.110060268583811 2.65345464607188 1.19571218167022 0.0761328966547771 0.0414781043070556 0.0920457868297986 0.905103014217878 NA NA NA 0.949789974927353 86.2483027702754 a2247 CDKN1A_mut 263 FR-180204 ERK 3 16 2.99573227355399 NA 5.081984184403 5.0301865166767 0.0517976677263032 0.508746319966546 0.70117750400116 0.076020423854566 0.101814333968469 0.073872403821754 0.905242486543658 NA NA NA 0.887700034115359 86.2483027702754 a2248 gain_cnaBLCA9 156 AZD6482 PI3Kbeta 4 15 1.63315443905142 NA 1.9237932874784 2.0200101700357 -0.0962168825573042 1.76412828265737 1.33265997502629 0.0678361832433617 0.0545407516580195 0.0721991238278212 0.905462311551344 NA NA NA 0.923989925603126 86.2483027702754 a2249 NRAS_mut 177 GSK-650394 SGK3 3 16 2.77258872223978 NA 3.07034003361939 2.90925018916953 0.161089844449867 2.99950964637121 1.98416613062448 0.0756680209607815 0.0537053930280746 0.0811876797832277 0.905679505715332 NA NA NA 0.935825712608084 86.2483027702754 a2250 ARID1A_mut 172 Embelin XIAP 5 14 3.46573590279973 NA 2.6899144985975 2.73775391819187 -0.047839419594371 0.59654744561573 0.810021657527413 0.0625213445695565 0.0801938218761346 0.0590594327322069 0.90588577747053 NA NA NA 0.892105283458712 86.2483027702754 a2251 CDKN1A_mut 202 GSK-1904529A IGF1R 3 16 0.0237165266173161 NA 2.0432186450969 2.08496622189869 -0.0417475768017908 0.549137248732959 0.555089678947654 0.0753032571208708 0.0760239391848143 0.0752087066020329 0.90613188665132 NA NA NA 0.912045897706621 86.2483027702754 a2252 CDKN1A_mut 281 CH5424802 ALK 3 16 1.63315443905142 NA 4.07226969761462 4.10000003398122 -0.0277303363665995 0.206196395908069 0.385761236653846 0.0751098530333046 0.134485068201497 0.071884714511849 0.90637176031958 NA NA NA 0.863229268141902 86.2483027702754 a2253 MLL2_mut 276 CAY10603 HDAC6 3 16 2.99573227355399 NA 1.32751159350865 1.23582199505773 0.0916895984509147 0.400571225729229 1.29239506447866 0.0750481313448035 0.228897116321813 0.0709454879324392 0.9064483139611 NA NA NA 0.82153669589248 86.2483027702754 a2254 loss_cnaBLCA5_(FAT1,IRF2) 265 Tubastatin A HDAC6 5 14 2.99573227355399 NA 4.79680786049497 4.85525253221175 -0.0584446717167824 1.01899080840554 0.924000404179314 0.0617020140545548 0.0573554454413903 0.0632517815494813 0.907112995743905 NA NA NA 0.913613884305096 86.2483027702754 a2255 MLL2_mut 204 Tipifarnib Farnesyl-transferase (FNTA) 3 16 2.77258872223978 NA 1.20860542218028 1.30513998606556 -0.0965345638852799 1.41583560210231 1.28643890473679 0.0741245306219915 0.0681820429871518 0.0750401465081867 0.9075939721734 NA NA NA 0.920251607011701 86.2483027702754 a2256 ARID1A_mut 1047 Nutlin-3a MDM2 5 10 2.07944154167984 1.38629436111989 3.67877142376431 3.75647639157901 -0.0777049678146975 1.14413772568402 1.22682954269668 0.0646468276665345 0.0679157465664736 0.0633380311692652 0.907849319836931 NA NA NA 0.906445080101446 86.2483027702754 a2257 NRAS_mut 175 PAC-1 CASP3 agonist 3 16 0.940007258491471 NA 2.6752750143461 2.60511250053593 0.0701625138101698 0.984190481867223 0.945866569908858 0.0738198850391082 0.071289567520564 0.0741780247259722 0.907971908536726 NA NA NA 0.917065298296297 86.2483027702754 a2258 EP300_mut 1498 AZD6244 MAP2K1 (MEK1), MAP2K2 (MEK2) 4 15 1.38629436111989 NA 1.30537381908663 1.38783349166739 -0.0824596725807549 1.71049686946346 1.12864086872975 0.0659075690369382 0.0482080230913374 0.0730610372753564 0.90813689101956 NA NA NA 0.931976157557104 86.2483027702754 a2259 loss_cnaBLCA5_(FAT1,IRF2) 253 XMD14-99 EPHB3, CAMK1 5 14 2.32630161961136 NA 4.74496700932943 4.71555453525909 0.0294124740703392 0.471371928862015 0.486777004353825 0.0608706313197005 0.0623975936397967 0.0604228914005151 0.908358513389458 NA NA NA 0.908686800454378 86.2483027702754 a2260 loss_cnaBLCA18_(CHD9,CNOT1,CYLD,MMP2,NUP93) 1031 Elesclomol HSP70 3 11 -1.6094379124341 NA -3.56050393498716 -3.67799081735842 0.117486882371251 0.19071374879205 1.7154195546789 0.0749330680323965 0.616037821685082 0.0684887158076279 0.910312356699257 NA NA NA 0.828318856220399 86.3562729138308 a2261 loss_cnaBLCA5_(FAT1,IRF2) 211 TL-2-105 CRAF 5 14 2.32630161961136 1.63315443905142 4.41723656885426 4.36620519162668 0.051031377227579 1.11090245622714 0.764380545384682 0.0594362094439215 0.0459368659611146 0.0667617426106743 0.910508036582138 NA NA NA 0.927728786268423 86.3562729138308 a2262 ARID1A_mut 1032 Afatinib ERBB2, EGFR 3 11 -0.693147180559945 NA 0.619980196717454 0.505757058805333 0.114223137912121 1.58267529364948 1.55178417983304 0.0733622047431095 0.0721709237330258 0.0736076185055646 0.912183844266219 NA NA NA 0.918133695773165 86.3562729138308 a2263 CDKN1A_mut 136 Mitomycin C DNA crosslinker 3 16 2.77258872223978 NA -1.31286449886125 -1.19871628727166 -0.114148211589592 1.15254314513592 1.69087935754718 0.0697402785611624 0.0990402936942806 0.0675081939347685 0.913035127611533 NA NA NA 0.892122564658284 86.3562729138308 a2264 loss_cnaBLCA18_(CHD9,CNOT1,CYLD,MMP2,NUP93) 255 CP724714 ERBB2 3 16 2.32630161961136 NA 4.34684457157654 4.27986425546336 0.0669803161131757 0.464650244341907 1.01025412267124 0.069607411840977 0.144152116411864 0.0663004630320844 0.913200095106742 NA NA NA 0.861334358396127 86.3562729138308 a2265 CDKN1A_mut 266 Zibotentan, ZD4054 Endothelin A Receptor 3 16 2.99573227355399 NA 5.48319065757571 5.4562369017718 0.0269537558039019 0.302563117438189 0.397544176853892 0.069543734205257 0.0890847372016793 0.0678006555578554 0.913279158789431 NA NA NA 0.900751700399633 86.3562729138308 a2266 RB1_mut 185 OSI-906 IGF1R 6 13 0.940007258491471 NA 2.32095161764786 2.25220978611785 0.0687418315300117 0.819265267461492 1.40545083349011 0.054486111775217 0.0839066835373229 0.048910876063382 0.913387550878299 NA NA NA 0.895230166480641 86.3562729138308 a2267 ARID1A_mut 1219 PFI-1 BRD2, BRD3, BRD4 5 14 2.30258509299405 NA 2.26552442766907 2.31856746802975 -0.0530430403606776 0.88522928863586 0.935625654639427 0.0574049557733404 0.0599201145303462 0.0566925886412546 0.913553147879616 NA NA NA 0.912795929040739 86.3562729138308 a2268 EP300_mut 157 JNK-9L JNK 4 15 1.63315443905142 NA -0.469353362064103 -0.407107981353807 -0.0622453807102959 0.978547002352235 1.01196770190006 0.0618648745853353 0.0636100060198133 0.0615092562671959 0.913746899799853 NA NA NA 0.915126708232669 86.3562729138308 a2269 loss_cnaBLCA18_(CHD9,CNOT1,CYLD,MMP2,NUP93) 1194 SB-505124 TGFR1 (ALK5) 3 16 2.30258509299405 NA 4.02081411779103 4.09314567239926 -0.0723315546082377 0.271973090915996 1.11174798113967 0.0689881378418745 0.265951143786422 0.0650611072251192 0.913969040199528 NA NA NA 0.823847563963336 86.3562729138308 a2270 RB1_mut 260 NG-25 MAP3K7 (TAK1) 6 13 2.32630161961136 NA 3.16013901502532 3.07874098041096 0.0813980346143679 1.57446871759487 1.47616328248839 0.05405838385134 0.0516987309463411 0.0551416198871671 0.914064593382898 NA NA NA 0.917222086335175 86.3562729138308 a2271 MLL2_mut 200 LAQ824 HDAC 3 16 0.0237165266173161 NA -2.69822203649417 -2.76866571571992 0.0704436792257486 0.498263624831032 1.0813855811056 0.0683878361213027 0.141378330095112 0.0651420552082148 0.914714511472519 NA NA NA 0.863870502451438 86.3562729138308 a2272 EP300_mut 182 Obatoclax Mesylate BCL2, BCL2L1, MCL1 4 15 2.77258872223978 NA -0.799265831317559 -0.883620408644973 0.0843545773274134 1.47785808394383 1.35877011817939 0.061102935937028 0.0570789429945152 0.0620815664098056 0.914804769261061 NA NA NA 0.922340860522383 86.3562729138308 a2273 loss_cnaBLCA5_(FAT1,IRF2) 151 QS11 ARFGAP 5 14 2.32630161961136 NA 2.98074727489407 3.07605086998389 -0.0953035950898209 0.76915816126474 1.88633424491643 0.0563520201989859 0.123906369183045 0.0505231749604606 0.915132182017885 NA NA NA 0.877818735238593 86.3562729138308 a2274 loss_cnaBLCA18_(CHD9,CNOT1,CYLD,MMP2,NUP93) 1149 TW 37 BCL2, BCL2L1 3 16 1.6094379124341 NA -0.484207733677374 -0.585722531773713 0.101514798096338 0.16600092868267 1.62287018635649 0.066545958152235 0.611531507094129 0.0625526298713082 0.91700231400982 NA NA NA 0.810642405326475 86.4409674204814 a2275 loss_cnaBLCA18_(CHD9,CNOT1,CYLD,MMP2,NUP93) 1248 FK866 NAMPT 3 16 0 NA -2.17050933688194 -1.97482663409477 -0.195682702787162 2.00058524964493 3.06697023224811 0.0660752975636495 0.097812728961134 0.0638032611890482 0.917587044118709 NA NA NA 0.894501824662518 86.4409674204814 a2276 gain_cnaBLCA23_(MYC) 292 Masitinib KIT 4 15 2.99573227355399 NA 4.22983534142136 4.28401356990194 -0.054178228480577 1.2411962909407 0.847219298764296 0.0583209843604754 0.0436500083637177 0.0639482936231483 0.918668590575593 NA NA NA 0.938554948551966 86.4409674204814 a2277 NRAS_mut 152 CP466722 ATM 3 16 2.77258872223978 NA 3.15652055576125 3.07527043941548 0.0812501163457711 0.637708173571184 1.32009323594889 0.0645274657441298 0.127409557714727 0.0615487710512872 0.919510350153926 NA NA NA 0.874879071534261 86.4409674204814 a2278 NRAS_mut 208 SB-715992 KIF11 3 16 -2.05572501506252 NA -1.08009234039812 -1.18274621257399 0.102653872175867 2.08380095555195 1.5151538721261 0.0644556983955004 0.049262801181832 0.0677514502416976 0.919599539432928 NA NA NA 0.941396470076494 86.4409674204814 a2279 gain_cnaBLCA9 329 QL-XI-92 DDR1 4 15 2.32630161961136 NA 4.20055891234913 4.25507173134727 -0.0545128189981448 1.18826626511238 0.886884981526958 0.0575597557611622 0.0458759291571653 0.0614654889118649 0.919726221714513 NA NA NA 0.935948787083467 86.4409674204814 a2280 EP300_mut 170 Shikonin unknown 4 15 2.77258872223978 NA -0.264373039255747 -0.178018040996982 -0.0863549982587651 1.22318432477357 1.56350053882767 0.0572254284658496 0.0705985161106042 0.0552318314667898 0.92019077639237 NA NA NA 0.910076394984395 86.4409674204814 a2281 EP300_mut 1199 Tamoxifen ER 4 15 1.6094379124341 NA 3.55707299280134 3.5231608405744 0.0339121522269403 0.217450387058205 0.646882792387226 0.0570814362769818 0.155953515124639 0.052423951643222 0.920390865671691 NA NA NA 0.867093145445717 86.4409674204814 a2282 loss_cnaBLCA5_(FAT1,IRF2) 273 CUDC-101 HDAC, EGFR 5 14 1.63315443905142 NA -0.112072002852398 -0.0344918804819657 -0.0775801223704325 0.70421374035173 1.63278792102522 0.0528430140934957 0.110165590253442 0.0475139002263812 0.920397059970179 NA NA NA 0.8871771507084 86.4409674204814 a2283 loss_cnaBLCA18_(CHD9,CNOT1,CYLD,MMP2,NUP93) 1010 Gefitinib EGFR 3 11 -0.693147180559945 NA 0.529550268899465 0.597048741158399 -0.0674984722589339 0.441118505812999 1.10902993607833 0.0656412649654009 0.153016641490775 0.0608626242296193 0.921390158797333 NA NA NA 0.875851552422922 86.4409674204814 a2284 CDKN1A_mut 265 Tubastatin A HDAC6 3 16 2.99573227355399 NA 4.7897088715433 4.84927800867559 -0.0595691371322822 0.94476922149181 0.947660589089596 0.0628816887686392 0.0630515217655178 0.0628591479039024 0.921555924041696 NA NA NA 0.926919454358246 86.4409674204814 a2285 loss_cnaBLCA5_(FAT1,IRF2) 1378 Bleomycin (50 uM) DNA damage 5 13 3.91202300542815 NA 0.792442943429275 0.877424231534679 -0.0849812881054043 1.42704329103916 1.6764127066655 0.0525328753631488 0.0595506027315552 0.0506923431011435 0.921721143592203 NA NA NA 0.916770584588228 86.4409674204814 a2286 EP300_mut 200 LAQ824 HDAC 4 15 0.0237165266173161 NA -2.71208723011357 -2.76966457603646 0.0575773459228901 0.407774530342754 1.11933277868313 0.0558937933797202 0.141198975508582 0.0514389884933315 0.922041403884065 NA NA NA 0.872920585713242 86.4409674204814 a2287 gain_cnaBLCA23_(MYC) 203 BMS-345541 IKBKB 4 15 2.77258872223978 NA 3.47520119125035 3.51995365386298 -0.0447524626126343 1.12926796076348 0.714852753104254 0.0556854071986986 0.0396296221690183 0.0626037493991544 0.922331048576117 NA NA NA 0.943876006806047 86.4409674204814 a2288 ARID1A_mut 1495 AZD-2281 PARP1, PARP2 3 14 2.30258509299405 NA 3.26981104841083 3.31588810462982 -0.0460770562189903 0.358118169491604 0.776595343518913 0.0627153150429082 0.128664391098622 0.0593321304377202 0.922779723165375 NA NA NA 0.879482813115037 86.4409674204814 a2289 gain_cnaBLCA9 134 Etoposide TOP2 4 15 2.77258872223978 NA 1.22625642532624 1.1421464807672 0.0841099445590436 1.02200257197211 1.61852582766642 0.0549648914819583 0.0822991515537387 0.0519670079533504 0.923332609881361 NA NA NA 0.901907909087543 86.4409674204814 a2290 EP300_mut 185 OSI-906 IGF1R 4 15 0.940007258491471 NA 2.32864654022909 2.25932338430019 0.069323155928898 0.389698149895764 1.37861503406896 0.05494259340885 0.17788936372277 0.0502846365488208 0.923363607702396 NA NA NA 0.866412900020593 86.4409674204814 a2291 gain_cnaBLCA23_(MYC) 305 TPCA-1 IKK 4 15 2.99573227355399 NA 3.4926881322136 3.5792232088499 -0.0865350766363004 1.82264979379744 1.52433971976235 0.0547317006502538 0.0474776212801732 0.0567688918122475 0.923656788002998 NA NA NA 0.93454039879472 86.4409674204814 a2292 MLL2_mut 133 Doxorubicin DNA intercalating 3 16 0.0237165266173161 NA -1.98556961748584 -2.09261054609056 0.107040928604718 2.25048317654327 1.69902497740612 0.0603786246716598 0.0475635320096603 0.0630013861056567 0.924668119906194 NA NA NA 0.943534329218893 86.4409674204814 a2293 ARID1A_mut 150 Bicalutamide ANDR (androgen receptor) 5 14 0.0237165266173161 NA 2.38542110036125 2.36022542861985 0.0251956717413995 0.680598544031886 0.435499853253845 0.0499904449732141 0.037019873113656 0.0578546044347652 0.924679843443449 NA NA NA 0.94124625450475 86.4409674204814 a2294 gain_cnaBLCA23_(MYC) 1026 17-AAG HSP90 3 12 0 NA -1.48677364306684 -1.59373638018492 0.10696273711808 0.570073797561309 1.87565936223313 0.0614804554382768 0.187629632471534 0.0570267391146823 0.925572643807449 NA NA NA 0.868812251830713 86.4409674204814 a2295 ARID1A_mut 1378 Bleomycin (50 uM) DNA damage 5 13 3.91202300542815 NA 0.911944861044305 0.831461955528898 0.0804829055154067 2.21960095433321 1.35911427087812 0.0497505137686809 0.0362600788030317 0.0592171734488571 0.925853650891575 NA NA NA 0.942409211287587 86.4409674204814 a2296 TP53_mut 1060 PD-0325901 MAP2K1 (MEK1), MAP2K2 (MEK2) 11 4 -1.38629436111989 0.693147180559945 -1.10524249730286 -1.02323705630774 -0.0820054409951192 1.51237238895082 1.37021779923492 0.0553799236389226 0.054223048234839 0.0598484715648185 0.925881125623185 NA NA NA 0.923926832901564 86.4409674204814 a2297 EP300_mut 163 JQ1 BRD4 4 15 0.940007258491471 NA -0.192301841994185 -0.266689323058537 0.0743874810643524 1.36519965248323 1.40835304343214 0.0531022683821259 0.0544883533547972 0.0528187739652773 0.92592238099685 NA NA NA 0.927216559065292 86.4409674204814 a2298 gain_cnaBLCA23_(MYC) 159 HG-6-64-1 BRAFV600E, TAK, MAP4K5 4 15 1.63315443905142 NA 0.278582057520725 0.340350482886831 -0.0617684253661068 1.13224034552701 1.17320238919419 0.0529710761334791 0.0545541638841321 0.0526494200276323 0.926104821910661 NA NA NA 0.92718675784858 86.4409674204814 a2299 TP53_mut 252 WZ3105 CLK2, CNSK1E, FLT3, ULK1 15 4 0.246860077931526 2.32630161961136 0.688933635552323 0.603545530665979 0.0853881048863442 1.63747775097998 1.66088010293262 0.0520141628946725 0.052146116083252 0.0514113599985779 0.92743566923734 NA NA NA 0.930775803670357 86.5097452005237 a2300 ARID1A_mut 197 Bryostatin 1 PRKC 5 14 -4.8283137373023 NA -3.06895947061045 -3.10958304270488 0.0406235720944301 0.70289030173666 0.887191079714039 0.0479368203066766 0.0577950385630016 0.0457889771699734 0.92776459192505 NA NA NA 0.92009924794988 86.5097452005237 a2301 RB1_mut 1024 CEP-701 FLT3, JAK2, NTRK1, RET 5 9 0.693147180559945 NA -0.129572733606078 -0.200370489227831 0.0707977556217535 1.51335375906 1.30907618356929 0.05128297528534 0.0467820264745823 0.0540822272304416 0.928260924289186 NA NA NA 0.93228031729586 86.5097452005237 a2302 gain_cnaBLCA23_(MYC) 1057 NVP-BEZ235 PI3K (Class 1) and MTORC1/2 3 12 -1.38629436111989 0.693147180559945 -2.46041138091957 -2.53594907360921 0.0755376926896356 1.70945180804145 1.20344122817539 0.0583649375015598 0.0441882551671232 0.062768077843039 0.929332898401794 NA NA NA 0.947784751254338 86.5097452005237 a2303 gain_cnaBLCA9 292 Masitinib KIT 4 15 2.99573227355399 NA 4.23547911539774 4.28250856350823 -0.0470294481104947 1.2891610389574 0.831827097445498 0.0506216284731132 0.0364806619881481 0.0565375283576598 0.929372760355038 NA NA NA 0.948398018352713 86.5097452005237 a2304 TP53_mut 276 CAY10603 HDAC6 15 4 2.99573227355399 NA 1.23736392174243 1.29880696882831 -0.0614430470858753 1.06677370331902 1.77505123244703 0.0502820346919096 0.0575970769570995 0.0346148020759784 0.929845223473763 NA NA NA 0.95079068224246 86.5097452005237 a2305 RB1_mut 275 I-BET BRD2, BRD3, BRD4 6 13 2.99573227355399 NA 4.60608834458798 4.65604127959501 -0.0499529350070231 1.49201132227532 0.956699028248266 0.0437979842629369 0.033480265371475 0.0522138452450275 0.930324747791421 NA NA NA 0.942178640297986 86.5097452005237 a2306 gain_cnaBLCA9 165 DMOG Prolyl-4-Hydroxylase 4 15 8.29404964010203 NA 5.77949314674792 5.73014715179146 0.0493459949564636 0.981708930616815 1.00063961102205 0.0494783488629445 0.0502654029290119 0.0493144528888496 0.930963466209849 NA NA NA 0.932695762899457 86.5097452005237 a2307 gain_cnaBLCA23_(MYC) 282 EKB-569 EGFR 4 15 0.916290731874155 2.99573227355399 1.8558447171864 1.93373322884306 -0.0778885116566603 1.38772488880521 1.63966293766395 0.0487384414413297 0.0561267671171624 0.0475027579556255 0.931993099581049 NA NA NA 0.927062624297536 86.5097452005237 a2308 MLL2_mut 1175 AG-014699 PARP1, PARP2 3 16 1.6094379124341 NA 3.17538530987186 3.127258770612 0.0481265392598655 1.16035962133815 0.841963831503283 0.0543566172892342 0.041475537734039 0.0571598653756161 0.932160663320826 NA NA NA 0.950632230729374 86.5097452005237 a2309 EP300_mut 1009 ATRA Retinoic acid and retinoid X receptor agonist 3 11 2.30258509299405 NA 3.99979607362042 4.02464435825758 -0.0248482846371534 0.400280254282195 0.447737101456011 0.0564498864115416 0.0620772180774011 0.0554974884957008 0.932365215354684 NA NA NA 0.931073903965694 86.5097452005237 a2310 gain_cnaBLCA23_(MYC) 179 5-Fluorouracil DNA antimetabolite 4 15 3.46573590279973 NA 4.31205682340514 4.25376777773865 0.0582890456664904 1.85750080247688 1.03310815050391 0.0477868760863542 0.031380360960687 0.0564210490818983 0.933317452069541 NA NA NA 0.955173785757897 86.5097452005237 a2311 gain_cnaBLCA15_(ASXL1) 1239 YK 4-279 RNA helicase A 5 12 2.30258509299405 NA 1.26741864618548 1.22161624480639 0.0458024013790888 1.10416156483691 0.979531254607278 0.0451582413896299 0.0414816117837376 0.0467595098815425 0.933512499612236 NA NA NA 0.938167105981443 86.5097452005237 a2312 loss_cnaBLCA5_(FAT1,IRF2) 309 Y-39983 ROCK 5 14 2.99573227355399 NA 4.40784695836894 4.33912742695042 0.068719531418524 1.18143617440777 1.65959015191357 0.0440418919199106 0.0581660972527542 0.0414075314554547 0.933618373443793 NA NA NA 0.922602232810853 86.5097452005237 a2313 gain_cnaBLCA15_(ASXL1) 1028 VX-702 p38 4 10 0.693147180559945 NA 2.87376173104589 2.9114652547979 -0.0377035237520071 1.3010177012336 0.439414464123684 0.0500284576126639 0.0289800236509137 0.0858040115434037 0.93400281867508 NA NA NA 0.958080138606574 86.5097452005237 a2314 EP300_mut 136 Mitomycin C DNA crosslinker 4 15 2.77258872223978 NA -1.27777375052715 -1.20046393938811 -0.0773098111390356 1.89333744951313 1.57667529120667 0.0472261161173293 0.0408325579568056 0.0490334386352108 0.934097990994448 NA NA NA 0.943649949954071 86.5097452005237 a2315 MLL2_mut 180 Thapsigargin sarco-endoplasmic reticulum Ca2+-ATPases 3 16 -0.669430653942629 NA -4.43862552968284 -4.34862681976636 -0.0899987099164807 1.77310673796649 1.70492199468931 0.0525360569799807 0.0507576379861356 0.0527875821866449 0.934427117363801 NA NA NA 0.940868229064428 86.5097452005237 a2316 ARID1A_mut 1062 AZD6244 MAP2K1 (MEK1), MAP2K2 (MEK2) 5 9 1.38629436111989 0.693147180559945 1.99650804224112 2.07394507210767 -0.0774370298665477 1.49074486319245 1.7319678390171 0.0467764545828141 0.051945193157141 0.0447104317540292 0.934548277879609 NA NA NA 0.931842703276275 86.5097452005237 a2317 CDKN1A_mut 203 BMS-345541 IKBKB 3 16 2.77258872223978 NA 3.47546201310935 3.51710772085113 -0.0416457077417816 0.662733821317739 0.820709107640765 0.0518150933785974 0.0628392672928263 0.0507435671836243 0.935324821549878 NA NA NA 0.929149572704785 86.5097452005237 a2318 MLL2_mut 255 CP724714 ERBB2 3 16 2.32630161961136 NA 4.33220826588123 4.28260856278123 0.0495997030999993 0.308231944930732 1.01836815947193 0.0515367189678814 0.160916815780226 0.0487050804158283 0.935671462105339 NA NA NA 0.87580988245459 86.5097452005237 a2319 gain_cnaBLCA23_(MYC) 1029 AMG-706 VEGFR, RET, c-KIT, PDGFR 3 12 0.693147180559945 NA 2.58290243803751 2.62450301228492 -0.0416005742474082 1.10252193440028 0.717136498848006 0.0527404638264635 0.0377321964755622 0.0580092831897895 0.936125730970958 NA NA NA 0.955170401692738 86.5097452005237 a2320 RB1_mut 269 NSC-207895 MDM4 6 13 2.99573227355399 NA 3.64094329383361 3.5875911678415 0.0533521259921148 1.64637984854795 1.17439159667002 0.0400931334354885 0.0324057209757332 0.0454295876634287 0.936204199897183 NA NA NA 0.944933423422594 86.5097452005237 a2321 gain_cnaBLCA15_(ASXL1) 1236 UNC0638 G9a(EHMT2), GLP(EHMT1) 6 13 2.99573227355399 NA 3.59626394011744 3.6481170971235 -0.0518531570060596 1.63701912406798 1.12927382008505 0.0399063068756303 0.0316753520125074 0.0459172576958831 0.936500789729553 NA NA NA 0.945878403537562 86.5097452005237 a2322 gain_cnaBLCA23_(MYC) 1149 TW 37 BCL2, BCL2L1 4 15 1.6094379124341 NA -0.624480686034726 -0.555084064351508 -0.0693966216832181 1.04682201687878 1.60988119542523 0.045485318449695 0.0662926653855948 0.0431066726416963 0.936521496940341 NA NA NA 0.920082871071727 86.5097452005237 a2323 loss_cnaBLCA18_(CHD9,CNOT1,CYLD,MMP2,NUP93) 282 EKB-569 EGFR 3 16 0.916290731874155 2.99573227355399 1.8494875275153 1.93005716992785 -0.0805696424125524 1.39041796617214 1.62383288958915 0.0504145474642245 0.0579463473378173 0.0496169543855817 0.937068959407818 NA NA NA 0.93406442611991 86.5230539140238 a2324 gain_cnaBLCA23_(MYC) 1001 AICAR AAPK1 (AMPK) agonist 4 10 7.60090245954208 NA 7.9920856448983 7.96107748229928 0.0310081625990142 0.958138167745516 0.526890872522297 0.0468682769948828 0.0323629343270772 0.0588512047107097 0.938161951403592 NA NA NA 0.954369411444703 86.5401918962643 a2325 NRAS_mut 170 Shikonin unknown 3 16 2.77258872223978 NA -0.259022475757142 -0.184418459044143 -0.0746040167129987 1.38544687179103 1.52496069542206 0.049432271637275 0.0538483418108663 0.0489219275860423 0.938292411189205 NA NA NA 0.938220136764442 86.5401918962643 a2326 NRAS_mut 286 KIN001-236 TIE2 3 16 2.32630161961136 NA 4.29449295491842 4.33608312114054 -0.0415901662221119 1.24837979378419 0.773942505202115 0.0492937388228098 0.0333153151222035 0.0537380566935661 0.93846497050542 NA NA NA 0.960032706437983 86.5401918962643 a2327 loss_cnaBLCA18_(CHD9,CNOT1,CYLD,MMP2,NUP93) 1259 BMN-673 PARP1 3 15 2.30258509299405 NA 1.83325364824007 1.91410869774217 -0.0808550495021019 0.456190346662376 1.76721013242649 0.0486807829718275 0.17723972042298 0.0457529345370393 0.939600857437827 NA NA NA 0.880218590677334 86.5417233164748 a2328 loss_cnaBLCA5_(FAT1,IRF2) 288 KIN001-055 JAK3, MNK1 5 14 2.32630161961136 NA 4.10533648043489 4.13883492863341 -0.033498448198519 0.925537351801089 0.816954172544453 0.0397013362961131 0.0361935130260613 0.041004072595879 0.940146498022406 NA NA NA 0.945124646503862 86.5417233164748 a2329 gain_cnaBLCA9 163 JQ1 BRD4 4 15 0.940007258491471 NA -0.298327201828215 -0.238415893769463 -0.0599113080587522 1.13512832881234 1.45160789667959 0.0427643685098112 0.05277932594761 0.0412723767870051 0.940310828294829 NA NA NA 0.932701208292997 86.5417233164748 a2330 EP300_mut 1037 BX-795 TBK1, PDPK1, IKK, AURKB, AURKC 4 11 1.6094379124341 NA 1.90627918711412 1.96216112104463 -0.0558819339305021 0.879454754542212 1.34801429106039 0.0445095914586732 0.0635415678201555 0.0414550011087373 0.940395643685147 NA NA NA 0.927817977461869 86.5417233164748 a2331 gain_cnaBLCA15_(ASXL1) 262 VX-11e ERK 6 13 1.63315443905142 NA 2.80962599810451 2.86500377059327 -0.0553777724887614 1.83305417838741 1.31919455531692 0.0371948665740454 0.0302106577872559 0.041978472595695 0.940806298909519 NA NA NA 0.948733770221894 86.5417233164748 a2332 gain_cnaBLCA15_(ASXL1) 159 HG-6-64-1 BRAFV600E, TAK, MAP4K5 6 13 1.63315443905142 NA 0.356726177514044 0.313786800638547 0.0429393768754972 1.73318778508593 0.821600985163896 0.0368201819349314 0.0247747977714765 0.0522630542695022 0.941401413961412 NA NA NA 0.955793148218646 86.5417233164748 a2333 RB1_mut 1529 MLN4924 NEDD8-activating enzyme 5 11 0 NA -0.187073842194923 -0.252591863815563 0.06551802162064 2.19437757314053 1.37447155813264 0.0396881686145471 0.029857223489061 0.0476677900193534 0.942382545628105 NA NA NA 0.953137537002394 86.5417233164748 a2334 CDKN1A_mut 257 NPK76-II-72-1 PLK3 3 16 2.32630161961136 NA 3.40358931643042 3.46745643634619 -0.0638671199157725 1.11822025890405 1.42531078061073 0.0458584423224375 0.0571149730182562 0.0448092589943131 0.942745031867947 NA NA NA 0.935886481469446 86.5417233164748 a2335 gain_cnaBLCA23_(MYC) 291 KIN001-266 MAP3K8 (COT) 4 15 2.99573227355399 NA 3.61774786865029 3.66551599030838 -0.0477681216580943 1.53834868157259 1.07077328001995 0.0409331051632617 0.0310515569261339 0.0446108644560166 0.942861973092456 NA NA NA 0.956330752156819 86.5417233164748 a2336 NRAS_mut 344 THZ-2-49 CDK9 3 16 2.99573227355399 NA 4.17134050665664 4.26265483663988 -0.0913143299832369 2.18004192860894 1.97019043992155 0.0457481053428971 0.0418865017158195 0.046347971309247 0.942882532138232 NA NA NA 0.950900755440532 86.5417233164748 a2337 CDKN1A_mut 163 JQ1 BRD4 3 16 0.940007258491471 NA -0.304146901014619 -0.241069156925684 -0.0630777440889352 0.84354997442114 1.45931481127886 0.0450236877542294 0.0747765348842792 0.0432242197512253 0.94378533623897 NA NA NA 0.921736370793579 86.5417233164748 a2338 gain_cnaBLCA15_(ASXL1) 1050 ZM-447439 AURKB 4 11 1.38629436111989 0.693147180559945 2.16561775556112 2.22093502353465 -0.0553172679735279 1.12216850815283 1.38519396073485 0.0416193507905479 0.0492949744816703 0.0399346730794163 0.944258768862925 NA NA NA 0.93929691782912 86.5417233164748 a2339 NRAS_mut 1371 PLX4720 (rescreen) BRAF 3 15 2.30258509299405 NA 3.89361817217027 3.93557213308854 -0.0419539609182782 0.746926208560258 0.961840400785888 0.0447425962799469 0.0561688161928965 0.043618422436819 0.944478004204255 NA NA NA 0.937419947460091 86.5417233164748 a2340 EP300_mut 166 FTI-277 Farnesyl transferase (FNTA) 4 15 0.0237165266173161 NA 1.48542329717457 1.51712384942829 -0.0317005522537224 0.697053969080194 0.837901317055638 0.0389051211110272 0.0454779022283644 0.0378332765547108 0.945687915583376 NA NA NA 0.941098239288385 86.5417233164748 a2341 NRAS_mut 294 MPS-1-IN-1 MPS1 3 16 2.99573227355399 NA 4.3274515007644 4.37914204519858 -0.0516905444341775 1.45140023269077 1.15745029786372 0.0432271445081383 0.035614259437142 0.0446589754476555 0.946024612102916 NA NA NA 0.957840245976779 86.5417233164748 a2342 NRAS_mut 1066 AZD6482 PI3Kbeta 3 15 1.6094379124341 NA 2.04958816021278 2.00168431646586 0.0479038437469161 0.622005616119397 1.15712787319823 0.0433712012976868 0.0770151305799798 0.0413989195632396 0.94617691931179 NA NA NA 0.922050875791077 86.5417233164748 a2343 RB1_mut 1375 Temozolomide DNA akylating agent 6 12 3.40119738166216 NA 5.29405350430389 5.31815172593097 -0.024098221627086 0.807448347915493 0.664535108514035 0.0338323964948215 0.0298449079613549 0.036263278370607 0.946890844941277 NA NA NA 0.951077774961486 86.5417233164748 a2344 gain_cnaBLCA15_(ASXL1) 1259 BMN-673 PARP1 6 12 2.30258509299405 NA 1.93806499284759 1.88191678781394 0.0561482050336481 1.99980583973371 1.48159247174309 0.0338039864076533 0.0280768282190459 0.0378971991991765 0.946935370138814 NA NA NA 0.952944504259429 86.5417233164748 a2345 gain_cnaBLCA23_(MYC) 275 I-BET BRD2, BRD3, BRD4 4 15 2.99573227355399 NA 4.60613140830043 4.64936940460408 -0.0432379963036524 1.17336959145684 1.13350646815478 0.037906707078351 0.0368494263175583 0.0381453458964722 0.947079455528226 NA NA NA 0.950177695172966 86.5417233164748 a2346 gain_cnaBLCA15_(ASXL1) 1194 SB-505124 TGFR1 (ALK5) 6 13 2.30258509299405 NA 4.05792227064324 4.09271072983861 -0.0347884591953695 1.25526763455639 0.949449714746032 0.0331730945643894 0.0277139776711154 0.0366406547446013 0.947195925193349 NA NA NA 0.953378284740484 86.5417233164748 a2347 TP53_mut 1016 Temsirolimus MTOR 10 4 -1.6094379124341 NA -2.67876726046319 -2.62001308809972 -0.0587541723634728 1.37592065499971 1.73808923060165 0.0398380820664579 0.0427017155022543 0.0338038872395146 0.947421083337149 NA NA NA 0.954333448553333 86.5417233164748 a2348 loss_cnaBLCA18_(CHD9,CNOT1,CYLD,MMP2,NUP93) 1057 NVP-BEZ235 PI3K (Class 1) and MTORC1/2 3 12 -1.38629436111989 0.693147180559945 -2.56520684826897 -2.50975020677186 -0.0554566414971118 0.418029883900087 1.39584594409771 0.0428429066424203 0.132661906798908 0.0397297722801061 0.948091590027509 NA NA NA 0.907983974657636 86.5417233164748 a2349 NRAS_mut 1268 XAV 939 TNKS1 (tankyrase-1) 3 15 1.6094379124341 NA 3.23237494940902 3.20040459556363 0.0319703538453906 1.0123732966131 0.730204099883667 0.0414584261371373 0.0315796099643753 0.0437827640936061 0.948546954741453 NA NA NA 0.962450352466766 86.5417233164748 a2350 EP300_mut 300 CX-5461 RNA Pol I 4 15 2.32630161961136 NA 4.08327343844219 4.03523392908488 0.0480395093573085 0.895757636550775 1.39967346056108 0.036263086011202 0.0536300304871422 0.0343219405889508 0.949370634343961 NA NA NA 0.935659888788281 86.5417233164748 a2351 EP300_mut 156 AZD6482 PI3Kbeta 4 15 1.63315443905142 NA 2.03946958632234 1.98916315701065 0.0503064293116899 1.51148394963116 1.39815424590511 0.03545673810386 0.0332828074846352 0.0359806004659546 0.950494837331295 NA NA NA 0.954692409017647 86.5417233164748 a2352 CDKN1A_mut 274 PXD101, Belinostat HDAC 3 16 2.99573227355399 NA 0.403441616174342 0.461000218806263 -0.057558602631921 1.49155122220758 1.44793311524236 0.039610013622909 0.0385897592888102 0.0397522523837619 0.950534524793407 NA NA NA 0.955057551597257 86.5417233164748 a2353 CDKN1A_mut 310 YM201636 FYV1 3 16 1.63315443905142 NA 2.83659291285888 2.78840823334198 0.0481846795169036 0.500462782280981 1.29025467447528 0.0393640251869769 0.0962802454506012 0.0373450919962753 0.950841292739394 NA NA NA 0.914029537577765 86.5417233164748 a2354 loss_cnaBLCA5_(FAT1,IRF2) 222 BX-912 PDPK1 (PDK1) 5 14 2.32630161961136 NA 3.26749615308919 3.31688657631706 -0.0493904232278721 1.60636989180325 1.50792193627534 0.0322464298499627 0.0307466066687968 0.0327539655997508 0.951368529921859 NA NA NA 0.953933560779445 86.5417233164748 a2355 MLL2_mut 273 CUDC-101 HDAC, EGFR 3 16 1.63315443905142 NA -0.102955726412675 -0.0458986976107179 -0.0570570288019566 0.43164021066589 1.55526941279795 0.0388564947328992 0.132186546554444 0.0366862669145599 0.951474250284497 NA NA NA 0.903538915983931 86.5417233164748 a2356 loss_cnaBLCA18_(CHD9,CNOT1,CYLD,MMP2,NUP93) 231 FMK RSK 3 11 2.99573227355399 2.32630161961136 5.2756510717476 5.25791247341374 0.0177385983338594 0.348504405763061 0.457847642328255 0.0401772675235854 0.0508992082754885 0.0387434523931471 0.951829878175479 NA NA NA 0.945423885521306 86.5417233164748 a2357 loss_cnaBLCA5_(FAT1,IRF2) 257 NPK76-II-72-1 PLK3 5 14 2.32630161961136 NA 3.49012034505018 3.4456763718271 0.044443973223073 1.3809620943024 1.39637711892674 0.0319105953580741 0.0321833404453611 0.0318280589252514 0.951874334767671 NA NA NA 0.952571694866635 86.5417233164748 a2358 gain_cnaBLCA23_(MYC) 281 CH5424802 ALK 4 15 1.63315443905142 NA 4.08565855763462 4.09827836040032 -0.0126198027657036 0.552141375833058 0.316687016143258 0.0341711397767266 0.022856107725423 0.0398494479483014 0.952287428161402 NA NA NA 0.967396100183323 86.5417233164748 a2359 gain_cnaBLCA15_(ASXL1) 1495 AZD-2281 PARP1, PARP2 5 12 2.30258509299405 NA 3.29121604971834 3.31464886345485 -0.0234328137365152 0.524114714080473 0.79779946650391 0.0318878063158881 0.0447093224192849 0.0293718092332171 0.953020762149789 NA NA NA 0.944371492597234 86.5417233164748 a2360 TP53_mut 1375 Temozolomide DNA akylating agent 14 4 3.40119738166216 NA 5.3154869244683 5.2913311986097 0.024155725858602 0.69482965549265 0.783539086951184 0.0339120686446983 0.0347649609766225 0.0308289991665814 0.953043515084714 NA NA NA 0.957982862635624 86.5417233164748 a2361 gain_cnaBLCA15_(ASXL1) 238 CAL-101 PI3Kdelta 6 13 2.99573227355399 2.32630161961136 4.84394165182788 4.81804350884663 0.025898142981247 1.10574871068701 0.77961991458263 0.0291625745206375 0.0234213639418638 0.0332189346331816 0.953571365226697 NA NA NA 0.960105085593279 86.5417233164748 a2362 CDKN1A_mut 329 QL-XI-92 DDR1 3 16 2.32630161961136 NA 4.27313746323412 4.23805620186895 0.035081261365165 0.738797057055765 0.971681449160395 0.0370344719090187 0.0474843003638508 0.0361036648332412 0.953746825474732 NA NA NA 0.94696170014692 86.5417233164748 a2363 MLL2_mut 301 PHA-793887 CDK-pan 3 16 2.32630161961136 NA 3.27793063354372 3.2273025659729 0.0506280675708215 0.990364356733814 1.42399953733909 0.0366850433138526 0.0511206478974981 0.0355534297893283 0.954182708754771 NA NA NA 0.943895693132813 86.5417233164748 a2364 EP300_mut 1042 BIRB 0796 p38, JNK2 4 11 2.30258509299405 NA 4.01247309300436 3.97955096620116 0.0329221268032014 0.461108959020539 1.0704227947865 0.034130308516679 0.0713977166549369 0.030756189949942 0.954275277503455 NA NA NA 0.935193910894465 86.5417233164748 a2365 RB1_mut 1033 Vismodegib SMO 5 9 2.30258509299405 NA 4.48642612103057 4.51208338328612 -0.0256572622555504 0.948404561157779 0.722353639062332 0.0318806926749911 0.027053077669965 0.0355189769499264 0.955360785754617 NA NA NA 0.959590986772081 86.5417233164748 a2366 MLL2_mut 172 Embelin XIAP 3 16 3.46573590279973 NA 2.74818262237092 2.72084871753505 0.0273339048358681 0.514686277868115 0.792883842170726 0.0357109463256014 0.0531078950639368 0.0344740343819271 0.95539789265133 NA NA NA 0.942619060949466 86.5417233164748 a2367 RB1_mut 211 TL-2-105 CRAF 6 13 2.32630161961136 1.63315443905142 4.39586019143316 4.37214572141891 0.0237144700142577 0.649493585542804 0.932295654170219 0.0276122014109545 0.0365122466828348 0.0254366411644003 0.956036854039275 NA NA NA 0.94986242737679 86.5417233164748 a2368 loss_cnaBLCA18_(CHD9,CNOT1,CYLD,MMP2,NUP93) 155 AP-24534 ABL 3 16 -0.669430653942629 NA 0.241826640108301 0.205710400577032 0.0361162395312687 0.140043283479868 1.0940272479313 0.0351058357409957 0.257893407194073 0.033012193800073 0.956152823927829 NA NA NA 0.900737535825965 86.5417233164748 a2369 loss_cnaBLCA5_(FAT1,IRF2) 1047 Nutlin-3a MDM2 3 12 2.07944154167984 1.38629436111989 3.69593115721722 3.73923563024667 -0.0433044730294432 1.33957302341392 1.17585232222128 0.0360122790445976 0.0323270715911262 0.0368281562327807 0.95635745175383 NA NA NA 0.962516186784647 86.5417233164748 a2370 loss_cnaBLCA18_(CHD9,CNOT1,CYLD,MMP2,NUP93) 1014 RDEA119 MAP2K1 (MEK1), MAP2K2 (MEK2) 3 12 1.6094379124341 NA 1.04889255445814 1.09540780964973 -0.0465152551915966 1.04707662419888 1.34720254995039 0.0356294604719924 0.044423926689401 0.0345272915296289 0.956820871967645 NA NA NA 0.951602751404828 86.5417233164748 a2371 EP300_mut 192 LFM-A13 BTK 4 15 2.77258872223978 NA 4.37281783438806 4.39348424854535 -0.0206664141572963 0.835283907281307 0.632394085885313 0.0307234287942911 0.024741784173194 0.0326796448900445 0.957096061477854 NA NA NA 0.965467684864589 86.5417233164748 a2372 MLL2_mut 225 Genentech Cpd 10 AURKA, AURKB 3 16 2.32630161961136 NA 3.06654017399508 3.01288242811149 0.0536577458835894 1.26897023218703 1.62125481317525 0.0338773707282923 0.0422844795902832 0.033096429659012 0.957685578505689 NA NA NA 0.952518402649461 86.5417233164748 a2373 EP300_mut 253 XMD14-99 EPHB3, CAMK1 4 15 2.32630161961136 NA 4.71184964527604 4.72634666394469 -0.0144970186686555 0.285645212941771 0.515951548564029 0.0299927945220813 0.0507518348350922 0.0280976357353765 0.958115325707892 NA NA NA 0.942449177493715 86.5417233164748 a2374 CDKN1A_mut 249 XL-184 VEGFR, MET, RET, KIT, FLT1, FLT3, FLT4, Tie2,AXL 3 16 1.63315443905142 NA 3.09556705768371 3.06278691527356 0.0327801424101479 1.00637666917041 0.984267694802591 0.0332154488552693 0.0325724387442028 0.0333040925586026 0.958511528893795 NA NA NA 0.962084525055411 86.5417233164748 a2375 ARID1A_mut 1038 NU-7441 PRKDC (DNAPK) 5 10 0.693147180559945 NA 2.22148180686302 2.18876657971398 0.0327152271490387 1.16358151412543 1.11062283908196 0.0290238863026751 0.0281159736141288 0.0294566490061388 0.958545418243961 NA NA NA 0.959756931591632 86.5417233164748 a2376 gain_cnaBLCA23_(MYC) 225 Genentech Cpd 10 AURKA, AURKB 4 15 2.32630161961136 NA 2.98433455867002 3.03122674247261 -0.0468921838025871 1.72899322404501 1.55102858871765 0.0296057489163439 0.0271210917142185 0.0302329590464586 0.958655300284571 NA NA NA 0.962908464919772 86.5417233164748 a2377 MLL2_mut 300 CX-5461 RNA Pol I 3 16 2.32630161961136 NA 4.08174493368748 4.03852299306122 0.0432219406262639 1.09706818256562 1.35227702913341 0.0326250936615558 0.0393976794816749 0.0319623418094755 0.959248218922054 NA NA NA 0.955492726855249 86.558818020815 a2378 loss_cnaBLCA18_(CHD9,CNOT1,CYLD,MMP2,NUP93) 1012 Vorinostat HDAC inhibitor Class I, IIa, IIb, IV 3 11 2.30258509299405 NA 1.48980785170338 1.50901614466933 -0.0192082929659501 0.686533800359447 0.548357935005741 0.0334812490323509 0.027978655902875 0.0350287499090334 0.959849578828143 NA NA NA 0.967382920869781 86.5766597346179 a2379 gain_cnaBLCA23_(MYC) 312 AV-951 VEGFR 4 15 -2.05572501506252 NA 0.400682900727278 0.411527776094634 -0.0108448753673557 0.55038232360341 0.342326246512577 0.0280047319952362 0.0197042581170724 0.0316799412193398 0.960889125751993 NA NA NA 0.97203465686173 86.6120664075338 a2380 RB1_mut 291 KIN001-266 MAP3K8 (COT) 6 13 2.99573227355399 NA 3.63635872629026 3.66427530549887 -0.0279165792086036 1.21623916793142 1.14597642346799 0.0239199988145879 0.0229531986345121 0.0243605179276913 0.961910197719317 NA NA NA 0.963234582136591 86.6120664075338 a2381 loss_cnaBLCA18_(CHD9,CNOT1,CYLD,MMP2,NUP93) 1072 BMS-708163 g-secretase 3 15 1.6094379124341 NA 3.45538560555846 3.43552463140107 0.0198609741573907 0.835408104573986 0.619431827575821 0.030538286019203 0.0237739783091029 0.032063212242609 0.962086489102091 NA NA NA 0.97177081974056 86.6120664075338 a2382 gain_cnaBLCA15_(ASXL1) 1377 Afatinib (rescreen) ERBB2, EGFR 6 12 2.30258509299405 NA 3.37023002666171 3.33716766140412 0.0330623652575861 0.933012927697447 1.53565551581684 0.0240282124363367 0.0354361277063756 0.0215298059473968 0.962266030508828 NA NA NA 0.955630308876853 86.6120664075338 a2383 RB1_mut 1036 PLX4720 BRAF 5 10 2.30258509299405 NA 3.76796467041268 3.74976694877496 0.0181977216377249 0.852400570696506 0.603478583977556 0.0263847565546235 0.0213487910066219 0.0301547099116308 0.96231157033786 NA NA NA 0.967317010501444 86.6120664075338 a2384 EP300_mut 1175 AG-014699 PARP1, PARP2 4 15 1.6094379124341 NA 3.1161693757895 3.13984125041664 -0.0236718746271363 0.954803160142617 0.869956891044737 0.0267321531203431 0.0247924133636094 0.0272103995850973 0.962664936477466 NA NA NA 0.966164951893034 86.6120664075338 a2385 loss_cnaBLCA18_(CHD9,CNOT1,CYLD,MMP2,NUP93) 1371 PLX4720 (rescreen) BRAF 3 15 2.30258509299405 NA 3.90545702513535 3.93320436249553 -0.0277473373601738 0.823623609264407 0.952945762398804 0.0295890701587126 0.033689341888773 0.0291174361175884 0.963264019881899 NA NA NA 0.961752069421921 86.62962869577 a2386 EP300_mut 135 Gemcitabine DNA replication 4 15 0.0237165266173161 NA -2.28810170881758 -2.36266688846141 0.0745651796438298 2.94085323073121 2.94191292099727 0.0253474256435907 0.0253549476269817 0.0253458146608069 0.964597473276693 NA NA NA 0.965899693154366 86.7131929884839 a2387 gain_cnaBLCA9 199 Pazopanib VEGFR, PDGFRA, PDGFRB, KIT 4 15 2.07944154167984 NA 2.89209359663101 2.85714151096673 0.0349520856642704 1.48645540471343 1.38456463791709 0.0249109158636675 0.0235137129263618 0.0252440981858757 0.965206717433264 NA NA NA 0.968012116871434 86.731611221779 a2388 NRAS_mut 196 Phenformin AAPK1 (AMPK) agonist 3 16 8.29404964010203 NA 8.96592825681965 9.00115563461137 -0.0352273777917205 1.82793040342233 1.18938395040684 0.027497029088707 0.0192717281389742 0.0296181714741238 0.965648929915709 NA NA NA 0.97691625080208 86.7350111710577 a2389 EP300_mut 201 Epothilone B Microtubules 4 15 -3.44201937618241 NA -5.19432233814244 -5.25241787962249 0.058095541480049 2.94729059365401 2.33694243655386 0.0236574374308597 0.0197115077845185 0.0248596373497837 0.966956340473944 NA NA NA 0.972618288072497 86.8160882160283 a2390 EP300_mut 293 MP470 PDGFR 4 15 2.99573227355399 NA 3.9459281864118 3.97980826707966 -0.0338800806678559 0.99410206242927 1.55077407784083 0.0230797317063353 0.0340810888019523 0.0218472059547369 0.967762769301666 NA NA NA 0.959056893059377 86.8183778539356 a2391 MLL2_mut 328 SNX-2112 HSP90 3 15 0.940007258491471 NA -0.4143178072178 -0.468520094636364 0.0542022874185648 1.3365892348744 2.19507901279173 0.0257250511538778 0.0405526888922297 0.0246926361660347 0.968058328383523 NA NA NA 0.957255493400861 86.8183778539356 a2392 gain_cnaBLCA15_(ASXL1) 155 AP-24534 ABL 6 13 -0.669430653942629 NA 0.225065460962884 0.205111812598471 0.0199536483644127 1.1266226224453 0.985221068416039 0.0193945212604993 0.0177110311535409 0.0202529655567482 0.969112107280085 NA NA NA 0.971089592961791 86.8183778539356 a2393 gain_cnaBLCA15_(ASXL1) 194 AUY922 HSP90 6 13 -1.36257783450257 NA -2.76604318469903 -2.80998251639161 0.0439393316925796 2.18778242859247 2.3024061682505 0.01936255244038 0.0200839585867084 0.0190840922416253 0.969162993444407 NA NA NA 0.968843134039784 86.8183778539356 a2394 EP300_mut 291 KIN001-266 MAP3K8 (COT) 4 15 2.99573227355399 NA 3.67553955319654 3.65010487442938 0.0254346787671529 1.27176037012922 1.14343983760799 0.021792866854418 0.0199995843277995 0.0222440026406293 0.969559252810514 NA NA NA 0.972650479587582 86.8183778539356 a2395 gain_cnaBLCA23_(MYC) 164 JQ12 HDAC 4 15 1.63315443905142 NA 1.20590801299341 1.23844223782822 -0.0325342248348071 1.85497515599936 1.42084258005362 0.0215948680199585 0.0175389005775009 0.0228978391354089 0.969835677489214 NA NA NA 0.975544572934447 86.8183778539356 a2396 NRAS_mut 197 Bryostatin 1 PRKC 3 16 -4.8283137373023 NA -3.08174818516442 -3.1021072122142 0.0203590270497824 0.888579064407374 0.842002002341681 0.0240192054322782 0.0229118914289981 0.0241793095422127 0.969991256387148 NA NA NA 0.97323843778664 86.8183778539356 a2397 EP300_mut 345 KIN001-270 CDK9 4 15 2.99573227355399 NA 4.90988153879775 4.92951256896778 -0.0196310301700313 0.724226012508643 0.97692703235263 0.0209443121550524 0.0271062207528717 0.0200946739315381 0.970743941250968 NA NA NA 0.965895417300081 86.8183778539356 a2398 NRAS_mut 269 NSC-207895 MDM4 3 16 2.99573227355399 NA 3.57896783585141 3.60921508983668 -0.0302472539852725 1.78670829515275 1.25772020044266 0.0227267122649827 0.016929038762137 0.0240492710339127 0.971605286880938 NA NA NA 0.979798036927373 86.8183778539356 a2399 loss_cnaBLCA5_(FAT1,IRF2) 1053 MK-2206 AKT1, AKT2 3 12 1.38629436111989 0.693147180559945 1.92634455949672 1.95262381712128 -0.0262792576245567 1.36882809449512 1.08120534659207 0.023251263302049 0.0191983622561821 0.0243055194902506 0.971813089837943 NA NA NA 0.977497523227858 86.8183778539356 a2400 CDKN1A_mut 1242 (5Z)-7-Oxozeaenol MAP3K7 (TAK1) 3 16 2.30258509299405 NA 0.564059818998927 0.541056764757464 0.023003054241463 0.651826578884034 1.0709042502749 0.0223225476937818 0.0352901446284157 0.0214800288966619 0.972110023027576 NA NA NA 0.962463011486894 86.8183778539356 a2401 NRAS_mut 271 VNLG/124 HDAC, RAR 3 16 1.63315443905142 NA 3.9536748043937 3.94294741843261 0.0107273859610988 0.667947105371539 0.46034426269575 0.0219212166486974 0.0160602327262602 0.0233029643907797 0.972611232611435 NA NA NA 0.980813712559777 86.8183778539356 a2402 EP300_mut 172 Embelin XIAP 4 15 3.46573590279973 NA 2.73677685498607 2.72206799518196 0.0147088598041094 0.42085826102031 0.820697221640406 0.0192155329493182 0.0349496758563083 0.0179223950273761 0.973157747900728 NA NA NA 0.961689823043408 86.8183778539356 a2403 gain_cnaBLCA15_(ASXL1) 1004 Vinblastine Microtubules 4 10 -2.30258509299405 NA -4.40052731180973 -4.37157966738289 -0.0289476444268404 1.26919126064267 1.50022648457547 0.0200200502608353 0.0228079449681859 0.0192955161933646 0.973561062301756 NA NA NA 0.971935564904126 86.8183778539356 a2404 MLL2_mut 269 NSC-207895 MDM4 3 16 2.99573227355399 NA 3.6281111273235 3.60000072268567 0.0281104046378311 1.68988804690675 1.27544571075454 0.0211210490828215 0.0166344774668865 0.0220396716228723 0.973610571433737 NA NA NA 0.980226902332715 86.8183778539356 a2405 RB1_mut 1268 XAV 939 TNKS1 (tankyrase-1) 6 12 1.6094379124341 NA 3.19714325793488 3.21002785283935 -0.0128845949044742 0.503689369201633 0.865917698831329 0.0167067886633582 0.0255804384454189 0.0148796992160614 0.973758072735258 NA NA NA 0.96875857981099 86.8183778539356 a2406 loss_cnaBLCA5_(FAT1,IRF2) 266 Zibotentan, ZD4054 Endothelin A Receptor 5 14 2.99573227355399 NA 5.46544146266296 5.45872536341151 0.00671609925144612 0.439326237258031 0.370379067601162 0.0173226341642261 0.0152872710115456 0.0181330421693222 0.973862835027935 NA NA NA 0.976610409878059 86.8183778539356 a2407 EP300_mut 1004 Vinblastine Microtubules 3 11 -2.30258509299405 NA -4.35592688102153 -4.38637502527302 0.0304481442514941 0.879974069997345 1.53428012736519 0.0210577009795381 0.0346011834775836 0.0198452314596438 0.974740508651555 NA NA NA 0.966120472512662 86.823371370555 a2408 NRAS_mut 172 Embelin XIAP 3 16 3.46573590279973 NA 2.73818730871101 2.72272283884629 0.0154644698647171 1.00314506340887 0.727940430252243 0.0202025755334372 0.0154159856124557 0.0212441419957377 0.974757719594837 NA NA NA 0.981633132993422 86.823371370555 a2409 TP53_mut 192 LFM-A13 BTK 15 4 2.77258872223978 NA 4.3866550997033 4.39842714254577 -0.0117720428424679 0.56270037311765 1.04244531614478 0.0174997026054418 0.0209206238432805 0.0112927197812196 0.975553739874555 NA NA NA 0.983831521025821 86.823371370555 a2410 ARID1A_mut 1030 KU-55933 ATM 5 10 2.30258509299405 NA 3.50726585504338 3.490736669145 0.0165291858983774 0.905925578199444 1.00651152402412 0.0169240930435844 0.0182456333016114 0.0164222520098849 0.97581941607527 NA NA NA 0.975110902728624 86.823371370555 a2411 loss_cnaBLCA5_(FAT1,IRF2) 274 PXD101, Belinostat HDAC 5 14 2.99573227355399 NA 0.435294748091225 0.457846757783365 -0.0225520096921398 0.989176489963967 1.56867705355714 0.0155181772535921 0.0227987724343927 0.0143764515717245 0.976584578322345 NA NA NA 0.971115230930902 86.823371370555 a2412 MLL2_mut 274 PXD101, Belinostat HDAC 3 16 2.99573227355399 NA 0.429027663165859 0.456202834995354 -0.0271751718294949 0.62460708534744 1.53021437877274 0.0186994015833918 0.043507626581563 0.0177590618716378 0.976635264106882 NA NA NA 0.960086249037418 86.823371370555 a2413 ARID1A_mut 1192 GSK269962A ROCK1, ROCK2 5 14 1.6094379124341 NA 1.83397275305349 1.81903066218715 0.0149420908663314 0.870794906063612 1.01042013296316 0.0152570009107381 0.0171591390375449 0.0147879979613155 0.976978547760716 NA NA NA 0.975601808336516 86.823371370555 a2414 gain_cnaBLCA9 180 Thapsigargin sarco-endoplasmic reticulum Ca2+-ATPases 4 15 -0.669430653942629 NA -4.38495555079974 -4.35693890014075 -0.0280166506589827 0.777382443089437 1.8534564925328 0.0163515581425703 0.0360397265310498 0.0151158933440608 0.977157148927618 NA NA NA 0.964459693449187 86.823371370555 a2415 loss_cnaBLCA18_(CHD9,CNOT1,CYLD,MMP2,NUP93) 1527 GDC0941 (rescreen) PI3K 3 16 1.38629436111989 NA 0.828368380108242 0.847731308484635 -0.0193629283763923 0.813279175462251 1.22719297402009 0.0163259894813907 0.0238084644985368 0.0157782262336154 0.979600065487603 NA NA NA 0.974124817087756 86.9936376245375 a2416 ARID1A_mut 1527 GDC0941 (rescreen) PI3K 5 14 1.38629436111989 NA 0.833024264608781 0.848834625216784 -0.0158103606080029 0.883111589880818 1.26470935812866 0.0133306096237622 0.0179030156428324 0.0125011810076244 0.979884580109728 NA NA NA 0.976317665846373 86.9936376245375 a2417 gain_cnaBLCA23_(MYC) 147 NSC-87877 PTPN6 (SHP-1), PTPN11 (SHP-2) 4 15 2.77258872223978 NA 5.05671497772317 5.06647743614181 -0.00976245841863665 0.653164586092205 0.717085699368212 0.0138234191048628 0.0149463988503175 0.013614074896819 0.980688095666834 NA NA NA 0.980236120799366 87.0289513960974 a2418 RB1_mut 140 Vinorelbine Microtubules 6 13 -2.74887219562247 NA -3.99987758327878 -3.98419915701324 -0.0156784262655396 0.994124766026226 1.44834942588268 0.0117799273499757 0.0157710850804073 0.0108250301932385 0.981235953470785 NA NA NA 0.978483374846144 87.0415575712271 a2419 ARID1A_mut 170 Shikonin unknown 5 14 2.77258872223978 NA -0.183500530931048 -0.200732865523034 0.017232334591986 0.93662979236911 1.64609954514805 0.0114161527672324 0.0183982345344777 0.0104685859629687 0.9827728974331 NA NA NA 0.977803651217225 87.1418549715726 a2420 TP53_mut 1371 PLX4720 (rescreen) BRAF 14 4 2.30258509299405 NA 3.92611367127779 3.93721127873747 -0.0110976074596723 0.876867544711296 1.16562931700411 0.0118335641993767 0.0126559678558135 0.00952070036141097 0.983605490180699 NA NA NA 0.98674601980366 87.179640909698 a2421 NRAS_mut 1009 ATRA Retinoic acid and retinoid X receptor agonist 3 11 2.30258509299405 NA 4.02379443738232 4.01809934995887 0.00569508742344915 0.241631944531275 0.470078783512362 0.012934162466577 0.0235692653738175 0.0121151764836019 0.984483170428473 NA NA NA 0.977975506748786 87.2213902103007 a2422 loss_cnaBLCA18_(CHD9,CNOT1,CYLD,MMP2,NUP93) 1015 CI-1040 MAP2K1 (MEK1), MAP2K2 (MEK2) 3 11 2.30258509299405 NA 2.27655466108431 2.28904839362606 -0.0124937325417465 0.947096976734894 1.14873279552209 0.0111785146738179 0.0131916085138593 0.0108760998122876 0.986589140777892 NA NA NA 0.985569608804025 87.3005147241519 a2423 loss_cnaBLCA5_(FAT1,IRF2) 1268 XAV 939 TNKS1 (tankyrase-1) 4 14 1.6094379124341 NA 3.19993617959085 3.20738921880843 -0.00745303921757623 0.737240341179645 0.778874150477867 0.00966372155389271 0.010109375194595 0.00956899033432233 0.986611299312425 NA NA NA 0.986621753058169 87.3005147241519 a2424 EP300_mut 1264 SGC0946 Q8TEK3 (DOT1L) 3 15 -0.693147180559945 NA 1.58127834615281 1.58564615466781 -0.00436780851500007 0.216641168799543 0.475091682070185 0.00968558224458549 0.0201614888767591 0.00919361184343956 0.987970812092438 NA NA NA 0.980825364365206 87.3005147241519 a2425 loss_cnaBLCA18_(CHD9,CNOT1,CYLD,MMP2,NUP93) 1502 Bicalutamide ANDR (androgen receptor) 3 14 2.30258509299405 NA 4.28842542147234 4.29448341019073 -0.00605798871838736 0.483705203668122 0.645358662218766 0.00967388981629677 0.0125241338576623 0.0093870107787192 0.988068621476876 NA NA NA 0.986218717452052 87.3005147241519 a2426 loss_cnaBLCA5_(FAT1,IRF2) 329 QL-XI-92 DDR1 5 14 2.32630161961136 NA 4.24907964828701 4.24163666986933 0.00744297841768837 1.0144534178338 0.925724532925149 0.00785663116919389 0.00733693463577817 0.00804016546279669 0.988143726680479 NA NA NA 0.988936729511154 87.3005147241519 a2427 ARID1A_mut 1241 CHIR-99021 GSK3B 5 14 2.30258509299405 NA 3.61921285496309 3.61243946715089 0.00677338781219783 1.00910933702433 0.872689877765892 0.00747089152697635 0.00671224372194521 0.00776150610287571 0.988725794751734 NA NA NA 0.989774959222182 87.3005147241519 a2428 loss_cnaBLCA18_(CHD9,CNOT1,CYLD,MMP2,NUP93) 279 BIX02189 MAP2K5 (MEK5) 3 16 2.99573227355399 NA 4.69691134245317 4.68738817407529 0.00952316837787581 0.662227253677483 1.15299195712663 0.00860571537148708 0.0143805141286344 0.00825952715369192 0.989245914043312 NA NA NA 0.984945763576487 87.3005147241519 a2429 loss_cnaBLCA5_(FAT1,IRF2) 1264 SGC0946 Q8TEK3 (DOT1L) 4 14 -0.693147180559945 NA 1.58755350649005 1.58416523803682 0.00338826845322981 0.453603899735924 0.450348477495736 0.00751344576027027 0.00746966341162935 0.00752365917182854 0.989590208825385 NA NA NA 0.989997911204566 87.3005147241519 a2430 loss_cnaBLCA5_(FAT1,IRF2) 1114 Cetuximab EGFR 4 14 4.18661983833127 NA 5.80758749087725 5.81195309677405 -0.00436560589680468 0.603296720142043 0.579861475403926 0.0074711668887257 0.00723625000940967 0.00752870484069258 0.989648782094372 NA NA NA 0.990255704973802 87.3005147241519 a2431 RB1_mut 266 Zibotentan, ZD4054 Endothelin A Receptor 6 13 2.99573227355399 NA 5.45887466106055 5.46123957190097 -0.00236491084041823 0.395429156695964 0.384458580289644 0.00609957295448692 0.00598061827351936 0.00615127600647266 0.990283378816941 NA NA NA 0.990498569484703 87.3005147241519 a2432 CDKN1A_mut 230 GSK429286A ROCK2 3 16 2.99573227355399 2.32630161961136 4.78691995953369 4.80025953933793 -0.0133395798042422 1.34984606019497 1.76777359129563 0.00773814741442019 0.00988229709861535 0.00754597753350605 0.990330004550943 NA NA NA 0.988941741799722 87.3005147241519 a2433 loss_cnaBLCA5_(FAT1,IRF2) 1037 BX-795 TBK1, PDPK1, IKK, AURKB, AURKC 3 12 1.6094379124341 NA 1.93946421908227 1.94920803522505 -0.00974381614277453 1.07810404221724 1.28544519907579 0.00775919430486041 0.00903791819826153 0.00758011010487273 0.990591781199907 NA NA NA 0.98998503460302 87.3005147241519 a2434 gain_cnaBLCA9 225 Genentech Cpd 10 AURKA, AURKB 4 15 2.32630161961136 NA 3.01300151544114 3.02358222066697 -0.0105807052258284 2.59452875423289 1.26659724657193 0.00667969535155765 0.00407808362446026 0.00835364616058129 0.990667419863046 NA NA NA 0.994132638457543 87.3005147241519 a2435 loss_cnaBLCA5_(FAT1,IRF2) 199 Pazopanib VEGFR, PDGFRA, PDGFRB, KIT 5 14 2.07944154167984 NA 2.8697933951473 2.86260929109204 0.00718410405526271 1.71613767365248 1.29169155500435 0.00511994642640842 0.00418620496802723 0.00556177984398026 0.992273420445307 NA NA NA 0.993479083575366 87.3471703339658 a2436 loss_cnaBLCA18_(CHD9,CNOT1,CYLD,MMP2,NUP93) 1019 Bosutinib SRC, ABL, TEC 3 11 0.693147180559945 NA 1.44087325322397 1.4346783215668 0.00619493165716989 1.37045355227809 0.933312448809935 0.00607779487150848 0.00452035141714372 0.00663757529974987 0.992708198978979 NA NA NA 0.994656162634681 87.3471703339658 a2437 MLL2_mut 167 OSU-03012 PDPK1 (PDK1) 3 16 2.77258872223978 NA 1.86598293453599 1.87660877047433 -0.0106258359383435 3.23775154750912 1.66419904294376 0.00554133924076561 0.00328185649282394 0.00638495496280766 0.993075161370434 NA NA NA 0.996035106890401 87.3471703339658 a2438 gain_cnaBLCA9 1091 BMS-536924 IGF1R 4 15 1.38629436111989 NA 2.38960081953828 2.39431083461302 -0.00471001507473945 0.793026019371994 1.07436638831865 0.0045714293587618 0.00593929449940288 0.00438399332476371 0.993612913084373 NA NA NA 0.99253373125195 87.3471703339658 a2439 MLL2_mut 1230 IOX2 EGLN1 3 16 -2.30258509299405 NA -0.154062243717111 -0.150455785313641 -0.00360645840346913 0.111471439677842 0.752880627167251 0.00509213446022067 0.0323532055734813 0.00479021278185706 0.993636505008031 NA NA NA 0.985746350533549 87.3471703339658 a2440 EP300_mut 1239 YK 4-279 RNA helicase A 3 14 2.30258509299405 NA 1.23939550606268 1.23416440360114 0.00523110246154346 0.892649154770837 1.03197640438603 0.00515630717784044 0.00586019987089597 0.00506901363181426 0.993640235292442 NA NA NA 0.993378292087617 87.3471703339658 a2441 CDKN1A_mut 272 AR-42 HDAC 3 16 1.63315443905142 NA 0.0515256115599862 0.0583847293315511 -0.00685911777156484 1.16849792284861 1.48170318236047 0.00473573285799293 0.0058700299225551 0.00462921174309534 0.994081880669296 NA NA NA 0.993394329295027 87.350194455474 a2442 RB1_mut 271 VNLG/124 HDAC, RAR 6 13 1.63315443905142 NA 3.94543920740616 3.94427291258968 0.00116629481648189 0.488926585317491 0.489565996670672 0.00238321862830222 0.0023854191027975 0.00238230355950651 0.996203445446498 NA NA NA 0.996241984905013 87.3623425836552 a2443 gain_cnaBLCA23_(MYC) 1009 ATRA Retinoic acid and retinoid X receptor agonist 4 10 2.30258509299405 NA 4.01848100099199 4.01965521577266 -0.0011742147806677 0.549059649566604 0.397518082918093 0.00266672781995821 0.00213859237624648 0.00295386507211962 0.99647754281954 NA NA NA 0.997069921020311 87.3623425836552 a2444 loss_cnaBLCA5_(FAT1,IRF2) 1526 RDEA119 (rescreen) MAP2K1 (MEK1), MAP2K2 (MEK2) 5 14 1.6094379124341 NA 1.43821034379557 1.44044185645411 -0.00223151265854216 0.570637467273456 1.07310206261616 0.0022808404222388 0.00391056105937886 0.00207949712919372 0.996557906225751 NA NA NA 0.995445670673697 87.3623425836552 a2445 EP300_mut 1054 PD-0332991 CDK4, CDK6 4 11 1.38629436111989 0.693147180559945 1.94503281389956 1.9494796892968 -0.00444687539723576 1.43558906333124 1.86064950595601 0.00251004234524509 0.00309759631834818 0.00238995865852282 0.99663521948875 NA NA NA 0.996241557351812 87.3623425836552 a2446 MLL2_mut 295 NVP-BHG712 EPHB4 3 16 2.32630161961136 NA 3.64007248496629 3.63629023478074 0.00378225018555423 1.43460780410119 1.4953971011114 0.00254119559264282 0.00263643497180325 0.00252926141340196 0.996824312882119 NA NA NA 0.996950343081357 87.3623425836552 a2447 NRAS_mut 1047 Nutlin-3a MDM2 3 12 2.07944154167984 1.38629436111989 3.73300136337173 3.72996807870804 0.0030332846636929 0.90173473569479 1.24958374186144 0.00252219864905859 0.00336383255920129 0.00242743608297462 0.996941699589287 NA NA NA 0.996397534935673 87.3623425836552 a2448 gain_cnaBLCA23_(MYC) 265 Tubastatin A HDAC6 4 15 2.99573227355399 NA 4.83838880343712 4.84026796931272 -0.00187916587559656 1.03087940320996 0.928781961517605 0.00198308168495993 0.00182287653603825 0.0020232583679016 0.997229261607574 NA NA NA 0.997507265862744 87.3623425836552 a2449 EP300_mut 1011 ABT-263 BCL2, BCL2L1, BCL2L2 4 11 0.693147180559945 NA 2.25213662291059 2.2505620661389 0.00157455677168361 0.784189366756247 0.852343332658668 0.00188094787254355 0.00200787824782255 0.00184732690613322 0.997478534192532 NA NA NA 0.997432555330129 87.3623425836552 a2450 MLL2_mut 185 OSI-906 IGF1R 3 16 0.940007258491471 NA 2.27515741475102 2.27368529257288 0.00147212217814152 0.458944934367756 1.33310702817315 0.0011664147379423 0.00320762267518983 0.00110427906164359 0.998542348851259 NA NA NA 0.997309323361217 87.4198187265007 a2451 loss_cnaBLCA18_(CHD9,CNOT1,CYLD,MMP2,NUP93) 249 XL-184 VEGFR, MET, RET, KIT, FLT1, FLT3, FLT4, Tie2,AXL 3 16 1.63315443905142 NA 3.06848295166514 3.06786518515205 0.000617766513091755 0.516239414133036 1.03366786471253 0.000625918901177379 0.00119666669413303 0.000597645079412 0.999217798121301 NA NA NA 0.998803782840829 87.4432614486481 a2452 gain_cnaBLCA23_(MYC) 328 SNX-2112 HSP90 4 14 0.940007258491471 NA -0.459900502321742 -0.459368059422278 -0.000532442899463581 2.80038715052868 1.91172469530939 0.000252690678876881 0.000190131889215054 0.000278514422484567 0.999649889145463 NA NA NA 0.999732774142383 87.4453970378914